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Extract from the Register of European Patents

EP About this file: EP3351544

EP3351544 - BENZENE DISULFONAMIDE FOR THE TREATMENT OF CANCER [Right-click to bookmark this link]
Status	The application has been refused Status updated on 21.08.2018 Database last updated on 03.08.2024
Former	The application has been published Status updated on 22.06.2018
Most recent event Tooltip	07.12.2018	Refusal of application	published on 09.01.2019 [2019/02]
Applicant(s)	For all designated states Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hofgartenstraße 8 80539 München / DE
	[2018/30]
Representative(s)	Arth, Hans-Lothar ABK Patent Attorneys Jasminweg 9 14052 Berlin / DE
	[2018/30]
Application number, filing date	17151296.5	12.01.2017
	[2018/30]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP3351544
	Date:	25.07.2018
	Language:	EN
	[2018/30]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	16.03.2017
Classification	IPC:	C07D401/14, C07D405/14, C07D309/04, C07C311/20, C07C311/21, C07D401/12, C07D239/42, C07D409/12, C07D409/14, C07D241/04, C07D493/10, C07D209/12, C07D211/14, C07D211/16, C07D211/26, C07D317/58, C07D407/12, C07D295/26, C07D213/42, A61K31/4525, A61P35/00	[2018/30]
	CPC:	C07D401/14 (EP); C07C311/16 (EP,US); A61P35/00 (EP); C07C311/20 (EP); C07C311/21 (EP); C07D209/12 (EP); (+) C07D211/14 (EP); C07D211/16 (EP); C07D211/26 (EP); C07D213/42 (EP); C07D221/00 (US); C07D239/26 (US); C07D239/42 (EP); C07D241/04 (EP,US); C07D295/26 (EP); C07D307/52 (EP); C07D309/04 (EP); C07D317/58 (EP); C07D401/12 (EP,US); C07D405/14 (EP,US); C07D407/12 (EP); C07D409/12 (EP); C07D409/14 (EP); C07D493/10 (EP,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/30]
Extension states	BA	Not yet paid
	ME	Not yet paid
Validation states	MA	Not yet paid
	MD	Not yet paid
Title	German:	BENZENDISULFONAMID ZUR BEHANDLUNG VON KREBS	[2018/30]
	English:	BENZENE DISULFONAMIDE FOR THE TREATMENT OF CANCER	[2018/30]
	French:	BENZÈNE DISULFONAMIDE POUR LE TRAITEMENT DU CANCER	[2018/30]
Examination procedure	22.08.2018	Despatch of communication that the application is refused, reason: Examination on filing A.90(5) [2019/02]
	01.09.2018	Application refused, date of legal effect [2019/02]
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XA]EP1990335 (ASTELLAS PHARMA INC [JP]) [X] 10-12,14 * example 43; claims 1, 5-7; table 11 * [A] 1-9,13;
		[XA]WO2010025308 (UNIVERSTIY OF SOUTHERN CALIFOR [US], et al) [X] 10-12,14 * claim 1; table 2; compound D3P24 * [A] 1-9,13;
		[XA]WO2007056099 (ICAGEN INC [US], et al) [X] 10 * compound 47 * [A] 1-9,11-13;
		[A] - BJÖRN PAPKE ET AL, "Identification of pyrazolopyridazinones as PDE[delta] inhibitors", NATURE COMMUNICATIONS, (20160420), vol. 7, doi:10.1038/ncomms11360, page 11360, XP055348695 [A] 1-14 * figure 1; table 1 * DOI: http://dx.doi.org/10.1038/ncomms11360
		[XA] - ZAHRAH ZAWAHIR ET AL, "Pharmacophore Guided Discovery of Small-Molecule Human Apurinic/Apyrimidinic Endonuclease 1 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 52, no. 1, doi:10.1021/JM800739M, ISSN 0022-2623, (20090108), pages 20 - 32, (20081210), XP008144539 [X] 10-12,14 * table 1S; compound S125 * [A] 1-9,13 DOI: http://dx.doi.org/10.1021/jm800739m
		[ ] - Zahrah Zawahir ET AL, "Supporting Information Pharmacophore Guided Discovery of Small-Molecule Human Apurinic/Apyrimidinic Endonuclease 1 Inhibitors", (20081012), URL: http://pubs.acs.org/doi/suppl/10.1021/jm800739m, (20170223), XP055349152 [ ] * table S1; compound S125 *
		[XA] - ISLAM A M ET AL, "The possible use of sulphonamibdes as insecticides Part II. Derivatives of benzene and naphthalene-disulphonamides", EGYPTIAN JOURNAL OF CHEMISTRY, NATIONAL INFORMATION AND DOCUMENTATION CENTRE (NIDOC), CAIRO; EG, (19760101), vol. 19, no. 6, ISSN 0449-2285, pages 969 - 987, XP009142569 [X] 10 * compound XIVa * [A] 1-9,11-14
		[XA] - VENKAT K. PULLA ET AL, "Targeting NAMPT for Therapeutic Intervention in Cancer and Inflammation: Structure-Based Drug Design and Biological Screening", CHEMICAL BIOLOGY & DRUG DESIGN., GB, (20151024), vol. 86, no. 4, doi:10.1111/cbdd.12562, ISSN 1747-0277, pages 881 - 894, XP055348923 [X] 10-12,14 * table 1; compound lead 17 * [A] 1-9,13 DOI: http://dx.doi.org/10.1111/cbdd.12562
		[ ] - Venkat K. Pulla ET AL, "supporting information Targeting NAMPT for Therapeutic Intervention in Cancer+ and Inflammation: Structure-Based Drug Design and Biological Screening", (20150424), URL: http://onlinelibrary.wiley.com/store/10.1111/cbdd.12562/asset/supinfo/cbdd12562-sup-0002-FigS2.tif?v=1&s=3b1f96f40d87e77af9107392ff88c060044daa99, (20170224), XP055349251 [ ] * compound lead 17 *
	by applicant	- CANCER RES., (2012), vol. 72, no. 10, page 2457
		- NATURE CELL BIOL., (2012), vol. 14, pages 148 - 158
		- PAPKE ET AL., NAT. COMMUN., (2016), vol. 7, page 11360
		- S. A. ISMAIL ET AL., NAT. CHEM. BIOL., (2011), vol. 7, pages 942 - 949
		- CANCER CELL, (2009), vol. 15, page 489
		- G. ZIMMERMANN; B. PAPKE; S. ISMAIL; N. VARTAK; A. CHANDRA; M. HOFFMANN; S. A. HAHN; G. TRIOLA; A. WITTINGHOFER; P. I. H. BASTIAENS, NATURE, (2013), vol. 497, pages 638 - 42
		- B. PAPKE; S. MURARKA; H. A. VOGEL; P. MARTIN-GAGO; M. KOVACEVIC; D. C. TRUXIUS; E. K. FANSA; S. ISMAIL; G. ZIMMERMANN; K. HEINELT, NAT. COMMUN., (2016), vol. 7, page 11360
		- D. AROSIO; L. MANZONI; E. M. V. ARALDI; C. SCOLASTICO, BIOCONJUG. CHEM., (2011), vol. 22, pages 664 - 672
		- NAT. CHEM. BIOL., (2011), vol. 7, pages 375 - 383
		- NATURE, (2013), vol. 497, page 638
		- M. M. SAVITSKI; F. B. M. REINHARD; H. FRANKEN; T. WERNER; M. F. SAVITSKI; D. EBERHARD; D. MARTINEZ MOLINA; R. JAFARI; R. B. DOVEGA, SCIENCE, (2014), vol. 346, page 1255784
		- F. B. M. REINHARD; D. EBERHARD; T. WERNER; H. FRANKEN; D. CHILDS; C. DOCE; M. F. SAVITSKI; W. HUBER; M. BANTSCHEFF; M. M. SAVITSKI, NAT. METHODS, (2015), vol. 12, pages 1129 - 1131
		- H. FRANKEN; T. MATHIESON; D. CHILDS; G. M. A. SWEETMAN; T. WERNER; I. TOGEL; C. DOCE; S. GADE; M. BANTSCHEFF; G. DREWES ET AL., NAT. PROTOC., (2015), vol. 10, pages 1567 - 93
		- H. E. GRECCO; P. RODA-NAVARRO; A. GIROD; J. HOU; T. FRAHM; D. C. TRUXIUS; R. PEPPERKOK; A. SQUIRE; P. I. H. BASTIAENS, NAT. METHODS, (2010), vol. 7, pages 467 - 472

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