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Extract from the Register of European Patents

EP About this file: EP3432930

EP3432930 - INHIBITORS OF CDK12 AND THEIR USES [Right-click to bookmark this link]
Former [2019/05]INHIBITORS AND THEIR USES
[2022/18]
StatusNo opposition filed within time limit
Status updated on  11.08.2023
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  02.09.2022
FormerGrant of patent is intended
Status updated on  25.04.2022
FormerExamination is in progress
Status updated on  12.06.2020
FormerRequest for examination was made
Status updated on  30.12.2018
FormerThe international publication has been made
Status updated on  29.09.2017
Formerunknown
Status updated on  14.04.2017
Most recent event   Tooltip24.05.2024Lapse of the patent in a contracting state
New state(s): IT		published on 26.06.2024  [2024/26]
Applicant(s)For all designated states
The University of Nottingham
University Park
Nottingham, Nottinghamshire NG7 2RD / GB
[2019/05]
Inventor(s)01 / HAYES, Christopher James
41d Church Street
Cropwell Bishop
Nottingham Nottinghamshire NG12 3BY / GB
02 / BROOK, John David
25 Villiers Road
West Bridgford
Nottingham Nottinghamshire NG2 6FR / GB
03 / KETLEY, Ami
Rosedene
Main Street
South Muskham
Newark Nottinghamshire NG23 6EE / GB
 [2019/05]
Representative(s)Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
[2019/05]
Application number, filing date17715522.323.03.2017
[2019/05]
WO2017GB50824
Priority number, dateGB2016000512624.03.2016         Original published format: GB 201605126
[2019/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017163076
Date:28.09.2017
Language:EN
[2017/39]
Type: A1 Application with search report 
No.:EP3432930
Date:30.01.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 28.09.2017 takes the place of the publication of the European patent application.
[2019/05]
Type: B1 Patent specification 
No.:EP3432930
Date:05.10.2022
Language:EN
[2022/40]
Search report(s)International search report - published on:EP28.09.2017
ClassificationIPC:A61K31/506, A61K45/06, A61K31/426, A61K31/454, A61K31/519, A61K31/7088, A61P21/00, A61K31/635
[2022/18]
CPC:
A61K31/506 (EP,US); A61K31/426 (EP,US); A61K31/454 (EP,US);
A61K31/519 (EP,US); A61K31/635 (EP,US); A61K31/7088 (EP,US);
A61K45/06 (EP,US); A61P21/00 (EP,US); G01N2333/9121 (EP,US);
G01N2500/04 (EP,US); G01N2800/2814 (EP,US); G01N2800/2835 (EP,US);
G01N2800/2892 (EP,US) (-)
Former IPC [2019/05]A61K45/06, A61K31/426, A61K31/454, A61K31/506, A61K31/519, A61K31/7088, A61P21/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/05]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:INHIBITOREN VON CDK12 UND DEREN VERWENDUNGEN[2022/18]
English:INHIBITORS OF CDK12 AND THEIR USES[2022/18]
French:INHIBITEURS DE CDK12 ET LEURS UTILISATIONS[2022/18]
Former [2019/05]INHIBITOREN UND DEREN VERWENDUNGEN
Former [2019/05]INHIBITORS AND THEIR USES
Former [2019/05]INHIBITEURS ET LEURS UTILISATIONS
Entry into regional phase15.10.2018National basic fee paid 
15.10.2018Designation fee(s) paid 
15.10.2018Examination fee paid 
Examination procedure15.10.2018Examination requested  [2019/05]
15.10.2018Date on which the examining division has become responsible
23.05.2019Amendment by applicant (claims and/or description)
16.06.2020Despatch of a communication from the examining division (Time limit: M06)
15.12.2020Reply to a communication from the examining division
26.04.2022Communication of intention to grant the patent
25.08.2022Fee for grant paid
25.08.2022Fee for publishing/printing paid
25.08.2022Receipt of the translation of the claim(s)
Opposition(s)06.07.2023No opposition filed within time limit [2023/37]
Fees paidRenewal fee
30.05.2019Renewal fee patent year 03
30.03.2020Renewal fee patent year 04
25.03.2021Renewal fee patent year 05
29.03.2022Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.03.201903   M06   Fee paid on   30.05.2019
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
IT05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SI05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
IE23.03.2023
LU23.03.2023
BE31.03.2023
CH31.03.2023
LI31.03.2023
[2024/26]
Former [2024/12]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SI05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
IE23.03.2023
LU23.03.2023
BE31.03.2023
CH31.03.2023
LI31.03.2023
Former [2024/09]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SI05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
IE23.03.2023
LU23.03.2023
CH31.03.2023
LI31.03.2023
Former [2024/08]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SI05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
IE23.03.2023
LU23.03.2023
Former [2024/02]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SI05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
LU23.03.2023
Former [2023/51]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SI05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/48]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
MC05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/38]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SK05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/37]AL05.10.2022
AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/35]AT05.10.2022
CZ05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
PL05.10.2022
RO05.10.2022
RS05.10.2022
SE05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/34]AT05.10.2022
DK05.10.2022
EE05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
PL05.10.2022
RS05.10.2022
SE05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/33]AT05.10.2022
DK05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
PL05.10.2022
RS05.10.2022
SE05.10.2022
SM05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/25]AT05.10.2022
ES05.10.2022
FI05.10.2022
HR05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
PL05.10.2022
RS05.10.2022
SE05.10.2022
NO05.01.2023
GR06.01.2023
IS05.02.2023
PT06.02.2023
Former [2023/23]AT05.10.2022
ES05.10.2022
FI05.10.2022
LT05.10.2022
LV05.10.2022
NL05.10.2022
SE05.10.2022
NO05.01.2023
GR06.01.2023
PT06.02.2023
Former [2023/22]AT05.10.2022
ES05.10.2022
FI05.10.2022
LT05.10.2022
NL05.10.2022
SE05.10.2022
NO05.01.2023
PT06.02.2023
Former [2023/20]LT05.10.2022
NL05.10.2022
NO05.01.2023
Former [2023/17]NL05.10.2022
Cited inInternational search[A]US2002119963  (SANNER MARK A [US], et al) [A] 1-36,38-40 * paragraph 211; claims 50, 51 *;
 [XA]WO03051886  (SMITHKLINE BEECHAM CORP [US], et al) [X] 38,39 * Examples 1, 7, 26, 28, 56, 60; biological data; claims 30, 31 * [A] 1-36,40;
 [XA]  - CHRISTIAN A. BÖSKEN ET AL, "The structure and substrate specificity of human Cdk12/Cyclin K", NATURE COMMUNICATIONS, (20140324), vol. 5, doi:10.1038/ncomms4505, XP055377119 [X] 38 * Fig. 6; p. 13, "Kinase inhibition assays" * [A] 1-36,39,40

DOI:   http://dx.doi.org/10.1038/ncomms4505
 [A]  - P. PAOLETTI ET AL, "Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5", JOURNAL OF NEUROSCIENCE, US, (20081001), vol. 28, no. 40, doi:10.1523/JNEUROSCI.3237-08.2008, ISSN 0270-6474, pages 10090 - 10101, XP055377409 [A] 1-36,38-40 * p. 10096, chapter bridging left and right col.; Fig. 7 *

DOI:   http://dx.doi.org/10.1523/JNEUROSCI.3237-08.2008
Examination   - AMI KETLEY ET AL, "CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model", SCIENCE TRANSLATIONAL MEDICINE, US, (20200429), vol. 12, no. 541, doi:10.1126/scitranslmed.aaz2415, ISSN 1946-6234, page eaaz2415, XP055703518

DOI:   http://dx.doi.org/10.1126/scitranslmed.aaz2415
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    - SAVITSKI, M.M., ANALYTICAL CHEMISTRY, (2011), vol. 83, pages 8959 - 8967
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.