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Extract from the Register of European Patents

EP About this file: EP3218472

EP3218472 - TAG REMOVAL FROM PROTEINS EXPRESSED IN PRO- AND EUKARYOTIC HOSTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.05.2021
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  05.06.2020
FormerGrant of patent is intended
Status updated on  23.02.2020
FormerExamination is in progress
Status updated on  22.06.2018
FormerRequest for examination was made
Status updated on  18.08.2017
FormerThe international publication has been made
Status updated on  09.05.2017
Most recent event   Tooltip15.07.2022Lapse of the patent in a contracting state
New state(s): BE		published on 17.08.2022  [2022/33]
Applicant(s)For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Hofgartenstraße 8
80539 München / DE
[2017/38]
Inventor(s)01 / FREY, Steffen
Henri-Dunant-Str. 44e
37075 Goettingen / DE
02 / GOERLICH, Dirk
Stiegel 19
37077 Goettingen / DE
 [2017/38]
Representative(s)Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte und Rechtsanwalt PartG mbB
Schweigerstraße 2
81541 München / DE
[N/P]
Former [2017/38]Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte PartG mbB
Schweigerstraße 2
81541 München / DE
Application number, filing date15801694.910.11.2015
[2017/38]
WO2015EP76218
Priority number, dateEP2014019255710.11.2014         Original published format: EP 14192557
[2017/38]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2016075143
Date:19.05.2016
Language:EN
[2016/20]
Type: A2 Application without search report 
No.:EP3218472
Date:20.09.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 19.05.2016 takes the place of the publication of the European patent application.
[2017/38]
Type: B1 Patent specification 
No.:EP3218472
Date:08.07.2020
Language:EN
[2020/28]
Search report(s)International search report - published on:EP21.07.2016
ClassificationIPC:C12N9/50, C12N9/64, C07K1/22
[2017/38]
CPC:
C12N9/641 (EP,US); C12N9/60 (EP,US); C07K1/22 (EP,US);
C12N9/6405 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/38]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:MARKIERUNGSENTFERNUNG VON IN PRO- UND EUKARYOTISCHEN WIRTSZELLEN EXPRIMIERTEN PROTEINEN[2017/38]
English:TAG REMOVAL FROM PROTEINS EXPRESSED IN PRO- AND EUKARYOTIC HOSTS[2017/38]
French:ÉLIMINATION D'ÉTIQUETTES PRÉSENTES SUR DES PROTÉINES EXPRIMÉES DANS DES HÔTES PROCARYOTES ET EUCARYOTES[2017/38]
Entry into regional phase08.05.2017National basic fee paid 
08.05.2017Designation fee(s) paid 
08.05.2017Examination fee paid 
Examination procedure08.05.2017Examination requested  [2017/38]
08.05.2017Date on which the examining division has become responsible
14.12.2017Amendment by applicant (claims and/or description)
20.06.2018Despatch of a communication from the examining division (Time limit: M06)
18.12.2018Reply to a communication from the examining division
01.07.2019Despatch of a communication from the examining division (Time limit: M04)
30.10.2019Reply to a communication from the examining division
24.02.2020Communication of intention to grant the patent
28.05.2020Fee for grant paid
28.05.2020Fee for publishing/printing paid
28.05.2020Receipt of the translation of the claim(s)
Opposition(s)09.04.2021No opposition filed within time limit [2021/24]
Fees paidRenewal fee
20.11.2017Renewal fee patent year 03
27.11.2018Renewal fee patent year 04
28.11.2019Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.11.2015
AL08.07.2020
AT08.07.2020
CY08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
MK08.07.2020
MT08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SI08.07.2020
SK08.07.2020
SM08.07.2020
TR08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
IE10.11.2020
LU10.11.2020
BE30.11.2020
FR30.11.2020
[2022/33]
Former [2022/32]HU10.11.2015
AL08.07.2020
AT08.07.2020
CY08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
MK08.07.2020
MT08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SI08.07.2020
SK08.07.2020
SM08.07.2020
TR08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
IE10.11.2020
LU10.11.2020
FR30.11.2020
Former [2022/27]HU10.11.2015
AL08.07.2020
AT08.07.2020
CY08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
MT08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SI08.07.2020
SK08.07.2020
SM08.07.2020
TR08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
IE10.11.2020
LU10.11.2020
FR30.11.2020
Former [2021/48]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SI08.07.2020
SK08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
IE10.11.2020
LU10.11.2020
FR30.11.2020
Former [2021/46]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SI08.07.2020
SK08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
IE10.11.2020
LU10.11.2020
Former [2021/36]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SI08.07.2020
SK08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
LU10.11.2020
Former [2021/33]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SK08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
LU10.11.2020
Former [2021/31]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
MC08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SK08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/28]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SK08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/25]AL08.07.2020
AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/22]AT08.07.2020
CZ08.07.2020
DK08.07.2020
EE08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
NL08.07.2020
PL08.07.2020
RO08.07.2020
RS08.07.2020
SE08.07.2020
SM08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/20]AT08.07.2020
DK08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
IT08.07.2020
LT08.07.2020
LV08.07.2020
NL08.07.2020
PL08.07.2020
RS08.07.2020
SE08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/17]AT08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
LT08.07.2020
LV08.07.2020
NL08.07.2020
PL08.07.2020
RS08.07.2020
SE08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/10]AT08.07.2020
ES08.07.2020
FI08.07.2020
HR08.07.2020
LT08.07.2020
LV08.07.2020
PL08.07.2020
RS08.07.2020
SE08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
IS08.11.2020
PT09.11.2020
Former [2021/09]AT08.07.2020
ES08.07.2020
FI08.07.2020
LT08.07.2020
SE08.07.2020
BG08.10.2020
NO08.10.2020
GR09.10.2020
PT09.11.2020
Former [2021/08]ES08.07.2020
FI08.07.2020
LT08.07.2020
SE08.07.2020
BG08.10.2020
NO08.10.2020
PT09.11.2020
Former [2021/07]FI08.07.2020
LT08.07.2020
NO08.10.2020
Cited inInternational search[AP]WO2015049230  (MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V [DE]) [AP] 1-15,27,28,31-63 * claims 1-42 * * figures 1-21 ** examples 1-5 *;
 [X]  - "Protein fig|8364.3.peg.17647: Xenopus tropicalis (western clawed frog)", UniParc, (20130319), Database accession no. UPI00004D3CE0, URL: EBI, XP002754660 [X] 1-5,8-15 * sequence . *
 [I]  - FREY STEFFEN ET AL, "Purification of protein complexes of defined subunit stoichiometry using a set of orthogonal, tag-cleaving proteases", JOURNAL OF CHROMATOGRAPHY, (20140219), vol. 1337, doi:10.1016/J.CHROMA.2014.02.030, ISSN 0021-9673, pages 106 - 115, XP028634159 [I] 6,7,27-29,31-63 * abstract * * figures 1,8 * * table 2 *

DOI:   http://dx.doi.org/10.1016/j.chroma.2014.02.030
 [I]  - FREY STEFFEN ET AL, "A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins", JOURNAL OF CHROMATOGRAPHY, (20140219), vol. 1337, doi:10.1016/J.CHROMA.2014.02.029, ISSN 0021-9673, pages 95 - 105, XP028634158 [I] 6,7,27-29,31-63 * abstract * * tables 1-2 * * figures 3-4 *

DOI:   http://dx.doi.org/10.1016/j.chroma.2014.02.029
 [XP]  - STEFFEN FREY ET AL, "The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts", PLOS ONE, (20150429), vol. 10, no. 4, doi:10.1371/journal.pone.0125099, page e0125099, XP055252249 [XP] 1-15,27,28,31-63 * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.pone.0125099
 [A]  - M. LI ET AL, "Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates", JOURNAL OF BIOLOGICAL CHEMISTRY, US, (20101222), vol. 286, no. 9, doi:10.1074/jbc.M110.199059, ISSN 0021-9258, pages 7327 - 7338, XP055252060 [A] 1-15,27,28,31-63 * abstract * * figure 1 *

DOI:   http://dx.doi.org/10.1074/jbc.M110.199059
 [A]  - CHIH-WEN SHU ET AL, "Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4)", AUTOPHAGY, (20101001), vol. 6, no. 7, doi:10.4161/auto.6.7.13075, ISSN 1554-8627, pages 936 - 947, XP055158991 [A] 1-15,27,28,31-63 * abstract * * figure 1 *

DOI:   http://dx.doi.org/10.4161/auto.6.7.13075
 [A]  - "RecName: Full=Cysteine protease ATG4B; EC=3.4.22.-; AltName: Full=Autophagy-related protein 4 homolog B;", UniProt, (20050315), Database accession no. Q640G7, URL: EBI, XP002754661 [A] 1-15,27,28,31-63 * sequence . *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.