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Extract from the Register of European Patents

EP About this file: EP3405465

EP3405465 - IRAK4 INHIBITING AGENTS [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 19.08.2022 Database last updated on 31.05.2024
Former	The patent has been granted Status updated on 10.09.2021
Former	Grant of patent is intended Status updated on 25.04.2021
Former	Examination is in progress Status updated on 14.04.2020
Former	Request for examination was made Status updated on 26.10.2018
Former	The international publication has been made Status updated on 28.07.2017
Former	unknown Status updated on 14.02.2017
Most recent event Tooltip	27.04.2024	Lapse of the patent in a contracting state New state(s): MK	published on 29.05.2024 [2024/22]
Applicant(s)	For all designated states Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	[2018/48]
Inventor(s)	01 / CHAN, Timothy c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	02 / GUCKIAN, Kevin c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	03 / JENKINS, Tracy c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	04 / THOMAS, Jermaine c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	05 / VESSELS, Jeffrey c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	06 / KUMARAVEL, Gnanasambandam c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	07 / MEISSNER, Robert c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	08 / LYSSIKATOS, Joseph, P. c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	09 / LUCAS, Brian c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	10 / LEAF, Irina c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	11 / DUFFIELD, Jeremy c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	12 / GENUNG, Nathan c/o Biogen MA INC. 225 Binney Street Cambridge, MA 02142 / US
	[2018/48]
Representative(s)	HGF HGF Limited 1 City Walk Leeds LS11 9DX / GB
	[N/P]
Former [2021/41]	HGF 1 City Walk Leeds LS11 9DX / GB
Former [2018/48]	HGF Limited 4th Floor Merchant Exchange 17-19 Whitworth Street West Manchester M1 5WG / GB
Application number, filing date	17703277.8	18.01.2017
	[2018/48]
	WO2017US13946
Priority number, date	US201662280962P	20.01.2016 Original published format: US 201662280962 P
	[2018/48]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2017127430
	Date:	27.07.2017
	Language:	EN
	[2017/30]
	Type:	A1 Application with search report
	No.:	EP3405465
	Date:	28.11.2018
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 27.07.2017 takes the place of the publication of the European patent application.
	[2018/48]
	Type:	B1 Patent specification
	No.:	EP3405465
	Date:	13.10.2021
	Language:	EN
	[2021/41]
Search report(s)	International search report - published on:	EP	27.07.2017
Classification	IPC:	C07D401/14, A61K31/4439, A61K31/506, A61K31/497, A61P29/00, A61P37/00, A61P35/00	[2018/48]
	CPC:	C07D401/14 (EP,US); A61K45/06 (US); A61P29/00 (EP); A61P35/00 (EP); A61P37/00 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/48]
Extension states	BA	Not yet paid
	ME	Not yet paid
Validation states	MA	Not yet paid
	MD	Not yet paid
Title	German:	IRAK4-HEMMER	[2018/48]
	English:	IRAK4 INHIBITING AGENTS	[2018/48]
	French:	AGENTS INHIBITEURS D'IRAK4	[2018/48]
Entry into regional phase	17.08.2018	National basic fee paid
	17.08.2018	Designation fee(s) paid
	17.08.2018	Examination fee paid
Examination procedure	17.08.2018	Examination requested [2018/48]
	17.08.2018	Date on which the examining division has become responsible
	21.03.2019	Amendment by applicant (claims and/or description)
	17.04.2020	Despatch of a communication from the examining division (Time limit: M06)
	27.10.2020	Reply to a communication from the examining division
	26.04.2021	Communication of intention to grant the patent
	02.09.2021	Fee for grant paid
	02.09.2021	Fee for publishing/printing paid
	02.09.2021	Receipt of the translation of the claim(s)
Opposition(s)	14.07.2022	No opposition filed within time limit [2022/38]
Fees paid	Renewal fee
	09.01.2019	Renewal fee patent year 03
	30.01.2020	Renewal fee patent year 04
	13.01.2021	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	18.01.2017
	AL	13.10.2021
	AT	13.10.2021
	CY	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	MK	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SI	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IE	18.01.2022
	LU	18.01.2022
	BE	31.01.2022
	CH	31.01.2022
	LI	31.01.2022
	IS	13.02.2022
	PT	14.02.2022
	[2024/22]
Former [2024/20]	HU	18.01.2017
	AL	13.10.2021
	AT	13.10.2021
	CY	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SI	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IE	18.01.2022
	LU	18.01.2022
	BE	31.01.2022
	CH	31.01.2022
	LI	31.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2024/18]	HU	18.01.2017
	AL	13.10.2021
	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SI	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IE	18.01.2022
	LU	18.01.2022
	BE	31.01.2022
	CH	31.01.2022
	LI	31.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2023/09]	AL	13.10.2021
	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SI	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IE	18.01.2022
	LU	18.01.2022
	BE	31.01.2022
	CH	31.01.2022
	LI	31.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2023/03]	AL	13.10.2021
	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SI	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	LU	18.01.2022
	BE	31.01.2022
	CH	31.01.2022
	LI	31.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2023/01]	AL	13.10.2021
	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SI	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	LU	18.01.2022
	BE	31.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/49]	AL	13.10.2021
	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	LU	18.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/46]	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	LU	18.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/39]	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	MC	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/35]	AT	13.10.2021
	CZ	13.10.2021
	DK	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SK	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/34]	AT	13.10.2021
	EE	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RO	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/33]	AT	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	SM	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/25]	AT	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	BG	13.01.2022
	NO	13.01.2022
	GR	14.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/24]	AT	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	NL	13.10.2021
	PL	13.10.2021
	RS	13.10.2021
	SE	13.10.2021
	BG	13.01.2022
	GR	14.01.2022
	IS	13.02.2022
	PT	14.02.2022
Former [2022/23]	AT	13.10.2021
	FI	13.10.2021
	HR	13.10.2021
	LT	13.10.2021
	LV	13.10.2021
	PL	13.10.2021
	RS	13.10.2021
	BG	13.01.2022
	PT	14.02.2022
Former [2022/22]	AT	13.10.2021
	FI	13.10.2021
	LT	13.10.2021
	RS	13.10.2021
	BG	13.01.2022
Former [2022/21]	AT	13.10.2021
	RS	13.10.2021
	BG	13.01.2022
Former [2022/19]	BG	13.01.2022
Cited in	International search	[IP]WO2016011390 (BIOGEN MA INC [US]) [IP] 1-39 * pages 488-491; examples 422,439,440,467-469,496,501,538,588; claims 1-43 *;
		[A] - DIVYA CHAUDHARY ET AL, "Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders", JOURNAL OF MEDICINAL CHEMISTRY, (2015), vol. 58, no. 1, doi:10.1021/jm5016044, ISSN 0022-2623, pages 96 - 110, XP055225289 [A] 1-39 * the whole document * * figures 6, 15, 19; table 7 * DOI: http://dx.doi.org/10.1021/jm5016044
		[A] - ZHULUN WANG ET AL, "IRAK-4 Inhibitors for Inflammation", CURRENT TOPICS IN MEDICINAL CHEMISTRY, (2009), vol. 9, no. 8, doi:10.2174/156802609789044407, ISSN 1568-0266, pages 724 - 737, XP055256417 [A] 1-39 * the whole document * * figures 6, 11, 12; table 2 * DOI: http://dx.doi.org/10.2174/156802609789044407
		[AP] - W. MICHAEL SEGANISH, "Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015)", EXPERT OPINION ON THERAPEUTIC PATENTS., (20160629), vol. 26, no. 8, doi:10.1080/13543776.2016.1202926, ISSN 1354-3776, pages 917 - 932, XP055308579 [AP] 1-39 * the whole document * * figure 6 * DOI: http://dx.doi.org/10.1080/13543776.2016.1202926
	by applicant	US4938949
		- CAMERON, B. ET AL., "Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease", THE JOURNAL OF NEUROSCIENCE, (20121024), vol. 32, no. 43, pages 15112 - 15123

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