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Extract from the Register of European Patents

EP About this file: EP3337893

EP3337893 - INCREASING PRODUCTIVITY OF E. COLI HOST CELLS THAT FUNCTIONALLY EXPRESS P450 ENZYMES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.05.2024
Database last updated on 09.09.2024
FormerThe patent has been granted
Status updated on  16.06.2023
FormerGrant of patent is intended
Status updated on  24.04.2023
FormerExamination is in progress
Status updated on  07.07.2020
FormerRequest for examination was made
Status updated on  25.05.2018
FormerThe international publication has been made
Status updated on  04.03.2017
Most recent event   Tooltip02.08.2024Lapse of the patent in a contracting state
New state(s): SI		published on 04.09.2024  [2024/36]
Applicant(s)For all designated states
Manus Bio Inc.
1030 Massachusetts Avenue
Cambridge, MA 02138 / US
[2020/17]
Former [2018/26]For all designated states
Manus Biosynthesis, Inc.
1030 Massachusetts Avenue
Cambridge, MA 02138 / US
Inventor(s)01 / PIRIE, Christopher
c/o Manus Biosynthesis, Inc.
1030 Massachusetts Avenue
Cambirdge, MA 02138 / US
02 / LI, Liwei
c/o Manus Biosynthesis, Inc.
1030 Massachusetts Avenue
Cambridge, MA 02138 / US
03 / MAK, Huey-ming
c/o Manus Biosynthesis, Inc.
1030 Massachusetts Avenue
Cambridge, MA 02138 / US
04 / TIBREWALA, Srishti
c/o Manus Biosynthesis, Inc.
1030 Massachusetts Avenue
Cambridge, MA 02138 / US
05 / DONALD, Jason
c/o Manus Biosynthesis, Inc.
1030 Massachusetts Avenue
Cambridge, MA 02138 / US
06 / KUMARAN, Ajikumar, Parayil
c/o Manus Biosynthesis, Inc.
1030 Massachusetts Inc.
Cambridge, MA 02138 / US
 [2018/26]
Representative(s)Grund, Martin
Grund Intellectual Property Group
Patentanwälte und Solicitor PartG mbB
Steinsdorfstraße 2
80538 München / DE
[2023/29]
Former [2018/26]Grund, Martin
Grund Intellectual Property Group
Patentanwalt und Solicitor PartG mbB
Postfach 44 05 16
80754 München / DE
Application number, filing date16839862.619.08.2016
[2018/26]
WO2016US47692
Priority number, dateUS201562208166P21.08.2015         Original published format: US 201562208166 P
[2018/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017034942
Date:02.03.2017
Language:EN
[2017/09]
Type: A1 Application with search report 
No.:EP3337893
Date:27.06.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 02.03.2017 takes the place of the publication of the European patent application.
[2018/26]
Type: B1 Patent specification 
No.:EP3337893
Date:19.07.2023
Language:EN
[2023/29]
Search report(s)International search report - published on:US02.03.2017
(Supplementary) European search report - dispatched on:EP04.12.2018
ClassificationIPC:C12N9/00, C12N5/00, C12N1/21, C12N5/04
[2018/26]
CPC:
C12N9/0079 (EP,US); C12N15/52 (EP,US); C12N15/70 (US);
C12N9/00 (US); C12P19/56 (EP,US); C12P5/007 (EP,US);
C07K2319/03 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/26]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:ERHÖHUNG DER PRODUKTIVITÄT VON E. COLI-WIRTSZELLEN MIT FUNKTIONELLER EXPRESSION VON P450-ENZYMEN[2018/26]
English:INCREASING PRODUCTIVITY OF E. COLI HOST CELLS THAT FUNCTIONALLY EXPRESS P450 ENZYMES[2018/26]
French:RENFORCEMENT DE LA PRODUCTIVITÉ DE CELLULES HÔTES E. COLIEXPRIMANT DE MANIÈRE FONCTIONELLE DES ENZYMES P450[2023/29]
Former [2018/26]RENFORCEMENT DE LA PRODUCTIVITÉ DE CELLULES HÔTES E. COLIEXPRIMANT DE MANIÈRE FONCTIONNNELLE DES ENZYMES P450
Entry into regional phase14.03.2018National basic fee paid 
14.03.2018Search fee paid 
14.03.2018Designation fee(s) paid 
14.03.2018Examination fee paid 
Examination procedure14.03.2018Examination requested  [2018/26]
14.03.2018Date on which the examining division has become responsible
26.06.2019Amendment by applicant (claims and/or description)
10.07.2020Despatch of a communication from the examining division (Time limit: M06)
05.01.2021Reply to a communication from the examining division
16.02.2022Despatch of a communication from the examining division (Time limit: M02)
12.04.2022Reply to a communication from the examining division
25.04.2023Communication of intention to grant the patent
12.06.2023Fee for grant paid
12.06.2023Fee for publishing/printing paid
12.06.2023Receipt of the translation of the claim(s)
Opposition(s)22.04.2024No opposition filed within time limit [2024/26]
Fees paidRenewal fee
14.08.2018Renewal fee patent year 03
12.08.2019Renewal fee patent year 04
12.08.2020Renewal fee patent year 05
16.08.2021Renewal fee patent year 06
08.08.2022Renewal fee patent year 07
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT19.07.2023
CZ19.07.2023
DK19.07.2023
EE19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
MC19.07.2023
PL19.07.2023
RO19.07.2023
RS19.07.2023
SE19.07.2023
SI19.07.2023
SK19.07.2023
SM19.07.2023
IE19.08.2023
LU19.08.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
[2024/36]
Former [2024/33]AT19.07.2023
CZ19.07.2023
DK19.07.2023
EE19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
MC19.07.2023
PL19.07.2023
RO19.07.2023
RS19.07.2023
SE19.07.2023
SK19.07.2023
SM19.07.2023
IE19.08.2023
LU19.08.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
Former [2024/23]AT19.07.2023
CZ19.07.2023
DK19.07.2023
EE19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
MC19.07.2023
PL19.07.2023
RO19.07.2023
RS19.07.2023
SE19.07.2023
SK19.07.2023
SM19.07.2023
LU19.08.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
Former [2024/22]AT19.07.2023
CZ19.07.2023
DK19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
PL19.07.2023
RO19.07.2023
RS19.07.2023
SE19.07.2023
SM19.07.2023
LU19.08.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
Former [2024/21]AT19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
PL19.07.2023
RS19.07.2023
SE19.07.2023
SM19.07.2023
LU19.08.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
Former [2024/20]AT19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
PL19.07.2023
RS19.07.2023
SE19.07.2023
SM19.07.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
Former [2024/10]AT19.07.2023
FI19.07.2023
HR19.07.2023
LT19.07.2023
LV19.07.2023
PL19.07.2023
RS19.07.2023
SE19.07.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
PT20.11.2023
Former [2024/09]AT19.07.2023
FI19.07.2023
LT19.07.2023
SE19.07.2023
NO19.10.2023
GR20.10.2023
IS19.11.2023
Former [2024/08]LT19.07.2023
NO19.10.2023
GR20.10.2023
Documents cited:Search[A]US2008233623  (CHANG MICHELLE CHIA-YU [US], et al) [A] 1-23 * abstract * * paragraphs [0094] - [0095] * * paragraphs [0109] - [0111]; figure 6 * * paragraph [0157] *;
 [A]US2012107893  (AJIKUMAR PARAYIL K [US], et al) [A] 1-23* the whole document *;
 [XP]WO2016029153  (MANUS BIOSYNTHESIS INC [US]) [XP] 1,4,7,8,13,18-23 * page 9, lines 24-29; figure 9 * * page 10, paragraph 1; figure 10 * * page 10, paragraph 4; figure 11 * * page 12, paragraph 1; figures 23A, 23B * * page 42, line 10 - page 43, line 8 * * examples 1-9 *;
 [XP]WO2016029187  (GIVAUDAN SA [CH], et al) [XP] 1,4,7,8,13,18-23 * the whole document * * example 5 *;
 [XYI]  - MICHELLE C Y CHANG ET AL, "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s", NATURE CHEMICAL BIOLOGY, Basingstoke, (20070415), vol. 3, no. 5, doi:10.1038/nchembio875, ISSN 1552-4450, pages 274 - 277, XP055368486 [X] 1,3,6,8,13-17,19,20,22 * abstract * * page 275, column l - page 276, column l, paragraph 3 * [Y] 4,5 [I] 2,23

DOI:   http://dx.doi.org/10.1038/nchembio875
 [Y]  - AJIKUMAR PARAYIL KUMARAN ET AL, "Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli", SCIENCE,, (20101001), vol. 330, no. 6000, doi:10.1126/SCIENCE.1191652, ISSN 0036-8075, pages 70 - 74, XP002618146 [Y] 4,5 * abstract * * page 70, column r, paragraph 1 * * page 72, column r, paragraph l - page 73, column l, paragraph 1 *

DOI:   http://dx.doi.org/10.1126/science.1191652
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DOI:   http://dx.doi.org/10.1016/j.bbrc.2013.07.057
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DOI:   http://dx.doi.org/10.2174/138920006776873472
International search[A]US2008233623  (CHANG MICHELLE CHIA-YU [US], et al) [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; figure 6; abstract; paragraphs [0094]-[0095], [0109]-[0111], [0157]. *;
 [A]US2009031455  (AHARONI ASAPH [IL], et al) [A] 147-150, 151/147-150, 152/151/147-150, 153/151/147-150, 154/151/147-150, 155/151/147-150, 156/151/147-150 * ; paragraphs [0009], [0082]. *;
 [PX]WO2016029153  (MANUS BIOSYNTHESIS INC [US]) [PX] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; entire document. *;
 [PX]WO2016029187  (GIVAUDAN SA [CH], et al) [PX] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15* ; entire document. *;
 [A]  - CHANG, MCY et al., "Engineering Escherichia Coli For Production Of Functionalized Terpenoids Using Plant P450s.", Nature Chemical Biology., (20070415), vol. 3, no. 5, pages 274 - 277, XP055368486 [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; scheme 1; abstract; page 275, first column first paragraph; page 276, first column, second and third paragraphs; page 276, second column, second and third paragraphs; doi:10.1038/nchembio875 *

DOI:   http://dx.doi.org/10.1038/nchembio875
 [A]  - LEONARD,E et al., "Functional Expression Of A P450 Flavonoid Hydroxylase For The Biosynthesis Of Plant-Specific Hydroxylated Flavonols In Escherichia Coli.", Metabolic Engineering., (20060300), vol. 8, no. 2, pages 172 - 181, XP024946932 [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; figure 1; abstract; page 175, first column, third and fourth paragraphs; page 175, second column, third paragraph; doi:10.1016/j.ymben.2005.11.001 *

DOI:   http://dx.doi.org/10.1016/j.ymben.2005.11.001
 [A]  - AJIKUMAR, PK et al., "Isoprenoid Pathway Optimization For Taxol Precursor Overproduction In Escherichia Coli.", Science ., (20101001), vol. 330, pages 70 - 74, XP002618146 [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106 * ; figure 1; abstract; page 2, second and fifth paragraphs; doi:10.1126/science.1191652 *

DOI:   http://dx.doi.org/10.1126/science.1191652
by applicantUS7273735
 US2011236927
 US2012107893
 WO2012075030
 US2012246767
 US2013171328
 US8512988
 US8722363
 WO2014122328
 US8927241
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DOI:   http://dx.doi.org/10.1146/annurev.arplant.49.1.311
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DOI:   http://dx.doi.org/10.1016/j.jmb.2004.03.016
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DOI:   http://dx.doi.org/10.1126/science.1191652
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.