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Extract from the Register of European Patents

EP About this file: EP3331994

EP3331994 - PREPARATION OF RETINAL PIGMENT EPITHELIUM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.07.2023
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  12.08.2022
FormerGrant of patent is intended
Status updated on  16.03.2022
FormerExamination is in progress
Status updated on  18.03.2019
FormerRequest for examination was made
Status updated on  11.05.2018
FormerThe international publication has been made
Status updated on  11.02.2017
Most recent event   Tooltip15.03.2024Lapse of the patent in a contracting state
New state(s): MC
published on 17.04.2024  [2024/16]
Applicant(s)For all designated states
Cell Cure Neurosciences Ltd.
P.O. Box 12247
9112102 Jerusalem / IL
[2018/24]
Inventor(s)01 / BOHANA-KASHTAN, Osnat
47 HaArgaman Street
P.O. Box 7290
4060000 Tel-Mond / IL
02 / WISER, Ofer
22 Yehuda Burlah Street
Apt. 25
9371422 Jerusalem / IL
 [2018/24]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2018/24]
Application number, filing date16753990.704.08.2016
[2018/24]
WO2016IL50857
Priority number, dateUS201562201156P05.08.2015         Original published format: US 201562201156 P
US201562253738P11.11.2015         Original published format: US 201562253738 P
[2018/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017021973
Date:09.02.2017
Language:EN
[2017/06]
Type: A1 Application with search report 
No.:EP3331994
Date:13.06.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 09.02.2017 takes the place of the publication of the European patent application.
[2018/24]
Type: B1 Patent specification 
No.:EP3331994
Date:14.09.2022
Language:EN
[2022/37]
Search report(s)International search report - published on:EP09.02.2017
ClassificationIPC:A61P25/28, A61P27/02, A61P31/00, A61P29/00, C12N5/079
[2022/04]
CPC:
C12N5/0621 (EP,US); A61P25/28 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P31/00 (EP); C12N2500/38 (EP,US);
C12N2500/98 (EP,US); C12N2501/115 (EP,US); C12N2501/15 (EP,US);
C12N2506/02 (EP,US); C12N2533/52 (EP,US); C12N2533/54 (EP,US) (-)
Former IPC [2018/24]C12N5/079
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/24]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:HERSTELLUNG VON RETINAPIGMENTEPITHELZELLEN[2018/24]
English:PREPARATION OF RETINAL PIGMENT EPITHELIUM CELLS[2018/24]
French:PRÉPARATION DE CELLULES DE L'ÉPITHÉLIUM PIGMENTAIRE RÉTINIEN[2018/24]
Entry into regional phase05.03.2018National basic fee paid 
05.03.2018Designation fee(s) paid 
05.03.2018Examination fee paid 
Examination procedure05.03.2018Examination requested  [2018/24]
05.03.2018Date on which the examining division has become responsible
26.09.2018Amendment by applicant (claims and/or description)
21.03.2019Despatch of a communication from the examining division (Time limit: M06)
29.10.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
08.01.2020Reply to a communication from the examining division
13.05.2020Despatch of a communication from the examining division (Time limit: M04)
23.09.2020Reply to a communication from the examining division
17.03.2022Communication of intention to grant the patent
26.07.2022Fee for grant paid
26.07.2022Fee for publishing/printing paid
26.07.2022Receipt of the translation of the claim(s)
Divisional application(s)EP22193431.8  / EP4155391
Opposition(s)15.06.2023No opposition filed within time limit [2023/34]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
08.01.2020Request for further processing filed
08.01.2020Full payment received (date of receipt of payment)
Request granted
15.01.2020Decision despatched
Fees paidRenewal fee
10.08.2018Renewal fee patent year 03
15.08.2019Renewal fee patent year 04
13.08.2020Renewal fee patent year 05
13.08.2021Renewal fee patent year 06
09.08.2022Renewal fee patent year 07
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL14.09.2022
CZ14.09.2022
EE14.09.2022
FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
MC14.09.2022
RO14.09.2022
RS14.09.2022
SI14.09.2022
SK14.09.2022
SM14.09.2022
GR15.12.2022
IS14.01.2023
PT16.01.2023
[2024/16]
Former [2023/37]AL14.09.2022
CZ14.09.2022
EE14.09.2022
FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RO14.09.2022
RS14.09.2022
SI14.09.2022
SK14.09.2022
SM14.09.2022
GR15.12.2022
IS14.01.2023
PT16.01.2023
Former [2023/29]AL14.09.2022
CZ14.09.2022
EE14.09.2022
FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RO14.09.2022
RS14.09.2022
SK14.09.2022
SM14.09.2022
GR15.12.2022
IS14.01.2023
PT16.01.2023
Former [2023/27]CZ14.09.2022
EE14.09.2022
FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RO14.09.2022
RS14.09.2022
SK14.09.2022
SM14.09.2022
GR15.12.2022
IS14.01.2023
PT16.01.2023
Former [2023/23]CZ14.09.2022
EE14.09.2022
FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RO14.09.2022
RS14.09.2022
SK14.09.2022
SM14.09.2022
GR15.12.2022
PT16.01.2023
Former [2023/22]CZ14.09.2022
FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RO14.09.2022
RS14.09.2022
SM14.09.2022
GR15.12.2022
PT16.01.2023
Former [2023/20]FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RS14.09.2022
SM14.09.2022
GR15.12.2022
Former [2023/10]FI14.09.2022
HR14.09.2022
LT14.09.2022
LV14.09.2022
RS14.09.2022
GR15.12.2022
Former [2023/09]FI14.09.2022
LT14.09.2022
LV14.09.2022
RS14.09.2022
Former [2023/08]FI14.09.2022
LT14.09.2022
RS14.09.2022
Cited inInternational search[XI]WO2008129554  (HADASIT MED RES SERVICE [IL], et al) [X] 31-36 * page 33 - page 35 * [I] 1-30;
 [XP]WO2016108239  (CELL CURE NEUROSCIENCES LTD [IL]) [XP] 1,31-36 * the whole document *;
 [XPI]WO2016108240  (CELL CURE NEUROSCIENCES LTD [IL]) [XP] 1,31-36 * the whole document *[I] 1-36;
 [XI]  - D. E. BUCHHOLZ ET AL, "Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium", STEM CELLS TRANSLATIONAL MEDICINE : SCTM, Durham, (20130418), vol. 2, no. 5, doi:10.5966/sctm.2012-0163, ISSN 2157-6564, pages 384 - 393, XP055114659 [X] 1-5,7,12-28,30,35 * page 2; figures 1, 2 * [I] 1-36

DOI:   http://dx.doi.org/10.5966/sctm.2012-0163
 [XI]  - A. LANE ET AL, "Engineering Efficient Retinal Pigment Epithelium Differentiation From Human Pluripotent Stem Cells", STEM CELLS TRANSLATIONAL MEDICINE : SCTM, Durham, (20141001), vol. 3, no. 11, doi:10.5966/sctm.2014-0094, ISSN 2157-6564, pages 1295 - 1304, XP055303892 [X] 35 * figure 1 * [I] 31-36

DOI:   http://dx.doi.org/10.5966/sctm.2014-0094
 [XI]  - Ruchira Singh ET AL, "Retinal Cell Biology Functional Analysis of Serially Expanded Human iPS Cell- Derived RPE Cultures", (20131001), pages 6767 - 6778, URL: http://iovs.arvojournals.org/article.aspx?articleid=2202986, (20150512), XP055188833 [X] 35 * figure 3 * [I] 31-36
 [X]  - MARIA IDELSON ET AL, "Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells", CELL STEM CELL, (20091001), vol. 5, no. 4, doi:10.1016/j.stem.2009.07.002, ISSN 1934-5909, pages 396 - 408, XP055046648 [X] 31-36 * material and methods;; figures 1, 6 *

DOI:   http://dx.doi.org/10.1016/j.stem.2009.07.002
 [A]  - KAPIL BHARTI ET AL, "The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells", PIGMENT CELL & MELANOMA RESEARCH, (20110207), vol. 24, no. 1, doi:10.1111/j.1755-148X.2010.00772.x, ISSN 1755-1471, pages 21 - 34, XP055116027 [A] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1755-148X.2010.00772.x
by applicantUS3791932
 US3839153
 US3850752
 US3850578
 US3853987
 US3867517
 US3879262
 US3901654
 US3935074
 US3984533
 US3996345
 US4034074
 US4098876
 US4666828
 US4683202
 US4801531
 US4879219
 US5011771
 US5192659
 US5272057
 US5281521
 US5755785
 US5843780
 GB2327675
 US5941250
 US5962027
 US6045791
 US6090622
 WO0155114
 WO02060875
 WO03068233
 WO2005014549
 WO2006040763
 WO2006070370
 WO2008129554
 EP2128244
 US2013196369
 WO2013114360
 WO2013184809
 US8956866
    - YAMANAKA S, CELL STEM CELL, (2007), vol. 1, no. 1, pages 39 - 49
    - IH PARK; ZHAO R; WEST JA ET AL., "Reprogramming of human somatic cells to pluripotency with defined factors", NATURE, (2008), vol. 451, pages 141 - 146
    - K TAKAHASHI; TANABE K; OHNUKI M ET AL., "Induction of pluripotent stem cells from adult human fibroblasts by defined factors", CELL, (2007), vol. 131, pages 861 - 872
    - REUBINOFF ET AL., NAT BIOTECHNOL, (200005), vol. 18, no. 5, page 559
    - SCIENCE, (1998), vol. 282, page 1145
    - CURR. TOP. DEV. BIOL., (1998), vol. 38, page 133
    - PROC. NATL. ACAD. SCI. USA, (1995), vol. 92, page 7844
    - BONGSO ET AL., HUM REPROD, (1989), vol. 4, page 706
    - GARDNER ET AL., FERTIL. STERIL., (1998), vol. 69, page 84
    - DOETSCHMAN ET AL., DEV BIOL., (1988), vol. 127, pages 224 - 7
    - IANNACCONE ET AL., DEV BIOL., (1994), vol. 163, pages 288 - 92
    - GILES ET AL., MOL REPROD DEV., (1993), vol. 36, pages 130 - 8
    - GRAVES; MOREADITH, MOL REPROD DEV., (1993), vol. 36, pages 424 - 33
    - NOTARIANNI ET AL., J REPROD FERTIL SUPPL., (1991), vol. 43, pages 255 - 60
    - WHEELER, REPROD FERTIL DEV., (1994), vol. 6, pages 563 - 8
    - MITALIPOVA ET AL., CLONING, (2001), vol. 3, pages 59 - 67
    - THOMSON ET AL., PROC NATL ACAD SCI USA., (1995), vol. 92, pages 7844 - 8
    - THOMSON ET AL., BIOL REPROD., (1996), vol. 55, pages 254 - 9
    - CHUNG ET AL., CELL STEM CELL, (20080207), vol. 2, no. 2, pages 113 - 117
    - SHAMBLOTT ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, page 13726
    - KALKAN ET AL., PHIL. TRANS. R. SOC. B, (2014), vol. 369
    - RICHARDS M; FONG CY; CHAN WK; WONG PC; BONGSO A, "Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells", NAT. BIOTECHNOL., (2002), vol. 20, pages 933 - 6
    - THOMSON JA ET AL., SCIENCE, (1998), vol. 282, pages 1145 - 7
    - EYE GRAEFES, ARCH CLIN EXP OPTHALMOL, (199703), vol. 235, no. 3, pages 149 - 58
    - BIOCHEM BIOPHYS RES COMMUN, (20000224), vol. 268, no. 3, pages 842 - 6
    - OPTHALMIC SURG, (199102), vol. 22, no. 2, pages 102 - 8
    - EYE, (1995), vol. 9, pages 6 - 12
    - CURR OPIN OPTHALMOL, (199208), vol. 3, no. 4, pages 473 - 81
    - OPHTHALMIC SURG LASERS, (199804), vol. 29, no. 4, pages 305 - 8
    - OPHTHALMOLOGY, (200004), vol. 107, no. 4, pages 719 - 24
    - JPN J OPHTHALMOL, (199911), vol. 43, no. 6, pages 502 - 8
    - "Neurotech USA CNTF delivery system", PNAS, (20060307), vol. 103, no. 10, pages 3896 - 3901
    - AUSUBEL, R. M.,, Current Protocols in Molecular Biology, (1994), vol. I-III
    - WATSON ET AL., Recombinant DNA, SCIENTIFIC AMERICAN BOOKS
    - BIRREN ET AL., Genome Analysis: A Laboratory Manual Series, COLD SPRING HARBOR LABORATORY PRESS, (1998), vol. 1-4
    - CELLIS, J. E.,, Cell Biology: A Laboratory Handbook, (1994), vol. I-III
    - COLIGAN J. E.,, Current Protocols in Immunology, (1994), vol. I-III
    - Methods in Enzymology, ACADEMIC PRESS, vol. 1-317
 US20030368045
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.