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Extract from the Register of European Patents

EP About this file: EP3170837

EP3170837 - EXPRESSION SYSTEM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.07.2020
Database last updated on 03.10.2024
FormerThe patent has been granted
Status updated on  19.07.2019
FormerGrant of patent is intended
Status updated on  27.03.2019
FormerExamination is in progress
Status updated on  20.04.2018
FormerRequest for examination was made
Status updated on  21.04.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
GlaxoSmithKline Biologicals S.A.
Rue de l'Institut, 89
1330 Rixensart / BE
[2017/21]
Inventor(s)01 / BLAIS, Normand
GlaxoSmithKline Biologicals Canada
525 Cartier Boulevard West
Laval, Québec H7V 3S8 / CA
02 / DEHOTTAY, Philippe Marc Helene
GlaxoSmithKline Biologicals s.a.
Rue de l'Institut 89
1330 Rixensart / BE
03 / DEWERCHIN, Marianne
GlaxoSmithKline Biologicals s.a.
Rue de l'Institut 89
1330 Rixensart / BE
04 / GOFFIN, Philippe
GlaxoSmithKline Biologicals s.a.
Rue de l'Institut 89
1330 Rixensart / BE
05 / MARTIN, Denis
GlaxoSmithKline Biologicals Canada
525 Cartier Boulevard West
Laval, Québec H7V 3S8 / CA
 [2017/21]
Representative(s)Thornley, Rachel Mary
GSK
Legal & Compliance - Global Patents
79 New Oxford Street
London WC1A 1DG / GB
[N/P]
Former [2017/21]Thornley, Rachel Mary
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
Application number, filing date16192258.807.10.2010
[2017/21]
Priority number, dateGB2009001764708.10.2009         Original published format: GB 0917647
[2017/21]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP3170837
Date:24.05.2017
Language:EN
[2017/21]
Type: A3 Search report 
No.:EP3170837
Date:19.07.2017
Language:EN
[2017/29]
Type: B1 Patent specification 
No.:EP3170837
Date:21.08.2019
Language:EN
[2019/34]
Search report(s)(Supplementary) European search report - dispatched on:EP20.06.2017
ClassificationIPC:C07K14/34, C12N15/62
[2017/21]
CPC:
C07K14/34 (EP,US); C12N15/62 (KR); A61K39/02 (KR);
A61P31/04 (EP); C07K1/00 (US); C07K14/195 (KR);
C12N15/63 (KR); C12N9/1077 (EP,US); C12Y204/02036 (EP,US);
C07K2319/034 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/21]
Extension statesBA04.10.2016
ME04.10.2016
TitleGerman:EXPRESSIONSSYSTEM[2017/21]
English:EXPRESSION SYSTEM[2017/21]
French:SYSTÈME D'EXPRESSION[2017/21]
Examination procedure04.10.2016Examination requested  [2017/21]
04.10.2016Date on which the examining division has become responsible
19.01.2018Amendment by applicant (claims and/or description)
18.04.2018Despatch of a communication from the examining division (Time limit: M04)
16.08.2018Reply to a communication from the examining division
12.10.2018Despatch of a communication from the examining division (Time limit: M04)
06.02.2019Reply to a communication from the examining division
28.03.2019Communication of intention to grant the patent
15.07.2019Fee for grant paid
15.07.2019Fee for publishing/printing paid
15.07.2019Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP10762693.9  / EP2486047
Divisional application(s)EP18167370.8  / EP3480209
Opposition(s)03.06.2020No opposition filed within time limit [2020/33]
Fees paidRenewal fee
04.10.2016Renewal fee patent year 03
04.10.2016Renewal fee patent year 04
04.10.2016Renewal fee patent year 05
04.10.2016Renewal fee patent year 06
04.10.2016Renewal fee patent year 07
10.10.2017Renewal fee patent year 08
08.10.2018Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.10.2010
AL21.08.2019
AT21.08.2019
CY21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
MK21.08.2019
MT21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
[2022/32]
Former [2021/34]HU07.10.2010
AL21.08.2019
AT21.08.2019
CY21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
MT21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2021/33]HU07.10.2010
AL21.08.2019
AT21.08.2019
CY21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2021/26]AL21.08.2019
AT21.08.2019
CY21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/37]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/36]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/35]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
SM21.08.2019
LU07.10.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/34]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
SM21.08.2019
CH31.10.2019
LI31.10.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/27]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
SM21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/25]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/24]AL21.08.2019
AT21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/23]AL21.08.2019
AT21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/22]AL21.08.2019
DK21.08.2019
EE21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/15]AL21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/12]FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/10]FI21.08.2019
LT21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
PT23.12.2019
Former [2020/09]FI21.08.2019
LT21.08.2019
NO21.11.2019
Former [2020/08]LT21.08.2019
NO21.11.2019
Documents cited:Search[X]WO9010015  (SERAGEN INC [US]) [X] 1-7,19,21-27 * page 12, lines 23-26 *;
 [XD]  - O'KEEFE D O ET AL, "CLONED DIPHTHERIA TOXIN WITHIN THE PERIPLASM OF ESCHERICHIA-COLI CAUSES LETHAL MEMBRANE DAMAGE AT LOW PH", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1989), vol. 86, no. 1, ISSN 0027-8424, pages 343 - 346, XP002614714 [XD] 1-7,19,21-27 * abstract * * page 343, column l, paragraph l *

DOI:   http://dx.doi.org/10.1073/pnas.86.1.343
 [AD]  - BISHAI W R ET AL, "HIGH-LEVEL EXPRESSION OF A PROTEOLYTICALLY SENSITIVE DIPHTHERIA TOXIN FRAGMENT IN ESCHERICHIA-COLI", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC; US, (19871101), vol. 169, no. 11, ISSN 0021-9193, pages 5140 - 5151, XP002561433 [AD] 1-7,19,21-27 * abstract * * page 5141, column l, paragraph l - column r, paragraph 1 *
 [A]  - HUMPHREYS D P ET AL, "High-Level Periplasmic Expression in Escherichia coli Using a Eukaryotic Signal Peptide: Importance of Codon Usage at the 5' End of the Coding Sequence", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, (20001101), vol. 20, no. 2, doi:10.1006/PREP.2000.1286, ISSN 1046-5928, pages 252 - 264, XP004435483 [A] 1-7,19,21-27 * the whole document *

DOI:   http://dx.doi.org/10.1006/prep.2000.1286
by applicantUS4235877
 US4365170
 EP0161188
 EP0208375
 US4673574
 US4709017
 US4950740
 EP0477508
 WO9315760
 WO9324148
 WO9508348
 WO9629094
 WO9700697
 US5601827
 WO9842721
 US5843711
 US5917017
 WO02055105
    - MOSKAUG ET AL., BIOL. CHEM., (1989), vol. 264, pages 15709 - 15713
    - LINGOOD ET AL., BRIT.J. EXP. PATH., (1963), vol. 44, page 177
    - UCHIDA ET AL., NATURE NEW BIOLOGY, (1971), vol. 233, pages 8 - 11
    - PAPPENHEIMER, ANN REV, BIOCHEM., (1977), vol. 46, pages 69 - 94
    - RAPPUOLI, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (198309), pages 560 - 564
    - BISHAI ET AL., J BACTERIOL., vol. 169, pages 5140 - 5151
    - O'KEEFE ET AL., PROC. NATL. ACAD. SCI., vol. 86, pages 343 - 346
    - BISHAI ET AL., J BACTERIOL, vol. 169, pages 5140 - 5151
    - CARILLO, H.; LIPMAN, D., SIAM J. APPLIED MATH., (1988), vol. 48, page 1073
    - DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, (1984), vol. 12, no. 1, page 387
    - ALTSCHUL, S.F. ET AL., J. MOLEC. BIOL., (1990), vol. 215, pages 403 - 410
    - PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 2444 - 2448
    - ALTSCHUL, S. ET AL., BLAST Manual, NCBI NLM NIH BETHESDA
    - ALTSCHUL, S. ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 410
    - NEEDLEMAN; WUNSCH, J. MOL BIOL., (1970), vol. 48, pages 443 - 453
    - PROC. NATL. ACAD. SCI. USA., (1992), vol. 89, pages 10915 - 10919
    - JAMESON; WOLF, CABIOS, (1988), vol. 4, pages 181 - 186
    - STURNIOLO, NATURE BIOTECH., (1999), vol. 17, pages 555 - 561
    - SAMBROOK ET AL., MOLECULAR CLONING, A LABORATORY MANUAL
    - BETHELL ET AL., J. BIOL. CHEM., (1979), vol. 254, pages 2572 - 4
    - HEARN ET AL., J. CHROMATOGR., (1981), vol. 218, pages 509 - 18
    - CHU C. ET AL., INFECT. IMMUNITY, (1983), vol. 245, page 256
    - ZABRISKIE ET AL., J. IND. MICROBIOL, (1987), vol. 2, pages 87 - 95
    - ZABRISKIE ET AL., J. IND. MICROBIOL., (1987), vol. 2, pages 87 - 95
    - CHEN ET AL., BIOCHEM. ENG. J., (2004), vol. 19, pages 211 - 215
    - J.IND. MICROBIOL. BIOTECHNOL., (2010), vol. 37, pages 195 - 204
    - DOEHLERT, APPLIED STATISTICS, (1970), vol. 19, pages 231 - 239
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.