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EP About this file: EP3056515

EP3056515 - METHODS FOR MANIPULATING PHAGOCYTOSIS MEDIATED BY CD47 [Right-click to bookmark this link]
Status	Patent maintained as amended Status updated on 18.07.2025 Database last updated on 28.03.2026
Former	The patent has been granted Status updated on 15.03.2019
Former	Grant of patent is intended Status updated on 03.03.2019
Former	Examination is in progress Status updated on 05.05.2017
Most recent event Tooltip	18.07.2025	Patent maintained (B2 publication)	published on 20.08.2025 [2025/34]
Applicant(s)	For all designated states The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170, Third Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 / US
	[2019/38]
Former [2016/33]	For all designated states The Board of Trustees of The Leland Stanford Junior University Office of The General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 / US
Inventor(s)	01 / JAISWAL, Siddhartha Department of Pathology Massachusetts General Hospital Warren 245 55 Fruit St Boston MA 02114 / US
	02 / WEISSMAN, Irving L. 747 Santa Ynez Street Stanford, CA 97305 / US
	03 / JAMIESON, Catriona, Helen M. Moores University of California San Diego Cancer Center, MC 0820, 3855 Healty Science Drive La Jolla, CA 92093-0820 / US
	04 / MAJETI, Ravindra Stanford Institute for Stem Cell Bio and Regenerative Medicine 1050 Arastradero Road Building A Stanford, CA 94304 / US
	[2019/16]
Former [2016/33]	01 / JAISWAL, Siddhartha Department of Pathology Massachusetts General Hospital Warren 245 55 Fruit St Boston MA 02114 / US
	02 / WEISSMAN, Irving, L. 747 Santa Ynez Street Stanford, CA 97305 / US
	03 / JAMIESON, Catriona, Helen, M. Moores University of California San Diego Cancer Center, MC 0820, 3855 Healty Science Drive La Jolla, CA 92093-0820 / US
	04 / MAJETI, Ravindra Stanford Institute for Stem Cell Bio and Regenerative Medicine 1050 Arastradero Road Building A Stanford, CA 94304 / US
Representative(s)	Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	[2025/34]
Former [2016/33]	Chapman, Desmond Mark Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
Application number, filing date	16160476.4	15.01.2009
	[2016/33]
Priority number, date	US20080011324P	15.01.2008 Original published format: US 11324 P
	US20080189786P	22.08.2008 Original published format: US 189786 P
	[2016/33]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP3056515
	Date:	17.08.2016
	Language:	EN
	[2016/33]
	Type:	B1 Patent specification
	No.:	EP3056515
	Date:	17.04.2019
	Language:	EN
	[2019/16]
	Type:	B2 New European patent specification
	No.:	EP3056515
	Date:	20.08.2025
	Language:	EN
	[2025/34]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	04.05.2016
Classification	IPC:	A61K39/00, C07K16/28	[2019/11]
	CPC:	C07K16/2803 (EP,US); A61P35/02 (EP,US); C07K16/28 (US); C07K16/2896 (EP,US); C07K16/30 (US); C12N5/0093 (EP,US); (+) C12N5/0694 (EP,US); C12Q1/6886 (EP,US); G01N33/5011 (US); G01N33/57505 (EP,US); A61K2039/505 (EP,US); A61K2039/507 (US); C07K2317/24 (US); C07K2317/73 (US); C07K2317/75 (EP,US); C07K2317/76 (EP,US); C12Q2600/112 (EP,US); C12Q2600/136 (EP,US); G01N2500/04 (EP,US) (-)
	Former IPC [2016/33]	C07K16/28, A61K39/395, C07K16/46, A61K47/48, C07K16/18, C07K16/30, A61K39/00
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2017/12]
Former [2016/33]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR
Title	German:	VERFAHREN ZUR BEHANDLUNG VON DURCH CD47 VERMITTELTER PHAGOZYTOSE	[2016/33]
	English:	METHODS FOR MANIPULATING PHAGOCYTOSIS MEDIATED BY CD47	[2016/33]
	French:	PROCÉDÉS PERMETTANT DE MANIPULER LA PHAGOCYTOSE MÉDIÉE PAR CD47	[2016/33]
Examination procedure	15.03.2016	Examination requested [2016/33]
	23.05.2016	Despatch of a communication from the examining division (Time limit: M04)
	03.10.2016	Reply to a communication from the examining division
	25.04.2017	Despatch of a communication from the examining division (Time limit: M06)
	19.09.2017	Reply to a communication from the examining division
	20.11.2017	Observations by third parties
	01.12.2017	Despatch of a communication from the examining division (Time limit: M04)
	11.01.2018	Reply to a communication from the examining division
	01.02.2018	Observations by third parties
	23.03.2018	Despatch of a communication from the examining division (Time limit: M06)
	28.09.2018	Reply to a communication from the examining division
	26.10.2018	Despatch of a communication from the examining division (Time limit: M04)
	12.11.2018	Reply to a communication from the examining division
	16.11.2018	Observations by third parties
	04.03.2019	Communication of intention to grant the patent
	05.03.2019	Fee for grant paid
	05.03.2019	Fee for publishing/printing paid
	05.03.2019	Receipt of the translation of the claim(s)
Parent application(s) Tooltip	EP09701993.9 / EP2242512
Divisional application(s)	EP19168096.6 / EP3539617
	EP22191294.2 / EP4144367
Opposition(s)	Opponent(s)	01 16.09.2019 21.01.2020 ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerther Straße 11 40545 Düsseldorf / DE
		02 23.12.2019 13.10.2023 WITHDRAWN Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Opponent's representative Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
		03 17.01.2020 24.01.2020 ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Opponent's representative J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
		04 17.01.2020 24.01.2020 ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Mathys & Squire 32 London Bridge Street The Shard London SE1 9SG / GB
		[N/P]
	Former [2023/47]
	Opponent(s)	01 16.09.2019 21.01.2020 ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerther Straße 11 40545 Düsseldorf / DE
		02 23.12.2019 13.10.2023 WITHDRAWN Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Opponent's representative Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
		03 17.01.2020 24.01.2020 ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Opponent's representative J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
		04 17.01.2020 24.01.2020 ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2023/42]
	Opponent(s)	01 16.09.2019 21.01.2020 ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerther Straße 11 40545 Düsseldorf / DE
		02 23.12.2019 07.01.2020 ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Opponent's representative Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
		03 17.01.2020 24.01.2020 ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Opponent's representative J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
		04 17.01.2020 24.01.2020 ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2022/30]
	Opponent(s)	01 16.09.2019 21.01.2020 ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerter Straße 11 40545 Düsseldorf / DE
		02 23.12.2019 07.01.2020 ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Opponent's representative Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
		03 17.01.2020 24.01.2020 ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Opponent's representative J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
		04 17.01.2020 24.01.2020 ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2020/09]
	Opponent(s)	01 16.09.2019 21.01.2020 ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König, Gregor Sebastian, et al, et al König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11 40545 Düsseldorf / DE
		02 23.12.2019 07.01.2020 ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Opponent's representative Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
		03 17.01.2020 ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Opponent's representative J A Kemp LLP 14 South Square Gray's Inn London WC1R 5JJ / GB
		04 17.01.2020 ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2020/07]
	Opponent(s)	01 16.09.2019 ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König, Gregor Sebastian, et al, et al König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11 40545 Düsseldorf / DE
		02 23.12.2019 07.01.2020 ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Opponent's representative Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
	Former [2019/43]
	Opponent(s)	01 16.09.2019 König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Opponent's representative König, Gregor Sebastian, et al, et al König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11 40545 Düsseldorf / DE
	03.02.2020	Invitation to proprietor to file observations on the notice of opposition
	13.08.2020	Reply of patent proprietor to notice(s) of opposition
	16.08.2023	Cancellation of oral proceeding that was planned for 19.10.2023
	19.10.2023	Date of oral proceedings
	17.10.2024	Legal effect of interlocutory decision in opposition
	18.10.2024	Cancellation of oral proceeding that was planned for 21.10.2024
	21.10.2024	Date of oral proceedings
	23.12.2024	Despatch of interlocutory decision in opposition
	23.12.2024	Despatch of minutes of oral proceedings
	19.05.2025	Despatch of communication that the patent will be maintained as amended
Fees paid	Renewal fee
	15.03.2016	Renewal fee patent year 03
	15.03.2016	Renewal fee patent year 04
	15.03.2016	Renewal fee patent year 05
	15.03.2016	Renewal fee patent year 06
	15.03.2016	Renewal fee patent year 07
	15.03.2016	Renewal fee patent year 08
	11.01.2017	Renewal fee patent year 09
	15.01.2018	Renewal fee patent year 10
	15.01.2019	Renewal fee patent year 11
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	15.01.2009
	CY	17.04.2019
	CZ	17.04.2019
	EE	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	MK	17.04.2019
	MT	17.04.2019
	PL	17.04.2019
	RO	17.04.2019
	SI	17.04.2019
	SK	17.04.2019
	TR	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
	[2022/32]
Former [2022/28]	HU	15.01.2009
	CY	17.04.2019
	CZ	17.04.2019
	EE	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	MT	17.04.2019
	PL	17.04.2019
	RO	17.04.2019
	SI	17.04.2019
	SK	17.04.2019
	TR	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2020/26]	CZ	17.04.2019
	EE	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	PL	17.04.2019
	RO	17.04.2019
	SI	17.04.2019
	SK	17.04.2019
	TR	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2020/17]	CZ	17.04.2019
	EE	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	PL	17.04.2019
	RO	17.04.2019
	SK	17.04.2019
	TR	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2020/11]	CZ	17.04.2019
	EE	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	PL	17.04.2019
	RO	17.04.2019
	SK	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2020/10]	CZ	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	PL	17.04.2019
	RO	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2020/09]	CZ	17.04.2019
	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	PL	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2019/52]	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	PL	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2019/51]	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	BG	17.07.2019
	GR	18.07.2019
Former [2019/50]	HR	17.04.2019
	LT	17.04.2019
	LV	17.04.2019
	GR	18.07.2019
Former [2019/47]	LT	17.04.2019
Documents cited:	Search	[XI] EP1693385 (CHUGAI PHARMACEUTICAL CO LTD et al.)
		[I] US2007111238 (JAMIESON CATRIONA H M et al.)
		[X] PARTHA MANNA ET AL: "CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.", CANCER RESEARCH, vol. 64, no. 3, 1 February 2004 (2004-02-01), pages 1026 - 1036, XP055030076, ISSN: 0008-5472 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-03-1708
		[A] Y. LIU ET AL: "Signal Regulatory Protein (SIRPalpha ), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 12, 15 March 2002 (2002-03-15), pages 10028 - 10036, XP055030073, ISSN: 0021-9258, DOI: 10.1074/jbc.M109720200 DOI: http://dx.doi.org/10.1074/jbc.M109720200
		RAVINDRA MAJETI1 ET AL: "CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells", DEVELOPMENTAL CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 138, no. 2, 23 July 2009 (2009-07-23), pages 286 - 299, XP002632714, ISSN: 1097-4172, [retrieved on 20090723], DOI: 10.1016/J.CELL.2009.05.045 DOI: http://dx.doi.org/10.1016/J.CELL.2009.05.045
		S. B. WILLINGHAM ET AL: "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 17, 26 March 2012 (2012-03-26), pages 6662 - 6667, XP055029983, ISSN: 0027-8424, DOI: 10.1073/pnas.1121623109 DOI: http://dx.doi.org/10.1073/pnas.1121623109
		[PI] MAJETI RAVINDRA ET AL: "CD47 Is An Independent Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 112, no. 11, 1 November 2008 (2008-11-01), pages 284, XP009160228, ISSN: 0006-4971
		[A] PETTERSEN R F ET AL: "CD47 SIGNALS T CELL DEATH", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 162, 1 January 1999 (1999-01-01), pages 7031 - 7040, XP002940659, ISSN: 0022-1767
		X. W. ZHAO ET AL: "Is targeting of CD47-SIRP enough for treating hematopoietic malignancy?", BLOOD, vol. 119, no. 18, 3 May 2012 (2012-05-03), pages 4333 - 4334, XP055116565, ISSN: 0006-4971, DOI: 10.1182/blood-2011-11-391367 DOI: http://dx.doi.org/10.1182/blood-2011-11-391367
		[X] P. P. MANNA ET AL: "The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 7, 1 April 2003 (2003-04-01), pages 3544 - 3553, XP055116597, ISSN: 0022-1767, DOI: 10.4049/jimmunol.170.7.3544 DOI: http://dx.doi.org/10.4049/jimmunol.170.7.3544
		M. P. CHAO ET AL: "Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia", CANCER RESEARCH, vol. 71, no. 4, 15 February 2011 (2011-02-15), pages 1374 - 1384, XP055029988, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-2238 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-2238
		JAISWAL S ET AL: "Macrophages as mediators of tumor immunosurveillance", TRENDS IN IMMUNOLOGY, ELSEVIER LTD. * TRENDS JOURNALS, GB, vol. 31, no. 6, 1 June 2010 (2010-06-01), pages 212 - 219, XP027079216, ISSN: 1471-4906, [retrieved on 20100601], DOI: 10.1016/J.IT.2010.04.001 DOI: http://dx.doi.org/10.1016/j.it.2010.04.001
		X. W. ZHAO ET AL: "CD47-signal regulatory protein- (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 45, 8 November 2011 (2011-11-08), pages 18342 - 18347, XP055055636, ISSN: 0027-8424, DOI: 10.1073/pnas.1106550108 DOI: http://dx.doi.org/10.1073/pnas.1106550108
	by applicant	US6465247
		US95627901
		WO9910478
		US5985660
		MOTEGI S. ET AL., EMBO J., vol. 22, no. 11, pages 2634 - 2644
		HARLOW; LANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
		AKASHI ET AL., NATURE, vol. 404, no. 6774, 2000, pages 193
		KONDO ET AL., CELL, vol. 91, no. 5, 1997, pages 661 - 7
		KONDO ET AL., ANNU REV IMMUNOL., vol. 21, 2003, pages 759 - 806
		CHEN ET AL., IMMUNOL REV, vol. 157, 1997, pages 41 - 51
		MORRISON ET AL., CELL, vol. 96, 1999, pages 737 - 49
		WAGERS; WEISSMAN, STEM CELLS, vol. 24, no. 4, 2006, pages 1087 - 94
		WRIGHT DE ET AL., J EXP MED, vol. 195, no. 9, 2002, pages 1145 - 54
		MIKAYE K ET AL., J EXP MED, vol. 173, no. 3, 1991, pages 599 - 607
		VALK ET AL., N ENGL J MED, vol. 350, 2004, pages 1617 - 1628
		BULLINGER ET AL., BLOOD, vol. 111, 2008, pages 4490 - 4495
		SUBRAMANIAN ET AL., BLOOD, vol. 107, 2006, pages 2548 - 2556
		MAJETI ET AL., CELL STEM CELL, vol. 1, 2007, pages 635 - 645
	other	WO9904094
		PIETSCH ET AL.: "Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies", BLOOD CANCER J., vol. 7, no. 2, 2017, pages e536, XP055395279 DOI: http://dx.doi.org/10.1038/bcj.2017.7
		LUCY E. MTAYER, ANNA VILALTA, G.A. AMOS BURKE, GUY C. BROWN: "Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis", ONCOTARGET, vol. 8, no. 37, 2017, pages 60892 - 60903, XP055456424 DOI: http://dx.doi.org/10.18632/oncotarget.18492
		PIETSCH ET AL.: "Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies", BLOOD CANCER JOURNAL, vol. 7, 2017, XP055395279 DOI: http://dx.doi.org/10.1038/bcj.2017.7
		HAYLEY RUTGER: "Students draw a crowd to annual research and community health symposium", STANFORD SCHOOL OF MEDICINE NEWS, 20 May 2008 (2008-05-20), XP055532055, Retrieved from the Internet
	Opposition	EP2111869
		EP1693385
		WO2004096133
		WO9940940
		EP1035132
		US2009000319
		WO9940940
		WO2004096133
		EP2111869
		WO2009131453
		EP1035132
		EP1693385
		US2007111238
		WO2014149477
		WO2011143624
		WO2014108483
		WO2009091601
		US1132408
		US18978608
		EP3056515
		WO2009091601
		US1132408
		US18978608
		EP1693385
		US2007111238
		EP2228772
		EP2111869
		EP1035132
		WO9940940
		EP1693385
		JP2007008895
		WO0166737
		US2004213792
		EP2111869
		US2007111238
		EP2212424
		MANNA ET AL.: "CD 47 mediates killing of breast tumor cells via Gi- dependent inhibition of protein kinase A", CANCER RESEARCH, vol. 64, 1 February 2004 (2004-02-01), pages 1026 - 1036, XP055030076, DOI: 10.1158/0008-5472.CAN-03-1708 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-03-1708
		KIM ET AL.: "Association of CD 47 with natural killer cell -mediated cytotoxicity of head-and-neck squamous cell carcinoma lines", TUMOR BIOLOGY, vol. 29, May 2008 (2008-05-01), pages 28 - 34, XP055347764 DOI: http://dx.doi.org/10.1159/000132568
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