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Extract from the Register of European Patents

EP About this file: EP3273987

EP3273987 - IN VITRO ARTIFICIAL LYMPH NODE METHOD FOR SENSITIZATION AND EXPANSION OF T CELLS FOR THERAPY AND EPITOPE MAPPING [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.06.2020
Database last updated on 15.06.2024
FormerExamination is in progress
Status updated on  29.05.2019
FormerRequest for examination was made
Status updated on  29.12.2017
FormerThe international publication has been made
Status updated on  25.10.2017
Most recent event   Tooltip26.06.2020Application deemed to be withdrawnpublished on 29.07.2020  [2020/31]
Applicant(s)For all designated states
Czerniecki, Brian, J.
77 Chews Landing Road
Haddonfield, NJ 08033 / US
[2018/05]
Inventor(s)01 / LOWENFELD, Lea
210 West Rittenhouse Square
Philadelphia, PA 19103 / US
02 / CZERNIECKI, Brian, J.
905 Harbour Bay Drive
Tampa, FL 33602 / US
 [2018/17]
Former [2018/05]01 / LOWENFELD, Lea
210 West Rittenhouse Square
Philadelphia, PA 19103 / US
02 / CZERNIECKI, Brian, J.
77 Chews Landing Road
Haddonfield, NJ 08033 / US
Representative(s)Biggi, Cristina
Bugnion S.p.A.
Viale Lancetti 17
20158 Milano / IT
[2018/05]
Application number, filing date16769839.828.03.2016
[2018/05]
WO2016US24540
Priority number, dateUS201562138969P26.03.2015         Original published format: US 201562138969 P
[2018/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016154625
Date:29.09.2016
Language:EN
[2016/39]
Type: A1 Application with search report 
No.:EP3273987
Date:31.01.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 29.09.2016 takes the place of the publication of the European patent application.
[2018/05]
Search report(s)International search report - published on:US29.09.2016
(Supplementary) European search report - dispatched on:EP10.07.2018
ClassificationIPC:A61K39/00, A61K38/00, C12N5/0783, C12N5/0784
[2018/05]
CPC:
C12N5/0636 (EP,US); A61K39/0011 (US); A61K39/4611 (EP);
A61K39/4615 (EP); A61K39/4622 (EP); A61K39/4631 (EP);
A61K39/464406 (EP); A61P35/00 (EP); G01N33/574 (US);
A61K2039/5154 (US); A61K2039/5158 (US); A61K2039/55533 (US);
A61K2239/49 (EP); C12N2501/11 (EP,US); C12N2502/1121 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/05]
TitleGerman:KÜNSTLICHES LYMPHKNOTENVERFAHREN IN VITRO ZUR SENSIBILISIERUNG UND EXPANSION VON T-ZELLEN FÜR THERAPIE UND EPITOPKARTIERUNG[2018/05]
English:IN VITRO ARTIFICIAL LYMPH NODE METHOD FOR SENSITIZATION AND EXPANSION OF T CELLS FOR THERAPY AND EPITOPE MAPPING[2018/05]
French:MÉTHODE UTILISANT UN GANGLION LYMPHATIQUE ARTIFICIEL IN VITRO POUR LA SENSIBILISATION ET L'EXPANSION DE LYMPHOCYTES T DANS LA THÉRAPIE ET LA CARTOGRAPHIE DES ÉPITOPES[2018/05]
Entry into regional phase25.10.2017National basic fee paid 
25.10.2017Search fee paid 
25.10.2017Designation fee(s) paid 
25.10.2017Examination fee paid 
Examination procedure25.10.2017Examination requested  [2018/05]
25.10.2017Date on which the examining division has become responsible
06.02.2019Amendment by applicant (claims and/or description)
04.06.2019Despatch of a communication from the examining division (Time limit: M06)
17.12.2019Application deemed to be withdrawn, date of legal effect  [2020/31]
17.01.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2020/31]
Fees paidRenewal fee
26.03.2018Renewal fee patent year 03
27.03.2019Renewal fee patent year 04
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Documents cited:Search[Y]US5846538  (CHEEVER MARTIN A [US], et al) [Y] 16* column 13, line 55 - column 14, line 25 *;
 [XY]US2011182870  (LEEN ANN M [US], et al) [X] 1-9 * paragraph [0234] * * paragraph [0069] * [Y] 4,6,12,14,15;
 [XY]WO2012140127  (IMMUNICUM AB [SE], et al) [X] 1-8 * page 15, line 31 - page 16, line 5; claims 12, 13 * [Y] 4,6,12,14,15;
 [XY]  - SONIA A PEREZ ET AL, "HER-2/neu-derived peptide 884-899 is expressed by human breast, colorectal and pancreatic adenocarcinomas and is recognized by in-vitro-induced specific CD4+ T cell clones", CANCER IMMUNOLOGY, IMMUNOTHE, SPRINGER, BERLIN/HEIDELBERG, vol. 50, no. 11, doi:10.1007/S002620100225, ISSN 0340-7004, (20020101), pages 615 - 624, (20011123), XP009138053 [X] 1-3,5,7-11,13 * page 617, column r, paragraph 3 * [Y] 4,6,12,14,15

DOI:   http://dx.doi.org/10.1007/s002620100225
 [XY]  - SOTIRIADOU R ET AL, "Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, GB, (20011116), vol. 85, no. 10, doi:10.1054/BJOC.2001.2089, ISSN 0007-0920, pages 1527 - 1534, XP002293865 [X] 1-3,5,7-11,13 * page 1529, column l, paragraph 3 * [Y] 4,6,12,14-16

DOI:   http://dx.doi.org/10.1054/bjoc.2001.2089
International search[A]US2013078270  (CHO HELEN KIM [US], et al) [A] 1-16 * entire document *;
 [Y]  - SCHLIENGER et al., "Efficient priming of protein antigen-specific human CD 4+ T cells by monocyte-derived dendritic cells", Blood, (20001115), vol. 96, pages 3490 - 8, XP000985928 [Y] 1-5, 8-13, 16 * . entire document *
 [Y]  - CZERNIECKI et al., "Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion", Cancer Res., (20070209), vol. 67, no. 4, pages 1842 - 52, XP055269484 [Y] 1-5, 8-13, 16 * . entire document *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-06-4038
 [Y]  - MACLEOD et al., "Memory CD 4 T cells: generation, reactivation and re-assignment", Immunology, (20100316), vol. 130, no. 1, pages 10 - 5, XP055318770 [Y] 4, 12 * . entire document *

DOI:   http://dx.doi.org/10.1111/j.1365-2567.2010.03260.x
 [A]  - FRACOL et al., "Response to HER-2 pulsed DC1 vaccines is predicted by both HER-2 and estrogen receptor expression in DCIS", Ann Surg Oncol., (20130713), vol. 20, no. 10, pages 3233 - 9, XP055318772 [A] 1-16 * . entire document *

DOI:   http://dx.doi.org/10.1245/s10434-013-3119-y
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