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EP About this file: EP3390646

EP3390646 - A NOVEL PROCESS FOR PRODUCTION OF PURIFIED RECOMBINANT CHOLERA TOXIN B (rCTB) AND FORMU LATION THEREON [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 16.10.2020 Database last updated on 28.09.2024
Former	Request for examination was made Status updated on 21.09.2018
Former	The international publication has been made Status updated on 23.06.2017
Most recent event Tooltip	16.10.2020	Application deemed to be withdrawn	published on 18.11.2020 [2020/47]
Applicant(s)	For all designated states Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. D-15 Ground Floor Jangpura Extension New Delhi 110014 / IN
	[2018/43]
Inventor(s)	01 / SHARMA, Tarun WZ-37 Second Floor Hari Singh Park New Multan Nagar New Delhi 110056 / IN
	02 / JOSHI, Neeraj A1/93 Gali No. 3 Rajapuri Uttam Nagar New Delhi 110059 / IN
	03 / KANCHAN, Vibhu Pocket D Flat No. 211 Ground Floor Sarita Vihar New Delhi 110076 / IN
	04 / SIKRIWAL, Deepa Pocket D Flat no. 211 Ground Floor Sarita Vihar New Delhi New Delhi 110076 / IN
	05 / SHUKLA, Nidhi A062 G. C Grand Apartments Vaibhav Khand Indirapuram Ghaziabad Uttar Pradesh Ghaziabad 201014 / IN
	06 / GILL, Dr. Davinder E-9/16 Ground Floor Vasant Vihar New Delhi New Delhi 110057 / IN
	[2018/43]
Representative(s)	Novitas Patent AB P.O. Box 55557 102 04 Stockholm / SE
	[2018/43]
Application number, filing date	16874999.2	09.12.2016
	[2018/43]
	WO2016IB57460
Priority number, date	IN2015DEL4089	14.12.2015 Original published format: IN 4089DE2015
	[2018/43]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2017103748
	Date:	22.06.2017
	Language:	EN
	[2017/25]
	Type:	A1 Application with search report
	No.:	EP3390646
	Date:	24.10.2018
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 22.06.2017 takes the place of the publication of the European patent application.
	[2018/43]
Search report(s)	International search report - published on:	IN	22.06.2017
	(Supplementary) European search report - dispatched on:	EP	30.09.2019
Classification	IPC:	C12P1/04, C07K14/28, A61P31/04	[2019/25]
	CPC:	A61K39/107 (EP,KR,US); C07K14/28 (EP,KR,US); A61P31/04 (EP,US); C12P1/04 (US); C12P21/02 (EP,KR,US); A61K2039/521 (EP,KR,US); (+) C12N1/20 (US); C12N15/86 (US); Y02A50/30 (EP) (-)
	Former IPC [2018/43]	C12P1/04, C07K14/28
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/43]
Title	German:	NEUARTIGES VERFAHREN ZUR HERSTELLUNG VON GEREINIGTEM REKOMBINANTEM CHOLERATOXIN B (RCTB) UND FORMULIERUNG DARAUS	[2018/43]
	English:	A NOVEL PROCESS FOR PRODUCTION OF PURIFIED RECOMBINANT CHOLERA TOXIN B (rCTB) AND FORMU LATION THEREON	[2018/43]
	French:	NOUVEAU PROCÉDÉ DE PRODUCTION DE TOXINE B DE CHOLÉRA, RECOMBINANTE, PURIFIÉE (TBCR) ET FORMULATION CORRESPONDANTE	[2018/43]
Entry into regional phase	07.05.2018	National basic fee paid
	07.05.2018	Search fee paid
	07.05.2018	Designation fee(s) paid
	07.05.2018	Examination fee paid
Examination procedure	07.05.2018	Examination requested [2018/43]
	07.05.2018	Date on which the examining division has become responsible
	03.06.2020	Application deemed to be withdrawn, date of legal effect [2020/47]
	24.06.2020	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2020/47]
Fees paid	Renewal fee
	29.11.2018	Renewal fee patent year 03
	09.12.2019	Renewal fee patent year 04
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A]RU2456996 (FEDERAL NOE G UCHREZHDENIE ZDRAVOOKHRANENIJA ROSSIJSKIJ NI PROTIVOCHUMNYJ INST MIKROB FEDERAL NOJ SL [RU]) [A] 1-11;
		[A] - C Bergquist ET AL, "Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina", Infection and Immunity, United States, (19970701), pages 2676 - 2684, URL: https://iai.asm.org/content/iai/65/7/2676.full.pdf, XP055585512 [A] 1-6
		[Y] - SANCHEZ J ET AL, "RECOMBINANT SYSTEM FOR OVEREXPRESSION OF CHOLERA TOXIN B SUBUNIT IN VIBRIO CHOLERAE AS A BASIS FOR VACCINE DEVELOPMENT", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATIONAL ACADEMY OF SCIENCES, US, (19890101), vol. 86, doi:10.1073/PNAS.86.2.481, ISSN 0027-8424, pages 481 - 485, XP009042243 [Y] 1-5,7-11 * page 482, column left * DOI: http://dx.doi.org/10.1073/pnas.86.2.481
		[Y] - KRYSTAL TEASLEY HAMORSKY ET AL, "Rapid and Scalable Plant-based Production of a Cholera Toxin B Subunit Variant to Aid in Mass Vaccination against Cholera Outbreaks", PLOS NEGLECTED TROPICAL DISEASES, (20130307), vol. 7, no. 3, doi:10.1371/journal.pntd.0002046, page e2046, XP055535643 [Y] 1-5,7-11 * page 3, column right * DOI: http://dx.doi.org/10.1371/journal.pntd.0002046
		[A] - JOHN CLEMENS ET AL, "New-generation vaccines against cholera", NATURE REVIEWS / GASTROENTEROLOGY & HEPATOLOGY, US, (20111108), vol. 8, no. 12, doi:10.1038/nrgastro.2011.174, ISSN 1759-5045, pages 701 - 710, XP055585502 [A] 1-11 DOI: http://dx.doi.org/10.1038/nrgastro.2011.174
		[Y] - Holmgren, "Single-strain improved oral cholera vaccine", (20150101), URL: https://www.msb.se/RibData/Filer/pdf/27943.pdf, (20190503), XP055585428 [Y] 1-5,7-11 * page 10 *
		[Y] - M. BOUSTANSHENAS ET AL, "Investigation into immunological responses against a native recombinant CTB whole-cell Vibrio cholerae vaccine in a rabbit model", JOURNAL OF APPLIED MICROBIOLOGY., GB, (20130201), vol. 114, no. 2, doi:10.1111/jam.12043, ISSN 1364-5072, pages 509 - 515, XP055392332 [Y] 1-5,7-11 * table 2 * DOI: http://dx.doi.org/10.1111/jam.12043
	International search	[Y] - "Single-strain improved oral cholera vaccine", Scientific report- Jan Holmgren, Sara Brunnberg, (20150900), XP055549131 [Y] 1-11 * . refer page 10, paragraph 3; page 10, paragraph 1; page 12, paragrapgh 1 lines 9-12
		[Y] - M. BOUSTANSHENAS et al., "Investigation into immunological responses against a native recombinant CTB whole- cell Vibrio cholerae vaccine in a rabbit model", Journal of Applied Microbiology, (20130200), vol. 114, no. 2, pages 509 - 515, XP 055392332 [Y] 1-11 refer material and method, Abstract
		[Y] - P. SLOS et al., "Recombinant Cholera Toxin B-Subunit in Escherichia coli: High-Level Secretion, Purification, and Characterization", Protein Expression and Purification, (19941000), vol. 5, no. 5, pages 518 - 526, XP 024799899 [Y] 1-11 * . refer whole document

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