EP3337893 - INCREASING PRODUCTIVITY OF E. COLI HOST CELLS THAT FUNCTIONALLY EXPRESS P450 ENZYMES [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 24.05.2024 Database last updated on 09.09.2024 | |
Former | The patent has been granted Status updated on 16.06.2023 | ||
Former | Grant of patent is intended Status updated on 24.04.2023 | ||
Former | Examination is in progress Status updated on 07.07.2020 | ||
Former | Request for examination was made Status updated on 25.05.2018 | ||
Former | The international publication has been made Status updated on 04.03.2017 | Most recent event Tooltip | 02.08.2024 | Lapse of the patent in a contracting state New state(s): SI | published on 04.09.2024 [2024/36] | Applicant(s) | For all designated states Manus Bio Inc. 1030 Massachusetts Avenue Cambridge, MA 02138 / US | [2020/17] |
Former [2018/26] | For all designated states Manus Biosynthesis, Inc. 1030 Massachusetts Avenue Cambridge, MA 02138 / US | Inventor(s) | 01 /
PIRIE, Christopher c/o Manus Biosynthesis, Inc. 1030 Massachusetts Avenue Cambirdge, MA 02138 / US | 02 /
LI, Liwei c/o Manus Biosynthesis, Inc. 1030 Massachusetts Avenue Cambridge, MA 02138 / US | 03 /
MAK, Huey-ming c/o Manus Biosynthesis, Inc. 1030 Massachusetts Avenue Cambridge, MA 02138 / US | 04 /
TIBREWALA, Srishti c/o Manus Biosynthesis, Inc. 1030 Massachusetts Avenue Cambridge, MA 02138 / US | 05 /
DONALD, Jason c/o Manus Biosynthesis, Inc. 1030 Massachusetts Avenue Cambridge, MA 02138 / US | 06 /
KUMARAN, Ajikumar, Parayil c/o Manus Biosynthesis, Inc. 1030 Massachusetts Inc. Cambridge, MA 02138 / US | [2018/26] | Representative(s) | Grund, Martin Grund Intellectual Property Group Patentanwälte und Solicitor PartG mbB Steinsdorfstraße 2 80538 München / DE | [2023/29] |
Former [2018/26] | Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16 80754 München / DE | Application number, filing date | 16839862.6 | 19.08.2016 | [2018/26] | WO2016US47692 | Priority number, date | US201562208166P | 21.08.2015 Original published format: US 201562208166 P | [2018/26] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2017034942 | Date: | 02.03.2017 | Language: | EN | [2017/09] | Type: | A1 Application with search report | No.: | EP3337893 | Date: | 27.06.2018 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.03.2017 takes the place of the publication of the European patent application. | [2018/26] | Type: | B1 Patent specification | No.: | EP3337893 | Date: | 19.07.2023 | Language: | EN | [2023/29] | Search report(s) | International search report - published on: | US | 02.03.2017 | (Supplementary) European search report - dispatched on: | EP | 04.12.2018 | Classification | IPC: | C12N9/00, C12N5/00, C12N1/21, C12N5/04 | [2018/26] | CPC: |
C12N9/0079 (EP,US);
C12N15/52 (EP,US);
C12N15/70 (US);
C12N9/00 (US);
C12P19/56 (EP,US);
C12P5/007 (EP,US);
C07K2319/03 (EP,US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/26] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | Title | German: | ERHÖHUNG DER PRODUKTIVITÄT VON E. COLI-WIRTSZELLEN MIT FUNKTIONELLER EXPRESSION VON P450-ENZYMEN | [2018/26] | English: | INCREASING PRODUCTIVITY OF E. COLI HOST CELLS THAT FUNCTIONALLY EXPRESS P450 ENZYMES | [2018/26] | French: | RENFORCEMENT DE LA PRODUCTIVITÉ DE CELLULES HÔTES E. COLIEXPRIMANT DE MANIÈRE FONCTIONELLE DES ENZYMES P450 | [2023/29] |
Former [2018/26] | RENFORCEMENT DE LA PRODUCTIVITÉ DE CELLULES HÔTES E. COLIEXPRIMANT DE MANIÈRE FONCTIONNNELLE DES ENZYMES P450 | Entry into regional phase | 14.03.2018 | National basic fee paid | 14.03.2018 | Search fee paid | 14.03.2018 | Designation fee(s) paid | 14.03.2018 | Examination fee paid | Examination procedure | 14.03.2018 | Examination requested [2018/26] | 14.03.2018 | Date on which the examining division has become responsible | 26.06.2019 | Amendment by applicant (claims and/or description) | 10.07.2020 | Despatch of a communication from the examining division (Time limit: M06) | 05.01.2021 | Reply to a communication from the examining division | 16.02.2022 | Despatch of a communication from the examining division (Time limit: M02) | 12.04.2022 | Reply to a communication from the examining division | 25.04.2023 | Communication of intention to grant the patent | 12.06.2023 | Fee for grant paid | 12.06.2023 | Fee for publishing/printing paid | 12.06.2023 | Receipt of the translation of the claim(s) | Opposition(s) | 22.04.2024 | No opposition filed within time limit [2024/26] | Fees paid | Renewal fee | 14.08.2018 | Renewal fee patent year 03 | 12.08.2019 | Renewal fee patent year 04 | 12.08.2020 | Renewal fee patent year 05 | 16.08.2021 | Renewal fee patent year 06 | 08.08.2022 | Renewal fee patent year 07 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 19.07.2023 | CZ | 19.07.2023 | DK | 19.07.2023 | EE | 19.07.2023 | FI | 19.07.2023 | HR | 19.07.2023 | LT | 19.07.2023 | LV | 19.07.2023 | MC | 19.07.2023 | PL | 19.07.2023 | RO | 19.07.2023 | RS | 19.07.2023 | SE | 19.07.2023 | SI | 19.07.2023 | SK | 19.07.2023 | SM | 19.07.2023 | IE | 19.08.2023 | LU | 19.08.2023 | NO | 19.10.2023 | GR | 20.10.2023 | IS | 19.11.2023 | PT | 20.11.2023 | [2024/36] |
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GR | 20.10.2023 | Documents cited: | Search | [A]US2008233623 (CHANG MICHELLE CHIA-YU [US], et al) [A] 1-23 * abstract * * paragraphs [0094] - [0095] * * paragraphs [0109] - [0111]; figure 6 * * paragraph [0157] *; | [A]US2012107893 (AJIKUMAR PARAYIL K [US], et al) [A] 1-23* the whole document *; | [XP]WO2016029153 (MANUS BIOSYNTHESIS INC [US]) [XP] 1,4,7,8,13,18-23 * page 9, lines 24-29; figure 9 * * page 10, paragraph 1; figure 10 * * page 10, paragraph 4; figure 11 * * page 12, paragraph 1; figures 23A, 23B * * page 42, line 10 - page 43, line 8 * * examples 1-9 *; | [XP]WO2016029187 (GIVAUDAN SA [CH], et al) [XP] 1,4,7,8,13,18-23 * the whole document * * example 5 *; | [XYI] - MICHELLE C Y CHANG ET AL, "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s", NATURE CHEMICAL BIOLOGY, Basingstoke, (20070415), vol. 3, no. 5, doi:10.1038/nchembio875, ISSN 1552-4450, pages 274 - 277, XP055368486 [X] 1,3,6,8,13-17,19,20,22 * abstract * * page 275, column l - page 276, column l, paragraph 3 * [Y] 4,5 [I] 2,23 DOI: http://dx.doi.org/10.1038/nchembio875 | [Y] - AJIKUMAR PARAYIL KUMARAN ET AL, "Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli", SCIENCE,, (20101001), vol. 330, no. 6000, doi:10.1126/SCIENCE.1191652, ISSN 0036-8075, pages 70 - 74, XP002618146 [Y] 4,5 * abstract * * page 70, column r, paragraph 1 * * page 72, column r, paragraph l - page 73, column l, paragraph 1 * DOI: http://dx.doi.org/10.1126/science.1191652 | [A] - ICHINOSE HIROFUMI ET AL, "High-level heterologous expression of fungal cytochrome P450s inEscherichia coli", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (20130723), vol. 438, no. 2, doi:10.1016/J.BBRC.2013.07.057, ISSN 0006-291X, pages 289 - 294, XP028695321 [A] 1-23 * figure 1; 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paragraphs [0009], [0082]. *; | [PX]WO2016029153 (MANUS BIOSYNTHESIS INC [US]) [PX] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; entire document. *; | [PX]WO2016029187 (GIVAUDAN SA [CH], et al) [PX] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15* ; entire document. *; | [A] - CHANG, MCY et al., "Engineering Escherichia Coli For Production Of Functionalized Terpenoids Using Plant P450s.", Nature Chemical Biology., (20070415), vol. 3, no. 5, pages 274 - 277, XP055368486 [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; scheme 1; abstract; page 275, first column first paragraph; page 276, first column, second and third paragraphs; page 276, second column, second and third paragraphs; doi:10.1038/nchembio875 * DOI: http://dx.doi.org/10.1038/nchembio875 | [A] - LEONARD,E et al., "Functional Expression Of A P450 Flavonoid Hydroxylase For The Biosynthesis Of Plant-Specific Hydroxylated Flavonols In Escherichia Coli.", Metabolic Engineering., (20060300), vol. 8, no. 2, pages 172 - 181, XP024946932 [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106, 147-150, 151/147-150, 152/151/147-150, 153/151/147/150, 154/15 * ; figure 1; abstract; page 175, first column, third and fourth paragraphs; page 175, second column, third paragraph; doi:10.1016/j.ymben.2005.11.001 * DOI: http://dx.doi.org/10.1016/j.ymben.2005.11.001 | [A] - AJIKUMAR, PK et al., "Isoprenoid Pathway Optimization For Taxol Precursor Overproduction In Escherichia Coli.", Science ., (20101001), vol. 330, pages 70 - 74, XP002618146 [A] 1-2, 3/1-2, 4/3/1-2, /14/3/1-2, 54-55, 56/54-55, 57/56/54-55, 58/57/56/54-55, 105-106, 107/105-106, 108/107/105/106, 109/108/107/105-106 * ; 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