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Extract from the Register of European Patents

EP About this file: EP3429594

EP3429594 - TRIAMCINOLONE ACETONIDE FORMULATIONS FOR JOINT PAIN IN DIABETICS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  11.10.2019
Database last updated on 07.10.2024
FormerRequest for examination was made
Status updated on  21.12.2018
FormerThe international publication has been made
Status updated on  22.09.2017
Formerunknown
Status updated on  04.04.2017
Most recent event   Tooltip11.10.2019Application deemed to be withdrawnpublished on 13.11.2019  [2019/46]
Applicant(s)For all designated states
Flexion Therapeutics, Inc.
10 Mall Road
Suite 301
Burlington, Massachusetts 01803 / US
[2019/04]
Inventor(s)01 / BODICK, Neil
c/o Flexion Therapeutics Inc.
10 Mall Road Suite 301
Burlington Massachusetts 01803 / US
 [2019/04]
Representative(s)Cooley (UK) LLP
22 Bishopsgate
London EC2N 4BQ / GB
[N/P]
Former [2019/04]Cooley (UK) LLP
Dashwood
69 Old Broad Street
London EC2M 1QS / GB
Application number, filing date17713558.914.03.2017
[2019/04]
WO2017US22277
Priority number, dateUS201662307879P14.03.2016         Original published format: US 201662307879 P
US201662323360P15.04.2016         Original published format: US 201662323360 P
[2019/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017160818
Date:21.09.2017
Language:EN
[2017/38]
Type: A1 Application with search report 
No.:EP3429594
Date:23.01.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 21.09.2017 takes the place of the publication of the European patent application.
[2019/04]
Search report(s)International search report - published on:EP21.09.2017
ClassificationIPC:A61K31/58, A61K9/00, A61K9/16, A61K45/06
[2019/04]
CPC:
A61K31/58 (EP,US); A61K45/06 (EP,US); A61K9/0019 (EP,US);
A61K9/1647 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/04]
TitleGerman:TRIAMCINOLONACETONID-FORMULIERUNGEN FÜR GELENKSCHMERZEN BEI DIABETIKERN[2019/04]
English:TRIAMCINOLONE ACETONIDE FORMULATIONS FOR JOINT PAIN IN DIABETICS[2019/04]
French:FORMULES D'ACÉTONIDE DE TRIAMCINOLONE POUR UNE DOULEUR ARTICULAIRE CHEZ LES DIABÉTIQUES[2019/04]
Entry into regional phase21.09.2018National basic fee paid 
21.09.2018Designation fee(s) paid 
21.09.2018Examination fee paid 
Examination procedure21.09.2018Examination requested  [2019/04]
21.09.2018Date on which the examining division has become responsible
03.05.2019Application deemed to be withdrawn, date of legal effect  [2019/46]
18.06.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time  [2019/46]
18.06.2019Despatch of communication of loss of particular rights: Claims {1}
Fees paidRenewal fee
13.03.2019Renewal fee patent year 03
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]WO2014153384  (FLEXION THERAPEUTICS INC [US]) [X] 1-26 * abstract * * paragraph [0073] * * paragraph [0105] - paragraph [0111] * * paragraph [0115] * * paragraph [0129] * * examples 1-4 * * claims 1-20 *;
 [X]WO2013019280  (FLEXION THERAPEUTICS [US], et al) [X] 1-26 * abstract * * paragraph [0172] * * claims 1-28 * * examples 1-12 *;
 [XP]  - Anonymous, "Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes - Full Text View - ClinicalTrials.gov", (20160503), URL: https://clinicaltrials.gov/ct2/show/NCT02762370?term=FX006&rank=3, (20170511), XP055371836 [XP] 1-26 * the whole document *
 [A]  - A. KUMAR ET AL, "Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis", OSTEOARTHRITIS AND CARTILAGE., GB, (20150101), vol. 23, no. 1, doi:10.1016/j.joca.2014.09.019, ISSN 1063-4584, pages 151 - 160, XP055371887 [A] 1-26 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.joca.2014.09.019
 [AD]  - GEORGE S. HABIB ET AL, "The Effect of Intra-Articular Triamcinolone Preparations on Blood Glucose Levels in Diabetic Patients : A Controlled Study", JOURNAL OF CLINICAL RHEUMATOLOGY, US, (20110901), vol. 17, no. 6, doi:10.1097/RHU.0b013e31822acd7c, ISSN 1076-1608, pages 302 - 305, XP055371879 [AD] 1-26 * the whole document *

DOI:   http://dx.doi.org/10.1097/RHU.0b013e31822acd7c
 [A]  - GEORGE S HABIB, "Systemic effects of intra-articular corticosteroids", CLINICAL RHEUMATOLOGY ; JOURNAL OF THE INTERNATIONAL LEAGUE OF ASSOCIATIONS FOR RHEUMATOLOGY, SPRINGER-VERLAG, LO, (20090228), vol. 28, no. 7, ISSN 1434-9949, pages 749 - 756, XP019663038 [A] 1-26 * the whole document *
by applicantWO2012019009
 US4293539
 WO9513799
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DOI:   http://dx.doi.org/10.1002/acr.21596
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DOI:   http://dx.doi.org/10.1016/j.joca.2005.01.005
    - LOUATI ET AL., "Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis", RMD OPEN, (2015), vol. 1, no. 1, page E000077
    - HABIB ET AL., "Increased blood glucose levels following intra-articular injection of methylprednisolone acetate in controlled diabetic patients with symptomatic osteoarthritis of the knee", ANN RHEUM DIS, (2008), vol. 67, pages 1790 - 1791
    - HABIB GS., "Systemic effects of intra-articular corticosteroids", CLIN RHEUMATOL, (2009), vol. 28, pages 749 - 756, XP019663038
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    - DERENDORF H; MOLLMANN H; GRUNER A; HAACK D; GYSELBY G, "Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration", CLIN PHARMACOL THER, (1986), vol. 39, pages 313 - 31
    - BODICK N; LUFKIN J; WILLWERTH C; BLANKS R; INDERJEETH C; KUMAR A; CLAYMAN M, "TCA/PLGA microparticles prolong the residency of triamcinolone acetonide in the synovial tissues of patients with knee osteoarthritis", OSTEOARTHRITIS CARTILAGE, (2013), vol. 21, pages 144 - 5
    - BODICK N; LUFKIN J; WILLWERTH C; KUMAR A; BOLOGNESE J; SCHOONMAKER C; BALLAL R; HUNTER D; LAYMAN, M, "An Intra-Articular, Extended-Release Formulation of Triamcinolone Acetonide Prolongs and Amplifies Analgesic Effect in Patients with Osteoarthritis of the Knee, A Randomized Clinical Trial", J BONE JOINT SURG AM., (2015), vol. 97, pages 877 - 88
    - BODICK N; LUFKIN J; WILLWERTH C; BLANKS R; INDERJEETH C; KUMAR A; CLAYMAN M., "TCA/PLGA microparticles prolong the residency of triamcinolone acetonide in the synovial tissues of patients with knee osteoarthritis", OSTEOARTHRITIS CARTILAGE, (2013), vol. 21, pages 144 - 5
    - ALTMAN ET AL., "Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association.", ARTHRITIS RHEUM., (1986), vol. 29, no. 8, pages 1039 - 49
    - DAMIANO ET AL., "A Comparative Effectiveness Analysis of Three Continuous Glucose Monitors: The Navigator, G4 Platinum, and Enlite", J DIABETES SCI TECHNOL, (2014), vol. 99, no. 5, pages 1701 - 1711
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    - QU ET AL., "Rate of hypoglycemia in insulin-treated patients with type 2 diabetes can be predicted from glycemic variability data", DIABETES TECHNOL THER, (2012), vol. 14, no. 11, pages 1008 - 1012
    - TESTA ET AL., "Comparative effectiveness of basal-bolus versus premix analog insulin on glycemic variability and patient-centered outcomes during insulin intensification in type 1 and type 2 diabetes: a randomized, controlled, crossover trial", J CLIN ENDOCRINOL METAB, (2012), vol. 97, pages 3504 - 3514
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DOI:   http://dx.doi.org/10.1007/s00125-007-0842-6
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.