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Extract from the Register of European Patents

EP About this file: EP3356367

EP3356367 - FUSED PYRAZOLE DERIVATIVES AS KINASE INHIBITORS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.06.2020
Database last updated on 03.08.2024
FormerExamination is in progress
Status updated on  19.07.2019
FormerRequest for examination was made
Status updated on  06.07.2018
FormerThe international publication has been made
Status updated on  08.04.2017
Most recent event   Tooltip26.06.2020Application deemed to be withdrawnpublished on 29.07.2020  [2020/31]
Applicant(s)For all designated states
UCB Biopharma SRL
Allée de la Recherche 60
1070 Brussels / BE
For all designated states
Katholieke Universiteit Leuven K.U. Leuven R&D
Waaistraat 6
3000 Leuven / BE
[N/P]
Former [2020/02]For all designated states
UCB Biopharma SRL
Allé de la Recherche 60
1070 Brussels / BE
For all designated states
Katholieke Universiteit Leuven K.U. Leuven R&D
Waaistraat 6
3000 Leuven / BE
Former [2018/32]For all designated states
UCB Biopharma SPRL
60, Allée de la Recherche
1070 Brussels / BE
For all designated states
Katholieke Universiteit Leuven K.U. Leuven R&D
Waaistraat 6
3000 Leuven / BE
Inventor(s)01 / FORD, Daniel James
c/o IPD
UCB Celltech
208 Bath Road
Slough Berkshire SL1 3WE / GB
02 / HORSLEY, Helen Tracey
c/o IPD
UCB Celltech
208 Bath Road
Slough Berkshire SL1 3WE / GB
03 / REUBERSON, James Thomas
c/o IPD
UCB Celltech
208 Bath Road
Slough Berkshire SL1 3WE / GB
 [2018/32]
Representative(s)UCB Intellectual Property
c/o UCB Celltech
IP Department
208 Bath Road
Slough, Berkshire SL1 3WE / GB
[2018/32]
Application number, filing date16770942.728.09.2016
[2018/32]
WO2016EP73028
Priority number, dateGB2015001726330.09.2015         Original published format: GB 201517263
[2018/32]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017055305
Date:06.04.2017
Language:EN
[2017/14]
Type: A1 Application with search report 
No.:EP3356367
Date:08.08.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 06.04.2017 takes the place of the publication of the European patent application.
[2018/32]
Search report(s)International search report - published on:EP06.04.2017
ClassificationIPC:C07D487/04, C07D491/107, C07D491/08, C07D498/04, C07D451/06, A61K31/519, A61K31/53, A61P29/00, A61P35/00, A61P31/00, A61P33/00, A61K31/5377, A61K31/5386
[2018/32]
CPC:
C07D487/04 (EP,US); A61P29/00 (EP); A61P31/00 (EP);
A61P31/12 (EP); A61P33/00 (EP); A61P33/06 (EP);
A61P35/00 (EP); A61P37/06 (EP); C07D451/06 (EP,US);
C07D491/08 (EP,US); C07D491/107 (EP,US); C07D498/04 (EP,US);
Y02A50/30 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/32]
TitleGerman:KONDENSIERTE PYRAZOLDERIVATE ALS KINASEINHIBITOREN[2018/32]
English:FUSED PYRAZOLE DERIVATIVES AS KINASE INHIBITORS[2018/32]
French:DÉRIVÉS DE PYRAZOLE CONDENSÉS EN TANT QU'INHIBITEURS DE KINASE[2018/32]
Entry into regional phase30.04.2018National basic fee paid 
30.04.2018Designation fee(s) paid 
30.04.2018Examination fee paid 
Examination procedure22.03.2018Date on which the examining division has become responsible
30.04.2018Examination requested  [2018/32]
22.11.2018Amendment by applicant (claims and/or description)
24.07.2019Despatch of a communication from the examining division (Time limit: M04)
04.12.2019Application deemed to be withdrawn, date of legal effect  [2020/31]
13.01.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2020/31]
Fees paidRenewal fee
01.10.2018Renewal fee patent year 03
30.09.2019Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]WO2004022561  (SCHERING CORP [US], et al) [X] 1-4,7-11 * inter alia the compounds of examples 268-275, 342, 343, 350-354, 369, 378-384, 385-387, 398, 401, 402, 405 and 411;; claims 1, 36, 40 *;
 [X]WO2004081013  (TEIJIN PHARMA LTD [JP], et al) [X] 1-5,7-11 * claims 1, 10; compounds 72, 81, 82, 95 *;
 [X]US2007082900  (GUZI TIMOTHY J [US], et al) [X] 1-5,7-11 * paragraph [0002]; claim 1; compounds 130-C *;
 [X]US2007225270  (GUZI TIMOTHY J [US], et al) [X] 1-5,7-11 * twenty-five compounds of claim 1, in particular on pages 426 (two compounds), 427 (two compounds), 428 (five compounds), 429 (eleven compounds), 430 (four compounds) and 431 (one compound);; claims 1, 3, 9 *;
 [X]WO2012027234  (SCHERING CORP [US], et al) [X] 1-5 * the starting material of step 4 on page 58 *;
 [AD]WO2014096423  (UCB PHARMA SA [BE], et al) [AD] 1-11 * claims 1, 15, 16 *;
 [A]WO2015086512  (UCB BIOPHARMA SPRL [BE]) [A] 1-11 * claims 1, 13, 16 *;
 [XDP]WO2015193169  (UCB BIOPHARMA SPRL [BE], et al) [XDP] 1,2,4,5,7-11* claims 1, 5, 6, 15-17 *;
 [X]  - HONGYI YU ET AL, "[3 a ,4]-Dihydropyrazolo[1,5 a ]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase [beta] Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, United States, (20130214), vol. 4, no. 2, doi:10.1021/ml300330m, ISSN 1948-5875, pages 230 - 234, XP055315541 [X] 1-4,7-11 * compounds 4a, 4b, 5b-5d, 6c, 7a-7l *

DOI:   http://dx.doi.org/10.1021/ml300330m
 [A]  - IVANA MEJDROVÁ ET AL, "Highly Selective Phosphatidylinositol 4-Kinase III[beta] Inhibitors and Structural Insight into Their Mode of Action", JOURNAL OF MEDICINAL CHEMISTRY, (20150514), vol. 58, no. 9, doi:10.1021/acs.jmedchem.5b00499, ISSN 0022-2623, pages 3767 - 3793, XP055206384 [A] 1-11 * tables 1, 2; compounds 1, 2a-2l, 3-15 *

DOI:   http://dx.doi.org/10.1021/acs.jmedchem.5b00499
 [A]  - M. ARITA ET AL, "Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity", JOURNAL OF VIROLOGY, (20101222), vol. 85, no. 5, doi:10.1128/JVI.02249-10, ISSN 0022-538X, pages 2364 - 2372, XP055111280 [A] 1-11 * compound T-00127-HEV1;; figure 1; table 1 *

DOI:   http://dx.doi.org/10.1128/JVI.02249-10
by applicantWO2010103130
 WO2011147753
 WO2012035423
 WO2013024291
 WO2013034738
 WO2013068458
 WO2014053581
 WO2014096423
 WO2015193167
 WO2015193168
 WO2015193169
    - C.W. MCNAMARA ET AL., NATURE, (2013), vol. 504, pages 248 - 253
    - I. MEJDROVA ET AL., J. MED. CHEM., (2015), vol. 58, pages 3767 - 3793
    - A.M. MACLEOD ET AL., ACS MED. CHEM. LETT., (2013), vol. 4, pages 585 - 589
    - M. ARITA ET AL., J. VIRAL., (2011), vol. 85, pages 2364 - 2372
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.