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Extract from the Register of European Patents

EP About this file: EP3193604

EP3193604 - SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS [Right-click to bookmark this link]
Former [2017/30]SUBSTITUTED PYRROLIDINE COMPOUNDS
[2020/18]
StatusNo opposition filed within time limit
Status updated on  22.04.2022
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  14.05.2021
FormerGrant of patent is intended
Status updated on  22.04.2020
FormerExamination is in progress
Status updated on  29.03.2019
FormerRequest for examination was made
Status updated on  23.06.2017
FormerThe international publication has been made
Status updated on  01.03.2017
Most recent event   Tooltip27.04.2024Lapse of the patent in a contracting state
New state(s): MK		published on 29.05.2024  [2024/22]
Applicant(s)For all designated states
Epizyme, Inc.
400 Technology Square, 4th Floor
Cambridge, MA 02139 / US
[2017/30]
Inventor(s)01 / FOLEY, Megan Alene Cloonan
34 Alpine St.
Somerville, Massachusetts 02144 / US
02 / KUNTZ, Kevin Wayne
8 New Village Rd.
Woburn, Massachusetts 01801 / US
03 / MITCHELL, Lorna Helen
1 Nichols Pl.
Cambridge, Massachusetts 02138 / US
04 / MUNCHHOF, Michael John
266 West Rd.
Salem, Connecticut 06420 / US
05 / HARVEY, Darren Martin
3 Barker Rd.
Acton, Massachusetts 01720 / US
 [2017/30]
Representative(s)Harris, Jennifer Lucy, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[2021/24]
Former [2017/30]Harris, Jennifer Lucy, et al
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Application number, filing date15840234.709.09.2015
[2017/30]
WO2015US49219
Priority number, dateUS201462048757P10.09.2014         Original published format: US 201462048757 P
US201562146808P13.04.2015         Original published format: US 201562146808 P
[2017/30]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016040504
Date:17.03.2016
Language:EN
[2016/11]
Type: A1 Application with search report 
No.:EP3193604
Date:26.07.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 17.03.2016 takes the place of the publication of the European patent application.
[2017/30]
Type: B1 Patent specification 
No.:EP3193604
Date:16.06.2021
Language:EN
[2021/24]
Search report(s)International search report - published on:US17.03.2016
(Supplementary) European search report - dispatched on:EP19.01.2018
ClassificationIPC:A61P35/00, C07D413/14, C07D413/12, A61K31/42
[2018/08]
CPC:
C07D487/04 (EP,US); A61P35/00 (EP,US); C07D413/12 (EP,US);
C07D413/14 (EP,US)
Former IPC [2017/30]A01N43/80
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/30]
Extension statesBA01.03.2017
ME01.03.2017
Validation statesMANot yet paid
TitleGerman:SUBSTITUIERTE N-(PYRROLIDINV3EYL)ISOXAZOL-3-CARBOXAMIDVERBINDUNGEN[2020/18]
English:SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS[2020/18]
French:COMPOSÉS DE N-(PYRROLIDIN-3YL)ISOXAZOL-3-CARBOXAMIDES SUBSTITUÉS[2020/18]
Former [2017/30]SUBSTITUIERTE PYRROLIDINVERBINDUNGEN
Former [2017/30]SUBSTITUTED PYRROLIDINE COMPOUNDS
Former [2017/30]COMPOSÉS PYRROLIDINES SUBSTITUÉS
Entry into regional phase01.03.2017National basic fee paid 
01.03.2017Search fee paid 
01.03.2017Designation fee(s) paid 
01.03.2017Examination fee paid 
Examination procedure01.03.2017Examination requested  [2017/30]
01.03.2017Date on which the examining division has become responsible
04.12.2018Amendment by applicant (claims and/or description)
02.04.2019Despatch of a communication from the examining division (Time limit: M06)
13.01.2020Reply to a communication from the examining division
23.04.2020Communication of intention to grant the patent
25.09.2020Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
02.12.2020Fee for grant paid
02.12.2020Fee for publishing/printing paid
02.12.2020Receipt of the translation of the claim(s)
Opposition(s)17.03.2022No opposition filed within time limit [2022/21]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
02.12.2020Request for further processing filed
02.12.2020Full payment received (date of receipt of payment)
Request granted
14.12.2020Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
13.01.2020Request for further processing filed
13.01.2020Full payment received (date of receipt of payment)
Request granted
22.01.2020Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
04.12.2018Request for further processing filed
04.12.2018Full payment received (date of receipt of payment)
Request granted
18.12.2018Decision despatched
The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application
04.12.2018Request for further processing filed
04.12.2018Full payment received (date of receipt of payment)
Request granted
10.01.2019Decision despatched
Fees paidRenewal fee
27.09.2017Renewal fee patent year 03
27.09.2018Renewal fee patent year 04
27.09.2019Renewal fee patent year 05
28.09.2020Renewal fee patent year 06
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.09.2015
AL16.06.2021
AT16.06.2021
CY16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
MK16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
IE09.09.2021
LU09.09.2021
BG16.09.2021
GB16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
CH30.09.2021
FR30.09.2021
LI30.09.2021
IS16.10.2021
PT18.10.2021
[2024/22]
Former [2023/30]HU09.09.2015
AL16.06.2021
AT16.06.2021
CY16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
IE09.09.2021
LU09.09.2021
BG16.09.2021
GB16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
CH30.09.2021
FR30.09.2021
LI30.09.2021
IS16.10.2021
PT18.10.2021
Former [2023/27]HU09.09.2015
AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
IE09.09.2021
LU09.09.2021
BG16.09.2021
GB16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
CH30.09.2021
FR30.09.2021
LI30.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/37]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
IE09.09.2021
LU09.09.2021
BG16.09.2021
GB16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
CH30.09.2021
FR30.09.2021
LI30.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/36]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
IE09.09.2021
LU09.09.2021
BG16.09.2021
GB16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
FR30.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/35]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
IE09.09.2021
LU09.09.2021
BG16.09.2021
GB16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
FR30.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/34]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
LU09.09.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
BE30.09.2021
FR30.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/29]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/25]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/21]AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/10]AT16.06.2021
CZ16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/09]AT16.06.2021
CZ16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
PT18.10.2021
Former [2022/08]AT16.06.2021
CZ16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
RS16.06.2021
SE16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2022/07]AT16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
RS16.06.2021
SE16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2021/51]FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
RS16.06.2021
SE16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2021/49]FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
SE16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2021/47]FI16.06.2021
LT16.06.2021
BG16.09.2021
Former [2021/46]FI16.06.2021
LT16.06.2021
Documents cited:Search[X]WO2007121920  (NOVARTIS AG [CH], et al) [X] 1,2,7,8 * intermediate P; example 93; *;
 [XP]WO2014175370  (SHIONOGI & CO [JP]) [XP] 1,5-8* compounds I-072 and I-626 *;
 [A]  - ANDREWD FERGUSON ET AL, "Structural Basis of Substrate Methylation and Inhibition of SMYD2", STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 19, no. 9, doi:10.1016/J.STR.2011.06.011, ISSN 0969-2126, (20110613), pages 1262 - 1273, (20110708), XP028284161 [A] 1-15 * Figure 1, compound AZ505 *

DOI:   http://dx.doi.org/10.1016/j.str.2011.06.011
International search[Y]  - PubChem, (20121022), Database accession no. 62378974, XP055417573 [Y] 1-2 * , Fig *
 [Y]  - PubChem, (20120819), Database accession no. 58952603, XP055417577 [Y] 1-2
 [A]  - PubChem, (20140228), Database accession no. 72928190, XP055417073 [A] 1-2
 [A]  - PubChem, (20101127), Database accession no. 49688186, XP055417579 [A] 1-2 * , Fig *
by applicant   - ANDREW FERGUS SON et al., STRUCTURE, ELSEVIER, (20110613), vol. 19, pages 1262 - 1273
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.