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Extract from the Register of European Patents

EP About this file: EP3146982

EP3146982 - GENE THERAPY FOR AMYOTROPHIC LATERAL SCLEROSIS AND OTHER SPINAL CORD DISORDERS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.07.2020
Database last updated on 24.07.2024
FormerThe patent has been granted
Status updated on  19.07.2019
FormerGrant of patent is intended
Status updated on  05.03.2019
FormerExamination is in progress
Status updated on  25.01.2019
FormerGrant of patent is intended
Status updated on  24.09.2018
FormerExamination is in progress
Status updated on  17.11.2017
FormerRequest for examination was made
Status updated on  06.10.2017
FormerThe application has been published
Status updated on  24.02.2017
Most recent event   Tooltip23.07.2021Lapse of the patent in a contracting state
New state(s): MT		published on 25.08.2021  [2021/34]
Applicant(s)For all designated states
Genzyme Corporation
50 Binney Street
Cambridge, MA 02142 / US
[2018/29]
Former [2017/13]For all designated states
Genzyme Corporation
500 Kendall Street
Cambridge, MA 02142 / US
Inventor(s)01 / O'Riordan, Catherine
Genzyme Corporation
15 Pleasant Street Connector
Framingham, MA 01701 / US
02 / Wadsworth, Samuel
Genzyme Corporation
15 Pleasant Street Connector
Framingham, MA 01701 / US
 [2017/13]
Representative(s)Mathys & Squire
The Shard
32 London Bridge Street
London SE1 9SG / GB
[2019/34]
Former [2017/13]Mathys & Squire LLP
The Shard
32 London Bridge Street
London SE1 9SG / GB
Application number, filing date16184966.603.10.2007
[2017/13]
Priority number, dateUS20060827977P03.10.2006         Original published format: US 827977 P
[2017/13]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3146982
Date:29.03.2017
Language:EN
[2017/13]
Type: B1 Patent specification 
No.:EP3146982
Date:21.08.2019
Language:EN
[2019/34]
Search report(s)(Supplementary) European search report - dispatched on:EP27.01.2017
ClassificationIPC:A61K48/00, C12N15/864, A61P21/00
[2017/13]
CPC:
C12N15/86 (EP,CN,US); A61K38/1709 (EP,CN,US); A61K48/0075 (EP,CN,US);
A61P21/00 (EP); A61P25/00 (EP); A61P25/28 (EP);
A61K48/005 (US); C07K2319/00 (US); C12N2750/14143 (EP,CN,US);
C12N2750/14145 (EP,US); C12N2810/6027 (EP,US); C12N2830/002 (EP,US);
C12N2830/15 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/45]
Former [2017/13]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:GENTHERAPIE FÜR AMYOTROPHE LATERALSKLEROSE UND ANDERE RÜCKENMARKSERKRANKUNGEN[2017/13]
English:GENE THERAPY FOR AMYOTROPHIC LATERAL SCLEROSIS AND OTHER SPINAL CORD DISORDERS[2017/13]
French:THERAPIE GENIQUE VISANT A TRAITER LA SCLEROSE LATERALE AMYOTROPHIQUE ET D'AUTRES AFFECTIONS DE LA MOELLE EPINIERE[2018/41]
Former [2017/13]THERAPIE GENIQUE VISANT A TRAITER LA SCLEROSE LATERALE AMYOTROPHIQUE ET D'AUTRES TROUBLES DE LA MOELLE EPINIERE
Examination procedure19.08.2016Date on which the examining division has become responsible
29.09.2017Amendment by applicant (claims and/or description)
29.09.2017Examination requested  [2017/45]
20.11.2017Despatch of a communication from the examining division (Time limit: M06)
30.05.2018Reply to a communication from the examining division
25.09.2018Communication of intention to grant the patent
24.01.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
06.03.2019Communication of intention to grant the patent
04.07.2019Fee for grant paid
04.07.2019Fee for publishing/printing paid
04.07.2019Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP07839216.4  / EP2066791
EP12157957.7  / EP2497500
Divisional application(s)EP19192274.9  / EP3632472
Opposition(s)03.06.2020No opposition filed within time limit [2020/33]
Fees paidRenewal fee
19.08.2016Renewal fee patent year 03
19.08.2016Renewal fee patent year 04
19.08.2016Renewal fee patent year 05
19.08.2016Renewal fee patent year 06
19.08.2016Renewal fee patent year 07
19.08.2016Renewal fee patent year 08
19.08.2016Renewal fee patent year 09
19.08.2016Renewal fee patent year 10
11.10.2017Renewal fee patent year 11
11.10.2018Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT21.08.2019
CY21.08.2019
DK21.08.2019
MC21.08.2019
MT21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
IE03.10.2019
LT03.10.2019
LU03.10.2019
LV03.10.2019
SK03.10.2019
HU04.10.2019
SE04.10.2019
SI04.10.2019
BE31.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
BG31.05.2020
[2021/34]
Former [2021/26]AT21.08.2019
CY21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
IE03.10.2019
LT03.10.2019
LU03.10.2019
LV03.10.2019
SK03.10.2019
HU04.10.2019
SE04.10.2019
SI04.10.2019
BE31.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
BG31.05.2020
Former [2020/51]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
IE03.10.2019
LT03.10.2019
LU03.10.2019
LV03.10.2019
SK03.10.2019
HU04.10.2019
SE04.10.2019
SI04.10.2019
BE31.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
BG31.05.2020
Former [2020/46]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
IE03.10.2019
LT03.10.2019
LU03.10.2019
LV03.10.2019
SK03.10.2019
HU04.10.2019
SE04.10.2019
BE31.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
BG31.05.2020
Former [2020/39]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
LT03.10.2019
LU03.10.2019
LV03.10.2019
SK03.10.2019
HU04.10.2019
SE04.10.2019
BE31.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
BG31.05.2020
Former [2020/37]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
LT03.10.2019
LU03.10.2019
LV03.10.2019
SK03.10.2019
HU04.10.2019
BE31.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
Former [2020/36]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
LT03.10.2019
LU03.10.2019
CH31.10.2019
EE31.10.2019
LI31.10.2019
GR22.11.2019
IS21.12.2019
Former [2020/35]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
CZ03.10.2019
FI03.10.2019
LT03.10.2019
LU03.10.2019
CH31.10.2019
LI31.10.2019
GR22.11.2019
IS24.02.2020
Former [2020/34]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
CH31.10.2019
LI31.10.2019
GR22.11.2019
IS24.02.2020
Former [2020/29]AT21.08.2019
DK21.08.2019
MC21.08.2019
PL21.08.2019
GR22.11.2019
IS24.02.2020
Former [2020/24]AT21.08.2019
DK21.08.2019
PL21.08.2019
GR22.11.2019
IS24.02.2020
Former [2020/23]AT21.08.2019
DK21.08.2019
PL21.08.2019
GR22.11.2019
IS21.12.2019
Former [2020/22]DK21.08.2019
GR22.11.2019
IS21.12.2019
Former [2020/12]GR22.11.2019
IS21.12.2019
Documents cited:Search[XI]WO03055983  (SALK INST FOR BIOLOGICAL STUDI [US], et al) [X] 1-3,10 * page 27, paragraph 109 - page 28, paragraph 116 * [I] 4-9,11;
 [XI]  - KASPAR B K ET AL, "Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, (20030808), vol. 301, no. 5634, doi:10.1126/SCIENCE.1086137, ISSN 0036-8075, pages 839 - 842, XP002347775 [X] 1-3,10 * figures 1-3 * [I] 4-9,11

DOI:   http://dx.doi.org/10.1126/science.1086137
 [A]  - GAO G-P ET AL, "Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.182412299, (20020903), vol. 99, no. 18, ISSN 0027-8424, pages 11854 - 11859, XP002229849 [A] 1 * page 11858; table 3 *

DOI:   http://dx.doi.org/10.1073/pnas.182412299
 [A]  - RUITENBERG MARC J ET AL, "Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system.", METHODS (SAN DIEGO, CALIF.) OCT 2002, (200210), vol. 28, no. 2, ISSN 1046-2023, pages 182 - 194, XP002766077 [A] 1 * Page 184, last paragraph, bottom 10 lines - page 185, line, 9 * * Figure 2 * * Pages 191-2, section 2.2.2 *

DOI:   http://dx.doi.org/10.1016/S1046-2023(02)00222-0
by applicantWO9500655
 WO9511984
 WO9527071
 WO9639426
 US5658776
 US5672344
 US6124131
 US6180613
 US6432927
 US6432947
 US6503888
 US6544785
 US6667174
 US7053062
    - DAVIDSON ET AL., NATURE REV., (2003), vol. 4, pages 353 - 364
    - KAPLITT ET AL., NAT. GENET., (1994), vol. 8, pages 148 - 154
    - BARTLETT ET AL., HUM. GENE THER., (1998), vol. 9, pages 1181 - 1186
    - PASSINI ET AL., J. NEUROSCI., (2002), vol. 22, pages 6437 - 6446
    - SOUDAS ET AL., FASEB J., (2001), vol. 15, pages 2283 - 2285
    - BREAKEFIELD ET AL., NEW BIOL., (1991), vol. 3, pages 203 - 218
    - DEFALCO ET AL., SCIENCE, (2001), vol. 291, pages 2608 - 2613
    - CHAMBERLIN ET AL., BRAIN RES., (1998), vol. 793, pages 169 - 175
    - KASPAR ET AL., MOL. THER., (2002), vol. 5, pages 50 - 56
    - KASPER ET AL., SCIENCE, (2003), vol. 301, pages 839 - 842
    - AZZOUZ ET AL., NATURE, (2004), vol. 429, pages 413 - 417
    - ROAUL ET AL., NAT. MED., (2005), vol. 11, no. 4, pages 423 - 428
    - RALPH ET AL., NAT. MED., (2005), vol. 11, no. 4, pages 429 - 433
    - NEUFELD ET AL., SCIENCE, (1970), vol. 169, pages 141 - 146
    - CLARK ET AL., HUM. GENE THER., (1999), vol. 10, pages 1031 - 1039
    - VELDWIJK ET AL., MOL. THER., (2002), vol. 6, pages 272 - 278
    - MCLAUGHLIN ET AL., J. VIROL., (1988), vol. 62, pages 1963 - 1973
    - XIAO ET AL., EXP. NEUROBIOL., (1997), vol. 144, pages 113 - 124
    - FISHER ET AL., J. VIROL., (1996), vol. 70, pages 520 - 532
    - HERMONAT; MUZYCZKA, PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, pages 6466 - 6470
    - LEBKOWSKI ET AL., MOL. CELL. BIOL., (1988), vol. 8, pages 3988 - 3996
    - BRACKEN ET AL., CELL. MOL. LIFE SCI., (2003), vol. 60, pages 1376 - 1393
    - JELKMAN, PHYSIOL. REV., (1992), vol. 72, pages 449 - 489
    - WHITE ET AL., CIRC. RES., (1992), vol. 71, pages 1490 - 1500
    - WOLFE ET AL., EUR. J. BIOCHEM., (1983), vol. 135, pages 405 - 412
    - JIANG ET AL., J. BIOL. CHEM., (1996), vol. 271, no. 30, pages 17771 - 17778
    - LEVY ET AL., J. BIOL. CHEM., (1995), vol. 270, page 13333
    - LIU ET AL., CIRC. RES., (1995), vol. 77, page 638
    - FORSYTHE ET AL., MOL. CELL. BIOL., (1996), vol. 16, page 4604
    - FIRTH ET AL., PROC. NATL. ACAD. SCI., (1994), vol. 91, page 6496
    - FIRTH ET AL., J. BIOL. CHEM., (1995), vol. 270, page 21021
    - SEMENZA ET AL., J. BIOL. CHEM., (1994), vol. 269, page 23757
    - LEE ET AL., J. BIOL. CHEM., vol. 272, page 5375
    - MELILLO ET AL., J. EXP. MED., (1995), vol. 182, page 1683
    - MOORE, A.W. ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 10436 - 41
    - PUGH ET AL., J. BIOL. CHEM., (1997), vol. 272, no. 17, pages 11205 - 11214
    - HUANG, L.; J. GU; M. SCHAU; H. BUNN, PROC. NATL. ACAD. SCI. U.S.A., (1998), vol. 95, pages 7987 - 7992
    - WENGER, R.H. ET AL., EUR. J. BIOCHEM., (1997), vol. 246, pages 155 - 165
    - WENGER, R.H. ET AL., BLOOD, (1998), vol. 91, pages 3471 - 3480
    - GORLACH, A. ET AL., BIOCHEM. BIOPHYS. ACTA, (2000), vol. 1493, pages 125 - 134
    - GOTHIE, E. ET AL., J. BIOL. CHEM., (2000), vol. 275, pages 6922 - 6927
    - CHUN, Y.S. ET AL., BIOCHEM. J., (2002), vol. 362, pages 71 - 79
    - CHUN, Y.S. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2000), vol. 268, pages 652 - 656
    - TIAN, H. ET AL., GENES DEV., (1997), vol. 11, pages 72 - 82
    - EMA, M. ET AL., PROC. NATL. ACAD. SCI. USA, (1997), vol. 94, pages 4273 - 4278
    - FLAMME, I. ET AL., MECH. DEV., (1997), vol. 63, pages 51 - 60
    - HOGENESCH, J.B. ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, pages 5474 - 5479
    - BRACKEN, C.P. ET AL., CMLS. CELL. MOL. LIFE SCI., (2003), vol. 60, pages 1376 - 93
    - LI ET AL., J. BIOL. CHEM., (1996), vol. 271, no. 35, pages 21262 - 21267
    - WENGER, R.H. ET AL., KIDNEY INT., (1997), vol. 51, pages 560 - 563
    - WIESENER, M.S. ET AL., BLOOD, (1998), vol. 92, pages 2260 - 2268
    - GU, Y.Z. ET AL., GENE EXPR., (1998), vol. 7, pages 205 - 213
    - WANG, G.L. ET AL., PROC. NATL. ACAD. SCI. USA, (1995), vol. 92, pages 5510 - 5514
    - YU, A.Y. ET AL., AM. J. PHYSIOL., (1998), vol. 275, pages L818 - L826
    - HUANG, L.E. ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, pages 7987 - 7992
    - HUANG, L.E. ET AL., J. BIOL. CHEM., (1996), vol. 271, pages 32253 - 32259
    - POWELL, J.D. ET AL., BIOL. REPROD., (2002), vol. 67, pages 995 - 1002
    - KALLIO, P.J. ET AL., PROC. NATL. ACAD. SCI. USA, (1997), vol. 94, pages 5667 - 5672
    - KALLIO, P.J. ET AL., J. BIOL. CHEM., (1999), vol. 274, pages 6519 - 6525
    - SUTTER, C.H. ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 4748 - 4753
    - CHO, S. ET AL., FEBS LETT., (2001), vol. 498, pages 62 - 66
    - LISZTWAN, J. ET AL., GENES DEV., (1999), vol. 13, pages 1822 - 1833
    - MAXWELL, P.H. ET AL., NATURE, (1999), vol. 399, pages 271 - 275
    - COCKMAN, M.E. ET AL., J. BIOL. CHEM., (2000), vol. 275, pages 25733 - 25741
    - OHH, M. ET AL., NAT. CELL BIOL., (2000), vol. 2, pages 423 - 4727
    - TANIMOTO, K. ET AL., EMBO J., (2000), vol. 19, pages 4298 - 4309
    - MASSON, N. ET AL., EMBO J., (2001), vol. 20, pages 5197 - 5206
    - SRINIVAS, V. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1999), vol. 260, pages 557 - 561
    - JAAKKOLA, P. ET AL., SCIENCE, (2001), vol. 292, pages 468 - 472
    - IVAN, M. ET AL., SCIENCE, (2001), vol. 292, pages 464 - 468
    - YU, F. ET AL., PROC. NATL. ACAD. SCI. USA, (2001), vol. 98, pages 9630 - 9635
    - CHAN, D.A. ET AL., J. BIOL. CHEM., (2002), vol. 277, pages 40112 - 40117
    - MIN, J.H. ET AL., SCIENCE, (2002), vol. 296, pages 1886 - 1889
    - BRUICK, R.K. ET AL., SCIENCE, (2001), vol. 294, pages 1337 - 1340
    - EPSTEIN, A.C. ET AL., CELL, (2001), vol. 107, pages 43 - 54
    - IVAN, M. ET AL., PROC. NATL. ACAD. SCI. USA, (2002), vol. 99, pages 13459 - 13464
    - LIEB, M.E. ET AL., BIOCHEM. CELL. BIOL., (2002), vol. 80, pages 421 - 426
    - HUANG, J. ET AL., J. BIOL. CHEM., (2002), vol. 277, pages 39792 - 39800
    - OEHME, F. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2002), vol. 296, no. 2, pages 343 - 349
    - BACON ET AL., BIOCHEM. BIOPHYS. RES. COMM., (1998), vol. 249, pages 811 - 816
    - MITCHELL; TJIAN, SCIENCE, (1989), vol. 245, pages 371 - 378
    - BRENT; PTASHNE, NATURE, (1985), vol. 312, pages 612 - 615
    - MA; PTASHNE, CELL, (1987), vol. 51, pages 113 - 119
    - MERMOD ET AL., CELL, (1989), vol. 58, pages 741 - 753
    - SADOWSKI ET AL., NATURE, (1988), vol. 335, pages 563 - 564
    - TRIEZENBERG ET AL., GENES & DEV., (1988), vol. 2, pages 718 - 729
    - CAMPBELL ET AL., J. MOL. BIOL., (1984), vol. 180, pages 1 - 19
    - KRISTIE; ROIZMAN, PROC. NATL. ACAD. SCI., (1984), vol. 81, pages 4065 - 4069
    - PELLET ET AL., PROC. NATL. ACAD. SCI., (1985), vol. 82, pages 5870 - 5874
    - MCKNIGHT ET AL., PROC. NATL. ACAD. SCI., (1987), vol. 84, pages 7061 - 7065
    - PRESTON ET AL., CELL, (1988), vol. 52, pages 425 - 434
    - MULLER ET AL., NATURE, (1988), vol. 336, pages 544 - 551
    - LUCIBELLO ET AL., ONCOGENE, (1988), vol. 3, pages 43 - 52
    - BOS ET AL., CELL, (1988), vol. 52, pages 705 - 712
    - OSTAPCHUK ET AL., MOL. CELL. BIOL., (1989), vol. 9, pages 2787 - 2797
    - ARYA ET AL., SCIENCE, (1985), vol. 229, pages 69 - 73
    - LAMBERT ET AL., J. VIROL., (1989), vol. 63, pages 3151 - 3154
    - RABINDRAN ET AL., PNAS, (1991), vol. 88, pages 6906 - 6910
    - LEVINE, CELL, (1997), vol. 88, pages 323 - 331
    - KO; PRIVES, GENES DEV., (1996), vol. 10, pages 1054 - 1072
    - KADONAGA ET AL., CELL, (1987), vol. 51, pages 1079 - 1090
    - LEE ET AL., NATURE, (1987), vol. 325, pages 368 - 372
    - NEUMAN ET AL., GENE, (1996), vol. 173, pages 163 - 169
    - PFEIFER ET AL., CELL, (1989), vol. 56, pages 291 - 301
    - PINKHAM ET AL., MOL. CELL. BIOL., (1987), vol. 7, pages 578 - 585
    - PASSMORE ET AL., J. MOL. BIOL., (1988), vol. 204, pages 593 - 606
    - SENGSTAG; HINNEN, NAR, (1987), vol. 15, pages 233 - 246
    - SUZUKI ET AL., MOL. CELL. BIOL., (1988), vol. 8, pages 4991 - 4999
    - TRIEZENBERG ET AL., GENES AND DEV., (1988), vol. 2, pages 718 - 729
    - SCHMITZ; BAEUERLE, EMBO J., (1991), vol. 10, pages 3805 - 3817
    - SCHMITZ ET AL., J.BIOL.CHEM., (1994), vol. 269, pages 25613 - 25620
    - SCHMITZ ET AL., J. BIOL. CHEM., (1995), vol. 270, pages 15576 - 15584
    - POLLOCK; GILMAN, PNAS, (1997), vol. 94, pages 13388 - 13389
    - BRINSTER ET AL., NATURE, (1982), vol. 296, pages 39 - 42
    - BENOIST; CHAMBON, NATURE, (1981), vol. 290, pages 304 - 310
    - YAMAMOTO ET AL., CELL, (1980), vol. 22, pages 787 - 797
    - WAGNER ET AL., PROC. NATL. ACAD. SCI., (1981), vol. 78, pages 144 - 1445
    - BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530
    - FISHMAN, CIRC. RES., (1998), vol. 82, pages 837 - 844
    - FISHMAN, TRENDS CARDIOVASC. MED., (1995), vol. 5, pages 211 - 217
    - GAO ET AL., PNAS, (2002), vol. 99, pages 11854 - 11859
    - MUZYSCKA, CURR. TOP. MICROB. IMMUNOL., (1992), vol. 158, pages 97 - 129
    - MANDEL ET AL., J. NEUROSCI., (1998), vol. 18, pages 4271 - 4284
    - XU ET AL., GENE THER., (2001), vol. 8, pages 1323 - 1332
    - KLEIN ET AL., EXP. NEUROL., (1998), vol. 150, pages 183 - 194
    - MIYAZAKI, GENE, (1989), vol. 79, pages 269 - 277
    - SHIPLEY ET AL., GENETICS, (1991), vol. 10, pages 1009 - 1018
    - DONELLO ET AL., J. VIROL., (1998), vol. 72, pages 5085 - 5092
    - HABERMAET, GENE THER., (1998), vol. 5, pages 1604 - 1611
    - YE ET AL., SCIENCE, (1995), vol. 283, pages 88 - 91
    - RAOUL ET AL., NAT. MED., (2005), vol. 11, no. 4, pages 423 - 428
    - ROSEN, D.R. ET AL., "Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis", NATURE, (1993), vol. 362, pages 59 - 62
    - ANDERSEN, P.M. ET AL., "Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes", AMYOTROPH LATERAL SCLER OTHER MOTOR NEURON DISORD, (2003), vol. 4, no. 2, pages 62 - 73
    - CLEVELAND, D.W.; J.D. ROTHSTEIN, "From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS", NAT REV NEUROSCI, (2001), vol. 2, no. 11, pages 806 - 819
    - GURNEY, M.E. ET AL., "Motor neuron degeneration in mice that express ? human Cu,Zn superoxide dismutase mutation", SCIENCE, (1994), vol. 264, pages 1772 - 1775
    - GURNEY, M.E. ET AL., "Benefit of vitamin E, riluzole, and gabapentin in ? transgenic model of familial amyotrophic lateral sclerosis [see comments]", ANN NEUROL, (1996), vol. 39, no. 2, pages 147 - 157
    - DRACHMAN, D.B. ET AL., "Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model ofALS", ANN NEUROL, (2002), vol. 52, no. 6, pages 771 - 778
    - KIERAN, D. ET AL., "Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression inALS mice", NAT MED, (2004), vol. 10, no. 4, pages 402 - 405
    - DOBROWOLNY, G. ET AL., "Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model", J CELL BIOL, (2005), vol. 168, no. 2, pages 193 - 199
    - KASPAR, B.K. ET AL., "Retrograde viral delivery of IGF-I prolongs survival in a mouse ALS model", SCIENCE, (2003), vol. 301, no. 5634, pages 839 - 842
    - IWASAKI, Y. ET AL., "Protective effect of interleukin-3 and erythropoietin on motor neuron death after neonatal axotomy", NEUROL RES, (2002), vol. 24, no. 7, pages 643 - 646
    - BROCKINGTON, A. ET AL., "Vascular endothelial growth factor and the nervous system", NEUROPATHOL APPL NEUROBIOL, (2004), vol. 30, no. 5, pages 427 - 446
    - STORKEBAUM, E.; D. LAMBRECHTS; P. CARMELIET, "VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection", BIOESSAYS, (2004), vol. 26, no. 9, pages 943 - 954
    - LAMBRECHTS, D. ET AL., "VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death", NAT GENET, (2003), vol. 34, no. 4, pages 383 - 394
    - OOSTHUYSE, B. ET AL., "Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration", NAT GENET, (2001), vol. 28, no. 2, pages 131 - 138
    - AZZOUZ, M. ET AL., "VEGF delivery with retrogradely transported lentivector prolongs survival in ? mouse ALS model", NATURE, (2004), vol. 429, no. 6990, pages 413 - 417
    - ZHENG, C. ET AL., "Vascular endothelial growth factor prolongs survival in ? transgenic mouse model ofALS", ANN NEUROL, (2004), vol. 56, no. 4, pages 564 - 567
    - STORKEBAUM, E. ET AL., "Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model ofALS", NAT NEUROSCI, (2005), vol. 8, no. 1, pages 85 - 92
    - YAMAKAWA, M. ET AL., "Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors", CIRC RES, (2003), vol. 93, no. 7, pages 664 - 673
    - VINCENT, K.A. ET AL., "Angiogenesis is induced in ? rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1 alpha/VP1 6 hybrid transcription factor", CIRCULATION, (2000), vol. 102, no. 18, pages 2255 - 2261
    - BURGER, C. ET AL., "Recombinant AA V viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system", MOL THER, (2004), vol. 10, no. 2, pages 302 - 317
    - CLEMENT, A.M. ET AL., "Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice", SCIENCE, (2003), vol. 302, no. 5642, pages 113 - 117
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