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Extract from the Register of European Patents

EP About this file: EP3239178

EP3239178 - BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  12.03.2021
Database last updated on 19.10.2024
FormerExamination is in progress
Status updated on  10.08.2018
FormerRequest for examination was made
Status updated on  11.05.2018
FormerThe application has been published
Status updated on  29.09.2017
Most recent event   Tooltip12.03.2021Refusal of applicationpublished on 14.04.2021  [2021/15]
Applicant(s)For all designated states
Bristol-Myers Squibb Company
Route 206 and Province Line Road
Princeton, NJ 08540 / US
For all designated states
Pfizer Inc.
235 East 42nd Street
New York, NY 10017 / US
[2017/44]
Inventor(s)01 / MIN, Jing
15309 Nooning Tree Court
Chesterfield, MO 63017 / US
02 / DEVAUX, Brigitte
320 Duluth Circle
Palo Alto, CA 94306 / US
03 / WU, Yi
1339 Kennedy Drive
Milpitas, CA 95035 / US
04 / TOY, Kristopher
1694 Ambergrove Drive
San Jose, CA 95131 / US
05 / LEBLANC, Heidi N
736 11th Ave
Menlo Park, CA 94025-1953 / US
06 / HUANG, Haichun
4329 Crestwood Street
Fremont, CA 94538 / US
07 / WU, Yanli
9726 Washington Blvd
Gaithersburg, MD 20878 / US
08 / FINN, Rory Francis
976 Sunburst Court
Manchester, MO 63021 / US
09 / THIELE, Barratt Richard
5619 Dantonaire Place
Saint Louis, MO 63128 / US
10 / LIAO, Wei
471 Barbin Street
Horsham, PA 19044 / US
11 / GLADUE, Ronald Paul
83 Rowley Drive
Stonington, CT 06378 / US
12 / RAJPAL, Arvind
150 Granville Way
San Francisco, CA 94127-1134 / US
13 / PARADIS, Timothy Joseph
5 Beaver River Road
Richmond, RI 02892 / US
14 / BRAMS, Peter
2740 11th Avenue
Sacremento, CA 95815 / US
 [2017/44]
Representative(s)Gill Jennings & Every LLP
The Broadgate Tower
20 Primrose Street
London EC2A 2ES / GB
[2017/44]
Application number, filing date17162625.211.12.2008
[2017/44]
Priority number, dateUS20070013947P14.12.2007         Original published format: US 13947 P
[2017/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3239178
Date:01.11.2017
Language:EN
[2017/44]
Search report(s)(Supplementary) European search report - dispatched on:EP15.09.2017
ClassificationIPC:C07K16/28, A61P35/00
[2017/44]
CPC:
C07K16/2878 (EP,US); A61P31/00 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P35/04 (EP); A61P37/04 (EP);
A61K2039/505 (EP,US); C07K2317/14 (US); C07K2317/21 (EP,US);
C07K2317/565 (US); C07K2317/92 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/24]
Former [2017/44]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:BINDUNG VON MOLEKÜLEN AN DEN HUMANEN OX40-REZEPTOR[2017/44]
English:BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR[2017/44]
French:MOLÉCULES DE LIAISON AU RÉCEPTEUR HUMAIN OX40[2017/44]
Biological materialThis application mentions deposited biological material, check the file for details
Examination procedure23.03.2017Date on which the examining division has become responsible
01.05.2018Amendment by applicant (claims and/or description)
01.05.2018Examination requested  [2018/24]
09.08.2018Despatch of a communication from the examining division (Time limit: M06)
18.02.2019Reply to a communication from the examining division
21.11.2019Cancellation of oral proceeding that was planned for 28.11.2019
28.11.2019Date of oral proceedings (cancelled)
03.12.2019Despatch of communication that the application is refused, reason: substantive examination [2021/15]
02.03.2021Application refused, date of legal effect [2021/15]
Appeal following examination03.02.2020Appeal received No.  T1692/20
29.01.2021Invitation to file observations in an appeal (Time limit: M02) [2021/05]
10.02.2021Date of receipt of observations in an appeal [2021/07]
02.03.2021Result of appeal procedure: appeal of the applicant withdrawn
Parent application(s)   TooltipEP08862558.7  / EP2242771
EP12195976.1  / EP2594590
EP14191564.5  / EP2851374
Fees paidRenewal fee
23.03.2017Renewal fee patent year 03
23.03.2017Renewal fee patent year 04
23.03.2017Renewal fee patent year 05
23.03.2017Renewal fee patent year 06
23.03.2017Renewal fee patent year 07
23.03.2017Renewal fee patent year 08
23.03.2017Renewal fee patent year 09
12.12.2017Renewal fee patent year 10
21.12.2018Renewal fee patent year 11
27.12.2019Renewal fee patent year 12
Penalty fee
Additional fee for renewal fee
31.12.202013   M06   Not yet paid
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Documents cited:Search[X]WO9942585  (SISTERS OF PROVIDENCE IN OREGO [US]) [X] 1-16 * page 3, line 10 - line 33 * * example 8 * * claims 1-9 *;
 [X]WO03106498  (CRUCELL HOLLAND BV [NL], et al) [X] 1-16 * page 1, paragraph 2 - page 4, paragraph 1 * * page 22, paragraph L - page 29, paragraph 2 * * page 56, paragraph L - page 58, paragraph 1 * * page 60, paragraph 2 - page 61, paragraph 2 * * examples 1-10 * * claims 1-10,18-28 *;
 [X]  - XIE F ET AL, "Characterization and application of two novel monoclonal antibodies against human OX40: costimulation of T cells and expression on tumor as well as normal gland tissues.", TISSUE ANTIGENS APR 2006, (200604), vol. 67, no. 4, ISSN 0001-2815, pages 307 - 317, XP002525127 [X] 1-16 * abstract * * page 310, column l, paragraph l - page 311, column l, paragraph 1 * * page 313, column R, paragraph 2 *

DOI:   http://dx.doi.org/10.1111/j.1399-0039.2006.00584.x
 [XI]  - WEINBERG ANDREW D ET AL, "Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic study", JOURNAL OF IMMUNOTHERAPY, LIPPINCOTT WILLIAMS & WILKINS, HAGERSTOWN, MD, US, (20061101), vol. 29, no. 6, ISSN 1524-9557, pages 575 - 585, XP009115398 [X] 1-5 * abstract * * page 576, column r, paragraph 3 * [I] 6-16

DOI:   http://dx.doi.org/10.1097/01.cji.0000211319.00031.fc
 [I]  - KJAERGAARD J ET AL, "Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.", CANCER RESEARCH 1 OCT 2000, (20001001), vol. 60, no. 19, ISSN 0008-5472, pages 5514 - 5521, XP007908325 [I] 1-16 * abstract * * page 5515, column L, paragraph 5 *
 [I]  - KJAERGAARD J ET AL, "Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 DEC 2001, (20011201), vol. 167, no. 11, ISSN 0022-1767, pages 6669 - 6677, XP007908324 [I] 1-16 * abstract * * page 6670, column R, paragraph 4 *
 [A]  - BALINT R F ET AL, "Antibody engineering by parsimonious mutagenesis", GENE, ELSEVIER, AMSTERDAM, NL, vol. 137, no. 1, doi:10.1016/0378-1119(93)90258-5, ISSN 0378-1119, (19931227), pages 109 - 118, (19931227), XP023539602 [A] 1-16 * abstract * * page 110, column r, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/0378-1119(93)90258-5
by applicantUS191293
 US4399216
 US4510245
 US4634665
 US4740461
 US4912040
 EP0368684
 US4959455
 US4968615
 WO9201047
 US5168062
 US5179017
 WO9306213
 EP0616640
 US5545806
 US5545807
 US5625825
 WO9824884
 US5939598
 WO9942585
 US5994619
 US6075181
 WO0037504
 US6114598
 US6150584
 US6162963
 US6172197
 WO0109187
 US6291158
 WO0243478
 WO02053596
 WO02055106
 WO03002609
 WO03040170
 WO03048731
 US6582915
 US6593081
 WO2004003019
 US6696245
 WO2004058821
 US6765087
 WO2004081026
 WO2004101790
 US6838254
 WO2005035572
 US2006153808
 WO2006079372
 WO2006088639
 WO2006129163
 US2007117809
 WO2007059782
    - SUGAMURA, K.; ISHII, N.; WEINBERG, A, "Therapeutic targeting of the effector T-cellco-stimulatory molecule 0X40", NATURE REV. IMM., (2004), vol. 4, doi:doi:10.1038/nri1371, pages 420 - 431, XP009040312

DOI:   http://dx.doi.org/10.1038/nri1371
    - HORI, T, "Roles of 0X40 in the pathogenesis and control of diseases", INTN. J. HEMATOLOGY., (2006), vol. 83, doi:doi:10.1532/IJH97.05151, pages 17 - 22, XP036524124

DOI:   http://dx.doi.org/10.1532/IJH97.05151
    - VETTO, J.T. ET AL., "Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph nodes cells from patients with melanoma and head and neck cancers", AM. J. SURG., (1997), vol. 174, doi:doi:10.1016/S0002-9610(97)00139-6, pages 258 - 265, XP002109414

DOI:   http://dx.doi.org/10.1016/S0002-9610(97)00139-6
    - WEINBERG, A.D ET AL., "Engagement of the OX-40 receptor in vivo enhances antitumor immunity", J. IMMUNOL., (2000), vol. 164, pages 2160 - 69, XP002224132
    - PETTY, J.K. ET AL., "Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134", AM. J. SURG., (2002), vol. 183, doi:doi:10.1016/S0002-9610(02)00831-0, pages 512 - 518, XP055361225

DOI:   http://dx.doi.org/10.1016/S0002-9610(02)00831-0
    - CHOTHIA; LESK, J. MOL. BIOL., (1987), vol. 196, pages 901 - 917
    - CHOTHIA ET AL., NATURE, (1989), vol. 342, pages 878 - 883
    - KIPRIYANOV ET AL., HUMAN ANTIBODIES AND HYBRIDOMAS, (1995), vol. 6, pages 93 - 101
    - KIPRIYANOV ET AL., MOL. IMMUNOL., (1994), vol. 31, pages 1047 - 1058
    - HARRIS R. J, J, OF CHROMOTOGRAPHY, (1995), vol. 705, pages 129 - 134
    - WARD, NATURE, (1989), vol. 341, pages 544 - 546
    - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426
    - HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883
    - SOJAHR, H. T.; BAHL, 0. P., ARCH. BIOCHEM. BIOPHYS., (1987), vol. 259, pages 52 - 57
    - EDGE, A. S. ET AL., ANAL. BIOCHEM., (1981), vol. 118, pages 13 1 - 137
    - THOTAKURA, N. R.; BAHL, O. P., METH. ENZYMOL., (1987), vol. 138, pages 350 - 359
    - HOLLIGER P. ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - POLJAK R. J. ET AL., STRUCTURE, (1994), vol. 2, pages 1121 - 1123
    - KOHLER; MILSTEIN, NATURE, (1975), vol. 256, page 495
    - LONBERG ET AL., NATURE, (1994), vol. 368, pages 856 - 859
    - HARDING, F.; LONBERG, N, ANN. N.Y. ACAD. SCI., (1995), vol. 764, pages 536 - 546
    - FISHWIID, D. ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851
    - TOMIZUKA ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 722 - 727
    - HUSTON, PROC, NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883
    - MCCAFFERTY, NATURE, (1990), vol. 348, pages 552 - 554
    - MCCAFFERTY ET AL., NATURE, (1990), vol. 348, pages 552 - 554
    - GRIFFITHS ET AL., EMBO J., (1993), vol. 12, pages 725 - 734
    - CHEN ET AL., EMBO J., (1993), vol. 12, pages 821 - 830
    - FISHWILD ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851
    - ISHIDA ET AL., CLONING AND STEM CELLS, (2002), vol. 4, pages 91 - 102
    - LONBERG ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859
    - RETH, M. G., NATURE, (1984), vol. 312, no. 29, pages 418 - 42
    - ALT, F. ET AL., CELL, (1981), vol. 27, pages 381 - 390
 WO2008US72640
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.