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Extract from the Register of European Patents

EP About this file: EP3323813

EP3323813 - HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  02.07.2021
Database last updated on 31.05.2024
FormerThe patent has been granted
Status updated on  24.07.2020
FormerGrant of patent is intended
Status updated on  08.06.2020
FormerExamination is in progress
Status updated on  22.01.2020
FormerRequest for examination was made
Status updated on  30.11.2018
FormerThe application has been published
Status updated on  20.04.2018
Most recent event   Tooltip22.07.2022Lapse of the patent in a contracting state
New state(s): BE, MK		published on 24.08.2022  [2022/34]
Applicant(s)For all designated states
The Trustees of Columbia University in the City of New York
412 Low Memorial Library
535 West 116th Street
New York, NY 10027 / US
[2020/35]
Former [2018/21]For all designated states
The Trustees of Columbia University in the City of New York
412 Low Memorial Library 535 West 116th Street
New York, New York 10027 / US
Inventor(s)01 / Francis, Yitshak
Techelet 83/3
Modiin / IL
02 / Fa, Mauro
2201 Amsterdam Ave. Apt 6N
New York, NY New York 10032 / US
03 / Arancio, Ottavio
2700 Broadway Apt. 5H
New York, NY New York 10025 / US
04 / Fiorito, Jole
412 Low Memorial Library
MC 4308/P&S 12-510
535 West 116th Street
New York, NY New York 10027 / US
05 / Deng, Shixian
34 Ogden Avenue
White Plains, NY New York 10605 / US
06 / Landry, Donald W.
29 Claremont Avenue
New York, NY New York 10027 / US
07 / Luzac, Michal
Techelet 83/3
Modiin / IL
08 / Feng, Yan
79 The 2nd Dong'an Village Room 602
Shanghai, Shanghai 200032 / CN
 [2018/23]
Former [2018/21]01 / Francis, Yitshak
629W 115st Apt. 1D
New York, NY New York 10025 / US
02 / Fa, Mauro
2201 Amsterdam Ave. Apt 6N
New York, NY New York 10032 / US
03 / Arancio, Ottavio
2700 Broadway Apt. 5H
New York, NY New York 10025 / US
04 / Fiorito, Jole
412 Low Memorial Library
MC 4308/P&S 12-510
535 West 116th Street
New York, NY New York 10027 / US
05 / Deng, Shixian
34 Ogden Avenue
White Plains, NY New York 10605 / US
06 / Landry, Donald W.
29 Claremont Avenue
New York, NY New York 10027 / US
07 / Luzac, Michal
629 W 115th Street
New York, NY New York 10025 / US
08 / Feng, Yan
79 The 2nd Dong'an Village Room 602
Shanghai, Shanghai 200032 / CN
Representative(s)Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
[2018/21]
Application number, filing date17207865.122.12.2011
[2018/21]
Priority number, dateUS201061426033P22.12.2010         Original published format: US 201061426033 P
US201161539697P27.09.2011         Original published format: US 201161539697 P
US201161541706P30.09.2011         Original published format: US 201161541706 P
[2018/21]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3323813
Date:23.05.2018
Language:EN
[2018/21]
Type: B1 Patent specification 
No.:EP3323813
Date:26.08.2020
Language:EN
[2020/35]
Search report(s)(Supplementary) European search report - dispatched on:EP15.02.2018
ClassificationIPC:C07D265/14, C07C217/22, C07C217/58, C07C235/60, C07C235/64, C07D265/36, C07C251/24, C07D209/48, C07D295/088, A61K31/167, A61P25/28
[2018/21]
CPC:
C07C217/22 (EP,CN,US); C07D295/088 (EP,CN,US); A61P21/00 (EP);
A61P25/00 (EP); A61P25/02 (EP); A61P25/14 (EP);
A61P25/16 (EP); A61P25/20 (EP); A61P25/28 (EP);
A61P25/32 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P39/02 (EP); A61P43/00 (EP); A61P5/38 (EP);
C07C217/58 (EP,CN,US); C07C235/60 (EP,CN,US); C07C235/64 (EP,CN,US);
C07C251/24 (EP,CN,US); C07D209/48 (EP,CN,US); C07D265/14 (EP,US);
C07D265/36 (EP,CN,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/01]
Former [2018/21]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:HISTON-ACETYLTRANSFERASE-MODULATOREN UND VERWENDUNGEN DAVON[2018/21]
English:HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF[2018/21]
French:MODULATEURS DE L'HISTONE ACÉTYLTRANSFÉRASE ET LEURS UTILISATIONS[2018/21]
Examination procedure22.11.2018Amendment by applicant (claims and/or description)
22.11.2018Examination requested  [2019/01]
22.11.2018Date on which the examining division has become responsible
27.01.2020Despatch of a communication from the examining division (Time limit: M04)
01.04.2020Reply to a communication from the examining division
09.06.2020Communication of intention to grant the patent
15.07.2020Fee for grant paid
15.07.2020Fee for publishing/printing paid
15.07.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP11850544.5  / EP2654428
Opposition(s)27.05.2021No opposition filed within time limit [2021/31]
Fees paidRenewal fee
15.12.2017Renewal fee patent year 03
15.12.2017Renewal fee patent year 04
15.12.2017Renewal fee patent year 05
15.12.2017Renewal fee patent year 06
15.12.2017Renewal fee patent year 07
31.12.2018Renewal fee patent year 08
27.12.2019Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.12.2011
AL26.08.2020
AT26.08.2020
CY26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
MC26.08.2020
MK26.08.2020
MT26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SI26.08.2020
SK26.08.2020
SM26.08.2020
TR26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
LU22.12.2020
IS26.12.2020
PT28.12.2020
BE31.12.2020
[2022/33]
Former [2022/27]HU22.12.2011
AL26.08.2020
AT26.08.2020
CY26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
MC26.08.2020
MT26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SI26.08.2020
SK26.08.2020
SM26.08.2020
TR26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
LU22.12.2020
IS26.12.2020
PT28.12.2020
Former [2021/47]AL26.08.2020
AT26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
MC26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SI26.08.2020
SK26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
LU22.12.2020
IS26.12.2020
PT28.12.2020
Former [2021/40]AL26.08.2020
AT26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
MC26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SI26.08.2020
SK26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/36]AL26.08.2020
AT26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SI26.08.2020
SK26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/28]AL26.08.2020
AT26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SK26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/25]AL26.08.2020
AT26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/23]AT26.08.2020
CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/22]CZ26.08.2020
DK26.08.2020
EE26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RO26.08.2020
RS26.08.2020
SE26.08.2020
SM26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/21]DK26.08.2020
FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RS26.08.2020
SE26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/10]FI26.08.2020
HR26.08.2020
LT26.08.2020
LV26.08.2020
PL26.08.2020
RS26.08.2020
SE26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
IS26.12.2020
PT28.12.2020
Former [2021/09]FI26.08.2020
LT26.08.2020
SE26.08.2020
BG26.11.2020
NO26.11.2020
GR27.11.2020
PT28.12.2020
Former [2021/08]FI26.08.2020
LT26.08.2020
SE26.08.2020
BG26.11.2020
NO26.11.2020
PT28.12.2020
Former [2021/07]FI26.08.2020
LT26.08.2020
NO26.11.2020
Documents cited:Search[X]US2006167107  (KUNDU TAPAS K [IN], et al) [X] 1-19 * the whole document *;
 [XP]WO2011072243  (UNIV COLUMBIA [US], et al) [XP] 1-19 * the whole document *;
 [X]WO2005121119  (HOFFMANN LA ROCHE [CH], et al) [X] 1-19 * pages 2-3 *;
 [X]WO2009010454  (ADDEX PHARMACEUTICALS SA [CH], et al) [X] 1-4 * table - *;
 [X]EP1649852  (INST MED MOLECULAR DESIGN INC [JP]) [X] 1-4 * table - *;
 [X]DE4428380  (BAYER AG [DE]) [X] 1-4 * example - *;
 [X]GB728098  (GEIGY AG J R) [X] 1-4 * example - *;
 [X]GB1436306  (GIVAUDAN & CIE SA) [X] 1-4 * example - *
 [X]  - K. MANTELINGU ET AL, "Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzyme Structure: Probed by Surface-Enhanced Raman Spectroscopy", THE JOURNAL OF PHYSICAL CHEMISTRY B, (20070501), vol. 111, no. 17, doi:10.1021/jp067655s, ISSN 1520-6106, pages 4527 - 4534, XP055075158 [X] 1-19 * pages 4531-32 *

DOI:   http://dx.doi.org/10.1021/jp067655s
 [X]  - RENAUD J ET AL, "Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20030101), vol. 46, doi:10.1021/JM030086H, ISSN 0022-2623, pages 2945 - 2957, XP002982225 [X] 1-4 * compounds 10,11 *

DOI:   http://dx.doi.org/10.1021/jm030086h
ExaminationWO2012088420
by applicantUS2010166781
 US2010144885
 US2009076155
 WO2011072243
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