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Extract from the Register of European Patents

EP About this file: EP3115045

EP3115045 - DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.06.2021
Database last updated on 24.04.2024
FormerThe patent has been granted
Status updated on  10.07.2020
FormerGrant of patent is intended
Status updated on  05.03.2020
FormerExamination is in progress
Status updated on  17.02.2020
FormerGrant of patent is intended
Status updated on  16.10.2019
FormerExamination is in progress
Status updated on  20.07.2018
FormerRequest for examination was made
Status updated on  29.09.2017
FormerThe application has been published
Status updated on  09.12.2016
Most recent event   Tooltip15.07.2022Lapse of the patent in a contracting state
New state(s): MK, PT		published on 17.08.2022  [2022/33]
Applicant(s)For all designated states
BASF SE
Carl-Bosch-Strasse 38
67056 Ludwigshafen am Rhein / DE
[2020/33]
Former [2017/02]For all designated states
BASF SE
Carl-Bosch-Strasse 38
67056 Ludwigshafen am Rhein / DE
Inventor(s)01 / SUBKOWSKI, Thomas
Wichernstr. 13
68526 Ladenburg / DE
02 / BOLLSCHWEILER, Claus
Karl-Christ-Str. 13
69118 Heidelberg / DE
03 / WITTENBERG, Jens
Mainstr. 6
67117 Limburgerhof / DE
04 / KROHN, Michael
Alexanderstr. 8
64653 Lorsch / DE
05 / ZINKE, Holger
Darmstädter Str. 36
64673 Zwingenberg / DE
 [2017/02]
Representative(s)(deleted)
[2020/33]
Former [2017/02]Reitstötter Kinzebach
Patentanwälte
Sternwartstrasse 4
81679 München / DE
Application number, filing date16175305.826.08.2009
[2017/02]
Priority number, dateEP2008016299726.08.2008         Original published format: EP 08162997
[2017/02]
Filing languageDE
Procedural languageDE
PublicationType: A2 Application without search report 
No.:EP3115045
Date:11.01.2017
Language:DE
[2017/02]
Type: A3 Search report 
No.:EP3115045
Date:17.05.2017
Language:DE
[2017/20]
Type: B1 Patent specification 
No.:EP3115045
Date:12.08.2020
Language:DE
[2020/33]
Search report(s)(Supplementary) European search report - dispatched on:EP20.04.2017
ClassificationIPC:A61K31/135, A61K31/155, A61K31/357, A61K31/381, A61K31/4164, A61K31/443, A61K31/445, A61K31/4743, A61K31/496, A61K31/506, A61P13/02, A61P35/00, A61P29/00, A61G9/00, A61K6/00, A61K8/00, A61Q11/02, A61Q17/02, A23G9/00
[2017/02]
CPC:
C07D495/22 (EP,US); A61K31/451 (CN); A23C13/125 (CN);
A23G9/32 (CN); A23L2/52 (CN); A23L27/88 (EP,US);
A23L29/035 (CN); A23L29/045 (CN); A23L29/055 (CN);
A61K31/00 (EP,US); A61K31/137 (CN); A61K31/165 (CN);
A61K31/17 (CN); A61K31/381 (CN); A61K31/403 (CN);
A61K31/4174 (CN); A61K31/4439 (CN); A61K31/445 (CN);
A61K31/495 (CN); A61K31/498 (CN); A61K8/42 (EP,CN,US);
A61K8/49 (EP,CN,US); A61K8/4926 (EP,CN,US); A61K8/494 (CN);
A61K8/4946 (EP,CN,US); A61K8/4953 (EP,US); A61K8/4973 (EP,CN,US);
A61K8/4986 (CN); A61K8/69 (EP,CN,US); A61P13/02 (EP);
A61P13/08 (EP); A61P13/10 (EP); A61P25/00 (EP);
A61P25/04 (EP); A61P29/00 (EP); A61P33/00 (EP);
A61P35/00 (EP); A61P43/00 (EP); A61Q11/00 (EP,CN,US);
A61Q17/02 (EP,US); A61Q17/04 (EP,US); A61Q19/00 (CN);
A61Q19/004 (EP,US); A61Q5/02 (EP,US); A61Q5/12 (CN);
C07C275/28 (US); C07D211/14 (EP,US); C07D233/84 (EP,US);
C07D241/44 (EP,US); C07D317/64 (EP,US); C07D401/04 (EP,US);
C07D401/12 (EP,US); C07D409/12 (EP,US); C07D495/20 (EP,US);
C08K5/20 (CN); C08K5/3432 (CN); C08K5/3462 (CN);
C08K5/45 (CN); D06M13/355 (CN); D06M13/402 (CN);
D06M13/408 (CN); D06M13/418 (CN); D06M13/432 (CN);
D21H17/07 (CN); D21H17/09 (CN); A61K2800/244 (EP,CN,US);
A61K2800/78 (US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2017/44]
Former [2017/02]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:NACHWEIS UND VERWENDUNG NIEDERMOLEKULARER MODULATOREN DES KÄLTE-MENTHOL-REZEPTORS TRPM8[2017/02]
English:DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8[2017/02]
French:VERIFICATION ET UTILISATION DE MODULATEURS SOUS-MOLECULAIRES DU RECEPTEUR DE FROID ET DE MENTHOL TRPM8[2017/02]
Examination procedure20.06.2016Date on which the examining division has become responsible
26.09.2017Amendment by applicant (claims and/or description)
26.09.2017Examination requested  [2017/44]
19.07.2018Despatch of a communication from the examining division (Time limit: M06)
11.12.2018Reply to a communication from the examining division
17.10.2019Communication of intention to grant the patent
14.02.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
06.03.2020Communication of intention to grant the patent
01.07.2020Fee for grant paid
01.07.2020Fee for publishing/printing paid
01.07.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP09782234.0  / EP2349239
Divisional application(s)EP19214768.4  / EP3698779
Opposition(s)14.05.2021No opposition filed within time limit [2021/29]
Fees paidRenewal fee
20.10.2016Renewal fee patent year 03
20.10.2016Renewal fee patent year 04
20.10.2016Renewal fee patent year 05
20.10.2016Renewal fee patent year 06
20.10.2016Renewal fee patent year 07
20.10.2016Renewal fee patent year 08
31.08.2017Renewal fee patent year 09
31.08.2018Renewal fee patent year 10
02.09.2019Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.08.2009
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MK12.08.2020
MT12.08.2020
PL12.08.2020
PT12.08.2020
RO12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
TR12.08.2020
AT26.08.2020
IE26.08.2020
LU26.08.2020
BE31.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
[2022/32]
Former [2022/27]HU26.08.2009
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MT12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
TR12.08.2020
AT26.08.2020
IE26.08.2020
LU26.08.2020
BE31.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/47]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
AT26.08.2020
IE26.08.2020
LU26.08.2020
BE31.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/37]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
IE26.08.2020
LU26.08.2020
BE31.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/36]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
LU26.08.2020
BE31.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/34]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SK12.08.2020
SM12.08.2020
LU26.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/28]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SK12.08.2020
SM12.08.2020
LU26.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/27]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SM12.08.2020
LU26.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/22]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
PL12.08.2020
RO12.08.2020
SE12.08.2020
SM12.08.2020
LU26.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/20]DK12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
PL12.08.2020
SE12.08.2020
LU26.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/10]FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
PL12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/09]FI12.08.2020
LT12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
Former [2021/08]FI12.08.2020
LT12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
Former [2021/07]FI12.08.2020
LT12.08.2020
NO12.11.2020
Documents cited:Search[A]WO9858905  (YAMANOUCHI PHARMA CO LTD [JP], et al) [A] 1-12 * claim - *;
 [A]JP2000302760  (HOKURIKU PHARMACEUTICAL) [A] 1-12 * abstract * * paragraph [0031] *;
 [A]DE10234876  (BAYER CROPSCIENCE GMBH [DE]) [A] 1-12 * tables 4,5 *;
 [AD]WO2004026840  (UNILEVER PLC [GB], et al) [AD] 1-12 * page 7, line 24 - line 25 * * compound - *;
 [A]US2005084447  (WEI EDWARD T [US]) [A] 1-12 * page 2, column 2 *;
 [A]US2005203159  (ZELLE ROBERT [US], et al) [A] 1-12 * claim - *;
 [A]WO2005099711  (ICAGEN INC [US], et al) [A] 1-12 * table 1 *;
 [A]US2005250836  (BOOTH RICHARD J [US], et al) [A] 1-12 * example 114 *;
 [A]WO2006097337  (BIONETWORKS GMBH [DE], et al) [A] 1-12* compound 7 *;
 [A]WO2007017093  (BAYER HEALTHCARE AG [DE], et al) [A] 1-12 * example - * * page 1 *;
 [A]WO2007080109  (BAYER HEALTHCARE AG [DE], et al) [A] 1-12 * claim - *;
 [A]WO2008015403  (UNIV EDINBURGH [GB], et al) [A] 1-12 * page 6, paragraph 1 *;
 [AP]WO2009064388  (LIU JUN O [US], et al) [AP] 1-12 * figure 1; compound 36 *;
 [IA]  - INGALE SANJAY J ET AL, "Synthesis and biological evaluation of some 4-substituted quinoxalinones", ASIAN JOURNAL OF CHEMISTRY, CHEMIC PUBLISHING, SAHIBADAD, IN, (20071031), vol. 19, no. 5, ISSN 0970-7077, pages 3797 - 3802, XP009193906 [I] 5,8-12 * tables 4,5 * [A] 1-4,6,7
 [A]  - DEMIRAYAK SEREF ET AL, "SYNTHESIS AND ANALGESIC ACTIVITIES OF SOME 2-(BENZAZOLYLACETYL)AMINO-3-ETHOXYCARBONYLTHIOPHENE DERIVATIVES", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, TAYLOR & FRANCIS INC, US, (20050101), vol. 180, doi:10.1080/104265090889503, ISSN 1042-6507, pages 1841 - 1848, XP009072026 [A] 1-12 * table 1 *

DOI:   http://dx.doi.org/10.1080/104265090889503
 [A]  - PATCH R J ET AL, "Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 16, no. 12, ISSN 0960-894X, (20060615), pages 3282 - 3286, (20060615), XP027965597 [A] 1-12 * table 2 *
 [XA]  - COOKE A ET AL, "Water-soluble propofol analogues with intravenous anaesthetic activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, (20010409), vol. 11, no. 7, doi:10.1016/S0960-894X(01)00088-9, ISSN 0960-894X, pages 927 - 930, XP004232526 [X] 5,8-12 * compound 3 * [A] 1-4,6,7

DOI:   http://dx.doi.org/10.1016/S0960-894X(01)00088-9
by applicantWO0215692
 US2003207904
 WO2004000023
 US2004028714
 WO2004026840
 US6893626
 WO2007019719
    - PEIER AM ET AL., "A TRP channel that senses cold stimuli and menthol", CELL, (20020308), vol. 108, no. 5, doi:doi:10.1016/S0092-8674(02)00652-9, pages 705 - 15, XP002246274

DOI:   http://dx.doi.org/10.1016/S0092-8674(02)00652-9
    - MCKEMY DD ET AL., "Identification of a cold receptor reveals a general role for TRP channels in thermosensation", NATURE, (20020307), vol. 416, no. 6876, doi:doi:10.1038/nature719, pages 52 - 8, XP002250383

DOI:   http://dx.doi.org/10.1038/nature719
    - ZUKER CS, "Neurobiology: a cool ion channel", NATURE, (20020307), vol. 416, no. 6876, pages 27 - 8
    - MCKEMY D.D., MOLECULAR PAIN, (2005), vol. 1, page 16
    - MCKEMY D.D., NATURE, (2002), vol. 416, pages 52 - 58
    - PEIER A.M., CELL, (2002), vol. 108, pages 705 - 715
    - DHAKA A., ANNU. REV. NEUROSCI., (2006), vol. 29, pages 135 - 161
    - WATSON H.R., J. SOC. COSMET. CHEM., (1978), vol. 29, pages 185 - 200
    - FURRER S.M., CHEM. PERCEPT., (2008), vol. 1, pages 119 - 126
    - WEI E.T., J. PHARM. PHARMACOL., (1983), vol. 35, pages 110 - 112
    - BECK B., CELL CALCIUM, (2007), vol. 41, pages 285 - 294
    - LEVINE J.D., BIOCHIM. BIOPHYS. ACTA, MOL. BASIS DIS., (2007), vol. 1772, pages 989 - 1003
    - MUKERJI G., BMC UROLOGY, (2006), vol. 6, page 6
    - BEHRENDT H.J. ET AL., BR. J. PHARMACOL., (2004), vol. 141, pages 737 - 745
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.