blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3064512

EP3064512 - ANTI-CLDN6 ANTIBODY [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  28.07.2023
Database last updated on 11.05.2024
FormerGrant of patent is intended
Status updated on  20.03.2023
FormerExamination is in progress
Status updated on  19.10.2018
FormerRequest for examination was made
Status updated on  18.04.2017
Most recent event   Tooltip10.05.2024Lapse of the patent in a contracting state
New state(s): CZ, ES, RO, SK
published on 12.06.2024 [2024/24]
Applicant(s)For all designated states
The University of Tokyo
3-1, Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
For all designated states
CHUGAI SEIYAKU KABUSHIKI KAISHA
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
[2023/35]
Former [2016/36]For all designated states
The University of Tokyo
3-1, Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
For all designated states
CHUGAI SEIYAKU KABUSHIKI KAISHA
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
Inventor(s)01 / ABURATANI, Hiroyuki
c/o The University of Tokyo
3-1 Hongo 7-chome
Bunkyo-ku Tokyo 113-8654 / JP
02 / TSUTSUMI, Shuichi
c/o The University of Tokyo
3-1 Hongo 7-chome
Bunkyo-ku Tokyo 113-8654 / JP
03 / NISHIMURA, Kunihiro
c/o The University of Tokyo
3-1 Hongo 7-chome
Bunkyo-ku Tokyo 113-8654 / JP
04 / SAKUMOTO, Hirofumi
c/o Forerunner Pharma Research Co. Ltd.
2-16 Komaba 4-chome
Meguro-ku Tokyo 153-0041 / JP
05 / KAWAI, Shigeto
c/o Forerunner Pharma Research Co. Ltd.
2-16 Komaba 4-chome
Meguro-ku Tokyo 153-0041 / JP
 [2016/36]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstraße 4
81675 München / DE
[2023/35]
Former [2016/36]Power, David
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date16165434.809.01.2009
[2016/36]
Priority number, dateJP2008000442311.01.2008         Original published format: JP 2008004423
[2016/36]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP3064512
Date:07.09.2016
Language:EN
[2016/36]
Type: A3 Search report 
No.:EP3064512
Date:19.10.2016
Language:EN
[2016/42]
Type: B1 Patent specification 
No.:EP3064512
Date:30.08.2023
Language:EN
[2023/35]
Search report(s)(Supplementary) European search report - dispatched on:EP15.09.2016
ClassificationIPC:C07K16/28, A61K39/395, G01N33/53, G01N33/574, C12N15/09, C12P21/08, A61P35/00, A61K39/00
[2022/24]
CPC:
G01N33/57484 (EP,US); A61P35/00 (EP); C07K16/28 (EP,US);
G01N33/57492 (EP,US); A61K2039/505 (EP,US); C07K2317/732 (EP,US);
C07K2317/734 (EP,US) (-)
Former IPC [2016/36]C07K16/28, A61K39/395, A61P35/00, G01N33/53, G01N33/574, C12N15/09, C12P21/08
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/20]  
Former [2016/36]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:ANTIKÖRPER GEGEN CLDN6[2016/36]
English:ANTI-CLDN6 ANTIBODY[2016/36]
French:ANTICORPS CONTRE CLDN6[2016/36]
Examination procedure14.04.2016Date on which the examining division has become responsible
11.04.2017Examination requested  [2017/20]
04.08.2017Amendment by applicant (claims and/or description)
17.10.2018Despatch of a communication from the examining division (Time limit: M06)
23.10.2018Observations by third parties
25.04.2019Reply to a communication from the examining division
10.07.2019Despatch of a communication from the examining division (Time limit: M06)
11.02.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
21.04.2020Reply to a communication from the examining division
08.07.2020Despatch of a communication from the examining division (Time limit: M06)
16.01.2021Reply to a communication from the examining division
06.04.2021Despatch of a communication from the examining division (Time limit: M06)
15.10.2021Reply to a communication from the examining division
06.05.2022Cancellation of oral proceeding that was planned for 25.05.2022
25.05.2022Date of oral proceedings (cancelled)
03.06.2022Despatch of a communication from the examining division (Time limit: M06)
12.12.2022Reply to a communication from the examining division
21.03.2023Communication of intention to grant the patent
20.07.2023Fee for grant paid
20.07.2023Fee for publishing/printing paid
20.07.2023Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP09700588.8  / EP2241578
Divisional application(s)EP23193707.9  / EP4282428
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
21.04.2020Request for further processing filed
21.04.2020Full payment received (date of receipt of payment)
Request granted
29.04.2020Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
04.08.2017Request for further processing filed
04.08.2017Full payment received (date of receipt of payment)
Request granted
18.08.2017Decision despatched
Fees paidRenewal fee
14.04.2016Renewal fee patent year 03
14.04.2016Renewal fee patent year 04
14.04.2016Renewal fee patent year 05
14.04.2016Renewal fee patent year 06
14.04.2016Renewal fee patent year 07
14.04.2016Renewal fee patent year 08
11.01.2017Renewal fee patent year 09
15.01.2018Renewal fee patent year 10
15.01.2019Renewal fee patent year 11
14.01.2020Renewal fee patent year 12
13.01.2021Renewal fee patent year 13
16.12.2021Renewal fee patent year 14
14.12.2022Renewal fee patent year 15
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCZ30.08.2023
ES30.08.2023
HR30.08.2023
PL30.08.2023
RO30.08.2023
SK30.08.2023
NO30.11.2023
GR01.12.2023
IS30.12.2023
[2024/23]
Former [2024/10]HR30.08.2023
PL30.08.2023
NO30.11.2023
GR01.12.2023
IS30.12.2023
Former [2024/09]NO30.11.2023
GR01.12.2023
IS30.12.2023
Former [2024/08]NO30.11.2023
GR01.12.2023
Documents cited:Search[A]WO0026360  (ADHEREX TECHNOLOGIES INC [CA], et al) [A] 1-12 * claim 75 * * page 60, line 19 - page 61, line 6 *;
 [A]CA2379661  (TURKSEN KURSAD [CA]) [A] 1-12 * figure 4 *;
 [A]  - E. RENDON ET AL., "Expression and subcellular redistribution of claudins 6, 7 and 9 in human gastric adenocarcinoma.", THE FASEB JOURNAL, (200704), vol. 21, no. 6, XP008180199 [A] 1-12 * abstract A753 *
 [AD]  - A. ARABZADEH ET AL., "Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis.", BMC CANCER, England, (2007), vol. 7, pages 196 - 203, XP008139355 [AD] 1-12 * section immunohistochemistry *

DOI:   http://dx.doi.org/10.1186/1471-2407-7-196
 [A]  - K. MORITA ET AL., "Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells.", THE JOURNAL OF CELL BIOLOGY, USA, (19991004), vol. 147, no. 1, pages 185 - 194, XP002239048 [A] 1-12 * page 186, column r, paragraph 2 * * figure 1 *

DOI:   http://dx.doi.org/10.1083/jcb.147.1.185
 [A]  - S. OFFNER ET AL., "Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy.", CANCER IMMUNOLOGY IMMUNOTHERAPY, Germany, (20050501), vol. 54, no. 5, pages 431 - 445, XP019333121 [A] 1-12 * the whole document *

DOI:   http://dx.doi.org/10.1007/s00262-004-0613-x
ExaminationWO03088808
 US2005042216
    - HEWITT KYLE J ET AL, "The claudin gene family: expression in normal and neoplastic tissues", BMC CANCER, BIOMED CENTRAL, LONDON, GB, (20060712), vol. 6, no. 1, doi:10.1186/1471-2407-6-186, ISSN 1471-2407, page 186, XP021016181

DOI:   http://dx.doi.org/10.1186/1471-2407-6-186
    - GERSHONI JONATHAN M ET AL, "Epitope mapping - The first step in developing epitope-based vaccines", BIODRUGS, ADIS INTERNATIONAL LTD, NZ, (20070101), vol. 21, no. 3, doi:10.2165/00063030-200721030-00002, ISSN 1173-8804, pages 145 - 156, XP009103541

DOI:   http://dx.doi.org/10.2165/00063030-200721030-00002
    - RATHANASWAMI ET AL, "High-affinity binding measurements of antibodies to cell-surface-expressed antigens", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, (20080201), vol. 373, no. 1, doi:10.1016/J.AB.2007.08.014, ISSN 0003-2697, pages 52 - 60, XP022575079

DOI:   http://dx.doi.org/10.1016/j.ab.2007.08.014
    - Eric Neil Kaufman ET AL, "Effect of Bivalent Interaction upon Apparent Antibody Affinity: Experimental Confirmation of Theory Using Fluorescence Photobleaching and Implications for Antibody Binding Assays1", CANCER RESEARCH, (19920801), vol. 52, pages 4157 - 4167, XP055345407
    - ONG G L ET AL, "Re-evaluation of the concept of functional affinity as applied to bivalent antibody binding to cell surface antigens", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 30, no. 16, doi:10.1016/0161-5890(93)90107-M, ISSN 0161-5890, (19931101), pages 1455 - 1462, (19931101), XP023935457

DOI:   http://dx.doi.org/10.1016/0161-5890(93)90107-M
by applicantEP0239400
 JPH0159878B
 EP0404097
 WO9201047
 WO9203918
 WO9220791
 WO9306213
 WO9311236
 WO9311161
 WO9312227
 WO9319172
 WO9402602
 WO9411523
 WO9425585
 WO9501438
 WO9515388
 WO9602576
 WO9954342
 WO0061739
 WO0231140
 WO02079255
 WO03035835
 WO03088808
 WO03104453
 WO2006067847
 WO2006067913
 JP2007020155
 JP2008004423
    - FURUSE; TSUKITA, TRENDS IN CELL BIOLOGY, (2006), vol. 16, page 181
    - WILCOX ET AL., CELL, (2001), vol. 104, page 165
    - RAHNER ET AL., GASTROENTEROLOGY, (2001), vol. 120, page 411
    - MORITA ET AL., PROC. NATL. ACAD. SCI. USA, (1999), vol. 96, page 511
    - HEWITT ET AL., BMC CANCER, (2006), vol. 6, page 186
    - OSANAI ET AL., CANCER SCI., (2007), vol. 98, page 1557
    - AZADEH ARABZADEH ET AL., BMC CANCER, (2007), vol. 7, page 196
    - QUAN; LU, CARCINOGENESIS, (2003), vol. 24, page 1593
    - MIKIO FURUSE; SHOICHIRO TSUKITA, "Claudins in occluding junctions of human and flies", TRENDS IN CELL BIOLOGY, (2006), vol. 16, page 181
    - EDWARD R. WILCOX; QUIANNA L. BURTON; SADAF NAZ; SAIMA RIAZUDDIN; TENESHA N. SMITH; BARBARA PLOPLIS; INNA BELYANTSEVA; TAMAR BEN-YO, "Mutations in the Gene Encoding Tight Junction Claudin-14 Cause Autosomal Recessive Deafness DFNB29", CELL, (2001), vol. 104, page 165
    - CHRISTOPH RAHNER; LAURA L. MITIC; JAMES M. ANDERSON, "Heterogeneity in Expression and Subcellular Localization of Claudin 2, 3, 4, and 5 in the Rat Liver, Pancreas, and Gut", GASTROENTEROLOGY, (2001), vol. 120, doi:doi:10.1053/gast.2001.21736, page 411, XP022380618

DOI:   http://dx.doi.org/10.1053/gast.2001.21736
    - KAZUMASA MORITA; MIKIO FURUSE; KAZUSHI FUJIMOTO; SHOICHIRO TSUKITA, "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands", PROC. NATL. ACAD. SCI. USA, (1999), vol. 96, doi:doi:10.1073/pnas.96.2.511, page 511, XP002181049

DOI:   http://dx.doi.org/10.1073/pnas.96.2.511
    - KYLE J HEWITT; RACHANA AGARWAL; PATRICE J MORIN, "The claudin gene family: expression in normal and neoplastic tissues", BMC CANCER, (2006), vol. 6, doi:doi:10.1186/1471-2407-6-186, page 186, XP021016181

DOI:   http://dx.doi.org/10.1186/1471-2407-6-186
    - MAKOTO OSANAI; MASAKI MURATA; HIDEKI CHIBA; TAKASHI KOJIMA; NORIMASA SAWADA, "Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells", CANCER SCI, (2007), vol. 98, doi:doi:10.1111/J.1349-7006.2007.00569.X, page 1557, XP002547907

DOI:   http://dx.doi.org/10.1111/J.1349-7006.2007.00569.X
    - AZADEH ARABZADEH; TAMMY-CLAIRE TROY; KURSAD TURKSEN, "Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis", BMC CANCER, (2007), vol. 7, page 196
    - CHENGSHI QUAN; SHI-JIANG LU, "Identification of genes preferentially expressed in mammary epithelial cells of Copenhagen rat using subtractive hybridization and microarrays", CARCINOGENESIS, (2003), vol. 24, page 1593
    - KOHLS MD; LAPPI DA, "Mab-ZAP: A tool for evaluating antibody efficacy for use in an immunotoxin", BIOTECHNIQUES, (2000), vol. 28, no. 1, page 162, XP001207983
    - NIMMERJAHN F; RAVETCH JV., "Divergent immunoglobulin G subclass activity through selective Fc receptor binding", SCIENCE, (2005), vol. 310, doi:doi:10.1126/science.1118948, page 1510, XP002441364

DOI:   http://dx.doi.org/10.1126/science.1118948
    - NIMMERJAHN F; RAVETCH JV., "Fey Receptors: Old friends and new family members", IMMUNITY, (2006), vol. 24, doi:doi:10.1016/j.immuni.2005.11.010, page 19, XP002498113

DOI:   http://dx.doi.org/10.1016/j.immuni.2005.11.010
    - LANGONE J. J. ET AL., METHODS IN ENZYMOLOGY, (1983), vol. 93, pages 307 - 308
    - NATURE MEDICINE, (1996), vol. 2, pages 350 - 353
    - FULTON R. J. ET AL., J. BIOL. CHEM., (1986), vol. 261, pages 5314 - 5319
    - SIVAM G. ET AL., CANCER RES., (1987), vol. 47, pages 3169 - 3173
    - CUMBER A. J. ET AL., J. IMMUNOL. METHODS, (1990), vol. 135, pages 15 - 24
    - WAWRZYNCZAK E. J. ET AL., CANCER RES., (1990), vol. 50, pages 7519 - 7562
    - GHEEITE V. ET AL., J. IMMUNOL. METHODS, (1991), vol. 142, pages 223 - 230
    - THORPE P. E. ET AL., CANCER RES., (1987), vol. 47, pages 5924 - 5931
    - WAWRZYNCZAK E. J. ET AL., BR. J. CANCER, (1992), vol. 66, pages 361 - 366
    - WAWRZYNCZAKE. J. ET AL., CANCER RES., (1990), vol. 50, pages 7519 - 7562
    - BOLOGNESI A. ET AL., CLIN. EXP. IMMUNOL., (1992), vol. 89, pages 341 - 346
    - STIRPE F.; BARBIERI L., FEBS LETTER, (1986), vol. 195, pages 1 - 8
    - CASELLAS P. ET AL., EUR. J. BIOCHEM., (1988), vol. 176, pages 581 - 588
    - ROWLAND G. F. ET AL., NATURE, (1975), vol. 255, pages 487 - 488
    - HURWITZ E.; HAIMOVICH J., METHOD IN ENZYMOLOGY, (1986), vol. 178, pages 369 - 375
    - SCHECHTER B. ET AL., INT. J. CANCER, (1991), vol. 48, pages 167 - 172
    - OTA, Y. ET AL., ASIA-OCEANIA J. OBSTET. GYNAECOL, (1993), vol. 19, pages 449 - 457
    - NOGUCHI, A. ET AL., BIOCONJUGATE CHEM, (1992), vol. 3, pages 132 - 137
    - SHIH, L. B. ET AL., CANCER RES., (1991), vol. 51, pages 4192 - 4198
    - ZHU, Z. ET AL., CANCER IMMUNOL. IMMUMOTHER, (1995), vol. 40, pages 257 - 267
    - TRAIL, P. A. ET AL., SCIENCE, (1993), vol. 261, pages 212 - 215
    - KONDO, Y. ET AL., JPN. J. CANCER RES., (1995), vol. 86, pages 1072 - 1079
    - DILLMAN, R. 0. ET AL., CANCER RES., (1988), vol. 48, pages 6097 - 6102
    - HUDECZ, F. ET AL., BIOCONJUGATE CHEM, (1990), vol. 1, pages 197 - 204
    - TUKADA Y. ET AL., J. NATL. CANCER INST, (1984), vol. 75, pages 721 - 729
    - MANABE, Y. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN, (1983), vol. 115, pages 1009 - 1014
    - KITAMURA K. ET AL., CANCER IMMUNOL. IMMUMOTHER, (1993), vol. 36, pages 177 - 184
    - YAMAGUCHI T. ET AL., JPN. J. CANCER RES., (1994), vol. 85, pages 167 - 171
    - KRALOVEC, J. ET AL., CANCER IMMUNOL. IMMUMOTHER, (1989), vol. 29, pages 293 - 302
    - KULKARNI, P. N. ET AL., CANCER RES., (1981), vol. 41, pages 2700 - 2706
    - SHIN, L. B. ET AL., INT. J. CANCER, (1988), vol. 41, pages 832 - 839
    - GAMETT M. C. ET AL., INT. J. CANCER, (1983), vol. 31, pages 661 - 670
    - SHIN, L. B., INT. J. CANCER, (1990), vol. 46, pages 1101 - 1106
    - GOERLACH A. ET AL., BIOCONJUGATE CHEM., (1991), vol. 2, pages 96 - 101
    - HURWITZ E. ET AL., J. MED. CHEM., (1985), vol. 28, pages 137 - 140
    - KANELLOS J. ET AL., IMMUNOL. CELL. BIOL., (1987), vol. 65, pages 483 - 493
    - JOHNSON J. R. ET AL., BR. J. CANCER, (1980), vol. 42, page 17
    - JOHNSON J. R. ET AL., BR. J. CANCER, (1981), vol. 44, pages 472 - 475
    - HERMANSON G. T., BIOCONJUGATE TECHNIQUES, (1996), pages 230 - 232
    - HERMANSON G. T., BIOCONJUGATE TECHNIQUES, (1996), pages 232 - 235
    - HERMANSON G. T., BIOCONJUGATE TECHNIQUES, (1996), pages 242 - 243
    - HERMANSON G. T., BIOCONJUGATE TECHNIQUES, (1996), pages 237 - 238
    - CASELLAS P. ET AL., EUR. J. BIOCHEM, (1988), vol. 176, pages 581 - 588
    - HASHIMOTO-GOTOH, T. ET AL., GENE, (1995), vol. 152, pages 271 - 275
    - ZOLLER, MJ; SMITH, M, METHODS ENZYMOL., (1983), vol. 100, pages 468 - 500
    - KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, pages 9441 - 9456
    - KRAMER W; FRITZ HJ, METHODS. ENZYMOL, (1987), vol. 154, pages 350 - 367
    - KUNKEL, TA, PROC NATL ACAD SCI USA., (1985), vol. 82, pages 488 - 492
    - KUNKEL, METHODS ENZYMOL., (1988), vol. 85, pages 2763 - 2766
    - MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, pages 5662 - 5666
    - ZOLLER, M. J.; SMITH, M., NUCLEIC ACIDS RESEARCH, (1982), vol. 10, pages 6487 - 6500
    - WANG, A. ET AL., SCIENCE, vol. 224, pages 1431 - 1433
    - DALBADIE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, (1982), vol. 79, pages 6409 - 6413
    - SAMBROOK, J. ET AL., Molecular Cloning, COLD SPRING HARBOR LAB. PRESS, (1989), pages 9.47 - 9.58
    - J. IMMUNOL., (1979), vol. 123, pages 1548 - 1550
    - CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, (1978), vol. 81, pages 1 - 7
    - KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., (1976), vol. 6, pages 511 - 519
    - MARGULIES. D. H. ET AL., CELL, (1976), vol. 8, pages 405 - 415
    - SHULMAN, M. ET AL., NATURE, (1978), vol. 276, pages 269 - 270
    - ST. GROTH, S. F. ET AL., J. IMMUNOL. METHODS, (1980), vol. 35, pages 1 - 21
    - TROWBRIDGE, I. S., J. EXP. MED., (1978), vol. 148, pages 313 - 323
    - GALFRE, G. ET AL., NATURE, (1979), vol. 277, pages 131 - 133
    - KOHLER. G.; MILSTEIN, C., METHODS ENZYMOL., (1981), vol. 73, pages 3 - 46
    - VANDAMME, A. M. ET AL., EUR. J. BIOCHEM., (1990), vol. 192, pages 767 - 775
    - CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, (1979), vol. 18, pages 5294 - 5299
    - CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., (1987), vol. 162, pages 156 - 159
    - FROHMAN, M. A. ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 8998 - 9002
    - BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., (1989), vol. 17, pages 2919 - 2932
    - J. MOL. BIOL., (1991), vol. 222, pages 581 - 597
    - MULLIGAN ET AL., NATURE, (1979), vol. 277, page 108
    - MIZUSHIMA ET AL., NUCLEIC ACIDS RES., (1990), vol. 18, page 5322
    - WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546
    - FASEBJ., (1992), vol. 6, pages 2422 - 2427
    - BETTER ET AL., SCIENCE, (1988), vol. 240, pages 1041 - 1043
    - LEI, S. P. ET AL., J. BACTERIOL., (1987), vol. 169, page 4379
    - EBERT, K. M. ET AL., BIO/TECHNOLOGY, (1994), vol. 12, pages 699 - 702
    - SHIMIZU Y. ET AL., CARBOHYDRATE RESEARCH, (2001), vol. 332, pages 381 - 388
    - KONDO A. ET AL., AGRICULTURAL AND BIOLOGICAL CHEMISTRY, (1990), vol. 54, no. 8, pages 2169 - 2170
    - SATO, K. ET AL., CANCER RES, (1993), vol. 53, pages 851 - 856
    - CO, M. S. ET AL., J. IMMUNOL., (1994), vol. 152, pages 2968 - 2976
    - BETTER, M.; HORWITZ, A. H., METHODS IN ENZYMOLOGY, (1989), vol. 178, pages 476 - 496
    - PLUECKTHUN, A.; SKERRA, A, METHODS IN ENZYMOLOGY, (1989), vol. 178, pages 476 - 496
    - LAMOYI, E., METHODS IN ENZYMOLOGY, (1989), vol. 121, pages 652 - 663
    - ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, (1989), vol. 121, pages 663 - 669
    - BIRD, R. E. ET AL., TIBTECH, (1991), vol. 9, pages 132 - 137
    - HOLLIGER P ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. U.S.A, (1988), vol. 85, pages 5879 - 5883
    - HUDSON ET AL., J IMMUNOL. METHODS, (1999), vol. 231, pages 177 - 189
    - Remington's Pharmaceutical Science, MARK PUBLISHING COMPANY
    - KOHLS; LAPPI, BIOTECHNIQUES, (2000), vol. 28, no. 1, page 162
otherWO0026360
 WO03088808
 US2005042216
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.