blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3478831

EP3478831 - ASPARTIC PROTEASES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.11.2021
Database last updated on 09.07.2024
FormerThe patent has been granted
Status updated on  18.12.2020
FormerGrant of patent is intended
Status updated on  03.08.2020
FormerExamination is in progress
Status updated on  14.02.2020
FormerRequest for examination was made
Status updated on  05.04.2019
FormerThe international publication has been made
Status updated on  06.01.2018
Formerunknown
Status updated on  19.07.2017
Most recent event   Tooltip27.04.2024Lapse of the patent in a contracting state
New state(s): MK
published on 29.05.2024  [2024/22]
Applicant(s)For all designated states
Danisco US Inc.
925 Page Mill Road
Palo Alto, California 94304 / US
[2019/19]
Inventor(s)01 / GU, Xiaogang
No. 10 Building Lane 10 Linhong Road
Shanghai 200335 / CN
02 / ZOU, Zhengzheng
1403 Building 8 Lane 99 South Qianyang Road
Shanghai 200031 / CN
03 / XIE, Zhiyong
No. 10 Building Lane
280 Ling Hong Road
Shanghai 200335 / CN
04 / HAO, Helong
No. 10 building Lane 280 Linghon Road
Shanghai 200335 / CN
05 / YU, Shukun
Gunnar Hejdemans Gata 29
S-212 40 Malmo / SE
06 / SHIPOVSKOV, Stepan
Tålforvej 4
8250 Egå / DK
 [2019/19]
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[2021/03]
Former [2019/19]Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Application number, filing date17737114.322.06.2017
[2019/19]
WO2017US38746
Priority number, dateWO2016CN8785230.06.2016         Original published format: PCT/CN2016/087852
[2019/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018005225
Date:04.01.2018
Language:EN
[2018/01]
Type: A1 Application with search report 
No.:EP3478831
Date:08.05.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 04.01.2018 takes the place of the publication of the European patent application.
[2019/19]
Type: B1 Patent specification 
No.:EP3478831
Date:20.01.2021
Language:EN
[2021/03]
Search report(s)International search report - published on:EP04.01.2018
ClassificationIPC:C12N9/64
[2019/19]
CPC:
C12N9/6478 (EP,US); A23K10/30 (US); A23K20/189 (US);
C12Y304/23 (US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/19]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:ASPARTAT-PROTEASEN[2019/19]
English:ASPARTIC PROTEASES[2019/19]
French:PROTÉASES ASPARTIQUES[2019/19]
Entry into regional phase12.12.2018National basic fee paid 
12.12.2018Designation fee(s) paid 
12.12.2018Examination fee paid 
Examination procedure12.12.2018Examination requested  [2019/19]
12.12.2018Date on which the examining division has become responsible
15.08.2019Amendment by applicant (claims and/or description)
18.02.2020Despatch of a communication from the examining division (Time limit: M02)
22.04.2020Reply to a communication from the examining division
04.08.2020Communication of intention to grant the patent
09.12.2020Fee for grant paid
09.12.2020Fee for publishing/printing paid
09.12.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20212694.2  / EP3825399
Opposition(s)21.10.2021No opposition filed within time limit [2021/52]
Fees paidRenewal fee
13.06.2019Renewal fee patent year 03
15.06.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.06.2017
AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
MK20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
BE30.06.2021
CH30.06.2021
DK30.06.2021
FR30.06.2021
LI30.06.2021
[2024/22]
Former [2023/33]HU22.06.2017
AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
BE30.06.2021
CH30.06.2021
DK30.06.2021
FR30.06.2021
LI30.06.2021
Former [2023/30]AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
BE30.06.2021
CH30.06.2021
DK30.06.2021
FR30.06.2021
LI30.06.2021
Former [2023/29]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
BE30.06.2021
CH30.06.2021
DK30.06.2021
FR30.06.2021
LI30.06.2021
Former [2022/36]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
BE30.06.2021
CH30.06.2021
DK30.06.2021
FR30.06.2021
LI30.06.2021
Former [2022/34]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
BE30.06.2021
CH30.06.2021
FR30.06.2021
LI30.06.2021
Former [2022/23]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
CH30.06.2021
FR30.06.2021
LI30.06.2021
Former [2022/22]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
GB22.06.2021
IE22.06.2021
LU22.06.2021
CH30.06.2021
LI30.06.2021
Former [2022/21]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
IE22.06.2021
LU22.06.2021
CH30.06.2021
LI30.06.2021
Former [2022/18]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
LU22.06.2021
Former [2022/13]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
Former [2022/10]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
Former [2022/08]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2022/07]AL20.01.2021
AT20.01.2021
CZ20.01.2021
EE20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/50]AT20.01.2021
CZ20.01.2021
EE20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/48]AT20.01.2021
CZ20.01.2021
EE20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
PL20.01.2021
RS20.01.2021
SE20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/46]AT20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
PL20.01.2021
RS20.01.2021
SE20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/42]AT20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
PL20.01.2021
RS20.01.2021
SE20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/39]AT20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
PL20.01.2021
RS20.01.2021
SE20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
Former [2021/38]AT20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
RS20.01.2021
SE20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
Former [2021/37]AT20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
RS20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
Former [2021/36]FI20.01.2021
HR20.01.2021
LT20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
Former [2021/35]FI20.01.2021
HR20.01.2021
LT20.01.2021
NO20.04.2021
PT20.05.2021
Former [2021/33]FI20.01.2021
LT20.01.2021
NO20.04.2021
PT20.05.2021
Cited inInternational search[I]WO2013135732  (DSM IP ASSETS BV [NL]) [I] 1-18 * sequence 59 *;
 [XI]WO2014138983  (UNIV CONCORDIA [CA]) [X] 1-18 * sequence 1470 * [I] 1-18;
    [ ] - "P. byssochlamydoides aspartic protease pep1 polypeptide, SEQ ID 1470.", Geneseq, (20141106), Database accession no. BBN40292, URL: EBI, XP002773022 [ ] * the whole document *
    [ ] - "Rasamsonia emersonii pepA aspartic protease, SEQ ID 59.", Geneseq, (20131107), Database accession no. BAT37865, URL: EBI, XP002773023 [ ] * the whole document *
by applicantEP0063909
 EP0215594
 EP0238023
 EP0244234
 US5055403
 WO9212645
 US5231020
 WO9600787
 WO9716076
 US5817498
 US5874276
 US6015707
 US6022725
 US6255115
 US6268328
 US6573086
 WO2005001036
 WO2007044968
 US7354752
 US2009280090
 WO2010076113
 US7754469
 US8053221
 US8144046
 WO2012110778
 WO2013029013
 US8673609
 US8927250
 WO2015017256
    - RAWLINGS, N.D.; WALLER, M.; BARRETT, A.J.; BATEMAN, A., "MEROPS: the database of proteolytic enzymes, their substrates and inhibitors", Nucleic Acids Res, vol. 42, (20140000), pages D503 - D509, URL: http://merops.sanger.ac.uk
    - JONES et al., EMBO J, (19850000), vol. 4, pages 2411 - 2418
    - DE ALMEIDA et al., Mol Gen Genetics, (19890000), vol. 218, pages 78 - 86
    - ALTSCHUL et al., J Mol Biol, (19900000), vol. 215, pages 403 - 410
    - KARLIN; ALTSCHUL, Proc Natl Acad Sci USA, (19930000), vol. 90, pages 5873 - 5787
    - ALTSCHUL et al., Nucleic Acids Res, (19970000), vol. 25, pages 3389 - 3402
    - SCHAFFER et al., Nucleic Acids Res, (20010000), vol. 29, pages 2994 - 3005
    - ALTSCHUL SF; MADDE TL; SHAFFER AA; ZHANG J; ZHANG Z; MILLER W; LIPMAN DJ, "Gapped BLAST and PSI BLAST a new generation of protein database search programs", Nucleic Acids Res, (19970901), vol. 25, no. 17, doi:doi:10.1093/nar/25.17.3389, pages 3389 - 402, XP002905950

DOI:   http://dx.doi.org/10.1093/nar/25.17.3389
    - RICE et al., Trends in Genetics, (20000000), vol. 16, no. 6, pages 276 - 277
    - HIGGINS; SHARP, CABIOS, (19890000), vol. 5, pages 151 - 153
    - HIGGINS et al., Nucleic Acids Res., (19940000), vol. 22, pages 4673 - 4680
    - CHENNA et al., Nucleic Acids Res, (20030000), vol. 31, no. 13, pages 3497 - 500
    - GRAESSLE et al., Appl. Environ. Microbiol., (19970000), vol. 63, pages 753 - 756
    - LEUKER et al., Gene, (19970000), vol. 192, pages 235 - 240
    - LIU et al., Eukary. Cell, (20060000), vol. 5, pages 638 - 649
    - NUNBERG et al., Mol. Cell Biol., (19840000), vol. 15, no. 4, pages 2306 - 2315
    - BOEL et al., EMBO J., (19840000), vol. 3, pages 1581 - 1585
    - VAN DEN HONDEL et al., VAN DEN HONDEL et al., Bennett and Lasure, MORE GENE MANIPULATIONS IN FUNGI, Academic Press, (19910000), pages 396 - 428
    - VAN DEN HONDEL et al., VAN DEN HONDEL et al., Bennett and Lasure, MORE GENE MANIPULATIONS IN FUNGI, Academic Press, (19910000), pages 70 - 76,396-428
    - NUNBERG et al., Mol. Cell Biol., (19840000), vol. 4, pages 2306 - 2315
    - BOEL et al., 30 EMBO J., (19840000), vol. 3, pages 1581 - 1585
    - KELLEY et al., EMBO J., (19850000), vol. 4, pages 475 - 479
    - PENTTILA et al., Gene, (19870000), vol. 61, pages 155 - 164
    - "Fungal Genetic Stock Center Catalogue of Strains", FGSC, URL: www.fgsc.net.
    - LORITO; HAYES; DIPIETRO; HARMAN, Curr. Genet., (19930000), vol. 24, pages 349 - 356
    - GOLDMAN; VANMONTAGU; HERRERA-ESTRELLA, Curr. Genet., (19900000), vol. 17, pages 169 - 174
    - PENTTILA; NEVALAINEN; RATTO; SALMINEN; KNOWLES, Gene, (19870000), vol. 6, pages 155 - 164
    - NEVALAINEN et al., "The Molecular Biology of Trichoderma and its Application to the Expression of Both Homologous and Heterologous Genes", NEVALAINEN et al., Leong and Berka, Molecular Industrial Mycology, Marcel Dekker Inc., NY, (19920000), pages 129 - 148
    - YELTON; HAMER; TIMBERLAKE, Proc. Natl. Acad. Sci. USA, (19840000), vol. 81, pages 1470 - 1474
    - BAJAR; PODILA; KOLATTUKUDY, Proc. Natl. Acad. Sci. USA, (19910000), vol. 88, pages 8202 - 8212
    - FERNANDEZ-ABALOS et al., Microbiol, (20030000), vol. 149, pages 1623 - 1632
    - BRIGIDI; DEROSSI; BERTARINI; RICCARDI; MATTEUZZI, FEMS Microbiol. Lett., (19900000), vol. 55, pages 135 - 138
    - YELTON et al., Proc. Natl. Acad. Sci. USA, (19840000), vol. 81, pages 1470 - 1474
    - CAO et al., Sci., (20000000), vol. 9, pages 991 - 1001
    - CAMPBELL et al., Curro Genet., (19890000), vol. 16, pages 53 - 56
    - PENTILLA et al., Gene, (19870000), vol. 61, pages 155 - 164
    - DE GROOT et al., Nat. Biotechnol., (19980000), vol. 16, pages 839 - 842
    - HARKKI, Enzyme Microb. Technol., (19910000), vol. 13, pages 227 - 233
    - HARKKI et al., Bio Technol., (19890000), vol. 7, pages 596 - 603
    - BAJAR et al., Proc. Natl. Acad. Sci. USA, (19910000), vol. 88, pages 8202 - 28212
    - ILMEN et al., "Regulation of cellulase gene expression in the filamentous fungus Trichoderma reesei", Appl. Envir. Microbiol., (19970000), vol. 63, pages 1298 - 1306, XP055301671
    - WARD, "Proteinases", WARD, Fogarty, Microbial Enzymes and Biotechnology, Applied Science, London, (19830000), pages 251 - 317
    - TWINING, S.S., "Fluorescein Isothiocyanate-Labeled Casein Assay for Proteolytic Enzymes", Anal. Biochem., (19840000), vol. 143, doi:doi:10.1016/0003-2697(84)90553-0, pages 30 - 34, XP024820116

DOI:   http://dx.doi.org/10.1016/0003-2697(84)90553-0
    - WELLS et al., Nucleic Acids Res., (19830000), vol. 11, pages 7911 - 7925
    - CHRISTIANSON et al., Anal. Biochem., (19940000), vol. 223, pages 119 - 129
    - HSIA et al., Anal Biochem., (19990000), vol. 242, pages 221 - 227
    - NORDAHL PETERSEN et al., Nature Methods, (20110000), vol. 8, pages 785 - 786
    - TE'O et al., J. Microbiol. Methods, (20020000), vol. 51, pages 393 - 99
    - MICHEL LOPEZ; LUPPO EDENS, J. Agric. Food Chem., (20050000), vol. 53, pages 7944 - 7949
    - ALTSCHUL et al., Nucleic Acids Res, (19970000), vol. 25, pages 3389 - 402
    - THOMPSON et al., Nucleic Acids Research, (19940000), vol. 22, pages 4673 - 4680
    - KOICHIRO TAMURA et al., Mol Biol Evol., (20110000), vol. 28, no. 10, pages 2731 - 2739
    - SAITOU, N.; NEI, M., "The neighbor-joining (NJ) method: a new method for reconstructing Guide Trees", Mol. Biol. Evol., (19870000), vol. 4, pages 406 - 425
 WO2010NL00045
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.