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Extract from the Register of European Patents

EP About this file: EP3088421

EP3088421 - MONOCLONAL ANTIBODIES FOR USE IN DIAGNOSIS AND THERAPY OF CANCERS AND AUTOIMMUNE DISEASE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.01.2020
Database last updated on 11.04.2026
FormerThe patent has been granted
Status updated on  25.01.2019
FormerGrant of patent is intended
Status updated on  20.09.2018
FormerExamination is in progress
Status updated on  13.07.2018
FormerGrant of patent is intended
Status updated on  11.07.2018
FormerExamination is in progress
Status updated on  30.05.2018
FormerGrant of patent is intended
Status updated on  12.03.2018
FormerExamination is in progress
Status updated on  24.05.2017
Most recent event   Tooltip03.01.2020No opposition filed within time limitpublished on 05.02.2020  [2020/06]
Applicant(s)For all designated states
Board of Regents, The University of Texas System
210 West 7th Street
Austin, TX 78701 / US
[2018/49]
Former [2016/44]For all designated states
Board of Regents, The University of Texas System
201 West 7th Street
Austin, TX 78701 / US
Inventor(s)01 / Molldrem, Jeffrey
1515 Holcombe Blvd.
Unit 0900
Houston, TX 77030 / US
02 / Sergeeva, Anna
3431 Linkwood Drive
Houston, TX 77025 / US
 [2016/44]
Representative(s)Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
[N/P]
Former [2019/09]Potter Clarkson
The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
Former [2016/44]Potter Clarkson LLP
The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
Application number, filing date16152641.303.07.2013
[2016/44]
Priority number, dateUS201261669967P10.07.2012         Original published format: US 201261669967 P
US201261702916P19.09.2012         Original published format: US 201261702916 P
[2016/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3088421
Date:02.11.2016
Language:EN
[2016/44]
Type: B1 Patent specification 
No.:EP3088421
Date:27.02.2019
Language:EN
[2019/09]
Search report(s)(Supplementary) European search report - dispatched on:EP08.09.2016
ClassificationIPC:C07K16/30, C07K16/28, A61K39/395, A61K39/00, A61P35/00, A61P37/00, // A61K45/06, C07K16/40, G01N33/574
[2018/10]
CPC:
C07K16/40 (EP,KR,US); C07K16/2833 (EP,KR,US); A61K39/395 (KR);
A61K45/06 (KR,US); A61K47/6851 (EP,KR,US); A61K47/6871 (EP,KR,US);
A61K49/0058 (KR); A61P29/00 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P35/04 (EP); A61P37/00 (EP);
A61P37/02 (EP); A61P37/06 (EP); A61P43/00 (EP);
C07K16/30 (EP,KR,US); C07K16/3061 (EP,KR,US); G01N33/57585 (KR,US);
A61K39/00 (EP,US); C07K2317/24 (EP,KR,US); C07K2317/32 (EP,KR,US);
C07K2317/34 (EP,KR,US); C07K2317/567 (EP,KR,US); C07K2317/71 (EP,KR,US);
C07K2317/73 (EP,KR,US); C07K2317/92 (EP,KR,US); G01N2333/96433 (KR,US) (-)
Former IPC [2016/44]C07K16/30, C07K16/28, A61K39/395, A61K39/00, A61P35/00, A61P37/00, // A61K45/06, A61K47/48, C07K16/40, G01N33/574
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/44]
Extension statesBA03.02.2016
ME03.02.2016
TitleGerman:MONOKLONALE ANTIKÖRPER ZUR VERWENDUNG IN DER DIAGNOSE UND THERAPIE VON KREBSERKRANKUNGEN UND AUTOIMMUNERKRANKUNGEN[2016/44]
English:MONOCLONAL ANTIBODIES FOR USE IN DIAGNOSIS AND THERAPY OF CANCERS AND AUTOIMMUNE DISEASE[2016/44]
French:ANTICORPS MONOCLONAUX DESTINÉS À ÊTRE UTILISÉS DANS LE DIAGNOSTIC ET LA THÉRAPIE DE CANCERS ET DE MALADIES AUTO-IMMUNES[2016/44]
Examination procedure03.02.2016Examination requested  [2016/44]
13.03.2017Amendment by applicant (claims and/or description)
30.05.2017Despatch of a communication from the examining division (Time limit: M04)
29.09.2017Reply to a communication from the examining division
13.03.2018Communication of intention to grant the patent
25.05.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
21.09.2018Communication of intention to grant the patent
17.01.2019Fee for grant paid
17.01.2019Fee for publishing/printing paid
17.01.2019Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP13816335.7  / EP2872174
Opposition(s)28.11.2019No opposition filed within time limit [2020/06]
Fees paidRenewal fee
03.02.2016Renewal fee patent year 03
11.07.2016Renewal fee patent year 04
12.07.2017Renewal fee patent year 05
11.07.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipSM27.02.2019
[2019/52]
Documents cited:Search[XI] WO2010065962  (UNIV TEXAS et al.)
 [ID]   A. SERGEEVA ET AL.: "An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells.", BLOOD, vol. 117, no. 16, 21 April 2011 (2011-04-21), USA, pages 4262 - 4272, XP002756081

DOI:   http://dx.doi.org/10.1182/blood-2010-07-299248
by applicantUS4680338
 US5141648
 US5563250
 US5856456
 US5880270
 US6013516
 US5994136
 US5846233
 US5846225
 US5801005
 US5739169
 US5830880
 US5846945
 US5824311
 US5599795
 US5443826
 US4843092
 US6491916
   "Remington's Pharmaceutical Sciences", pages: 1035 - 1038,157
   RASSENTI; KIPPS, J. EXP. MED., vol. 185, 1997, pages 1435
   BEBBINGTON, BIOLTECHNOLOGY, vol. 10, 1992, pages 169 - 175
   ALATRASH ET AL., J IMMUNOL., vol. 35, 2012, pages 309 - 320
   ANTIN, BLOOD, vol. 82, 1993, pages 2273 - 2277
   AREND ET AL., ANNU. REV. IMMUNOL., vol. 16, 1998, pages 27 - 55
   AREND, SEMIN. ARTHRITIS RHEUM., vol. 30, no. 5, 2001, pages 1 - 6
   AUSTIN-WARD; VILLASECA, REV. MED. CHIL., vol. 126, no. 7, 1998, pages 838 - 45
   BAICHWAL; SUGDEN: "Gene Transfer", 1986, NY, PLENUM PRESS, pages: 117 - 148
   BAJORIN ET AL., J CLIN. ONCOL., vol. 6, no. 5, 1988, pages 786 - 92
   BAKHSHI ET AL., CELL, vol. 41, no. 3, 1985, pages 899 - 906
   BASHA ET AL., PLOS ONE, vol. 3, 2008, pages E3247
   BEIDLER ET AL., J IMMUNOL., vol. 141, no. 11, 1988, pages 4053 - 4060
   BESNARD ET AL., GUT., vol. 43, no. 5, 1998, pages 634 - 638
   BLOMER ET AL., J VIROL., vol. 71, no. 9, 1997, pages 6641 - 6649
   BROUWER ET AL., CLIN. EXP. IMMUNOL., vol. 98, 1994, pages 448 - 453
   BRYNSKOV ET AL., N. ENGL. J. MED., vol. 321, no. 13, 1989, pages 845 - 850
   BUKOWSKI ET AL., CLIN. CANCER RES., vol. 4, no. 10, 1998, pages 2337 - 47
   BURCHERT ET AL., BLOOD, vol. 02, 2002, pages 659
   BURGDORF ET AL., J IMMUNOL., vol. 176, 2006, pages 6770 - 6776
   BURGER; DAYER, NEUROLOGY, vol. 45, no. 6S-6, 1995, pages S39 - 43
   CAPALDI ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 74, no. 2, 1977, pages 425 - 433
   CHEN; OKAYAMA, MOL. CELL BIOL., vol. 7, no. 8, 1987, pages 2745 - 2752
   CHRISTODOULIDES ET AL., MICROBIOLOGY, vol. 144, 1998, pages 3027 - 37
   CLEARY; SKLAR, PROC. NATL. ACAD. SCI. USA, 1985, pages 7439 - 7443
   CLEARY ET AL., J EXP. MED., vol. 164, no. 1, 1986, pages 315 - 320
   COTTEN ET AL., PROC. NATL. ACAD SCI. USA, vol. 89, no. 13, 1992, pages 6094 - 6098
   COUPAR ET AL., GENE, vol. 68, 1988, pages 1 - 10
   CRESSWELL ET AL., IMMUNOL. REV., vol. 207, 2005, pages 145 - 157
   CURIEL, NAT. IMMUN., vol. 13, no. 2-3, 1994, pages 141 - 164
   DAVIDSON ET AL., J IMMUNOTHER., vol. 21, no. 5, 1998, pages 389 - 98
   DESMEDT ET AL., INT. J CANCER, vol. 119, 2006, pages 2539 - 2545
   DILLMAN, CANCER BIOTHER. RADIOPHARM., vol. 14, no. 1, 1999, pages 5 - 10
   DINARELLO, INT. REV. IMMUNOL., vol. 16, 1998, pages 457 - 499
   DIONNE ET AL., CLIN. EXP. IMUNOL., vol. 112, no. 3, 1998, pages 435 - 442
   DUDLEY ET AL., SCIENCE, vol. 298, 2002, pages 850 - 854
   EASTGATE ET AL., LANCET, vol. 2, 1988, pages 706 - 709
   FECHHEIMER ET AL., PROC. NATL. ACAD SCI. USA, vol. 84, 1987, pages 8463 - 8467
   FELLERMAN ET AL., AM. J GASTROENTEROL., vol. 93, no. 10, 1998, pages 1860 - 1866
   FIRESTEIN ET AL., ARTHRITIS RHEUM., vol. 37, 1994, pages 644 - 652
   FRALEY ET AL., PROC. NATL. ACAD SCI. USA, vol. 76, 1979, pages 3348 - 3352
   FRANCOIS ET AL., BLOOD, vol. 114, 2009, pages 2632 - 2638
   FRANSSEN ET AL., LANCET, vol. 347, 1996, pages 116
   FRIEDMANN, SCIENCE, vol. 244, 1989, pages 1275 - 1281
   FUJIKAWA ET AL., ANN. RHEUM. DIS., vol. 54, 1995, pages 318 - 320
   FUNAKOSHI ET AL., DIGESTION, vol. 59, no. 1, 1998, pages 73 - 78
   GIRALT; KOLB, CURR. OPIN. ONCOL., vol. 8, 1996, pages 96 - 102
   GOPAL, MOL. CELL BIOL., vol. 5, 1985, pages 1188 - 1190
   GRAHAM; VAN DER EB, VIROLOGY, vol. 52, 1973, pages 456 - 467
   GRUNHAUS; HORWITZ, SEMINAR IN VIROLOGY, vol. 3, 1992, pages 237 - 252
   HANIBUCHI ET AL., INT. J CANCER, vol. 78, no. 4, 1998, pages 480 - 485
   HANNUM ET AL., NATURE, vol. 343, 1990, pages 336 - 340
   HARLAND; WEINTRAUB, J CELL BIOL., vol. 101, 1985, pages 1094 - 1099
   HELLSTRAND ET AL., ACTA ONCOL., vol. 37, no. 4, 1998, pages 347 - 353
   HOFFENBERG ET AL., J PEDIATR., vol. 134, no. 4, 1999, pages 447 - 452
   HOLLANDER ET AL., ANN. INTERN. MED., vol. 105, 1986, pages 883 - 885
   HOLLANDER, SCAND. J. GASTROENTEROL., vol. 27, 1992, pages 721 - 726
   HORWICH ET AL., J VIROL., vol. 64, 1990, pages 642 - 650
   HUI; HASHIMOTO, INFECT. IMMUN., vol. 66, no. 11, 1998, pages 5329 - 36
   IRIE ET AL., LANCET, vol. 1, no. 8641, 1989, pages 786 - 787
   JARVIS, CURR. OPIN. RHEUMATOL., vol. 10, no. 5, 1998, pages 459 - 467
   JARVIS, PEDIATR. ANN., vol. 31, no. 7, 2002, pages 437 - 446
   JENSEN ET AL., J CLIN. ONCOL., vol. 27, 2009, pages 4709 - 4717
   JENSEN ET AL., CANCER, vol. 118, 2012, pages 2476 - 2485
   JIANG ET AL., BR. J HAEMATOL., vol. 93, 1996, pages 606 - 612
   JOHNSON ET AL.: "Biotechnology And Pharmacy", 1993, CHAPMAN AND HALL, NY
   JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
   JONSSON ET AL., BR. J RHEUMATOL., vol. 32, no. 7, 1993, pages 578 - 581
   JONSSON ET AL., ORAL DIS., vol. 8, no. 3, 2002, pages 130 - 140
   JONSSON ET AL., TRENDS IMMUNOL., vol. 22, no. 12, 2001, pages 653 - 654
   KAEPPLER ET AL., PLANT-CELL REPORTS, vol. 9, 1990, pages 415 - 418
   KAHLE ET AL., ANN. RHEUM. DIS., vol. 51, 1992, pages 731 - 734
   KANEDA ET AL., SCIENCE, vol. 243, 1989, pages 375 - 378
   KATO ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 3361 - 3364
   KELLEHER; VOS, BIOTECHNIQUES, vol. 17, no. 6, 1994, pages 1110 - 7
   KERR ET AL., BR. J. CANCER, vol. 26, no. 4, 1972, pages 239 - 257
   KOLB; HOLLER, CURR. OPIN. ONCOL., vol. 9, 1997, pages 139 - 145
   KOLB ET AL., BLOOD, vol. 86, 1995, pages 2041 - 2050
   KOLB ET AL., BONE MARROW TRANSPLANT, vol. 17, 1996, pages 449 - 452
   KOTZIN, CELL, vol. 85, 1996, pages 303 - 306
   KOVACSOVICS-BANKOWSKI; ROCK, SCIENCE, vol. 267, 1995, pages 243 - 246
   KUBOYAMA, KURUME MED. J, vol. 45, no. 1, 1998, pages 33 - 37
   KURONITA, J. CELL SCI., vol. 115, 2002, pages 4117 - 4131
   KYTE; DOOLITTLE, J. MOL. BIOL., vol. 57, no. 1, 1982, pages 105 - 32
   LAUGHLIN ET AL., J. VIROL., vol. 60, no. 2, 1986, pages 515 - 524
   LEBKOWSKI ET AL., MOL. CELL. BIOL., vol. 8, no. 10, 1988, pages 3988 - 3996
   LEIPER ET AL., BAILLIERES CLIN. GASTROENTEROL., vol. 12, no. 1, 1998, pages 179 - 199
   LIPSKY ET AL.: "Harrison's principles of internal medicine", 1998, MCGRAW-HILL, pages: 1880 - 1888
   LUGERING ET AL., ITAL. J. GASTROENTEROL. HEPATOL., vol. 30, no. 3, 1998, pages 338 - 344
   MAKOWIEC ET AL., Z. GASTROENTEROL., vol. 36, no. 8, 1998, pages 619 - 624
   MANN ET AL., CELL, vol. 33, 1983, pages 153 - 159
   MCALINDON ET AL., GUT, vol. 42, no. 2, 1998, pages 214 - 219
   MCLAUGHLIN ET AL., J. VIROL., vol. 62, no. 6, 1988, pages 1963 - 1973
   MILLER ET AL., AM. J. CLIN. ONCOL., vol. 15, no. 3, 1992, pages 216 - 221
   MITTENDORF ET AL., CANCER RES., vol. 72, 2012, pages 3153 - 3162
   MOLLDREM ET AL., BLOOD, vol. 88, 1996, pages 2450 - 2457
   MOLLDREM ET AL., BLOOD, vol. 90, 1997, pages 2529 - 2534
   MOLLDREM ET AL., CANCER RES., vol. 59, 1999, pages 2675 - 2681
   MOLLDREM ET AL., NAT. MED., vol. 6, 2000, pages 1018 - 1023
   MOLLDREM ET AL., J. CLIN. INVEST., vol. 111, 2003, pages 639 - 647
   MORRISON, SCIENCE, vol. 229, no. 4719, 1985, pages 1202 - 1207
   MUKAI ET AL., J. IMMUNOL., vol. 183, 2009, pages 6561 - 6568
   MURCH, NUTRITION, vol. 14, 1998, pages 780 - 783
   MUZYCZKA, CURR. TOPICS MICROBIOL. IMMUNOL., vol. 158, 1992, pages 97 - 129
   NALDINI ET AL., SCIENCE, vol. 272, no. 5259, 1996, pages 263 - 267
   NICOLAU; SENE, BIOCHIM. BIOPHYS. ACTA, vol. 721, 1982, pages 185 - 190
   NICOLAU ET AL., METHODS ENZYMOL., vol. 149, 1987, pages 157 - 176
   OHNISHI ET AL., INT. IMMUNOL., vol. 6, 1994, pages 817 - 830
   OMIRULLEH ET AL., PLANT MOL. BIOL., vol. 21, no. 3, 1993, pages 415 - 28
   PASKINDETAL., VIROLOGY, vol. 67, 1975, pages 242 - 248
   PAUL, IMMUNOGENETICS, vol. 37, no. 6, 1993, pages 442 - 448
   PIETRAS ET AL., ONCOGENE, vol. 17, no. 17, 1998, pages 2235 - 49
   PORGADOR ET AL., IMMUNITY, vol. 6, 1997, pages 715 - 726
   POTRYKUS ET AL., MOL. GEN. GENET., vol. 199, 1985, pages 183 - 188
   PRANG ET AL., BR. J. CANCER, vol. 92, 2005, pages 342 - 349
   PRIEUR ET AL., LANCET., vol. 2, 1987, pages 1240 - 1242
   QIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, no. 24, 1998, pages 14411 - 14416
   QUEEN ET AL., CANCER RES., vol. 65, 2005, pages 8896 - 8904
   REIMUND ET AL., EUR. J. CLIN. INVEST., vol. 28, no. 2, 1998, pages 145 - 150
   "Remington's Pharmaceutical Sciences", 1980, MACK PUBLISHING COMPANY, pages: 1035 - 1038,157
   REZVANI ET AL., CYTOTHERAPY, vol. 9, 2007, pages 245 - 251
   REZVANI ET AL., BLOOD, vol. 111, 2008, pages 236 - 242
   RIDGEWAY: "Vectors: A survey of molecular cloning vectors and their uses", 1988, STONEHAM:BUTTERWORTH, pages: 467 - 492
   RIPPE ET AL., MOL. CELL BIOL., vol. 10, 1990, pages 689 - 695
   ROGLER; ANDUS, WORLD J. SURG., vol. 22, no. 4, 1998, pages 382 - 389
   ROONEY ET AL., RHEUMATOL. INT., vol. 10, 1990, pages 217 - 219
   ROSENBERG ET AL., ANN. SURG., vol. 210, no. 4, 1989, pages 474 - 548
   ROSENBERG ET AL., N. ENGL. J. MED., vol. 319, 1988, pages 1676
   ROUX ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 9079 - 9083
   RUEMMELE ET AL., GASTROENTEROL, vol. 115, no. 4, 1998, pages 822 - 829
   SAIKI ET AL., SCAND J GASTROENTEROL., vol. 33, no. 6, 1998, pages 616 - 622
   SALOMONSSON ET AL., SCAND. J. IMMUNOL., vol. 55, no. 4, 2002, pages 336 - 342
   SARTOR, AM. J GASTROENTEROL., vol. 92, no. 12, 1997, pages 5S - 11S
   SAVAGE ET AL., IMMUNITY, vol. 10, 1999, pages 485 - 492
   SCHEIBENBOGEN ET AL., BLOOD, vol. 100, 2002, pages 2132 - 2137
   SCHREIBER, NETH. J. MED., vol. 53, no. 6, 1998, pages 24 - 31
   SCHWARTZENTRUBER ET AL., N. ENGL. J MED., vol. 364, 2011, pages 2119 - 2127
   SERGEEVA ET AL., BLOOD, vol. 117, 2011, pages 4262 - 4272
   SHAW ET AL., J NATL. CANCER INST., vol. 80, no. 19, 1988, pages 1553 - 1559
   SODERHOLM ET AL., GASTROENTEROL., vol. 117, 1999, pages 65 - 72
   STACK ET AL., LANCET, vol. 349, no. 9051, 1997, pages 521 - 524
   STITES, J MOL. BIOL., vol. 235, no. 1, 1994, pages 27 - 32
   SUN ET AL., J. STEROID BIOCHEM., vol. 26, no. 1, 1987, pages 83 - 92
   TARGAN ET AL., N. ENGL. J MED., vol. 337, no. 15, 1997, pages 1029 - 1035
   TEMIN: "Gene Transfer", 1986, PLENUM PRESS, pages: 149 - 188
   TRATSCHIN ET AL., MOL. CELL. BIOL., vol. 4, 1984, pages 2072 - 2081
   TSUJIMOTO; CROCE, PROC. NATL. ACAD. SCI. USA, vol. 83, no. 14, 1986, pages 5214 - 5218
   TSUJIMOTO ET AL., SCIENCE, vol. 228, no. 4706, 1985, pages 1440 - 1443
   VAN DEN BERG, SEMIN. ARTHRITIS RHEUM., vol. 30, no. 5S-2, 2001, pages 7 - 16
   VAN DULLEMEN ET AL., GASTROENTEROL., vol. 109, no. 1, 1995, pages 129 - 135
   VANDENDRIESSCHE ET AL., BLOOD, vol. 100, no. 3, 2002, pages 813 - 822
   WADA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 2367 - 2411
   WARRINGTON ET AL., ARTHRITIS AND RHEUMATISM, vol. 44, 2001, pages 13 - 20
   WONG ET AL., GENE, vol. 10, 1980, pages 87 - 94
   WOOD ET AL., J. CLIN. LAB. IMMUNOL., vol. 17, no. 4, 1985, pages 167 - 171
   XANTHOU ET AL., ARTHRITIS RHEUM., vol. 44, no. 2, 2001, pages 408 - 418
   ZUFFEREY ET AL., NAT. BIOTECHNOL., vol. 15, no. 9, 1997, pages 871 - 875
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.