| EP3297636 - PHARMACEUTICAL COMPOSITION OF CARBOPLATIN BASED CO-CRYSTALS AND USE THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 24.12.2021 Database last updated on 11.04.2026 | |
| Former | The patent has been granted Status updated on 15.01.2021 | ||
| Former | Grant of patent is intended Status updated on 13.10.2020 | ||
| Former | Examination is in progress Status updated on 17.04.2020 | ||
| Former | Request for examination was made Status updated on 23.02.2018 | ||
| Former | The international publication has been made Status updated on 23.12.2016 | Most recent event Tooltip | 06.09.2024 | Lapse of the patent in a contracting state New state(s): MT | published on 09.10.2024 [2024/41] | Applicant(s) | For all designated states Syn-Nat Products Enterprise LLC 12 Augusta Avenue Edison, NJ 08820 / US | [2018/13] | Inventor(s) | 01 /
LIU, Xiaozhong 10608 Farmbrooke Ln Potomac, Maryland 20854 / US | [2018/13] | Representative(s) | Zacco GmbH Bayerstrasse 83 80335 München / DE | [2018/13] | Application number, filing date | 16812609.2 | 20.06.2016 | [2018/13] | WO2016US38340 | Priority number, date | US201562182142P | 19.06.2015 Original published format: US 201562182142 P | [2018/13] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2016205785 | Date: | 22.12.2016 | Language: | EN | [2016/51] | Type: | A1 Application with search report | No.: | EP3297636 | Date: | 28.03.2018 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.12.2016 takes the place of the publication of the European patent application. | [2018/13] | Type: | B1 Patent specification | No.: | EP3297636 | Date: | 17.02.2021 | Language: | EN | [2021/07] | Search report(s) | International search report - published on: | US | 22.12.2016 | (Supplementary) European search report - dispatched on: | EP | 16.10.2018 | Classification | IPC: | A61K31/70, A61K31/11, C07F15/00 | [2018/46] | CPC: |
C07F15/0093 (EP,KR,US);
A61K31/282 (EP,KR,US);
A61K45/06 (KR,US);
A61P35/00 (EP,KR,US);
C07D207/267 (EP,KR,US);
C07B2200/13 (US)
|
| Former IPC [2018/13] | A61K31/70, A61K31/11 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/13] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | Title | German: | PHARMAZEUTISCHE ZUSAMMENSETZUNG AUS CO-KRISTALLEN AUF CARBOPLATINBASIS UND VERWENDUNG DAVON | [2018/13] | English: | PHARMACEUTICAL COMPOSITION OF CARBOPLATIN BASED CO-CRYSTALS AND USE THEREOF | [2018/13] | French: | COMPOSITION PHARMACEUTIQUE DE CO-CRISTAUX À BASE DE CARBOPLATINE ET UTILISATION ASSOCIÉE | [2018/13] | Entry into regional phase | 20.12.2017 | National basic fee paid | 20.12.2017 | Search fee paid | 20.12.2017 | Designation fee(s) paid | 20.12.2017 | Examination fee paid | Examination procedure | 20.12.2017 | Examination requested [2018/13] | 20.12.2017 | Date on which the examining division has become responsible | 29.04.2019 | Amendment by applicant (claims and/or description) | 21.04.2020 | Despatch of a communication from the examining division (Time limit: M04) | 13.08.2020 | Reply to a communication from the examining division | 14.10.2020 | Communication of intention to grant the patent | 05.01.2021 | Fee for grant paid | 05.01.2021 | Fee for publishing/printing paid | 05.01.2021 | Receipt of the translation of the claim(s) | Opposition(s) | 18.11.2021 | No opposition filed within time limit [2022/04] | Fees paid | Renewal fee | 26.06.2018 | Renewal fee patent year 03 | 27.06.2019 | Renewal fee patent year 04 | 09.06.2020 | Renewal fee patent year 05 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 20.06.2016 | AL | 17.02.2021 | AT | 17.02.2021 | CY | 17.02.2021 | CZ | 17.02.2021 | DK | 17.02.2021 | EE | 17.02.2021 | ES | 17.02.2021 | FI | 17.02.2021 | HR | 17.02.2021 | IT | 17.02.2021 | LT | 17.02.2021 | LV | 17.02.2021 | MC | 17.02.2021 | MK | 17.02.2021 | MT | 17.02.2021 | NL | 17.02.2021 | PL | 17.02.2021 | RO | 17.02.2021 | RS | 17.02.2021 | SE | 17.02.2021 | SI | 17.02.2021 | SK | 17.02.2021 | SM | 17.02.2021 | TR | 17.02.2021 | BG | 17.05.2021 | NO | 17.05.2021 | GR | 18.05.2021 | IS | 17.06.2021 | PT | 17.06.2021 | IE | 20.06.2021 | LU | 20.06.2021 | BE | 30.06.2021 | CH | 30.06.2021 | LI | 30.06.2021 | [2024/41] |
| Former [2024/29] | HU | 20.06.2016 | |
| AL | 17.02.2021 | ||
| AT | 17.02.2021 | ||
| CY | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
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| EE | 17.02.2021 | ||
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| FI | 17.02.2021 | ||
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| IT | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| MK | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| TR | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| BE | 30.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2024/22] | HU | 20.06.2016 | |
| AL | 17.02.2021 | ||
| AT | 17.02.2021 | ||
| CY | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| IT | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| MK | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| BE | 30.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2023/30] | HU | 20.06.2016 | |
| AL | 17.02.2021 | ||
| AT | 17.02.2021 | ||
| CY | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| IT | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| BE | 30.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2023/28] | HU | 20.06.2016 | |
| AL | 17.02.2021 | ||
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| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| IT | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| BE | 30.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2022/34] | AL | 17.02.2021 | |
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| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| IT | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| BE | 30.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2022/23] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| IT | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2022/21] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| IE | 20.06.2021 | ||
| LU | 20.06.2021 | ||
| CH | 30.06.2021 | ||
| LI | 30.06.2021 | ||
| Former [2022/18] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| LU | 20.06.2021 | ||
| Former [2022/13] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SI | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2022/10] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2022/08] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| ES | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2022/07] | AL | 17.02.2021 | |
| AT | 17.02.2021 | ||
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| MC | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/50] | AT | 17.02.2021 | |
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RO | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SK | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/49] | AT | 17.02.2021 | |
| CZ | 17.02.2021 | ||
| DK | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/48] | AT | 17.02.2021 | |
| CZ | 17.02.2021 | ||
| EE | 17.02.2021 | ||
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/46] | AT | 17.02.2021 | |
| FI | 17.02.2021 | ||
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| SM | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/42] | FI | 17.02.2021 | |
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| IS | 17.06.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/39] | FI | 17.02.2021 | |
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| PL | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/38] | FI | 17.02.2021 | |
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| NL | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| SE | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/37] | FI | 17.02.2021 | |
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| LV | 17.02.2021 | ||
| RS | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/36] | FI | 17.02.2021 | |
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| BG | 17.05.2021 | ||
| NO | 17.05.2021 | ||
| GR | 18.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/35] | FI | 17.02.2021 | |
| HR | 17.02.2021 | ||
| LT | 17.02.2021 | ||
| NO | 17.05.2021 | ||
| PT | 17.06.2021 | ||
| Former [2021/33] | FI | 17.02.2021 | |
| LT | 17.02.2021 | ||
| NO | 17.05.2021 | ||
| PT | 17.06.2021 | Documents cited: | Search | [A] US2014255394 (HOESCHELE JAMES DAVID et al.) [A] 1-15 * the whole document * | [A] EP2743252 (UNITECH CO LTD et al.) [A] 1-15 * the whole document * | [A] EP1473298 (WANG JINGZUN et al.) [A] 1-15 * the whole document * | International search | [X] US7927613 (ALMARSSON OERN et al.) [X] 1-5 * , entire document, especially: col 8, ln 33-36; col 11, ln 37-48; col 29, ln 6-32; col 61-62, Table, last row, pyroglutamic acid co-crystal former; col 179-180, Table IV, row 19, carboplatin API * | [A] US2008161251 (CURRY JAYNE ELIZABETH et al.) [A] 1-5 * , entire document, especially: para [0641], 5. Platinum compounds; para [0642], carboplatin. * | [A] WO2015058067 (VERTEX PHARMA et al.) [A] 1-5 * . entire document. * | by applicant | US2014255394 | EP2743252 | EP1473298 | ALMARSSON M.ZAWOROTKO J.: "co-crystals in which the target molecule or ion is an active pharmaceutical ingredient, API, and it bonds to the co-crystal former(s) through hydrogen bonds", CHEM. COMMUN., 2004, pages 1889 | SHELDRICK G M., ACTA CRYSTALLOGR A, vol. 64, 2008, pages 112,122 | O. V. DOLOMANOV ET AL., J. APPL. CRYST., vol. 42, 2009, pages 339 - 341 |