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Extract from the Register of European Patents

EP About this file: EP3265825

EP3265825 - PD-L2 BIOMARKERS PREDICTIVE OF PD-1 PATHWAY INHIBITOR RESPONSES IN ESOPHAGOGASTRIC CANCERS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  26.11.2019
Database last updated on 26.06.2024
FormerRequest for examination was made
Status updated on  08.12.2017
FormerThe international publication has been made
Status updated on  03.10.2017
Most recent event   Tooltip28.03.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Dana-Farber Cancer Institute, Inc.
450 Brookline Avenue
Boston, MA 02115-5450 / US
[2018/02]
Inventor(s)01 / BASS, Adam
24 Banks Street
Somerville, MA 02144 / US
02 / DERKS, Sarah
Rietwijkerstraat 46-li
1059 XB Amsterdam / NL
03 / FREEMAN, Gordon, J.
305 Walnut Street
Brookline, MA 02445 / US
04 / RODIG, Scott, J.
101 Fearing Drive
Westwood, MA 02090 / US
 [2018/03]
Former [2018/02]01 / BASS, Adam
24 Banks Street
Somerville, MA 02144 / US
02 / DERKS, Sarah
122 Pembroke Street
Boston, MA 02118 / US
03 / FREEMAN, Gordon, J.
305 Walnut Street
Brookline, MA 02445 / US
04 / RODIG, Scott, J.
101 Fearing Drive
Westwood, MA 02090 / US
Representative(s)Hoefer & Partner Patentanwälte mbB
Pilgersheimer Straße 20
81543 München / DE
[N/P]
Former [2018/02]Helbig, Christian
Wagner + Helbig Patentanwälte Pfarrstrasse 14
80538 München / DE
Application number, filing date16762173.903.03.2016
[2018/02]
WO2016US20589
Priority number, dateUS201562129094P06.03.2015         Original published format: US 201562129094 P
[2018/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016144673
Date:15.09.2016
Language:EN
[2016/37]
Type: A1 Application with search report 
No.:EP3265825
Date:10.01.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 15.09.2016 takes the place of the publication of the European patent application.
[2018/02]
Search report(s)International search report - published on:US15.09.2016
(Supplementary) European search report - dispatched on:EP06.07.2018
ClassificationIPC:G01N33/68, C07K16/28, C07K14/705
[2018/02]
CPC:
G01N33/57407 (EP,US); C07K14/705 (EP,US); C07K16/2827 (US);
C12Q1/6886 (US); C07K2317/76 (US); G01N2333/70532 (US);
G01N2333/70596 (EP,US); G01N2800/52 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/02]
TitleGerman:PD-L2-BIOMARKER ZUR VORHERSAGE VON PD-1-WEG-INHIBITOR-REAKTIONEN BEI ÖSOPHAGOGASTRISCHEM KREBS[2018/02]
English:PD-L2 BIOMARKERS PREDICTIVE OF PD-1 PATHWAY INHIBITOR RESPONSES IN ESOPHAGOGASTRIC CANCERS[2018/02]
French:BIOMARQUEURS PD-L2 PRÉDICTIFS DE RÉPONSES D'INHIBITEURS DE LA VOIE PD-1 DANS LES CANCERS OESOPHAGOGASTRIQUES[2018/02]
Entry into regional phase03.10.2017National basic fee paid 
03.10.2017Search fee paid 
03.10.2017Designation fee(s) paid 
03.10.2017Examination fee paid 
Examination procedure03.10.2017Examination requested  [2018/02]
03.10.2017Date on which the examining division has become responsible
29.01.2019Amendment by applicant (claims and/or description)
29.11.2019Despatch of a communication from the examining division (Time limit: M04)
26.03.2020Reply to a communication from the examining division
07.10.2020Despatch of a communication from the examining division (Time limit: M04)
09.02.2021Reply to a communication from the examining division
22.02.2021Despatch of a communication from the examining division (Time limit: M02)
16.03.2021Reply to a communication from the examining division
14.09.2022Despatch of a communication from the examining division (Time limit: M06)
14.02.2023Reply to a communication from the examining division
Fees paidRenewal fee
27.03.2018Renewal fee patent year 03
27.03.2019Renewal fee patent year 04
27.03.2020Renewal fee patent year 05
29.03.2021Renewal fee patent year 06
28.03.2022Renewal fee patent year 07
27.03.2023Renewal fee patent year 08
27.03.2024Renewal fee patent year 09
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Documents cited:Search[A]WO2014194293  (AMPLIMMUNE INC [US]) [A] 1-15 * example 5 ** page 27 - page 28 *;
 [Y]  - OHIGASHI YUICHIRO ET AL, "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20050415), vol. 11, no. 8, doi:10.1158/1078-0432.CCR-04-1469, ISSN 1078-0432, pages 2947 - 2953, XP002419631 [Y] 1-3 * page 2950, column 2, line 50 - line 54 * * table 1 *

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-04-1469
 [X]  - ROY S. HERBST ET AL, "Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients", NATURE, GB, (20141126), vol. 515, no. 7528, doi:10.1038/nature14011, ISSN 0028-0836, pages 563 - 567, XP055262130 [X] 4-6 * abstract * * page 563, column 2, paragraphs 2, 5 * * page 564, column 2, paragraph 2 * * figure 4 *

DOI:   http://dx.doi.org/10.1038/nature14011
 [Y]  - TOPALIAN SUZANNE L ET AL, "Safety, activity, and immune correlates of anti-PD-1 antibody in cancer", NEW ENGLAND JOURNAL OF MEDICINE, THE - NEJM, MASSACHUSETTS MEDICAL SOCIETY, US, (20120628), vol. 366, no. 26, ISSN 1533-4406, pages 2443 - 2454, XP002767416 [Y] 1-3 * abstract * * page 2452, paragraph bridging column 1 and 2 * * figure 2B *

DOI:   http://dx.doi.org/10.1056/NEJMoa1200690
International search[XY]WO2014197369  (DANA FARBER CANCER INST INC [US]) [X] 1-4, 10-14 * page 5 In 28-30, page 6 In 3- 7; page 7 In 27-31; page 8 In 15-30; page 9 In 13-16, In 18-21, In 27-28; page 11 In 28-30; ; page 27 In 27-31; page 41 In 9-11; page 87 In 29-page 88 In 5; page 92 In 23-26; page 108, In 14-19, In 22-24; page 118 In 4-6; page 131 In 27-page 132 In 5; page 132 In 27-30 * [Y] 9, 15-16;
 [A]WO2015026634  (MERCK SHARP & DOHME [US], et al) [A] 1-4, 9-16* para [0003]-[0004], [0049], [0083]-[0089], [00108] *;
 [Y]  - WINOGRAD et al., "Induction of T- cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in PancreaticCarcinoma.", Cancer Immunol. Res., (20150212), vol. 3, no. Issue 4, pages 399 - 411, XP055309585 [Y] 9, 15-16 * . Abstract. *

DOI:   http://dx.doi.org/10.1158/2326-6066.CIR-14-0215
 [AP]  - KOYAMA et al., "Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.", Nat Commun., (20160217), vol. 7, no. 10501, pages 1 - 9, XP055309591 [AP] 1-4, 9-16 * . Entire document. *

DOI:   http://dx.doi.org/10.1038/ncomms10501
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