blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3485277

EP3485277 - NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  02.10.2020
Database last updated on 13.07.2024
FormerExamination is in progress
Status updated on  18.12.2019
FormerRequest for examination was made
Status updated on  19.04.2019
FormerThe international publication has been made
Status updated on  26.01.2018
Formerunknown
Status updated on  27.07.2017
Most recent event   Tooltip02.10.2020Application deemed to be withdrawnpublished on 04.11.2020  [2020/45]
Applicant(s)For all designated states
Ulsemer, Philippe
Mozartstrasse 25
16552 Schildow / DE
For all designated states
Goletz, Steffen
Eichhornstrasse 24
16548 Glienicke-Nordbahn / DE
For all designated states
Goetz, Peter
Lukasstrasse 1
91088 Budenreuth / DE
[2019/21]
Inventor(s)01 / see applicant
...
 [2019/21]
Representative(s)Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB
Ganghoferstraße 68 B
80339 München / DE
[2019/21]
Application number, filing date17740023.118.07.2017
[2019/21]
WO2017EP68115
Priority number, dateEP2016017988318.07.2016         Original published format: EP 16179883
[2019/21]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018015380
Date:25.01.2018
Language:EN
[2018/04]
Type: A1 Application with search report 
No.:EP3485277
Date:22.05.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 25.01.2018 takes the place of the publication of the European patent application.
[2019/21]
Search report(s)International search report - published on:EP25.01.2018
ClassificationIPC:G01N33/569, C12R1/01
[2019/21]
CPC:
C12N1/20 (EP,US); G01N33/56911 (US); A61K35/74 (US);
A61P1/00 (EP,US); C12N1/14 (EP,US); C12N1/16 (US);
C12N1/205 (EP,US); G01N33/56916 (EP,US); G01N33/56961 (US);
C12R2001/01 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/21]
TitleGerman:NATÜRLICHE MIKROORGANISMEN MIT NATÜRLICHER FÄHIGKEIT ZUR BINDUNG VON TOXINEN UND/ODER TOXINREZEPTOREN[2019/21]
English:NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS[2019/21]
French:MICRO-ORGANISMES NATURELS QUI SONT NATURELLEMENT CAPABLES DE SE LIER À DES TOXINES ET/OU DES RÉCEPTEURS DE TOXINE[2019/21]
Entry into regional phase18.02.2019National basic fee paid 
18.02.2019Designation fee(s) paid 
18.02.2019Examination fee paid 
Examination procedure09.10.2017Request for preliminary examination filed
International Preliminary Examining Authority: EP
18.02.2019Amendment by applicant (claims and/or description)
18.02.2019Examination requested  [2019/21]
18.02.2019Date on which the examining division has become responsible
02.01.2020Despatch of a communication from the examining division (Time limit: M04)
03.06.2020Application deemed to be withdrawn, date of legal effect  [2020/45]
26.06.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2020/45]
Fees paidRenewal fee
25.07.2019Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A]WO9714802  (TNO [NL], et al) [A] 1-30 * the whole document *;
 [A]WO0119960  (WOMENS & CHILDRENS HOSPITAL [AU], et al) [A] 1-30;
 [Y]US6346422  (BUTTY PASCAL JEAN-LUC [FR], et al) [Y] 2-15 * the whole document *;
 [A]WO2004003235  (PULEVA BIOTECH SA [ES], et al) [A] 1-30 * page 7, paragraph 1; figure 12; example 6 *;
 [A]DE102005062731  (ORGANOBALANCE GMBH [DE]) [A] 2-15;
 [AD]WO2012152270  (ORGANOBALANCE MEDICAL AG [DE], et al) [AD] 2-15;
 [XYI]  - M. GOURMELON ET AL, "First isolation of Shiga toxin 1d producing Escherichia coli variant strains in shellfish from coastal areas in France", JOURNAL OF APPLIED MICROBIOLOGY, (20060101), vol. 100, no. 1, doi:10.1111/j.1365-2672.2005.02753.x, ISSN 1364-5072, pages 85 - 97, XP055106711 [X] 1,4-13,16-21 * the whole document * [Y] 2-15 [I] 3,14,15,22-30

DOI:   http://dx.doi.org/10.1111/j.1365-2672.2005.02753.x
 [Y]  - I. STYRIAK ET AL, "Binding of extracellular matrix molecules by probiotic bacteria", LETTERS IN APPLIED MICROBIOLOGY, (20031001), vol. 37, no. 4, doi:10.1046/j.1472-765X.2003.01402.x, ISSN 0266-8254, pages 329 - 333, XP055106445 [Y] 2-15 * the whole document *

DOI:   http://dx.doi.org/10.1046/j.1472-765X.2003.01402.x
 [A]  - MUKAI T ET AL, "INHIBITION OF BINDING OF HELICOBACTER PYLORI TO THE GLYCOLIPID RECEPTORS BY PROBIOTIC LACTOBACILLUS REUTERI", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, (20020101), vol. 32, doi:10.1016/S0928-8244(01)00284-X, ISSN 0928-8244, pages 105 - 110, XP001170378 [A] 1-30 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0928-8244(01)00284-X
 [A]  - ANNE MARIE KRACHLER ET AL, "Targeting the bacteria-host interface: Strategies in anti-adhesion therapy", VIRULENCE, (20130515), vol. 4, no. 4, doi:10.4161/viru.24606, ISSN 2150-5594, pages 284 - 294, XP055100392 [A] 1-30

DOI:   http://dx.doi.org/10.4161/viru.24606
by applicantUS6833130
 US2007148149
 WO2008015239
 WO2011069992
 US8192978
 WO2012152270
    - SKERRA, Curr. Opin. Biotechnol., (20070000), vol. 18, pages 295 - 304
    - HOSSE et al., Protein Sci., (20060000), vol. 15, pages 14 - 27
    - NICAISE et al., Protein Sci., (20040000), vol. 13, pages 1882 - 1891
    - NYGREN; UHLEN, Curr. Opin. Struc. Biol., (19970000), vol. 7, pages 463 - 469
    - ROLLAN et al., Int. J. Food Microbiol., (20010000), vol. 70, pages 303 - 307
    - MATSUGUCHI et al., Clin. Diagn. Lab. Immunol., (20030000), vol. 10, pages 259 - 266
    - STENTZ et al., Appl. Environ. Microbiol., (20000000), vol. 66, pages 4272 - 4278
    - VARMANEN et al., J. Bacteriology, (20000000), vol. 182, pages 146 - 154
    - E.W. MARTIN, Remington's Pharmaceutical Sciences
    - R. C. ROWE, Handbook of Pharmaceutical Excipients
    - COZENS D; READ R. C., "Anti-adhesion methods as novel therapeutics for bacterial infections", Expert Rev Anti Infect Ther., (20120000), vol. 10, no. 12, pages 1457 - 1468
    - SA E. C; GRIFFITHS N. J.; MURILLO I.; VIRJI M., "Neisseria meningitidis", Cell. Microbiol., (20090000), vol. 11, no. 3, pages 389 - 405
    - HOLMES A. R.; MCNAB R.; MILLSAP K. W. et al., "The pavA gene of Streptococcus pneumonia encodes a fibronectin-binding protein that is essential for virulence", Mol. Microbiol., (20010000), vol. 41, no. 6, pages 1395 - 1408
    - CUNDELL D. R.; GERARD N. P.; GERARD C.; IDANPAAN-HEIKKILA I.; TUOMANEN E. I., "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor", Nature, (19950000), vol. 377, no. 6548, pages 435 - 438
    - IMBERTY A.; VARROT A., "Microbial recognition of human cell surface glycoconjugates", Curr. Opin. Struct. Biol., (20080000), vol. 18, no. 5, pages 567 - 576
    - PIETERS R. J., "Carbohydrate mediated bacterial adhesion", Adv. Exp. Med. Biol., (20110000), vol. 715, pages 227 - 240
    - BERNARDI A.; JIMENEZ-BARBERO J.; CASNATI A.; DE CASTRO C.; DARBRE T.; FIESCHI F. et al., "Multivalent glycoconjugates as anti-pathogenic agents", Chem Soc Rev., (20120000), vol. 42, no. 11, pages 4709 - 27
    - NAGAHAMA M.; ODA M.; KOBAYASHI K.; OCHI S.; TAKAGISHI T.; SHIBUTANI M.; SAKURAI J., "A recombinant carboxy-terminal domain of alpha-toxin protects mice against Clostridium perfringens", Microbiol Immunol., (20130000), vol. 57, no. 5, pages 340 - 345
    - FOCARETA A.; PATON J. C.; MORONA R.; COOK J.; PATON A. W., "A recombinant probiotic for treatment and prevention of cholera", Gastroenterology, (20060000), vol. 130, no. 6, pages 1688 - 1695
    - MALLY M.; FONTANA C.; LEIBUNDGUT-LANDMANN S.; LAACISSE L.; FAN Y. Y.; WIDMALM G.; AEBI M., "Glycoengineering of host mimicking type-2 LacNAc polymers and Lewis X antigens on bacterial cell surfaces", Mol Microbiol., (20130000), vol. 87, no. 1, pages 112 - 131
    - HOULISTON R. S.; VINOGRADOV E.; DZIECIATKOWSKA M.; LI J.; ST MICHAEL F.; KARWASKI M. F.; BROCHU D. et al., "Lipooligosaccharide of Campylobacter jejuni - similarity with multiple types of mammalian glycans beyondgangliosides", J Biol Chem., (20110000), vol. 286, no. 14, pages 12361 - 12370
    - YUKI N., "Human Gangliosides and Bacterial Lipo-oligosaccharides in the Development of Autoimmune Neuropathies", Methods Mol Biol., (20100000), vol. 600, pages 51 - 65
    - MARTIN S. L.; EDBROOKE M. R.; HODGMAN T. C.; VAN DEN EIJNDEN D. H.; BIRD M. I., "Lewis X Biosynthesis in Helicobacter pylori. Molecular cloning of an alpha(1,3)-fucosyltransferase gene", J Biol Chem., (19970000), vol. 272, no. 34, pages 21349 - 21356
    - VAN REMOORTERE A.; HOKKE C. H.; VAN DAM G. J.; VAN DIE I.; DEELDER A. M.; VAN DEN EIJNDEN D. H., "Various stages of schistosomas express Lewis(x), LacdiNAc, GalNAcG -4(Fucalpha1 -3)GIcNAc and GalNAcbetal -4(Fucalpha1 -2Fucalpha1 - 3)GIcNAc carbohydrate epitope: detection with monoclonal antibodies that are characterized by enzymatically synthesized neopglycoproteins", Glycobiology, (20000000), vol. 10, no. 6, pages 601 - 609
    - LEFFLER D. A.; LAMONT J. T., "Editorial: not so nosocomial anymore: the growing threat of community-acquired Clostridium difficile", Am J Gastroenterol, (20120000), vol. 107, pages 96 - 98
    - MILLER B. A.; CHEN L. F.; SEXTON D. J.; ANDERSON D. J., "Comparison of the Burdens of Hospital-Onset, Healthcare Facility-Associated Clostridium difficile Infection and of Healthcare-Associated Infection due to Methicillin-Resistant Staphylococcus aureus in Community Hospitals", Infect Control Hosp Epidemiol., (20110000), vol. 32, no. 4, pages 387 - 290
    - HOOKMAN P.; BARKIN J. S., "Clostridium difficile associated infection, diarrhea and colitis", World J Gastroenterol., (20090000), vol. 15, no. 13, pages 1554 - 1580
    - VAISHNAVI C., "Clinical spectrum & pathogenesis of Clostridium difficile associated diseases", Indian J Med Res., (20100000), vol. 131, pages 487 - 499
    - SUN X.; SAVIDGE T.; FENG H., "The Enterotoxicity of Clostridium difficile Toxins", Toxins (Basel, (20100000), vol. 2, no. 7, pages 1848 - 1880
    - PRUITT R. N.; CHAMBERS M. G.; NG K. K.; OHI M. D.; LACY D. B., "Structural organization of the functional domains of Clostridium difficile toxins A and B", Proc Natl Acad Sci USA., (20100000), vol. 107, no. 30, pages 13467 - 13472
    - JANK T.; GIESEMANN T.; AKTORIES K., "Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function", Glycobiology, (20070000), vol. 17, no. 4, pages 15 - 22
    - VOTH D. E.; BALLARD J. D., "Clostridium difficile Toxins: Mechanism of Action and Role in Disease", Clin Microbiol Rev., (20050000), vol. 18, no. 2, pages 247 - 263
    - OILING A.; GOY S.; HOFFMANN F.; TATGE H.; JUST I.; GERHARD R., "The Repetitive Oligopeptide Sequences Modulate Cytopathic Potency but Are Not Crucial for Cellular Uptake of Clostridium difficile Toxin A", PLoS ONE, (20110000), vol. 6, no. 3, page e17623
    - PRUITT R. N.; LACY D. B., "Toward a structural understanding of Clostridium difficile toxins A and B", Front. Cell. Inf. Microbio., (20120000), vol. 2, no. 28, pages 1 - 14
    - BERTHOLET-THOMAS A.; RANCHIN B.; KING L. A.; BACCHETTA J.; BELOT A.; GILLET Y.; COLLARDEAU-FRACHON S.; COCHAT P., "Post-diarrheal haemolytic uremic syndrome: when shall we consider it? Which follow-up?", Arch Pediatr., (20110000), vol. 18, no. 7, pages 823 - 830
    - OAKES R. S.; KIRKHAMM J. K.; NELSON R. D.; SIEGLER R. L., "Duration of oliguria and anuria as predictors of chronic renal-related sequelae in post-diarrheal hemolytic uremic syndrome", Pediatric Nephrology, (20080000), vol. 23, no. 8, pages 1303 - 1308
    - GARG A. X.; SURI R. S.; BARROWMAN N.; REHMAN F.; MATSELL D.; ROSAS-ARELLANO M. P.; SALVADORI M. et al., "Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression", J. Am Medl Assoc., (20030000), vol. 290, no. 10, pages 1360 - 1370
    - OBRIG T. G., "Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease", Toxins (Basel, (20100000), vol. 2, no. 12, pages 2769 - 2794
    - KOSEK M.; BERN C.; GUERRANT R. L., "The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000", Bull World Health Organ., (20030000), vol. 81, no. 3, pages 197 - 204
    - STEFFEN R.; DE BERNARDIS C.; BANOS A., "Travel epidemiology--a global perspective", Int J Antimicrob Agents, (20030000), vol. 21, no. 2, pages 89 - 95
    - QADRI F.; SVENNERHOLM A. M.; FARUQUE A. S.; SACK R. B., "Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention", Clin Microbiol Rev, (20050000), vol. 18, no. 3, pages 465 - 483
    - ISIDEAN S. D.; RIDDLE M. S.; SAVARINO S. J.; PORTER C. K., "A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression", Vaccine, (20110000), vol. 29, no. 37, pages 6167 - 6178
    - GAASTRA W.; SVENNERHOLM A. M., "Colonization factors of human enterotoxigenic Escherichia coli (ETEC", Trends Microbiol, (19960000), vol. 4, no. 11, pages 444 - 452
    - WOLF M., "Occurence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli", Clin Microbiol Rev, (19970000), vol. 10, no. 4, pages 569 - 584
    - JIANG Z. D.; LOWE B.; VERENKAR M. P.; ASHLEY D.; STEFFEN R.; TORNIEPORTH N.; VON SONNENBURG F. et al., "Prevalence of enteric pathogens among international travelers with diarrhea acquired in Kenya (Mombasa), India (Goa), or Jamaica (Montego Bay", J Infect Dis, (20020000), vol. 185, no. 4, pages 497 - 502
    - SACK DA; SHIMKO J; TORRES O; BOURGEOIS AL; FRANCIA DS; GUSTAFSSON B; KARNELL A et al., "Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. coli diarrhoea of travellers to Guatemala and Mexico", Vaccine, (20070000), vol. 25, no. 22, pages 4392 - 4400
    - MINKE W. E.; HONG F; VERLINDE C. L.; HOL W. G.; FAN E., "Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin", J Biol Chem., (19990000), vol. 274, no. 47, pages 33469 - 33473
    - WEIGLMEIER P. R.; ROSCH P.; BERKNER H., "Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C", Toxins (Basel, (20100000), vol. 2, no. 9, pages 2213 - 2229
    - JANSSON L.; TOBIAS J.; JAREFJALL C.; LEBENS M.; SVENNERHOLM A. M. et al., "Sulfatide Recognition by Colonization Factor Antigen CS6 from Enterotoxigenic Escherichia coli", PLoS ONE, (20090000), vol. 4, no. 2, page e4487
    - "World Health Organization. Cholera. Fact sheet no. 107", Geneva: World Health Organization, (20100000), URL: http://www.who.int/mediacentre/factsheets/fs107/en/index.html.
    - CLEMENTS, J. D.; R. J. YANCEY; R. A. FINKELSTEIN, "Properties of homogeneous heat-labile enterotoxin from Escherichia coli", Infect. Immun., (19800000), vol. 24, pages 91 - 97
    - HOLMGREN, J., "Receptors for cholera toxin and Escherichia coli heat labile enterotoxin revisited", Prog. Brain Res., (19940000), vol. 101, pages 163 - 177
    - BARNARD,J.A.; WARWICK G., "Butyrate rapidelly Induces Growth inhibition and Differentiation in HT-29 cells", Cell Growth & Differentiation, (19930000), vol. 4, pages 495 - 201
    - SAITO M; MYLVAGANUM M; TAM P; NOVAK A; BINNINGTON B et al., "Structure-dependent pseudoreceptor intracellular traffic of adamantyl globotriaosyl ceramide mimics", The Journal of biological chemistry, (20120000), vol. 287, pages 16073 - 16087
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.