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Extract from the Register of European Patents

EP About this file: EP3381472

EP3381472 - DRUG FOR TREATING OR PREVENTING DISORDER CAUSED BY TGF- SIGNALS, AND APPLICATION THEREOF [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  18.12.2020
Database last updated on 15.06.2024
FormerRequest for examination was made
Status updated on  31.08.2018
FormerThe international publication has been made
Status updated on  05.07.2017
Most recent event   Tooltip15.11.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
The Doshisha
601, Gembu-cho
Karasuma-higashi-iru
Imadegawa-dori
Kamigyo-ku, Kyoto-shi
Kyoto 602-8580 / JP
[2018/40]
Inventor(s)01 / KOIZUMI, Noriko
c/o DOSHISHA UNIVERSITY
1-3 Tatara Miyakodani
Kyotanabe-shi Kyoto 610-0394 / JP
02 / OKUMURA, Naoki
c/o DOSHISHA UNIVERSITY
1-3 Tatara Miyakodani
Kyotanabe-shi Kyoto 610-0394 / JP
 [2018/40]
Representative(s)Engelhard, Markus
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[2018/40]
Application number, filing date16877997.322.12.2016
[2018/40]
WO2016JP05215
Priority number, dateJP2015025178624.12.2015         Original published format: JP 2015251786
[2018/40]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017110093
Date:29.06.2017
Language:JA
[2017/26]
Type: A1 Application with search report 
No.:EP3381472
Date:03.10.2018
Language:EN
[2018/40]
Search report(s)International search report - published on:JP29.06.2017
(Supplementary) European search report - dispatched on:EP03.07.2019
ClassificationIPC:A61K31/4418, A61K31/4439, A61K31/4412, A61K45/00, A61P27/02, A61P43/00
[2019/31]
CPC:
A61K31/4439 (EP,US); A61K31/17 (US); A61K31/4412 (EP,US);
A61K31/4418 (EP,US); A61K31/573 (EP,US); A61K45/06 (EP,US);
A61P27/02 (EP,US); A61P43/00 (US) (-)
Former IPC [2018/40]A61K45/00, A61K31/4412, A61K31/4418, A61K31/4439, A61P27/02, A61P43/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/40]
TitleGerman:ARZNEIMITTEL ZUR BEHANDLUNG ODER VORBEUGUNG VON DURCH TGF-SIGNALE VERURSACHTEN STÖRUNGEN UND VERWENDUNG DAVON[2018/40]
English:DRUG FOR TREATING OR PREVENTING DISORDER CAUSED BY TGF- SIGNALS, AND APPLICATION THEREOF[2018/40]
French:MÉDICAMENT PERMETTANT LE TRAITEMENT OU LA PRÉVENTION D'UN TROUBLE PROVOQUÉ PAR DES SIGNAUX TGF-Â ET SON APPLICATION[2018/40]
Entry into regional phase29.06.2018Translation filed 
29.06.2018National basic fee paid 
29.06.2018Search fee paid 
29.06.2018Designation fee(s) paid 
29.06.2018Examination fee paid 
Examination procedure29.06.2018Examination requested  [2018/40]
29.06.2018Date on which the examining division has become responsible
08.01.2020Amendment by applicant (claims and/or description)
22.12.2020Despatch of a communication from the examining division (Time limit: M04)
16.04.2021Reply to a communication from the examining division
04.10.2022Despatch of a communication from the examining division (Time limit: M04)
07.02.2023Reply to a communication from the examining division
Fees paidRenewal fee
12.12.2018Renewal fee patent year 03
13.12.2019Renewal fee patent year 04
14.12.2020Renewal fee patent year 05
16.12.2021Renewal fee patent year 06
21.12.2022Renewal fee patent year 07
15.11.2023Renewal fee patent year 08
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Documents cited:Search[Y]  - MAHESH SHIVANNA ET AL, "Barrier Dysfunction of the Corneal Endothelium in Response to TNF-[alpha]: Role of p38 MAP Kinase", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, US, (20100301), vol. 51, no. 3, doi:10.1167/iovs.09-4343, ISSN 1552-5783, pages 1575 - 1582, XP055343172 [Y] 1-15 * discussion;; figures 5-10 *

DOI:   http://dx.doi.org/10.1167/iovs.09-4343
 [XY]  - JONG-SUK SONG ET AL, "Induction of FGF-2 Synthesis by IL-1? in Aqueous Humor through P13-Kinase and p38 in Rabbit Corneal Endothelium", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, US, (20100201), vol. 51, no. 2, doi:10.1167/iovs.09-4240, ISSN 1552-5783, pages 822 - 829, XP055387086 [X] 8,9 * § Transcorneal freezing procedure * [Y] 1-15

DOI:   http://dx.doi.org/10.1167/iovs.09-4240
International search[XY]WO2015072580  (DOSHISHA [JP]) [X] 1-9, 12-17 * , claims 1 to 8; examples 1 to 17; paragraph [0050] & US 2016/0331736 A1 claims 1 to 18; examples 1 to 17; paragraph [0083] & EP 3069732 A1 & CA 2928626 A * [Y] 1-17;
 [X]WO2013100208  (KYOTO PREFECTURAL PUBLIC UNIV CORP [JP], et al) [X] 10-11 * , claim 24; paragraph [0121]; example 13 & US 2015/0044178 A1 claim 24; example 13; paragraph [0208] & EP 2799537 A1 *;
 [X]WO2015015655  (KYOTO PREFECTURAL PUBLIC UNIV CORP [JP], et al) [X] 10 * , example 1 (Family: none) *;
 [Y]WO2015064768  (KYOTO PREFECTURAL PUBLIC UNIV CORP [JP], et al) [Y] 1-9, 12-17 * , & US 2016/0296505 A1 claims 1 to 14; examples 1 to 16 & EP 3064222 A1 & CA 2927898 A *;
 [Y]  - ADACHI, T. et al., "Contribution of p38 MAPK, NF-KB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability", Archives of biochemistry and biophysics, (20120000), vol. 520, no. 1, pages 30 - 35, XP055393408 [Y] 1-17 * , ABSTRACT *

DOI:   http://dx.doi.org/10.1016/j.abb.2012.01.014
 [Y]  - HUANG, Y. et al., "Endoplasmic reticulum stress- induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/ Caspase-12 pathways", Molecular and cellular biochemistry, (20140000), vol. 394, no. 1-2, pages 1 - 12, XP055496376 [Y] 1-17 * , Abstract, Fig. 8 *

DOI:   http://dx.doi.org/10.1007/s11010-014-2073-8
 [Y]  - KIM, DO-SUNG et al., "p38 Mitogen-activated protein kinase is involved in endoplasmic reticulum stress-induced cell death and autophagy in human gingival fibroblasts", B iological & pharmaceutical bulletin, (20100000), vol. 33, no. 4, pages 545 - 549, XP055393409 [Y] 1-17 * , Abstract *

DOI:   http://dx.doi.org/10.1248/bpb.33.545
 [Y]  - CORWIN, W.L. et al., "The unfolded protein response in human corneal endothelial cells following hypothermic storage: Implications of a novel stress pathway", Cryobiology, (20110000), vol. 63, no. 1, pages 46 - 55, XP055393410 [Y] 10-11 * , ABSTRACT *

DOI:   http://dx.doi.org/10.1016/j.cryobiol.2011.04.008
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