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Extract from the Register of European Patents

EP About this file: EP3147359

EP3147359 - MUTEIN, METHOD FOR PRODUCING SAID MUTEIN, GENE ENCODING SAID MUTEIN, RECOMBINANT VECTOR AND PLANT BEARING SAID GENE, METHOD FOR CONTROLLING AMOUNT OF MEVALONIC ACID PRODUCED AND AMOUNT OF ISOPRENOID PRODUCED, METHOD FOR CONTROLLING 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE ACTIVITY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.09.2022
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  01.10.2021
FormerGrant of patent is intended
Status updated on  06.06.2021
FormerExamination is in progress
Status updated on  09.11.2018
FormerRequest for examination was made
Status updated on  24.02.2017
FormerThe international publication has been made
Status updated on  02.12.2016
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
For all designated states
Sumitomo Rubber Industries, Ltd.
6-9, Wakinohama-cho 3-chome Chuo-ku
Kobe-shi, Hyogo 651-0072 / JP
[2017/13]
Inventor(s)01 / SUZUKI, Keiko
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
02 / JEKSON, Robertlee
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
03 / MURANAKA, Toshiya
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
04 / TAKAGI, Keiji
c/o SUMITOMO RUBBER INDUSTRIES LTD.
6-9 Wakinohama-cho 3-chome
Chuo-ku
Kobe-shi Hyogo 651-0072 / JP
05 / INOUE, Yukino
c/o SUMITOMO RUBBER INDUSTRIES LTD.
6-9 Wakinohama-cho 3-chome
Chuo-ku
Kobe-shi Hyogo 651-0072 / JP
06 / FUSHIHARA, Kazuhisa
c/o SUMITOMO RUBBER INDUSTRIES LTD.
6-9 Wakinohama-cho 3-chome
Chuo-ku
Kobe-shi Hyogo 651-0072 / JP
 [2017/13]
Representative(s)Manitz Finsterwald Patent- und Rechtsanwaltspartnerschaft mbB
Martin-Greif-Strasse 1
80336 München / DE
[2021/44]
Former [2017/13]Manitz, Finsterwald & Partner GbR
Martin-Greif-Strasse 1
80336 München / DE
Application number, filing date15795799.422.05.2015
[2017/13]
WO2015JP64821
Priority number, dateJP2014010750823.05.2014         Original published format: JP 2014107508
[2017/13]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015178493
Date:26.11.2015
Language:JA
[2015/47]
Type: A1 Application with search report 
No.:EP3147359
Date:29.03.2017
Language:EN
[2017/13]
Type: B1 Patent specification 
No.:EP3147359
Date:03.11.2021
Language:EN
[2021/44]
Search report(s)International search report - published on:JP26.11.2015
(Supplementary) European search report - dispatched on:EP12.01.2018
ClassificationIPC:C12N15/00, A01H5/00, C12N9/04, C12N15/09, C12P5/02, C12P7/40
[2017/13]
CPC:
C12N9/0006 (EP,US); A01N37/18 (US); C12N15/00 (EP,US);
C12N15/09 (EP,US); C12N15/8243 (US); C12Y101/01034 (EP,US);
C12P5/02 (EP,US); C12P7/40 (EP,US); Y02A40/146 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/13]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:MUTEIN, VERFAHREN ZUR HERSTELLUNG DES MUTEINS, GEN ZUR CODIERUNG DES BESAGTEN MUTEINS, REKOMBINANTER VEKTOR UND PFLANZE MIT BESAGTEM GEN, VERFAHREN ZUR STEUERUNG DER MENGE AN PRODUZIERTER MEVALONIKSÄURE UND DER MENGE AN PRODUZIERTEM ISOPRENOID, VERFAHREN ZUR STEUERUNG DER 3-HYDROXY-3-METHYLGLUTARYL-COA-REDUKTASEAKTIVITÄT[2017/13]
English:MUTEIN, METHOD FOR PRODUCING SAID MUTEIN, GENE ENCODING SAID MUTEIN, RECOMBINANT VECTOR AND PLANT BEARING SAID GENE, METHOD FOR CONTROLLING AMOUNT OF MEVALONIC ACID PRODUCED AND AMOUNT OF ISOPRENOID PRODUCED, METHOD FOR CONTROLLING 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE ACTIVITY[2017/13]
French:MUTÉINE, PROCÉDÉ PERMETTANT DE PRODUIRE LADITE MUTÉINE, GÈNE CODANT POUR LADITE MUTÉINE, VECTEUR RECOMBINANT ET PLANTE PORTANT LEDIT GÈNE, PROCÉDÉ DE RÉGULATION D'UNE QUANTITÉ D'ACIDE MÉVALONIQUE PRODUITE ET D'UNE QUANTITÉ D'ISOPRÉNOÏDE PRODUIT, PROCÉDÉ PERMETTANT DE RÉGULER L'ACTIVITÉ 3-HYDROXY-3-MÉTHYLGLUTARYL-COA RÉDUCTASE[2017/13]
Entry into regional phase02.12.2016Translation filed 
02.12.2016National basic fee paid 
02.12.2016Search fee paid 
02.12.2016Designation fee(s) paid 
02.12.2016Examination fee paid 
Examination procedure02.12.2016Examination requested  [2017/13]
02.12.2016Date on which the examining division has become responsible
07.08.2018Amendment by applicant (claims and/or description)
12.11.2018Despatch of a communication from the examining division (Time limit: M04)
18.03.2019Reply to a communication from the examining division
13.12.2019Despatch of a communication from the examining division (Time limit: M04)
17.04.2020Reply to a communication from the examining division
07.10.2020Despatch of a communication from the examining division (Time limit: M04)
26.01.2021Reply to a communication from the examining division
07.06.2021Communication of intention to grant the patent
27.09.2021Fee for grant paid
27.09.2021Fee for publishing/printing paid
27.09.2021Receipt of the translation of the claim(s)
Opposition(s)04.08.2022No opposition filed within time limit [2022/41]
Fees paidRenewal fee
30.05.2017Renewal fee patent year 03
30.05.2018Renewal fee patent year 04
29.05.2019Renewal fee patent year 05
29.05.2020Renewal fee patent year 06
27.05.2021Renewal fee patent year 07
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.05.2015
AL03.11.2021
AT03.11.2021
CY03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
MK03.11.2021
MT03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB22.05.2022
IE22.05.2022
LU22.05.2022
BE31.05.2022
CH31.05.2022
LI31.05.2022
[2024/41]
Former [2024/22]HU22.05.2015
AL03.11.2021
AT03.11.2021
CY03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
MK03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB22.05.2022
IE22.05.2022
LU22.05.2022
BE31.05.2022
CH31.05.2022
LI31.05.2022
Former [2024/20]HU22.05.2015
AL03.11.2021
AT03.11.2021
CY03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB22.05.2022
IE22.05.2022
LU22.05.2022
BE31.05.2022
CH31.05.2022
LI31.05.2022
Former [2024/18]HU22.05.2015
AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB22.05.2022
IE22.05.2022
LU22.05.2022
BE31.05.2022
CH31.05.2022
LI31.05.2022
Former [2023/27]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB22.05.2022
IE22.05.2022
LU22.05.2022
BE31.05.2022
CH31.05.2022
LI31.05.2022
Former [2023/25]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
IE22.05.2022
LU22.05.2022
BE31.05.2022
CH31.05.2022
LI31.05.2022
Former [2023/20]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
IE22.05.2022
LU22.05.2022
CH31.05.2022
LI31.05.2022
Former [2023/09]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
LU22.05.2022
CH31.05.2022
LI31.05.2022
Former [2023/08]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
LU22.05.2022
Former [2023/06]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2023/01]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SI03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/49]AL03.11.2021
AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/35]AT03.11.2021
CZ03.11.2021
DK03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/34]AT03.11.2021
EE03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
PL03.11.2021
RO03.11.2021
RS03.11.2021
SE03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/33]AT03.11.2021
ES03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
PL03.11.2021
RS03.11.2021
SE03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/25]AT03.11.2021
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FI03.11.2021
HR03.11.2021
LT03.11.2021
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NL03.11.2021
PL03.11.2021
RS03.11.2021
SE03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/24]AT03.11.2021
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SE03.11.2021
BG03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/23]AT03.11.2021
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FI03.11.2021
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BG03.02.2022
PT03.03.2022
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FI03.11.2021
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BG03.02.2022
Former [2022/21]AT03.11.2021
RS03.11.2021
BG03.02.2022
Former [2022/19]BG03.02.2022
Documents cited:Search[X]US2004072323  (MATSUDA SEIICHI P T [US], et al) [X] 1,2,4,6-13 * SEQ ID NO: 215 ; [0086]; [0008] *;
    [ ] - "HMG-CoA reductase polypeptide #48.", Geneseq, (20040701), Database accession no. ADM98795, URL: EBI [ ] * sequence . *
 [A]  - PABLO LEIVAR ET AL, "Multilevel Control of Arabidopsis 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase by Protein Phosphatase 2A", THE PLANT CELL, US, (20110401), vol. 23, no. 4, doi:10.1105/tpc.110.074278, ISSN 1040-4651, pages 1494 - 1511, XP055407419 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1105/tpc.110.074278
 [A]  - Kiyoshi Ohyama ET AL, "Chemical Phenotypes of the hmg1 and hmg2 Mutants of Arabidopsis Demonstrate the In-planta Role of HMG-CoA Reductase in Triterpene Biosynthesis", Chem. Pharm. Bull, Vol. 55, No.10, (20071001), page 1518, URL: https://www.jstage.jst.go.jp/article/cpb/55/10/55_10_1518/_pdf, (20170918), XP055407421 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1248/cpb.55.1518
 [A]  - TOMOKI SANDO ET AL, "Cloning and Characterization of Mevalonate Pathway Genes in a Natural Rubber Producing Plant, Hevea brasiliensis", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY., TOKYO, JAPAN, (20080823), vol. 72, no. 8, doi:10.1271/bbb.80165, ISSN 0916-8451, pages 2049 - 2060, XP055407408 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1271/bbb.80165
International search[XY]WO0131043  (UNIV BRISTOL [GB], et al) [X] 1, 7-32 * , (Family: none) * [Y] 1-32;
 [Y]  - CHYE M. L. et al., "hydroxymethylglutaryl-CoA reductase [Hevea brasiliens is", GenBank, (20050418), Database accession no. CAA38469.1, URL: ncbi, XP055238415 [Y] 1-3, 7-32
 [Y]  - CHYE M. L. et al., "3-hydroxy-3-methylglutaryl- coenzyme A reductase [Hevea brasiliens is", GenBank, (19930427), Database accession no. AAA33360.1, URL: ncbi, XP055238417 [Y] 1, 4, 7-32
 [Y]  - SANDO T. et al., "hydroxymethylglutaryl-CoA reductase [Hevea brasiliens is", GenBank, (20080913), Database accession no. BAF98281.1, URL: ncbi, XP055238418 [Y] 1, 5, 7-32
 [Y]  - SANDO T. et al., "hydroxymethylglutaryl-CoA reductase [Hevea brasiliens is", GenBank, (20080913), Database accession no. BAF98280.1, URL: ncbi, XP055238420 [Y] 1, 6-32
 [A]  - CHING Y. P. et al., "Analysis of the specificity of the AMP-activated protein kinase by site- directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site- elimination method", Eur. J. Biochem., (19960000), vol. 237, no. 3, pages 800 - 8, XP002604746 [A] 1-32
 [A]  - OMKUMAR R. V. et al., "Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation", J. Biol. Chem., (19940000), vol. 269, no. 9, ISSN 0021-9258, pages 6810 - 6814, XP002159997 [A] 1-32
Examination   - "HMG-CoA reductase polypeptide #61.", Geneseq, (20040701), Database accession no. ADM98808, URL: EBI, XP055521482
    - "HMG-CoA reductase polypeptide #74.", Geneseq, (20040701), Database accession no. ADM98821, URL: EBI, XP055521485
    - "HMG-CoA reductase polypeptide #17.", Geneseq, (20040701), Database accession no. ADM98764, URL: EBI, XP055521490
    - "Oryza sativa HMG CoA reductase SEQ ID NO:2.", Geneseq, (20130912), Database accession no. BAQ55714, URL: EBI, XP055521495
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.