blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3212794

EP3212794 - POLYNUCLEOTIDE AGENTS TARGETING SERPINC1 (AT3) AND METHODS OF USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.02.2022
Database last updated on 23.04.2024
FormerThe patent has been granted
Status updated on  05.03.2021
FormerGrant of patent is intended
Status updated on  18.10.2020
FormerExamination is in progress
Status updated on  13.07.2018
FormerRequest for examination was made
Status updated on  04.08.2017
FormerThe international publication has been made
Status updated on  31.03.2017
Most recent event   Tooltip23.06.2023Lapse of the patent in a contracting state
New state(s): CY
published on 26.07.2023  [2023/30]
Applicant(s)For all designated states
Genzyme Corporation
50 Binney Street
Cambridge, MA 02142 / US
[2019/07]
Former [2017/36]For all designated states
Alnylam Pharmaceuticals, Inc.
300 Third Street, 3rd Floor
Cambridge, MA 02142 / US
Inventor(s)01 / HINKLE, Gregory
300 Third Street 3rd Floor
Cambridge, MA 02142 / US
 [2017/36]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2017/36]
Application number, filing date15795074.228.10.2015
[2017/36]
WO2015US57717
Priority number, dateUS201462072686P30.10.2014         Original published format: US 201462072686 P
[2017/36]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2016069694
Date:06.05.2016
Language:EN
[2016/18]
Type: A2 Application without search report 
No.:EP3212794
Date:06.09.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 06.05.2016 takes the place of the publication of the European patent application.
[2017/36]
Type: B1 Patent specification 
No.:EP3212794
Date:07.04.2021
Language:EN
[2021/14]
Search report(s)International search report - published on:EP23.06.2016
(Supplementary) European search report - dispatched on:EP13.07.2018
ClassificationIPC:C12N15/113, A61K31/7088, C07H21/02
[2017/36]
CPC:
C12N15/113 (EP,US); C12N2310/11 (EP,US); C12N2310/315 (EP,US);
C12N2310/3231 (EP,US); C12N2310/3341 (EP,US); C12N2310/341 (EP,US);
C12N2310/346 (EP,US); C12N2310/351 (EP,US); C12N2320/35 (EP,US) (-)
C-Set:
C12N2310/321, C12N2310/3521 (US,EP);
C12N2310/321, C12N2310/3525 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/36]
Extension statesBA30.03.2017
ME30.03.2017
Validation statesMANot yet paid
TitleGerman:POLYNUKLEOTIDWIRKSTOFFE MIT ABZIELUNG AUF SERPINC1 (AT3) UND VERFAHREN ZUR VERWENDUNG DAVON[2017/36]
English:POLYNUCLEOTIDE AGENTS TARGETING SERPINC1 (AT3) AND METHODS OF USE THEREOF[2017/36]
French:AGENTS POLYNUCLÉOTIDIQUES CIBLANT SERPINC 1 (AT3) ET LEURS MÉTHODES D'UTILISATION[2017/36]
Entry into regional phase30.03.2017National basic fee paid 
30.03.2017Designation fee(s) paid 
30.03.2017Examination fee paid 
Examination procedure30.03.2017Examination requested  [2017/36]
30.03.2017Date on which the examining division has become responsible
24.01.2018Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
24.01.2018Despatch of communication of loss of particular rights: Claims {1}
29.03.2018Amendment by applicant (claims and/or description)
13.07.2018Despatch of a communication from the examining division to which search results under Rule 164(2) EPC are annexed (Time limit: M04) [2018/33]
13.07.2018Despatch of a communication from the examining division (Time limit: M04)
20.11.2018Reply to a communication from the examining division
11.11.2019Despatch of a communication from the examining division (Time limit: M04)
16.04.2020Reply to a communication from the examining division
19.10.2020Communication of intention to grant the patent
25.02.2021Fee for grant paid
25.02.2021Fee for publishing/printing paid
25.02.2021Receipt of the translation of the claim(s)
Divisional application(s)EP21158656.5  / EP3904519
Opposition(s)10.01.2022No opposition filed within time limit [2022/11]
Request for further processing for:29.03.2018Request for further processing filed
29.03.2018Full payment received (date of receipt of payment)
Request granted
12.04.2018Decision despatched
Fees paidRenewal fee
27.10.2017Renewal fee patent year 03
11.10.2018Renewal fee patent year 04
15.10.2019Renewal fee patent year 05
14.10.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.10.2015
AL07.04.2021
AT07.04.2021
CY07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
IT07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
IE28.10.2021
LU28.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
[2023/30]
Former [2023/27]HU28.10.2015
AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
IT07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
IE28.10.2021
LU28.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
Former [2022/48]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
IT07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
IE28.10.2021
LU28.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
Former [2022/37]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
IT07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
LU28.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
Former [2022/36]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
IT07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
LU28.10.2021
BE31.10.2021
Former [2022/35]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
LU28.10.2021
BE31.10.2021
Former [2022/33]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
MC07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
BE31.10.2021
Former [2022/29]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SI07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2022/26]AL07.04.2021
AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2022/23]AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2022/10]AT07.04.2021
CZ07.04.2021
DK07.04.2021
EE07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
PT09.08.2021
IS22.12.2021
Former [2022/09]AT07.04.2021
CZ07.04.2021
DK07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RO07.04.2021
RS07.04.2021
SE07.04.2021
SK07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2022/08]AT07.04.2021
CZ07.04.2021
DK07.04.2021
ES07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RS07.04.2021
SE07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2022/07]AT07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RS07.04.2021
SE07.04.2021
SM07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2021/52]AT07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
PL07.04.2021
RS07.04.2021
SE07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2021/51]AT07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
RS07.04.2021
SE07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
IS07.08.2021
PT09.08.2021
Former [2021/50]AT07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
SE07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
PT09.08.2021
Former [2021/49]AT07.04.2021
FI07.04.2021
HR07.04.2021
LT07.04.2021
LV07.04.2021
NL07.04.2021
SE07.04.2021
BG07.07.2021
NO07.07.2021
GR08.07.2021
Former [2021/47]AT07.04.2021
FI07.04.2021
LT07.04.2021
NL07.04.2021
BG07.07.2021
Former [2021/46]AT07.04.2021
FI07.04.2021
LT07.04.2021
Cited inInternational search[A]WO2009073809  (ALNYLAM PHARMACEUTICALS INC [US], et al) [A] 38-41* the whole document *;
 [A]WO2010144740  (ALNYLAM PHARMACEUTICALS INC [US], et al) [A] 48-50 * the whole document *;
 [Y]WO2013159108  (ISIS PHARMACEUTICALS INC [US]) [Y] 1-74 * the whole document *;
 [Y]WO2013163430  (ALNYLAM PHARMACEUTICALS [US], et al) [Y] 1-74 * the whole document *;
 [A]  - Akin Akinc, "ALN-AT3: An Investigational RNAi Therapeutic Targeting Antithrombin for the Treatment of Hemophilia", (20140515), URL: http://www.alnylam.com/web/assets/ALNY-HemophiliaProgram-WFH-May2014.pdf, (20150805), XP055206418 [A] 1-74 * the whole document *
 [A]  - H. SAFDAR ET AL, "Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production", BLOOD, (20130523), vol. 121, no. 21, doi:10.1182/blood-2012-11-465674, ISSN 0006-4971, pages 4413 - 4416, XP055206525 [A] 1-74 * the whole document *

DOI:   http://dx.doi.org/10.1182/blood-2012-11-465674
ExaminationWO2010144740
 WO2013159108
 WO2013163430
    - Akin Akinc, "ALN‐AT3: An Investigational RNAi Therapeutic Targeting Antithrombin for the Treatment of Hemophilia", (20140101), URL: http://www.alnylam.com/web/assets/ALNY-HemophiliaProgram-WFH-May2014.pdf, (20150805), XP055206418
by applicantUS513030
 US564562
 US3687808
 US4469863
 US4476301
 US4587044
 US4605735
 US4667025
 US4683202
 WO8804924
 US4762779
 US4789737
 US4824941
 US4828979
 US4835263
 US4837028
 US4845205
 US4876335
 US4897355
 US4904582
 US4948882
 US4958013
 US4981957
 US5023243
 US5032401
 US5034506
 WO9116024
 US5082830
 US5109124
 US5112963
 US5118800
 US5118802
 US5134066
 US5138045
 US5166315
 US5171678
 US5175273
 US5177195
 US5185444
 US5188897
 US5214134
 US5214136
 US5216141
 US5218105
 US5235033
 US5245022
 US5254469
 US5258506
 US5262536
 US5264423
 US5264564
 WO9324640
 US5272250
 US5276019
 WO9400569
 US5278302
 US5283185
 WO9402595
 US5286717
 US5292873
 US5317098
 US5319080
 US5321131
 US5359044
 US5367066
 US5371241
 US5391723
 US5393878
 US5399676
 US5405939
 US5405938
 US5414077
 US5416203
 US5432272
 US5434257
 US5446137
 US5445934
 US5451463
 US5453496
 US5455233
 US5457187
 US5459255
 US5466677
 US5466786
 US5470967
 US5476925
 US5484908
 US5486603
 US5489677
 US5502177
 US5510475
 US5512439
 US5512667
 US5514785
 US5519126
 US5519134
 US5525711
 US5525465
 US5536821
 US5539082
 US5541316
 US5541307
 US5541313
 US5543152
 US5545730
 US5550111
 US5552540
 US5552538
 US5561225
 US5563253
 US5565552
 US5567811
 US5567810
 US5571799
 US5574142
 US5576427
 US5578717
 US5578718
 WO9637194
 US5580731
 US5585481
 WO9640964
 US5587361
 US5587469
 US5587371
 US5591722
 US5591584
 US5594121
 US5596086
 US5596091
 US5595726
 US5597909
 US5597696
 US5599923
 US5599928
 US5602240
 US5608046
 US5607677
 US5610289
 US5610300
 US5614617
 US5618704
 WO9713499
 US5623070
 US5625050
 US5627053
 US5633360
 US5639873
 US5646265
 US5658873
 WO9730731
 US5663312
 US5670633
 US5677437
 US5677439
 US5677195
 US5681941
 US5688941
 US5698685
 US5700920
 US5705188
 US5714331
 US5719262
 US5744305
 US5750692
 US5770722
 WO9839359
 US5854033
 US5874219
 WO9914226
 US5976567
 US5981501
 US6015886
 WO0003683
 US6028188
 US6124445
 US6147200
 US6160109
 US6166197
 US6169170
 US6172209
 US6191105
 US6222025
 US6235887
 US6239265
 WO0149687
 US6268490
 US6277603
 US6294664
 US6320017
 US6326199
 US6346614
 US6380368
 US6444423
 US6525191
 US6528640
 US6531590
 US6534639
 US6534484
 US6576752
 US6586410
 US2003144217
 US6608035
 US6617438
 US6639062
 US6670461
 US6683167
 US6747014
 US2004127488
 US6770748
 US2004167116
 US6783931
 US2004171570
 US6794499
 US6815432
 US6858715
 US6858225
 US6867294
 US6878805
 US6900297
 US2005130923
 US2005148548
 US2005281781
 US6998484
 US7015315
 US7034133
 US7037646
 US7041816
 WO2006047842
 US7045610
 US7053207
 US2006128646
 US7063860
 US7070802
 US7084125
 US7157099
 USRE39464E
 US7273933
 WO2007134181
 US2008015162
 US7321029
 US2008039618
 US7399845
 WO2008101157
 US7427672
 US7427605
 US2009012281
 US7495088
 US7569686
 US2009209748
 US7687617
 WO2010036696
 US7741457
 US2010210712
 US2010324120
 US8022193
 US8030467
 US8058069
 US2011313020
 US8106022
 US8158601
 US2012142101
 US8278283
 US8278425
 US8278426
 US8314227
 US2013011922
 US2013096289
 WO2013159108
 US8580756
 US2014128586
 US2014128591
    - DIAS, N. ET AL., MOL CANCER THER, (2002), vol. 1, pages 347 - 355
    - Current protocols in nucleic acid chemistry, JOHN WILEY & SONS, INC.
    - NIELSEN ET AL., SCIENCE, (1991), vol. 254, pages 1497 - 1500
    - MARTIN ET AL., HELV. CHIM. ACTA, (1995), vol. 78, pages 486 - 504
    - ELMEN, J. ET AL., NUCLEIC ACIDS RESEARCH, (2005), vol. 33, no. 1, pages 439 - 447
    - MOOK, OR ET AL., MOL CANC THER, (2007), vol. 6, no. 3, pages 833 - 843
    - GRUNWELLER, A ET AL., NUCLEIC ACIDS RESEARCH, (2003), vol. 31, no. 12, pages 3185 - 3193
    - CHATTOPADHYAYA ET AL., J. ORG. CHEM., (2009), vol. 74, pages 118 - 134
    - BRAASCH ET AL., BIOCHEMISTRY, (2002), vol. 41, pages 4503 - 4510
    - SRIVASTAVA ET AL., J. AM. CHEM. SOC., (2007), vol. 129, no. 26, pages 8362 - 8379
    - ROBEYNS ET AL., J. AM. CHEM. SOC., (2008), vol. 130, no. 6, pages 1979 - 1984
    - HORVATH ET AL., TETRAHEDRON LETTERS, (2007), vol. 48, pages 3621 - 3623
    - NAUWELAERTS ET AL., J. AM CHEM. SOC., (2007), vol. 129, no. 30, pages 9340 - 9348
    - GU ET AL., NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, (2005), vol. 24, no. 5-7, pages 993 - 998
    - NAUWELAERTS ET AL., NUCLEIC ACIDS RESEARCH, (2005), vol. 33, no. 8, pages 2452 - 2463
    - ROBEYNS ET AL., ACTA CRYSTALLOGRAPHICA, SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, (2005), vol. F61, no. 6, pages 585 - 586
    - GU ET AL., TETRAHEDRON, (2004), vol. 60, no. 9, pages 2111 - 2123
    - GU ET AL., OLIGONUCLEOTIDES, (2003), vol. 13, no. 6, pages 479 - 489
    - WANG ET AL., J. ORG. CHEM., (2003), vol. 68, pages 4499 - 4505
    - VERBEURE ET AL., NUCLEIC ACIDS RESEARCH, (2001), vol. 29, no. 24, pages 4941 - 4947
    - WANG ET AL., J. ORG. CHEM., (2001), vol. 66, pages 8478 - 82
    - WANG ET AL., NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, (2001), vol. 20, no. 4-7, pages 785 - 788
    - WANG ET AL., J. AM. CHEM., (2000), vol. 122, pages 8595 - 8602
    - KROSCHWITZ, J. L., The Concise Encyclopedia Of Polymer Science And Engineering, JOHN WILEY & SONS, (1990), pages 858 - 859
    - ENGLISCH ET AL., ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, (1991), vol. 30, page 613
    - SANGHVI, Y S., "Chapter 15", SANGHVI, Y S., SANGHVI, Y S. ET AL, Antisense polynucleotide agent Research and Applications, CRC PRESS, (1993), pages 289 - 302
    - SANGHVI, Y S. ET AL, Antisense polynucleotide agent Research and Applications, CRC PRESS, (1993), pages 276 - 278
    - LETSINGER ET AL., PROC. NATL. ACID. SCI. USA, (1989), vol. 86, pages 6553 - 6556
    - MANOHARAN ET AL., BIORG. MED. CHEM. LET., (1994), vol. 4, pages 1053 - 1060
    - MANOHARAN ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 660, pages 306 - 309
    - MANOHARAN ET AL., BIORG. MED. CHEM. LET., (1993), vol. 3, pages 2765 - 2770
    - OBERHAUSER ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 533 - 538
    - SAISON-BEHMOARAS E, EMBO J, (1991), vol. 10, pages 1111 - 1118
    - KABANOV ET AL., FEBS LETT., (1990), vol. 259, pages 327 - 330
    - SVINARCHUK ET AL., BIOCHIMIE, (1993), vol. 75, pages 49 - 54
    - MANOHARAN ET AL., TETRAHEDRON LETT., (1995), vol. 36, pages 3651 - 3654
    - SHEA ET AL., NUCL. ACIDS RES., (1990), vol. 18, pages 3777 - 3783
    - MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, (1995), vol. 14, pages 969 - 973
    - MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, (1995), vol. 1264, pages 229 - 237
    - CROOKE ET AL., J. PHARMACOL. EXP. THER., (1996), vol. 277, pages 923 - 937
    - LAM ET AL., NATURE, (1991), vol. 354, pages 82 - 84
    - SIMEONI ET AL., NUCL. ACIDS RES., (2003), vol. 31, pages 2717 - 2724
    - KUBO, T. ET AL., BIOCHEM. BIOPHYS. RES. COMM., (2007), vol. 365, no. 1, pages 54 - 61
    - LETSINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, page 6553
    - MANOHARAN ET AL., BIOORG. MED. CHEM. LETT., (1994), vol. 4, page 1053
    - MANOHARAN ET AL., ANN. N.Y. ACAD. SCI.,, (1992), vol. 660, page 306
    - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1993), vol. 3, page 2765
    - OBERHAUSER ET AL., NUCL. ACIDS RES., (1992), vol. 20, page 533
    - SAISON-BEHMOARAS ET AL., EMBO J., (1991), vol. 10, page 111
    - KABANOV ET AL., FEBS LETT., (1990), vol. 259, page 327
    - SVINARCHUK ET AL., BIOCHIMIE, (1993), vol. 75, page 49
    - MANOHARAN ET AL., TETRAHEDRON LETT., (1995), vol. 36, page 3651
    - SHEA ET AL., NUCL. ACIDS RES., (1990), vol. 18, page 3777
    - MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, (1995), vol. 14, page 969
    - MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, (1995), vol. 1264, page 229
    - CROOKE ET AL., J. PHARMACOL. EXP. THER., (1996), vol. 277, page 923
    - AKHTAR S.; JULIAN RL., TRENDS CELL. BIOL., (1992), vol. 2, no. 5, pages 139 - 144
    - TOLENTINO, MJ. ET AL., RETINA, (2004), vol. 24, pages 132 - 138
    - REICH, SJ. ET AL., MOL. VIS., (2003), vol. 9, pages 210 - 216
    - PILLE, J. ET AL., MOL. THER, (2005), vol. 11, pages 267 - 274
    - KIM, WJ. ET AL., MOL. THER., (2006), vol. 14, pages 343 - 350
    - LI, S. ET AL., MOL. THER., (2007), vol. 15, pages 515 - 523
    - DORN, G. ET AL., NUCLEIC ACIDS, (2004), vol. 32, page E49
    - GENE THER, (2005), vol. 12, pages 59 - 66
    - MAKIMURA, H. ET AL., BMC NEUROSCI, (2002), vol. 3, page 18
    - SHISHKINA, GT. ET AL., NEUROSCIENCE, (2004), vol. 129, pages 521 - 528
    - THAKKER, ER. ET AL., PROC. NATL. ACAD. SCI. U.S.A., (2004), vol. 101, pages 17270 - 17275
    - AKANEYA,Y. ET AL., J. NEUROPHYSIOL., (2005), vol. 93, pages 594 - 602
    - HOWARD, KA. ET AL., MOL. THER., (2006), vol. 14, pages 476 - 484
    - ZHANG, X. ET AL., J. BIOL. CHEM., (2004), vol. 279, pages 10677 - 10684
    - BITKO, V. ET AL., NAT. MED., (2005), vol. 11, pages 50 - 55
    - KIM SH. ET AL., JOURNAL OF CONTROLLED RELEASE, (2008), vol. 129, no. 2, pages 107 - 116
    - SORENSEN, DR. ET AL., J. MOL. BIOL, (2003), vol. 327, pages 761 - 766
    - VERMA, UN ET AL., CLIN. CANCER RES., (2003), vol. 9, pages 1291 - 1300
    - ARNOLD, AS ET AL., J. HYPERTENS, (2007), vol. 25, pages 197 - 205
    - ZIMMERMANN, TS. ET AL., NATURE, (2006), vol. 441, pages 111 - 114
    - CHIEN, PY. ET AL., CANCER GENE THER., (2005), vol. 12, pages 321 - 328
    - PAL, A. ET AL., INT J. ONCOL., (2005), vol. 26, pages 1087 - 1091
    - AIGNER, A., J. BIOMED. BIOTECHNOL., (2006), page 71659
    - LIU, S., MOL. PHARM., (2006), vol. 3, pages 472 - 487
    - TOMALIA, DA. ET AL., BIOCHEM. SOC. TRANS, (2007), vol. 35, pages 61 - 67
    - YOO, H. ET AL., PHARM. RES., (1999), vol. 16, pages 1799 - 1804
    - BOLLIGER ET AL., THROMB HAEMOST, (2010), vol. 103, pages 1233 - 1238
    - BI L ET AL., NAT GENET, (1995), vol. 10, pages 119 - 21
    - LIN ET AL., BLOOD, (1997), vol. 90, pages 3962 - 6
    - KUNDU ET AL., BLOOD, (1998), vol. 92, pages 168 - 74
    - WANG ET AL., PROC NATL ACAD SCI U S A, (1997), vol. 94, pages 11563 - 6
    - JIN ET AL., BLOOD, (2004), vol. 104, page 1733
    - FELGNER, P. L ET AL., PROC. NATL. ACAD. SCI., USA, (1987), vol. 8, pages 7413 - 7417
    - BANGHAM ET AL., M. MOL. BIOL., (1965), vol. 23, page 238
    - OLSON ET AL., BIOCHIM. BIOPHYS. ACTA, (1979), vol. 557, page 9
    - SZOKA ET AL., PROC. NATL. ACAD. SCI., (1978), vol. 75, page 4194
    - MAYHEW ET AL., BIOCHIM. BIOPHYS. ACTA, (1984), vol. 775, page 169
    - KIM ET AL., BIOCHIM. BIOPHYS. ACTA, (1983), vol. 728, page 339
    - FUKUNAGA ET AL., ENDOCRINOL., (1984), vol. 115, page 757
    - MAYER ET AL., BIOCHIM. BIOPHYS. ACTA, (1986), vol. 858, page 161
    - WANG ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1987), vol. 147, pages 980 - 985
    - ZHOU ET AL., JOURNAL OF CONTROLLED RELEASE, (1992), vol. 19, pages 269 - 274
    - FELGNER, J. BIOL. CHEM., (1994), vol. 269, page 2550
    - NABEL, PROC. NATL. ACAD. SCI., (1993), vol. 90, page 11307
    - NABEL, HUMAN GENE THER., (1992), vol. 3, page 649
    - GERSHON, BIOCHEM., (1993), vol. 32, page 7143
    - STRAUSS, EMBO J., (1992), vol. 11, page 417
    - HU ET AL., S.T.P.PHARMA. SCI., (1994), vol. 4, no. 6, page 466
    - ALLEN ET AL., FEBS LETTERS, (1987), vol. 223, page 42
    - WU ET AL., CANCER RESEARCH, (1993), vol. 53, page 3765
    - PAPAHADJOPOULOS ET AL., ANN. N.Y. ACAD. SCI., (1987), vol. 507, page 64
    - GABIZON ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1988), vol. 85, page 6949
    - ROSOFF, Pharmaceutical Dosage Forms, (1988), vol. 1, page 245
    - FELGNER, P. L. ET AL., PROC. NATL. ACAD. SCI., USA, (1987), vol. 8, pages 7413 - 7417
    - GAO, X.; HUANG, L., BIOCHIM. BIOPHYS. RES. COMMUN, (1991), vol. 179, page 280
    - ZHOU, X ET AL., BIOCHIM. BIOPHYS. ACTA, (1991), vol. 1065, page 8
    - WEINER ET AL., JOURNAL OF DRUG TARGETING, (1992), vol. 2, pages 405 - 410
    - DU PLESSIS ET AL., ANTIVIRAL RESEARCH, (1992), vol. 18, pages 259 - 265
    - MANNINO, R. J.; FOULD-FOGERITE, S., BIOTECHNIQUES, (1988), vol. 6, pages 682 - 690
    - ITANI, T. ET AL., GENE, (1987), vol. 56, pages 267 - 276
    - NICOLAU, C. ET AL., METH. ENZ, (1987), vol. 149, pages 157 - 176
    - STRAUBINGER, R. M.; PAPAHADJOPOULOS, D, METH. ENZ., (1983), vol. 101, pages 512 - 527
    - WANG, C. Y; HUANG, L., PROC. NATL. ACAD. SCI. USA, (1987), vol. 84, pages 7851 - 7855
    - RIEGER, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), page 285
    - LIEBERMAN, RIEGER AND BANKER, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), vol. 1, page 199
    - ROSOFF, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), vol. 1, page 245
    - BLOCK, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), vol. 2, page 335
    - HIGUCHI ET AL., Remington's Pharmaceutical Sciences, MACK PUBLISHING CO., (1985), page 301
    - IDSON, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), vol. 1, page 199
    - RIEGER, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), vol. 1, page 285
    - BLOCK, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC., (1988), vol. 1, page 335
    - IDSON, Pharmaceutical Dosage Forms, MARCEL DEKKER, INC, (1988), vol. 1, page 199
    - IDSON, Pharmaceutical Dosage Forms, Lieberman, MARCEL DEKKER, INC., (1988), vol. 1, page 199
    - LEUNG; SHAH, Controlled Release of Drugs: Polymers and Aggregate Systems, VCH PUBLISHERS, (1989), pages 185 - 215
    - SCHOTT, Remington's Pharmaceutical Sciences, MACK PUBLISHING CO., (1985), page 271
    - CONSTANTINIDES ET AL., PHARMACEUTICAL RESEARCH, (1994), vol. 11, pages 1385 - 1390
    - RITSCHEL, METH. FIND. EXP. CLIN. PHARMACOL., (1993), vol. 13, page 205
    - CONSTANTINIDES ET AL., PHARMACEUTICAL RESEARCH, (1994), vol. 11, page 1385
    - HO ET AL., J. PHARM. SCI., (1996), vol. 85, pages 138 - 143
    - LEE ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, (1991), page 92
    - TAKAHASHI ET AL., J. PHARM. PHARMACOL., (1988), vol. 40, page 252
    - MURANISHI, CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, (1990), vol. 7, pages 1 - 33
    - EL HARIRI ET AL., J. PHARM. PHARMACOL., (1992), vol. 44, pages 651 - 654
    - BRUNTON ET AL., Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed., MCGRAW-HILL, (1996), pages 934 - 935
    - SWINYARD, Remington's Pharmaceutical Sciences, 18th Ed., MACK PUBLISHING CO., (1990), pages 782 - 783
    - YAMAMOTO ET AL., J. PHARM. EXP. THER., (1992), vol. 263, page 25
    - YAMASHITA ET AL., J. PHARM. SCI., (1990), vol. 79, pages 579 - 583
    - JARRETT, J. CHROMATOGR., (1993), vol. 618, pages 315 - 339
    - BUUR ET AL., J. CONTROL REL., (1990), vol. 14, pages 43 - 51
    - YAMASHITA ET AL., J. PHARM. PHARMACOL., (1987), vol. 39, pages 621 - 626
    - MIYAO ET AL., ANTISENSE POLYNUCLEOTIDE AGENT RES. DEV., (1995), vol. 5, pages 115 - 121
    - TAKAKURA ET AL., ANTISENSE POLYNUCLEOTIDE AGENT & NUCL. ACID DRUG DEV., (1996), vol. 6, pages 177 - 183
    - MELTON ET AL., NUC. ACIDS RES., vol. 12, page 7035
    - BARANY, PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 189 - 193
    - GUATELLI ET AL., PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, pages 1874 - 1878
    - KWOH ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 1173 - 1177
    - LIZARDI ET AL., BIOLTECHNOLOGY, (1988), vol. 6, page 1197
 WO2007US80331
 US20080018616
 US20080018611
 US20080039748
 US20080047087
 US20080051528
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.