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Extract from the Register of European Patents

EP About this file: EP3119406

EP3119406 - METHODS FOR IMPROVING COGNITIVE FUNCTION VIA MODULATION OF QUINONE REDUCTASE 2 [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.11.2021
Database last updated on 20.07.2024
FormerThe patent has been granted
Status updated on  18.12.2020
FormerGrant of patent is intended
Status updated on  11.08.2020
FormerExamination is in progress
Status updated on  12.04.2019
FormerRequest for examination was made
Status updated on  23.12.2016
FormerThe international publication has been made
Status updated on  16.11.2016
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR
published on 17.07.2024  [2024/29]
Applicant(s)For all designated states
Carmel-Haifa University Economic Corporation Ltd
Eshkol Tower, University of Haifa
Mount Carmel
3498838 Haifa / IL
[2017/04]
Inventor(s)01 / ROSENBLUM, Kobi
c/o Carmel-Haifa University Economic Corp. Ltd
Eshkol Tower
Haifa University
Mount Carmel
3498838 Haifa / IL
02 / RAPPAPORT, Akiva
c/o Carmel-Haifa University Economic Corp. Ltd
Eshkol Tower
Haifa University
Mount Carmel
3498838 Haifa / IL
 [2017/04]
Representative(s)Balder IP Law, S.L.
Paseo de la Castellana 93
5ª planta
28046 Madrid / ES
[2021/03]
Former [2017/04]Balder IP Law, S.L.
Castellana 93
28046 Madrid / ES
Application number, filing date15764336.218.03.2015
[2017/04]
WO2015IL50284
Priority number, dateUS201461954687P18.03.2014         Original published format: US 201461954687 P
[2017/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015140799
Date:24.09.2015
Language:EN
[2015/38]
Type: A1 Application with search report 
No.:EP3119406
Date:25.01.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 24.09.2015 takes the place of the publication of the European patent application.
[2017/04]
Type: B1 Patent specification 
No.:EP3119406
Date:20.01.2021
Language:EN
[2021/03]
Search report(s)International search report - published on:IL24.09.2015
(Supplementary) European search report - dispatched on:EP10.11.2017
ClassificationIPC:A61K31/713, A61K31/7105, A61K48/00, A61K31/05, A61P25/28, A61K31/352, A61K31/10, A61K31/136, A61K31/407
[2017/04]
CPC:
C12N15/1137 (EP,US); A61K31/05 (IL); A61K31/10 (IL);
A61K31/136 (IL); A61K31/165 (EP,IL,US); A61K31/255 (EP,US);
A61K31/352 (IL); A61K31/404 (EP,IL,US); A61K31/4045 (EP,IL,US);
A61K31/407 (IL); A61K31/4375 (EP,IL,US); A61K31/455 (EP,IL,US);
A61K31/7064 (EP,IL,US); A61K31/7105 (EP,IL,US); A61K31/713 (EP,IL,US);
A61K48/00 (IL); A61P25/28 (EP); C12Y106/05005 (EP,US);
C12N2310/14 (EP,US); C12N2310/531 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/04]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:VERFAHREN ZUR VERBESSERUNG DER KOGNITIVEN FUNKTION DURCH MODULATION VON CHINON-REDUKTASE 2[2017/04]
English:METHODS FOR IMPROVING COGNITIVE FUNCTION VIA MODULATION OF QUINONE REDUCTASE 2[2017/04]
French:PROCÉDÉS POUR AMÉLIORER LA FONCTION COGNITIVE PAR L'INTERMÉDIAIRE DE LA MODULATION DE L'ACTIVITÉ DE LA QUINONE RÉDUCTASE 2[2017/04]
Entry into regional phase13.10.2016National basic fee paid 
13.10.2016Search fee paid 
13.10.2016Designation fee(s) paid 
13.10.2016Examination fee paid 
Examination procedure13.10.2016Examination requested  [2017/04]
13.10.2016Date on which the examining division has become responsible
22.05.2018Amendment by applicant (claims and/or description)
16.04.2019Despatch of a communication from the examining division (Time limit: M04)
14.08.2019Reply to a communication from the examining division
19.12.2019Despatch of a communication from the examining division (Time limit: M04)
21.04.2020Reply to a communication from the examining division
12.08.2020Communication of intention to grant the patent
09.12.2020Fee for grant paid
09.12.2020Fee for publishing/printing paid
09.12.2020Receipt of the translation of the claim(s)
Opposition(s)21.10.2021No opposition filed within time limit [2021/52]
Fees paidRenewal fee
24.03.2017Renewal fee patent year 03
23.03.2018Renewal fee patent year 04
26.03.2019Renewal fee patent year 05
24.03.2020Renewal fee patent year 06
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.03.2015
AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
DK20.01.2021
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IE18.03.2021
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BE31.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
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PT20.05.2021
[2024/29]
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Documents cited:Search[I]WO2008144455  (HELICON THERAPEUTICS INC [US], et al) [I] 1-12 *cf. abstract, page 3, lines 1-5, claims 1, 6, 26 and 35*;
 [Y]  - ANTOINE M ET AL, "Characterization of cofactors, substrates and inhibitor binding to flavoenzyme quinone reductase 2 by automated supramolecular nano-electrospray ionization mass spectrometry", INSPEC, THE INSTITUTION OF ELECTRICAL ENGINEERS, STEVENAGE, GB, (20120215), Database accession no. 13163738, XP002774960 [Y] 1-12 * abstract *

DOI:   http://dx.doi.org/10.1016/j.ijms.2011.07.011
 [Y]  - CAI JING-BO ET AL, "NEGATIVE REGULATION OF QUINONE REDUCTASE 2 BY RESVERATROL IN CULTURED VASCULAR SMOOTH MUSCLE CELLS", vol. 35, no. 12, doi:10.1111/J.1440-1681.2008.05006.X, ISSN 0305-1870, (20081201), pages 1419 - 1425, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, WILEY-BLACKWELL PUBLISHING ASIA, AU, URL: http://epo.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07b9swECbaTl36SIrUaQtwKDJFqB4kZY2qLDsGFMnVw0AmQqKpLEkQxCkQ__veUawVAx2KoppOL0KiPt6DuvtIyFeP-S3vW-V4QccdpoLWiXg_dVq28cE9Epr1WI18lbB6EZYLlo3l0QM9xH6-DQeGUdfPxvf-h6SYejYXkuMvhadvbYezA-oRFDJaRQD3is3GfA-7rFqA1JuA0sO0nj-2eGCrrMYea572FsuU3h86t8Y6, XP009500819 [Y] 1-12 *cf. summary*

DOI:   http://dx.doi.org/10.1111/j.1440-1681.2008.05006.x
 [Y]  - BURYANOVSKYY LEONID ET AL, "Crystal structure of quinone reductase 2 in complex with resveratrol", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20040914), vol. 43, no. 36, doi:10.1021/BI049162O, ISSN 0006-2960, pages 11417 - 11426, XP009500820 [Y] 1-12 *cf. abstract, right-hand col. at page 11424*

DOI:   http://dx.doi.org/10.1021/bi049162o
 [Y]  - CHOMARAT ET AL, "Cellular knock-down of quinone reductase 2: A laborious road to successful inhibition by RNA interference", BIOCHIMIE, MASSON, PARIS, FR, (20071001), vol. 89, no. 10, doi:10.1016/J.BIOCHI.2007.07.004, ISSN 0300-9084, pages 1264 - 1275, XP022323805 [Y] 1-12 *cf. abstract*

DOI:   http://dx.doi.org/10.1016/j.biochi.2007.07.004
International search[X]WO0238141  (MASSACHUSETTS INST TECHNOLOGY [US], et al) [X] 1, 7-13, 15-17, 23-26, 29 * examples, claims *;
 [X]WO2008013764  (TOPPO FRANK [US], et al) [X] 1, 7-13, 15-17, 23-26, 29 * examples, claims *;
 [X]  - BENOIT, CHARLES-ETIENNE et al., "Loss of quinone reductase 2 function selectively facilitates learning behaviors.", The Journal of Neuroscience, vol. 30, no. 38, ISSN 0270-6474, (20100922), pages 12690 - 12700., URL: http://www.jneurosci.org/content/30/38/12690.full, XP055225330 [X] 1-31 * Figs 4-5 *

DOI:   http://dx.doi.org/10.1523/JNEUROSCI.2808-10.2010
 [X]  - WU, YUANYUAN., "Neuroprotective effects of lithium on scopolamine-induced amnesia through decreasing quinone reductase 2 in rats.", Alzheimer's & Dementia, vol. 8.4, (20120731), pages 199 - 200., URL: http://www.alzheimersanddementia.com/article/S1552-5260(12)00678-4/fulltext [X] 131 * abstract *
 [PX]  - FITZPATRICK, JESSE et al., "Inhibition Of Quinone Oxidoreductase 2 Improves Learning In A Mouse Model Of Vascular Dementia (P1. 237).", Neurology, vol. 82.10, (20140428), pages 1 - 237, URL: http://www.neurology.org/content/82/10_Supplement/P1.237, XP055358453 [PX] 1-31 * abstract *
 [A]  - HASHIMOTO, TETSUYA; et al., "Increased hippocampal quinone reductase 2 in Alzheimer's disease.", Neuroscience letters, (20110908), vol. 502.1, pages 10 - 12, XP028383453 [A] 1-31 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.neulet.2011.07.008
by applicantUS6610287
 US7749973
 US2013287736
    - BENOIT et al., "Loss of quinone reductase 2 function selectively facilitates learning behaviors.", The Journal ofNeuroscience, (20100922), vol. 30, no. 38, doi:doi:10.1523/JNEUROSCI.2808-10.2010, ISSN 0270-6474, pages 12690 - 12700, XP055225330

DOI:   http://dx.doi.org/10.1523/JNEUROSCI.2808-10.2010
    - HASHIMOTO et al., "Increased hippocampal quinone reductase 2 in Alzheimer's disease", Neuroscience letters, (20110908), vol. 502, no. 1, doi:doi:10.1016/j.neulet.2011.07.008, pages 10 - 12, XP028383453

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