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Extract from the Register of European Patents

EP About this file: EP3337908

EP3337908 - METHODS AND COMPOSITIONS FOR ALTERING FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND/OR DOMAINS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  28.09.2019
Database last updated on 11.05.2024
FormerRequest for examination was made
Status updated on  25.05.2018
FormerThe international publication has been made
Status updated on  25.02.2017
Most recent event   Tooltip11.04.2024New entry: Despatch of examination report + time limit 
Applicant(s)For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
Baylor College of Medicine
One Baylor Plaza
Houston, TX 77030 / US
[2023/23]
Former [2018/26]For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
Baylor College of Medicine
One Baylor Plaza
Houston, TX 77030 / US
For all designated states
Lieberman Aiden, Erez
2205 Maroneal Street
Houston, TX 77030 / US
For all designated states
Rao, Suhas
216 Rosse Lane Apt 201
Stanford, CA 94305 / US
For all designated states
Huang, Su-chen
5730 Reamer Street
Houston, TX 77096 / US
For all designated states
Sanborn, Adrian L.
One Baylor Plaza
Houston, TX 77030 / US
For all designated states
Durand, Neva C.
One Baylor Plaza
Houston, TX 77030 / US
For all designated states
Huntley, Miriam
One Baylor Plaza
Houston, TX 77030 / US
For all designated states
Jewett, Andrew
One Baylor Plaza
Houston, TX 77030 / US
Inventor(s)01 / LIEBERMAN AIDEN, Erez
2205 Maroneal Street
Houston, TX 77030 / US
02 / LANDER, Eric, S.
74R Fayerweather Street
Cambridge, MA 02138 / US
03 / RAO, Suhas
216 Rosse Lane Apt 201
Stanford, CA 94305 / US
04 / HUANG, Su-Chen
5730 Reamer Street
Houston, TX 77096 / US
05 / SANBORN, Adrian, L.
One Baylor Plaza
Houston, TX 77030 / US
06 / DURAND, Neva, C.
One Baylor Plaza
Houston, TX 77030 / US
07 / HUNTLEY, Miriam
One Baylor Plaza
Houston, TX 77030 / US
08 / JEWETT, Andrew
One Baylor Plaza
Houston, TX 77030 / US
 [2018/26]
Representative(s)Impact Intellectual Property LLP
1 Sans Walk
London EC1R 0LT / GB
[N/P]
Former [2018/26]Icely, Dominic Michael
The IP Asset Partnership Limited
Prama House
267 Banbury Road
Oxford OX2 7HT / GB
Application number, filing date16837870.118.08.2016
[2018/26]
WO2016US47644
Priority number, dateUS201562206606P18.08.2015         Original published format: US 201562206606 P
US201562239135P08.10.2015         Original published format: US 201562239135 P
US201662347585P08.06.2016         Original published format: US 201662347585 P
[2018/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017031370
Date:23.02.2017
Language:EN
[2017/08]
Type: A1 Application with search report 
No.:EP3337908
Date:27.06.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 23.02.2017 takes the place of the publication of the European patent application.
[2018/26]
Search report(s)International search report - published on:US23.02.2017
(Supplementary) European search report - dispatched on:EP02.01.2019
ClassificationIPC:C12Q1/68, C12N15/63, C12N15/87, C12N9/22
[2018/26]
CPC:
C07K14/47 (EP,US); C12N15/113 (US); C07K14/4702 (EP,US);
C12N15/11 (US); C12N2310/14 (US); C12N2310/20 (US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/26]
TitleGerman:VERFAHREN UND ZUSAMMENSETZUNGEN ZUR VERÄNDERUNG DER FUNKTION UND STRUKTUR VON CHROMATINSCHLEIFEN UND/ODER -DOMÄNEN[2018/26]
English:METHODS AND COMPOSITIONS FOR ALTERING FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND/OR DOMAINS[2018/26]
French:PROCÉDÉS ET COMPOSITIONS PERMETTANT DE CHANGER LA FONCTION ET LA STRUCTURE DE BOUCLES ET/OU DE DOMAINES DE CHROMATINE[2018/26]
Entry into regional phase14.03.2018National basic fee paid 
14.03.2018Search fee paid 
14.03.2018Designation fee(s) paid 
14.03.2018Examination fee paid 
Examination procedure14.03.2018Examination requested  [2018/26]
14.03.2018Date on which the examining division has become responsible
19.07.2019Amendment by applicant (claims and/or description)
02.10.2019Despatch of a communication from the examining division (Time limit: M04)
11.02.2020Reply to a communication from the examining division
25.05.2020Despatch of a communication from the examining division (Time limit: M04)
25.09.2020Reply to a communication from the examining division
29.10.2020Despatch of a communication from the examining division (Time limit: M04)
26.02.2021Reply to a communication from the examining division
31.05.2021Despatch of a communication from the examining division (Time limit: M06)
29.11.2021Reply to a communication from the examining division
30.01.2023Despatch of a communication from the examining division (Time limit: M06)
28.07.2023Reply to a communication from the examining division
10.04.2024Despatch of a communication from the examining division (Time limit: M04)
Fees paidRenewal fee
27.08.2018Renewal fee patent year 03
27.08.2019Renewal fee patent year 04
27.08.2020Renewal fee patent year 05
27.08.2021Renewal fee patent year 06
29.08.2022Renewal fee patent year 07
28.08.2023Renewal fee patent year 08
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Documents cited:Search[XI]  - LUPIÁÑEZ DARÍO G ET AL, "Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions", CELL, CELL PRESS, AMSTERDAM, NL, (20150507), vol. 161, no. 5, doi:10.1016/J.CELL.2015.04.004, ISSN 0092-8674, pages 1012 - 1025, XP029129100 [X] 1-12,19,22-25 * abstract * [I] 13-18,20,21

DOI:   http://dx.doi.org/10.1016/j.cell.2015.04.004
    [ ] - REN BING ET AL, "A CRISPR Connection between Chromatin Topology and Genetic Disorders", CELL, CELL PRESS, AMSTERDAM, NL, (20150521), vol. 161, no. 5, doi:10.1016/J.CELL.2015.04.047, ISSN 0092-8674, pages 955 - 957, XP029129141

DOI:   http://dx.doi.org/10.1016/j.cell.2015.04.047
 [XI]  - VARUN NARENDRA ET AL, "CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation", SCIENCE, US, (20150226), vol. 347, no. 6225, doi:10.1126/science.1259145, ISSN 0036-8075, pages 1017 - 1021, XP055534368 [X] 1-12,19,22-25 * abstract * [I] 13-18,20,21

DOI:   http://dx.doi.org/10.1126/science.1259145
 [A]  - SUHAS S.P. RAO ET AL, "A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping", CELL, AMSTERDAM, NL, (20141201), vol. 159, no. 7, doi:10.1016/j.cell.2014.11.021, ISSN 0092-8674, pages 1665 - 1680, XP055534145 [A] 1-25 * abstract *

DOI:   http://dx.doi.org/10.1016/j.cell.2014.11.021
 [A]  - AMY D MARSHALL ET AL, "CTCF and BORIS in genome regulation and cancer", CURRENT OPINION IN GENETICS & DEVELOPMENT., XX, (20140201), vol. 24, doi:10.1016/j.gde.2013.10.011, ISSN 0959-437X, pages 8 - 15, XP055534160 [A] 1-25 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.gde.2013.10.011
International search[Y]US2012115227  (COHEN-HAGUENAUER ODILE [FR], et al) [Y] 4, 5, 8, 10 * . Especially para [0010], [0011], [0016]. *;
 [Y]WO2014172470  (WHITEHEAD BIOMEDICAL INST [US]) [Y] 6 * . Especially para [00107], [00108], [00406]. *;
 [Y]WO2015033293  (CSIR [ZA]) [Y] 6 * . Especially pg 7 para 1-2. *;
 [Y]  - GUO et al., "CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.", CELL, (20150813), vol. 162, no. 4, pages 900 - 910, XP055365405 [Y] 1-10 * . Especially abstract, pg 901 col 1 para 1, pg 901 col1 para 4, pg 901 col 2 para 2, pg 903 col 1 para 2, pg 905 col 2 para 4. *

DOI:   http://dx.doi.org/10.1016/j.cell.2015.07.038
 [Y]  - ALIPOUR et al., "Self-organization of domain structures by DNA-loop-extruding enzymes.", Nucl Acids Res, (20121200), vol. 40, no. 22, pages 11202 - 11212, XP055365406 [Y] 1-10 * . Especially abstract, pg 11203 para 2. *

DOI:   http://dx.doi.org/10.1093/nar/gks925
 [XP]  - SANBORN et al., "Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.", PNAS, vol. 112, no. 47, pages E6456 - E6465, XP055365407 [XP] 1-5, 7-10 * . Entire article, especially abstract, pg E6461 fig 5A, pg E6463 fig 7. *

DOI:   http://dx.doi.org/10.1073/pnas.1518552112
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