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Extract from the Register of European Patents

EP About this file: EP3377116

EP3377116 - COMPOSITIONS AND METHODS FOR CORRECTION OF HERITABLE OCULAR DISEASE [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  03.09.2020
Database last updated on 19.07.2024
FormerRequest for examination was made
Status updated on  24.08.2018
FormerThe international publication has been made
Status updated on  26.05.2017
Most recent event   Tooltip05.04.2024New entry: Reply to examination report 
Applicant(s)For all designated states
The Trustees of The University of Pennsylvania
3160 Chestnut Street, Suite 200
Philadelphia, PA 19104 / US
For all designated states
Mitchell, Lloyd G.
4519 Gretna Street
Bethesda MD 20814 / US
[2018/39]
Inventor(s)01 / MITCHELL, Lloyd, G.
4519 Gretna Street
Bethesda, MD 20814 / US
02 / BENNETT, Jean
182 Fishers Road
Bryn Mawr, PA 19010 / US
03 / BENNICELLI, Jeannette
4602 Springfield Avenue
Philadelphia, PA 19143 / US
04 / DOOLEY, Scott, J.
4514 Pine Street
Apt. 104
Philadelphia, PA 19143 / US
 [2018/39]
Representative(s)Appleyard Lees IP LLP
15 Clare Road
Halifax HX1 2HY / GB
[2018/39]
Application number, filing date16867296.218.11.2016
[2018/39]
WO2016US62941
Priority number, dateUS201562257500P19.11.2015         Original published format: US 201562257500 P
[2018/39]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017087900
Date:26.05.2017
Language:EN
[2017/21]
Type: A1 Application with search report 
No.:EP3377116
Date:26.09.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 26.05.2017 takes the place of the publication of the European patent application.
[2018/39]
Search report(s)International search report - published on:US26.05.2017
(Supplementary) European search report - dispatched on:EP12.06.2019
ClassificationIPC:A61K48/00, C07H21/02, C07H21/04
[2018/39]
CPC:
A61K48/005 (EP,US); A61K48/0075 (US); C12N15/00 (EP,US);
C12N15/11 (US); C12N15/86 (EP,US); C12N2740/10043 (EP,US);
C12N2750/14143 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/39]
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR KORREKTUR VON ERBLICHER AUGENERKRANKUNG[2018/39]
English:COMPOSITIONS AND METHODS FOR CORRECTION OF HERITABLE OCULAR DISEASE[2018/39]
French:COMPOSITIONS ET PROCÉDÉS DE CORRECTION DE MALADIE OCULAIRE HÉRÉDITAIRE[2018/39]
Entry into regional phase16.05.2018National basic fee paid 
16.05.2018Search fee paid 
16.05.2018Designation fee(s) paid 
16.05.2018Examination fee paid 
Examination procedure16.05.2018Examination requested  [2018/39]
16.05.2018Date on which the examining division has become responsible
08.01.2020Amendment by applicant (claims and/or description)
02.09.2020Despatch of a communication from the examining division (Time limit: M06)
07.06.2021Reply to a communication from the examining division
07.07.2021Despatch of a communication from the examining division (Time limit: M04)
08.12.2021Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
02.02.2022Reply to a communication from the examining division
07.12.2023Despatch of a communication from the examining division (Time limit: M04)
04.04.2024Reply to a communication from the examining division
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
02.02.2022Request for further processing filed
02.02.2022Full payment received (date of receipt of payment)
Request granted
09.02.2022Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
07.06.2021Request for further processing filed
07.06.2021Full payment received (date of receipt of payment)
Request granted
17.06.2021Decision despatched
Fees paidRenewal fee
14.11.2018Renewal fee patent year 03
14.11.2019Renewal fee patent year 04
13.11.2020Renewal fee patent year 05
10.11.2021Renewal fee patent year 06
26.10.2022Renewal fee patent year 07
27.10.2023Renewal fee patent year 08
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Documents cited:Search[X]  - GERARD XAVIER ET AL, "Intravitreal Injection of Splice-switching Oligonucleotides to Manipulate Splicing in Retinal Cells", MOLECULAR THERAPY-NUCLEIC ACIDS, (201509), vol. 4, XP002788928 [X] 1-15 * the whole document *
 [Y]  - COLLIN ROB W J ET AL, "Antisense Oligonucleotide (AON)-based Therapy for Leber Congenital Amaurosis Caused by a Frequent Mutation in CEP290", MOLECULAR THERAPY-NUCLEIC ACIDS, (201203), vol. 1, XP002788929 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1038/mtna.2012.3
 [Y]  - GARANTO ALEJANDRO ET AL, "Species-dependent splice recognition of a cryptic exon resulting from a recurrent intronic CEP290 mutation that causes congenital blindness.", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 09 MAR 2015, (20150309), vol. 16, no. 3, ISSN 1422-0067, pages 5285 - 5298, XP002788937 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.3390/ijms16035285
 [Y]  - U. KOLLER ET AL, "A novel screening system improves genetic correction by internal exon replacement", NUCLEIC ACIDS RESEARCH, (20110901), vol. 39, no. 16, doi:10.1093/nar/gkr465, ISSN 0305-1048, pages e108 - e108, XP055087654 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/gkr465
 [XP]  - GARANTO ALEJANDRO ET AL, "In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery", HUMAN MOLECULAR GENETICS, (20160615), vol. 25, no. 12, pages 2552 - 2563, XP002788931 [XP] 1-15 * the whole document *
 [XP]  - ALEJANDRO GARANTO ET AL, "Species-Dependent Splice Recognition of a Cryptic Exon Resulting from a Recurrent Intronic CEP290 Mutation that Causes Congenital Blindness", INT. J. MOL. SCI., (20151209), vol. 16, no. 12, doi:10.3390/ijms16035285, ISSN 1661-6596, pages 5285 - 5298, XP055557072 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.3390/ijms16035285
International search[Y]US2013059901  (BAUER JOHANN [AT], et al) [Y] 16 * entire document *;
 [Y]US2014087444  (BENNETT JEAN [US], et al) [Y] 12 * entire document *;
 [Y]US2014243388  (HASTINGS MICHELLE L [US]) [Y] 19* entire document *;
 [XY]US2015252358  (MAEDER MORGAN L [US], et al) [X] 1, 2, 5, 8, 10, 11, 13-15, 17, 21 * entire document * [Y] 3, 4, 6, 7, 9, 12, 16, 18-20;
 [Y]  - ZHANG et al., "Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations", Human Molecular Genetics, (20150224), vol. 24, no. 11, pages 3220 - 3237, XP055382585 [Y] 3, 6, 7, 18, 20 * . entire document *

DOI:   http://dx.doi.org/10.1093/hmg/ddv073
 [Y]  - MAIA-LOPES et al., "ABCA4 mutations in Portuguese Stargardt patients: identification of new mutations and their phenotypic analysis", Molecular Vision, (20090325), vol. 15, pages 584 - 591, XP055382588 [Y] 4, 9 * . entire document *
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