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Extract from the Register of European Patents

EP About this file: EP3263588

EP3263588 - ISOLATED STAPHYLOCOCCUS-SPECIFIC SOLUBLE BINDING MOLECULE [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  03.12.2019
Database last updated on 03.09.2024
FormerRequest for examination was made
Status updated on  06.07.2018
FormerThe application has been published
Status updated on  01.12.2017
Most recent event   Tooltip01.08.2023Change - representative 
Applicant(s)For all designated states
The Rockefeller University
1230 York Avenue
New York, NY 10065 / US
[2018/01]
Inventor(s)01 / FISCHETTI, Vincent, A
448 Joan Court
West Hempstead
New York, NY 11552 / US
02 / DANIEL, Anu
12419 Main Campus Drive
Lexington
Massachusetts, MA 02421 / US
03 / EULER, Chad
1230 York Avenue
New York, NY 10021 / US
 [2018/01]
Representative(s)Sagittarius IP
Marlow International
Parkway
Marlow SL7 1YL / GB
[N/P]
Former [2018/01]Ruscoe, Peter James
Sagittarius IP
Three Globeside
Fieldhouse Lane
Marlow
Buckinghamshire SL7 1HZ / GB
Application number, filing date17158578.901.07.2009
[2018/01]
Priority number, dateUS20080078277P03.07.2008         Original published format: US 78277 P
[2018/01]
Previously filed application, dateWO2009US4934901.07.2009
[2018/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3263588
Date:03.01.2018
Language:EN
[2018/01]
Search report(s)(Supplementary) European search report - dispatched on:EP01.12.2017
ClassificationIPC:C07K14/005
[2018/01]
CPC:
C12N9/2462 (EP,US); A01N63/00 (US); A01N63/50 (EP,US);
A61P31/04 (EP); C07K14/005 (EP,US); A61K38/00 (EP,US);
A61K38/47 (EP,US); C07K2319/00 (EP,US); C12N2795/10322 (EP,US);
Y02A50/30 (EP) (-)
C-Set:
A01N63/50, A01N63/40 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2018/32]
Former [2018/01]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:MOLÉCULE ISOLÉE SOLUBLE SE LIANT SPÉCIFIQUEMENT À STAPHYLOCOCCUS[2018/01]
English:ISOLATED STAPHYLOCOCCUS-SPECIFIC SOLUBLE BINDING MOLECULE[2018/01]
French:ISOLIERTES AN STAPHYLOCOCCUS SPEZIFISCH BINDENDES MOLEKÜL[2018/01]
Examination procedure28.02.2017Date on which the examining division has become responsible
03.07.2018Amendment by applicant (claims and/or description)
03.07.2018Examination requested  [2018/32]
06.12.2019Despatch of a communication from the examining division (Time limit: M06)
18.05.2020Reply to a communication from the examining division
Parent application(s)   TooltipEP09774409.8  / EP2307557
Fees paidRenewal fee
28.02.2017Renewal fee patent year 03
28.02.2017Renewal fee patent year 04
28.02.2017Renewal fee patent year 05
28.02.2017Renewal fee patent year 06
28.02.2017Renewal fee patent year 07
28.02.2017Renewal fee patent year 08
24.07.2017Renewal fee patent year 09
23.07.2018Renewal fee patent year 10
29.07.2019Renewal fee patent year 11
27.07.2020Renewal fee patent year 12
27.07.2021Renewal fee patent year 13
27.07.2022Renewal fee patent year 14
27.07.2023Renewal fee patent year 15
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO9708553  (UNIV CALIFORNIA [US]) [Y] 1-11 * page 8, lines 19-23 * * page 71, line 12 - page 72, line 2 * * claim 62 *;
 [E]WO2010041970  (LUSOMEDICAMENTA S A [PT], et al) [E] 1,6 * The query sequence SEQ ID NO:1 has 100 % identity (100 % similarity) over 94 positions in a common overlap (range (q:s): 1-94:158-251) with subject GSP:AXX86830 (length: 251) from WO2010041970-A2 published on 2010-04-15. *;
 [E]WO2010090542  (TECHNOPHAGE INVESTIGACAO E DES [PT], et al) [E] 1,6 * The query sequence SEQ ID NO:1 has 100 % identity (100 % similarity) over 94 positions in a common overlap (range (q:s): 1-94:158-251) with subject GSP:AYG90537 (length: 251) from WO2010090542-A2 published on 2010-08-12. The query sequence SEQ ID NO:1 has 100 % identity (100 % similarity) over 94 positions in a common overlap (range (q:s): 1-94:158-251) with subject GSP:AYG90471 (length: 255) from WO2010090542-A2 published on 2010-08-12. *;
 [X]  - "SubName: Full=ORF016;", UniProt, (20050607), Database accession no. Q4ZE09, URL: EBI, XP002669507 [X] 1,6 * the whole document *
 [X]  - KWAN TONY ET AL, "The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 102, no. 14, doi:10.1073/PNAS.0501140102, ISSN 0027-8424, (20050405), pages 5174 - 5179, (20050323), XP009136820 [X] 1,6 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.0501140102
 [Y]  - AHMED ET AL, "Evaluation of cell wall binding domain of Staphylococcus aureus autolysin as affinity reagent for bacteria and its application to bacterial detection", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, (20070701), vol. 104, no. 1, doi:10.1263/JBB.104.55, ISSN 1389-1723, pages 55 - 61, XP022196798 [Y] 1-11 * the whole document * * in particular the abstract *

DOI:   http://dx.doi.org/10.1263/jbb.104.55
 [Y]  - LOESSNER ET AL, "Bacteriophage endolysins - current state of research and applications", CURRENT OPINION IN MICROBIOLOGY, CURRENT BIOLOGY LTD, GB, vol. 8, no. 4, ISSN 1369-5274, (20050801), pages 480 - 487, (20050801), XP027848308 [Y] 1-11 * page 485, column l, paragraph 1 *
 [A]  - CROUX C ET AL, "INTERCHANGE OF FUNCTIONAL DOMAINS SWITCHES ENZYME SPECIFICITY: CONSTRUCTION OF A CHIMERIC PNEUMOCOCCAL-CLOSTRIDIAL CELL WALL LYTIC ENZYME", MOLECULAR MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, (19930101), vol. 9, no. 5, doi:10.1111/J.1365-2958.1993.TB01231.X, ISSN 0950-382X, pages 1019 - 1025, XP000992669 [A] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1365-2958.1993.tb01231.x
by applicant   - American Journal of Infection Control, vol. 31, pages 481 - 498
    - MASSEY RC; HORSBURGH MJ; LINA G; HOOK M; RECKER M., "The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?", Nat Rev Microbiol, (20060000), vol. 4, no. 12, pages 953 - 8
    - GILL SR; FOUTS DE; ARCHER GL; MONGODIN EF; DEBOY RT; RAVEL J; PAULSEN IT; KOLONAY JF; BRINKAC L; BEANAN M, "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain", J Bacteriol, (20050000), vol. 187, no. 7, doi:doi:10.1128/JB.187.7.2426-2438.2005, pages 2426 - 38, XP002463146

DOI:   http://dx.doi.org/10.1128/JB.187.7.2426-2438.2005
    - AKSOY DY; UNAL S., "New antimicrobial agents for the treatment of Gram-positive bacterial infections", Clin Microbiol Infect, (20080000), vol. 14, no. 5, pages 411 - 20
    - TSIODRAS S; GOLD HS; SAKOULAS G; ELIOPOULOS GM; WENNERSTEN C; VENKATARAMAN L; MOELLERING RC; FERRARO MJ., "Linezolid resistance in a clinical isolate of Staphylococcus aureus", Lancet, (20010000), vol. 358, no. 9277, doi:doi:10.1016/S0140-6736(01)05410-1, pages 207 - 8, XP005017531

DOI:   http://dx.doi.org/10.1016/S0140-6736(01)05410-1
    - MANGILI A; BICA I; SNYDMAN DR; HAMER DH., "Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia", Clin Infect Dis, (20050000), vol. 40, no. 7, pages 1058 - 60
    - SKIEST DJ., "Treatment failure resulting from resistance of Staphylococcus aureus to daptomycin", J Clin Microbiol, (20060000), vol. 44, no. 2, pages 655 - 6
    - FISCHETTI VA; NELSON D; SCHUCH R., "Reinventing phage therapy: are the parts greater than the sum?", Nat Biotechnol, (20060000), vol. 24, no. 12, doi:doi:10.1038/nbt1206-1508, pages 1508 - 11, XP002624151

DOI:   http://dx.doi.org/10.1038/nbt1206-1508
    - SHEEHAN MM; GARCIA JL; LOPEZ R; GARCIA P., "Analysis of the catalytic domain of the lysin of the lactococcal bacteriophage Tuc2009 by chimeric gene assembling", FEMS Microbiol Lett, (19960000), vol. 140, no. 1, doi:doi:10.1016/0378-1097(96)00151-6, pages 23 - 8, XP000992665

DOI:   http://dx.doi.org/10.1016/0378-1097(96)00151-6
    - LOPEZ R GE; GARCIA P; GARCIA JL., "The pneumococcal cell wall degrading enzymes: a modular design to create new lysins?", Microb Drug Res, (19970000), vol. 3, pages 199 - 211
    - CROUX C; RONDA C; LOPEZ R; GARCIA JL., "Interchange of functional domains switches enzyme specificity: construction of a chimeric pneumococcal-clostridial cell wall lytic enzyme", Mol Microbiol, (19930000), vol. 9, no. 5, doi:doi:10.1111/j.1365-2958.1993.tb01231.x, pages 1019 - 25, XP000992669

DOI:   http://dx.doi.org/10.1111/j.1365-2958.1993.tb01231.x
    - DONOVAN DM; DONG S; GARRETT W; ROUSSEAU GM; MOINEAU S; PRITCHARD DG., "Peptidoglycan hydrolase fusions maintain their parental specificities", Appl Environ Microbiol, (20060000), vol. 72, no. 4, pages 2988 - 96
    - NELSON D; LOOMIS L; FISCHETTI VA., "Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme", Proc Natl Acad Sci U S A, (20010000), vol. 98, no. 7, doi:doi:10.1073/pnas.061038398, pages 4107 - 12, XP002165225

DOI:   http://dx.doi.org/10.1073/pnas.061038398
    - LOEFFLER JM; NELSON D; FISCHETTI VA, "Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase", Science, (20010000), vol. 294, no. 5549, doi:doi:10.1126/science.1066869, pages 2170 - 2, XP002392510

DOI:   http://dx.doi.org/10.1126/science.1066869
    - SCHUCH R; NELSON D; FISCHETTI VA, "A bacteriolytic agent that detects and kills Bacillus anthracis", Nature, (20020000), vol. 418, no. 6900, doi:doi:10.1038/nature01026, pages 884 - 9, XP002903133

DOI:   http://dx.doi.org/10.1038/nature01026
    - YOONG P; SCHUCH R; NELSON D; FISCHETTI VA., "Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium", J Bacteriol, (20040000), vol. 186, no. 14, pages 4808 - 12, XP009136845
    - CHENG Q; NELSON D; ZHU S; FISCHETTI VA., "Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme", Antimicrob Agents Chemother, (20050000), vol. 49, no. 1, doi:doi:10.1128/AAC.49.1.111-117.2005, pages 111 - 7, XP002503533

DOI:   http://dx.doi.org/10.1128/AAC.49.1.111-117.2005
    - RASHEL M; UCHIYAMA J; UJIHARA T; UEHARA Y; KURAMOTO S; SUGIHARA S; YAGYU K; MURAOKA A; SUGAI M; HIRAMATSU K, "Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage phi MR11", J Infect Dis, (20070000), vol. 196, no. 8, doi:doi:10.1086/521305, pages 1237 - 47, XP009100811

DOI:   http://dx.doi.org/10.1086/521305
    - FINNIN; MORGAN, J Pharm Sci, (19991000), vol. 88, no. 10, pages 955 - 958
    - "The use of interspecies scaling in toxicokinetics", MORDENTI, J.; CHAPPELL, W. et al., Toxicokinetics and New Drug Development, Pergamon Press, (19890000), pages 42 - 96
    - LUE et al., J. Biol. Chem., (20060000), vol. 281, no. 1, pages 549 - 58
    - KLUYTMANS, J.; A. VAN BELKUM., "Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks", Clin Microbiol Rev, (19970000), vol. 10, no. 3, pages 505 - 20
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.