EP3193604 - SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS [Right-click to bookmark this link] | |||
Former [2017/30] | SUBSTITUTED PYRROLIDINE COMPOUNDS | ||
[2020/18] | Status | No opposition filed within time limit Status updated on 22.04.2022 Database last updated on 03.09.2024 | |
Former | The patent has been granted Status updated on 14.05.2021 | ||
Former | Grant of patent is intended Status updated on 22.04.2020 | ||
Former | Examination is in progress Status updated on 29.03.2019 | ||
Former | Request for examination was made Status updated on 23.06.2017 | ||
Former | The international publication has been made Status updated on 01.03.2017 | Most recent event Tooltip | 27.04.2024 | Lapse of the patent in a contracting state New state(s): MK | published on 29.05.2024 [2024/22] | Applicant(s) | For all designated states Epizyme, Inc. 400 Technology Square, 4th Floor Cambridge, MA 02139 / US | [2017/30] | Inventor(s) | 01 /
FOLEY, Megan Alene Cloonan 34 Alpine St. Somerville, Massachusetts 02144 / US | 02 /
KUNTZ, Kevin Wayne 8 New Village Rd. Woburn, Massachusetts 01801 / US | 03 /
MITCHELL, Lorna Helen 1 Nichols Pl. Cambridge, Massachusetts 02138 / US | 04 /
MUNCHHOF, Michael John 266 West Rd. Salem, Connecticut 06420 / US | 05 /
HARVEY, Darren Martin 3 Barker Rd. Acton, Massachusetts 01720 / US | [2017/30] | Representative(s) | Harris, Jennifer Lucy, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | [2021/24] |
Former [2017/30] | Harris, Jennifer Lucy, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | Application number, filing date | 15840234.7 | 09.09.2015 | [2017/30] | WO2015US49219 | Priority number, date | US201462048757P | 10.09.2014 Original published format: US 201462048757 P | US201562146808P | 13.04.2015 Original published format: US 201562146808 P | [2017/30] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2016040504 | Date: | 17.03.2016 | Language: | EN | [2016/11] | Type: | A1 Application with search report | No.: | EP3193604 | Date: | 26.07.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 17.03.2016 takes the place of the publication of the European patent application. | [2017/30] | Type: | B1 Patent specification | No.: | EP3193604 | Date: | 16.06.2021 | Language: | EN | [2021/24] | Search report(s) | International search report - published on: | US | 17.03.2016 | (Supplementary) European search report - dispatched on: | EP | 19.01.2018 | Classification | IPC: | A61P35/00, C07D413/14, C07D413/12, A61K31/42 | [2018/08] | CPC: |
C07D487/04 (EP,US);
A61P35/00 (EP,US);
C07D413/12 (EP,US);
C07D413/14 (EP,US)
|
Former IPC [2017/30] | A01N43/80 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/30] | Extension states | BA | 01.03.2017 | ME | 01.03.2017 | Validation states | MA | Not yet paid | Title | German: | SUBSTITUIERTE N-(PYRROLIDINV3EYL)ISOXAZOL-3-CARBOXAMIDVERBINDUNGEN | [2020/18] | English: | SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS | [2020/18] | French: | COMPOSÉS DE N-(PYRROLIDIN-3YL)ISOXAZOL-3-CARBOXAMIDES SUBSTITUÉS | [2020/18] |
Former [2017/30] | SUBSTITUIERTE PYRROLIDINVERBINDUNGEN | ||
Former [2017/30] | SUBSTITUTED PYRROLIDINE COMPOUNDS | ||
Former [2017/30] | COMPOSÉS PYRROLIDINES SUBSTITUÉS | Entry into regional phase | 01.03.2017 | National basic fee paid | 01.03.2017 | Search fee paid | 01.03.2017 | Designation fee(s) paid | 01.03.2017 | Examination fee paid | Examination procedure | 01.03.2017 | Examination requested [2017/30] | 01.03.2017 | Date on which the examining division has become responsible | 04.12.2018 | Amendment by applicant (claims and/or description) | 02.04.2019 | Despatch of a communication from the examining division (Time limit: M06) | 13.01.2020 | Reply to a communication from the examining division | 23.04.2020 | Communication of intention to grant the patent | 25.09.2020 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time | 02.12.2020 | Fee for grant paid | 02.12.2020 | Fee for publishing/printing paid | 02.12.2020 | Receipt of the translation of the claim(s) | Opposition(s) | 17.03.2022 | No opposition filed within time limit [2022/21] | Request for further processing for: | The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent | 02.12.2020 | Request for further processing filed | 02.12.2020 | Full payment received (date of receipt of payment) Request granted | 14.12.2020 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the examination report | 13.01.2020 | Request for further processing filed | 13.01.2020 | Full payment received (date of receipt of payment) Request granted | 22.01.2020 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 04.12.2018 | Request for further processing filed | 04.12.2018 | Full payment received (date of receipt of payment) Request granted | 18.12.2018 | Decision despatched | The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application | 04.12.2018 | Request for further processing filed | 04.12.2018 | Full payment received (date of receipt of payment) Request granted | 10.01.2019 | Decision despatched | Fees paid | Renewal fee | 27.09.2017 | Renewal fee patent year 03 | 27.09.2018 | Renewal fee patent year 04 | 27.09.2019 | Renewal fee patent year 05 | 28.09.2020 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 09.09.2015 | AL | 16.06.2021 | AT | 16.06.2021 | CY | 16.06.2021 | CZ | 16.06.2021 | DK | 16.06.2021 | EE | 16.06.2021 | ES | 16.06.2021 | FI | 16.06.2021 | HR | 16.06.2021 | IT | 16.06.2021 | LT | 16.06.2021 | LV | 16.06.2021 | MC | 16.06.2021 | MK | 16.06.2021 | NL | 16.06.2021 | PL | 16.06.2021 | RO | 16.06.2021 | RS | 16.06.2021 | SE | 16.06.2021 | SI | 16.06.2021 | SK | 16.06.2021 | SM | 16.06.2021 | IE | 09.09.2021 | LU | 09.09.2021 | BG | 16.09.2021 | GB | 16.09.2021 | NO | 16.09.2021 | GR | 17.09.2021 | BE | 30.09.2021 | CH | 30.09.2021 | FR | 30.09.2021 | LI | 30.09.2021 | IS | 16.10.2021 | PT | 18.10.2021 | [2024/22] |
Former [2023/30] | HU | 09.09.2015 | |
AL | 16.06.2021 | ||
AT | 16.06.2021 | ||
CY | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
IT | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
IE | 09.09.2021 | ||
LU | 09.09.2021 | ||
BG | 16.09.2021 | ||
GB | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
BE | 30.09.2021 | ||
CH | 30.09.2021 | ||
FR | 30.09.2021 | ||
LI | 30.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2023/27] | HU | 09.09.2015 | |
AL | 16.06.2021 | ||
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
IT | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
IE | 09.09.2021 | ||
LU | 09.09.2021 | ||
BG | 16.09.2021 | ||
GB | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
BE | 30.09.2021 | ||
CH | 30.09.2021 | ||
FR | 30.09.2021 | ||
LI | 30.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/37] | AL | 16.06.2021 | |
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
IT | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
IE | 09.09.2021 | ||
LU | 09.09.2021 | ||
BG | 16.09.2021 | ||
GB | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
BE | 30.09.2021 | ||
CH | 30.09.2021 | ||
FR | 30.09.2021 | ||
LI | 30.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/36] | AL | 16.06.2021 | |
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
IT | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
IE | 09.09.2021 | ||
LU | 09.09.2021 | ||
BG | 16.09.2021 | ||
GB | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
BE | 30.09.2021 | ||
FR | 30.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/35] | AL | 16.06.2021 | |
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
IE | 09.09.2021 | ||
LU | 09.09.2021 | ||
BG | 16.09.2021 | ||
GB | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
BE | 30.09.2021 | ||
FR | 30.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/34] | AL | 16.06.2021 | |
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
LU | 09.09.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
BE | 30.09.2021 | ||
FR | 30.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/29] | AL | 16.06.2021 | |
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SI | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/25] | AL | 16.06.2021 | |
AT | 16.06.2021 | ||
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
MC | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/21] | AT | 16.06.2021 | |
CZ | 16.06.2021 | ||
DK | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/10] | AT | 16.06.2021 | |
CZ | 16.06.2021 | ||
EE | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
NL | 16.06.2021 | ||
PL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
IS | 16.10.2021 | ||
PT | 18.10.2021 | ||
Former [2022/09] | AT | 16.06.2021 | |
CZ | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
NL | 16.06.2021 | ||
RO | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SK | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
PT | 18.10.2021 | ||
Former [2022/08] | AT | 16.06.2021 | |
CZ | 16.06.2021 | ||
ES | 16.06.2021 | ||
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
NL | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
Former [2022/07] | AT | 16.06.2021 | |
FI | 16.06.2021 | ||
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
NL | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
SM | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
Former [2021/51] | FI | 16.06.2021 | |
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
RS | 16.06.2021 | ||
SE | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
Former [2021/49] | FI | 16.06.2021 | |
HR | 16.06.2021 | ||
LT | 16.06.2021 | ||
LV | 16.06.2021 | ||
SE | 16.06.2021 | ||
BG | 16.09.2021 | ||
NO | 16.09.2021 | ||
GR | 17.09.2021 | ||
Former [2021/47] | FI | 16.06.2021 | |
LT | 16.06.2021 | ||
BG | 16.09.2021 | ||
Former [2021/46] | FI | 16.06.2021 | |
LT | 16.06.2021 | Documents cited: | Search | [X]WO2007121920 (NOVARTIS AG [CH], et al) [X] 1,2,7,8 * intermediate P; example 93; *; | [XP]WO2014175370 (SHIONOGI & CO [JP]) [XP] 1,5-8* compounds I-072 and I-626 *; | [A] - ANDREWD FERGUSON ET AL, "Structural Basis of Substrate Methylation and Inhibition of SMYD2", STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 19, no. 9, doi:10.1016/J.STR.2011.06.011, ISSN 0969-2126, (20110613), pages 1262 - 1273, (20110708), XP028284161 [A] 1-15 * Figure 1, compound AZ505 * DOI: http://dx.doi.org/10.1016/j.str.2011.06.011 | International search | [Y] - PubChem, (20121022), Database accession no. 62378974, XP055417573 [Y] 1-2 * , Fig * | [Y] - PubChem, (20120819), Database accession no. 58952603, XP055417577 [Y] 1-2 | [A] - PubChem, (20140228), Database accession no. 72928190, XP055417073 [A] 1-2 | [A] - PubChem, (20101127), Database accession no. 49688186, XP055417579 [A] 1-2 * , Fig * | by applicant | - ANDREW FERGUS SON et al., STRUCTURE, ELSEVIER, (20110613), vol. 19, pages 1262 - 1273 | - Pure & Appl. Chem, (19960000), vol. 68, page 2193 | - M. CAIRA et al., J. Pharmaceut. Sci., (20040000), vol. 93, no. 3, pages 601 - 611 | - E.C. VAN TONDER et al., AAPS Pharm. Sci. Tech., (20040000), vol. 5, no. 1 | - A.L. BINGHAM et al., Chem. Commun., (20010000), pages 603 - 604 | - ABU-FARHA et al., JMol Cell Biol, (20110000), vol. 3, no. 5, pages 301 - 308 | - HAMAMOTO et al., Nat Cell. Biol., (20040000), vol. 6, pages 731 - 740 | - HU et al., Canncer Research, (20090000), pages 4067 - 4072 | - KOMATSU et al., Carcinogenesis, (20090000), vol. 30, pages 301139 - 1146 | - HAMAMOTO, R. et al., Nat. Cell Biol., (20040000), vol. 6, no. 8, pages 731 - 40 | - HAMAMOTO, R. et al., Cancer Sci., (20060000), vol. 97, no. 2, pages 113 - 8 | - VAN ALLER, G.S. et al., Epigenetics, (20120000), vol. 7, no. 4, pages 340 - 3 | - LIU, C. et al., J. Natl. Cancer Inst., (20130000), vol. 105, no. 22, pages 1719 - 28 | - MAZUR, P.K. et al., Nature, (20140000), vol. 510, no. 7504, pages 283 - 7 | - PROSERPIO et al., Genes Dev., (20130601), vol. 27, no. 11, pages 1299 - 312 | - FUJII et al., PLoS One, (20110000), vol. 6, no. 8, page e23491 | - CHO et al., Neoplasia, (20120600), vol. 14, no. 6, pages 476 - 86 | - KOMATSU et al., Br J Cancer, (20150120), vol. 112, no. 2, pages 357 - 64 | - SAKAMOTO et al., Leuk Res., (20140400), vol. 38, no. 4, pages 496 - 502 | - XU et al., J. Biol. Chem., (20150227), vol. 290, no. 9, pages 5414 - 23 |