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Extract from the Register of European Patents

EP About this file: EP3488002

EP3488002 - SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.02.2022
Database last updated on 07.06.2024
FormerThe patent has been granted
Status updated on  26.02.2021
FormerGrant of patent is intended
Status updated on  22.10.2020
FormerExamination is in progress
Status updated on  27.04.2020
FormerRequest for examination was made
Status updated on  26.04.2019
FormerThe international publication has been made
Status updated on  26.01.2018
Formerunknown
Status updated on  01.09.2017
Most recent event   Tooltip03.05.2024Lapse of the patent in a contracting state
New state(s): MK		published on 05.06.2024  [2024/23]
Applicant(s)For all designated states
Oregon Health & Science University
3181 SW Sam Jackson Park Road
Portland, OR 97239 / US
For all designated states
Illumina, Inc.
5200 Illumina Way
San Diego, CA 92122 / US
[2019/22]
Inventor(s)01 / ADEY, Andrew, C.
3181 S.W. Sam Jackson Park Road
Portland, OR 97239 / US
02 / VITAK, Sarah, A.
11411 Swains Creek Ct
Potomac MD 20854 / US
03 / STEEMERS, Frank, J.
5200 Illumina Way
San Diego, CA 92122 / US
 [2021/13]
Former [2019/22]01 / ADEY, Andrew, C.
3181 S.W. Sam Jackson Park Road
Portland, OR 97239 / US
02 / VITAK, Sarah, A.
3181 S.W. Sam Jackson Park Road
Portland, OR 97239 / US
03 / STEEMERS, Frank, J.
5200 Illumina Way
San Diego, CA 92122 / US
Representative(s)Murgitroyd & Company
165-169 Scotland Street
Glasgow G5 8PL / GB
[N/P]
Former [2021/13]Murgitroyd & Company
Murgitroyd House
165-169 Scotland Street
Glasgow G5 8PL / GB
Former [2019/22]Murgitroyd & Company
Scotland House
165-169 Scotland Street
Glasgow G5 8PL / GB
Application number, filing date17755575.221.07.2017
[2019/22]
WO2017US43381
Priority number, dateUS201662365916P22.07.2016         Original published format: US 201662365916 P
US201762451305P27.01.2017         Original published format: US 201762451305 P
[2019/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018018008
Date:25.01.2018
Language:EN
[2018/04]
Type: A1 Application with search report 
No.:EP3488002
Date:29.05.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 25.01.2018 takes the place of the publication of the European patent application.
[2019/22]
Type: B1 Patent specification 
No.:EP3488002
Date:31.03.2021
Language:EN
[2021/13]
Search report(s)International search report - published on:EP25.01.2018
ClassificationIPC:C12N15/10
[2019/22]
CPC:
C12Q1/6806 (EP,IL,KR,US); C12N15/1065 (EP,IL,KR,US); C12N15/1093 (EP,IL,KR,US);
C12Q1/6869 (EP,IL,KR,US); C12Q1/6874 (IL,KR,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/22]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:EINZELLIGE GESAMTGENOMBIBLIOTHEKEN UND KOMBINATORISCHE INDEXIERUNGSVERFAHREN ZUR HERSTELLUNG DAVON[2019/22]
English:SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF[2019/22]
French:BIBLIOTHÈQUES DE GÉNOME ENTIER DE CELLULES UNIQUES ET PROCÉDÉS D'INDEXAGE COMBINATOIRE POUR LEUR FABRICATION[2019/22]
Entry into regional phase18.12.2018National basic fee paid 
18.12.2018Designation fee(s) paid 
18.12.2018Examination fee paid 
Examination procedure18.12.2018Amendment by applicant (claims and/or description)
18.12.2018Examination requested  [2019/22]
18.12.2018Date on which the examining division has become responsible
30.04.2020Despatch of a communication from the examining division (Time limit: M04)
31.08.2020Reply to a communication from the examining division
23.10.2020Communication of intention to grant the patent
23.02.2021Fee for grant paid
23.02.2021Fee for publishing/printing paid
23.02.2021Receipt of the translation of the claim(s)
Divisional application(s)EP21164754.0  / EP3904514
Opposition(s)04.01.2022No opposition filed within time limit [2022/10]
Fees paidRenewal fee
15.07.2019Renewal fee patent year 03
14.07.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU21.07.2017
AL31.03.2021
CY31.03.2021
CZ31.03.2021
EE31.03.2021
GR31.03.2021
HR31.03.2021
LT31.03.2021
LV31.03.2021
MC31.03.2021
MK31.03.2021
PL31.03.2021
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SK31.03.2021
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BG30.06.2021
LU21.07.2021
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PT02.08.2021
[2024/23]
Former [2023/36]HU21.07.2017
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Cited inInternational search[A]WO2014189957  (UNIV LELAND STANFORD JUNIOR [US]) [A] 1-50 * the whole document *;
 [AD]  - D. A. CUSANOVICH ET AL, "Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing", SCIENCE, (20150521), vol. 348, no. 6237, doi:10.1126/science.aab1601, ISSN 0036-8075, pages 910 - 914, XP055416774 [AD] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.aab1601
 [A]  - SASAN AMINI ET AL, "Haplotype-resolved whole-genome sequencing by contiguity-preserving transposition and combinatorial indexing", NATURE GENETICS., NEW YORK, US, (20141019), vol. 46, no. 12, doi:10.1038/ng.3119, ISSN 1061-4036, pages 1343 - 1349, XP055279286 [A] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1038/ng.3119
 [A]  - MIRKOVITCH J ET AL, "Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold", CELL, CELL PRESS, US, vol. 39, no. 1, doi:10.1016/0092-8674(84)90208-3, ISSN 0092-8674, (19841101), pages 223 - 232, (19841101), XP023911583 [A] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1016/0092-8674(84)90208-3
 [XDP]  - SARAH A VITAK ET AL, "Sequencing thousands of single-cell genomes with combinatorial indexing", NATURE METHODS, GB, (20170130), vol. 14, no. 3, doi:10.1038/nmeth.4154, ISSN 1548-7091, pages 302 - 308, XP055416420 [XDP] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1038/nmeth.4154
 [AD]  - JASON D BUENROSTRO ET AL, "Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position", NATURE METHODS, GB, (20131006), vol. 10, no. 12, doi:10.1038/nmeth.2688, ISSN 1548-7091, pages 1213 - 1218, XP055416652 [AD] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1038/nmeth.2688
 [P]  - BUENROSTRO JASON D ET AL, "Supplemental Material: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position", INTERNET CITATION, ISSN 1548-7105, (20161117), pages 1 - 15, URL: http://www.nature.com/nmeth/journal/v10/n12/extref/nmeth.2688-S1.pdf, (20161116), XP002764311

DOI:   http://dx.doi.org/10.1038/nmeth.2688
 [A]  - TOMSCHIK MIROSLAV ET AL, "Fast, long-range, reversible conformational fluctuations in nucleosomes revealed by single-pair fluorescence resonance energy transfer", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, NATIONAL ACADEMY OF SCIENCES, US, (20050301), vol. 102, no. 9, doi:10.1073/PNAS.0500189102, ISSN 0027-8424, pages 3278 - 3283, XP002488497 [A] 1-50 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.0500189102
by applicantUS4683195
 US4683202
 WO8909835
 WO8912696
 WO9001069
 WO9106678
 US5130238
 US5185243
 US5223414
 EP0320308
 EP0336731
 WO9523875
 US5455166
 EP0439182
 US5573907
 US5679524
 WO9844151
 WO0018957
 US6172218
 US6210891
 US6214587
 US6258568
 US6274320
 US6306597
 WO0246456
 WO2004018497
 US2005100900
 WO2005065814
 US6969488
 US7001792
 US7057026
 WO2006064199
 US2006188901
 US7115400
 US2006240439
 US2006281109
 WO2007010251
 US7211414
 US2007166705
 WO2007123744
 US7315019
 US2008009420
 US7329492
 US2008108082
 US7399590
 US7405281
 US7427673
 US2009026082
 US2009127589
 US7582420
 US7611869
 US7670810
 US2010111768
 US2010120098
 US2010137143
 US7741463
 US7829284
 US2010282617
 US8003354
 US8053192
 WO2012061832
 US2012208705
 US2012208724
 US2012270305
 US2013079232
 US2013184796
 US2013260372
 US8563477
 US2013338042
 US8778848
 US8778849
 US2014243224
 US8895249
 WO2015002813
 US9079148
 WO2015106941
 US9169513
 US9309502
 WO2016066586
 WO2016130704
    - MCCONNELL, M. J. et al., Science (80., (20130000), vol. 342, pages 632 - 637
    - CAI, X. et al., Cell Rep., (20140000), vol. 8, pages 1280 - 1289
    - KNOUSE, K. A. et al., Proc Natl Acad Sci U S A, (20140000), vol. 111, pages 13409 - 13414
    - REHEN, S. K. et al., Proc. Natl. Acad. Sci. U. S. A., (20010000), vol. 98, pages 13361 - 6
    - NAVIN, N. et al., Nature, (20110000), vol. 472, pages 90 - 94
    - EIREW, P. et al., Nature, (20140000), vol. 518, pages 422 - 6
    - GAWAD, C. et al., Proc. Natl. Acad. Sci. U. S. A., (20140000), vol. 111, pages 17947 - 52
    - GAO, R. et al., Nat. Genet., (20160000), vol. 1, page 15
    - ZONG, C. et al., Science (80-., (20120000), vol. 338, pages 1622 - 1626
    - MCCONNELL, M. et al., Science (80., (20130000), vol. 342, pages 632 - 637
    - BASLAN, T. et al., Genome Res., (20150000), vol. 125, pages 714 - 724
    - GAWAD, C. et al., Nat. Rev. Genet., (20160000), vol. 17, pages 175 - 88
    - ADEY, A. et al., Genome Biol., (20100000), vol. 11, page R119
    - AMINI, S. et al., Nat. Genet., (20140000), vol. 46, pages 1343 - 9
    - ADEY, A. et al., Genome Res, (20140000), vol. 24, pages 2041 - 2049
    - ADEY, A. et al., Genome Res., (20140000), vol. 24, pages 2041 - 2049
    - BUENROSTRO, J. D. et al., Nat. Methods, (20130000), vol. 10, pages 1213 - 8
    - CUSANOVICH, D. A et al., Science, (20150000), vol. 348, pages 910 - 4
    - BENTLEY et al., Nature, (20080000), vol. 456, pages 53 - 59
    - HOFFMAN et al., J. Biol. Chem., (20150000), vol. 290, pages 26404 - 26411
    - NAGANO et al., Nature, (20130000), vol. 502, pages 59 - 64
    - GORYSHIN AND REZNIKOFF, J. Biol. Chem., (19980000), vol. 273, page 7367
    - MIZUUCHI, K., Cell, (19830000), vol. 35, page 785
    - SAVILAHTI, H et al., EMBO J., (19950000), vol. 14, page 4893
    - COLEGIO et al., J. Bacteriol., (20010000), vol. 183, pages 2384 - 8
    - KIRBY C et al., Mol. Microbiol., (20020000), vol. 43, pages 173 - 86
    - DEVINE; BOEKE, Nucleic Acids Res., (19940000), vol. 22, pages 3765 - 72
    - CRAIG, N L, Science, (19960000), vol. 271, page 1512
    - CRAIG, N L, Review in: Curr Top Microbiol Immunol., (19960000), vol. 204, pages 27 - 48
    - KLECKNERN et al., Curr Top Microbiol Immunol., (19960000), vol. 204, pages 49 - 82
    - LAMPE D J et al., EMBO J., (19960000), vol. 15, pages 5470 - 9
    - PLASTERK R H, Curr. Topics Microbiol. Immunol., (19960000), vol. 204, pages 125 - 43
    - GLOOR, G B, Methods Mol. Biol., (20040000), vol. 260, pages 97 - 114
    - ICHIKAWA; OHTSUBO, JBiol. Chem, (19900000), vol. 265, pages 18829 - 32
    - OHTSUBO; SEKINE, Curr. Top. Microbiol. Immunol, (19960000), vol. 204, no. 1, page 26
    - BROWN et al., Proc Natl Acad Sci USA, (19890000), vol. 86, pages 2525 - 9
    - BOEKE; CORCES, Annu Rev Microbiol., (19890000), vol. 43, pages 403 - 34
    - ZHANG et al., PLoS Genet., (20091016), vol. 5, page el000689
    - WILSON C. et al., J. Microbiol. Methods, (20070000), vol. 71, pages 332 - 5
    - ADEY et al., Genome Res., (20140000), vol. 24, pages 2041 - 2049
    - LIZARDI et al., Nat. Genet., (19980000), vol. 19, pages 225 - 232
    - DEAN et al., Proc. Natl. Acad. Sci. USA, (20020000), vol. 99, pages 5261 - 66
    - WALKER et al., Nucl. Acids Res., (19920000), vol. 20, pages 1691 - 96
    - LAGE et al., Genome Res., (20030000), vol. 13, pages 294 - 307
    - GROTHUES et al., Nucleic Acids Res., (19930000), vol. 21, no. 5, pages 1321 - 2
    - RONAGHI, M.; KARAMOHAMED, S.; PETTERSSON, B.; UHLEN, M.; NYREN, P., "Real-time DNA sequencing using detection of pyrophosphate release", Analytical Biochemistry, (19960000), vol. 242, no. 1, doi:doi:10.1006/abio.1996.0432, pages 84 - 9, XP002388725

DOI:   http://dx.doi.org/10.1006/abio.1996.0432
    - RONAGHI, M., "Pyrosequencing sheds light on DNA sequencing", Genome Res., (20010000), vol. 11, no. 1, doi:doi:10.1101/gr.11.1.3, pages 3 - 11, XP000980886

DOI:   http://dx.doi.org/10.1101/gr.11.1.3
    - RONAGHI, M.; UHLEN, M.; NYREN, P., "A sequencing method based on real-time pyrophosphate", Science, (19980000), vol. 281, no. 5375, doi:doi:10.1126/science.281.5375.363, page 363, XP002135869

DOI:   http://dx.doi.org/10.1126/science.281.5375.363
    - METZKER, Genome Res., (20050000), vol. 15, pages 1767 - 1776
    - RUPAREL et al., Proc Natl Acad Sci USA, (20050000), vol. 102, pages 5932 - 7
    - DEAMER, D. W.; AKESON, M., "Nanopores and nucleic acids: prospects for ultrarapid sequencing", Trends Biotechnol, (20000000), vol. 18, doi:doi:10.1016/S0167-7799(00)01426-8, pages 147 - 151, XP004194002

DOI:   http://dx.doi.org/10.1016/S0167-7799(00)01426-8
    - DEAMER, D.; D. BRANTON, "Characterization of nucleic acids by nanopore analysis", Acc. Chem. Res., (20020000), vol. 35, doi:doi:10.1021/ar000138m, pages 817 - 825, XP002226144

DOI:   http://dx.doi.org/10.1021/ar000138m
    - LI, J.; M. GERSHOW; D. STEIN; E. BRANDIN; J. A. GOLOVCHENKO, "DNA molecules and configurations in a solid-state nanopore microscope", Nat. Mater., (20030000), vol. 2, doi:doi:10.1038/nmat965, pages 611 - 615, XP009039572

DOI:   http://dx.doi.org/10.1038/nmat965
    - SONI, G. V.; MELLE, "A. Progress toward ultrafast DNA sequencing using solid-state nanopores", Clin. Chem., (20070000), vol. 53, doi:doi:10.1373/clinchem.2007.091231, pages 1996 - 2001, XP055076185

DOI:   http://dx.doi.org/10.1373/clinchem.2007.091231
    - HEALY, K., "Nanopore-based single-molecule DNA analysis", Nanomed., (20070000), vol. 2, doi:doi:10.2217/17435889.2.4.459, pages 459 - 481, XP009111262

DOI:   http://dx.doi.org/10.2217/17435889.2.4.459
    - COCKROFT, S. L.; CHU, J.; AMORIN, M.; GHADIRI, M. R., "A single-molecule nanopore device detects DNA polymerase activity with single-nucleotide resolution", J. Am. Chem. Soc., (20080000), vol. 130, doi:doi:10.1021/ja077082c, pages 818 - 820, XP055097434

DOI:   http://dx.doi.org/10.1021/ja077082c
    - LEVENE, M. J. et al., "Zero-mode waveguides for single-molecule analysis at high concentrations", Science, (20030000), vol. 299, doi:doi:10.1126/science.1079700, pages 682 - 686, XP002341055

DOI:   http://dx.doi.org/10.1126/science.1079700
    - LUNDQUIST, P. M. et al., "Parallel confocal detection of single molecules in real time", Opt. Lett., (20080000), vol. 33, doi:doi:10.1364/OL.33.001026, pages 1026 - 1028, XP001522593

DOI:   http://dx.doi.org/10.1364/OL.33.001026
    - KORLACH, J. et al., "Selective aluminum passivation for targeted immobilization of single DNA polymerase molecules in zero-mode waveguide nano structures", Proc. Natl. Acad. Sci. USA, (20080000), vol. 105, pages 1176 - 1181
    - VITAK et al., Nature Methods, (20170000), vol. 14, pages 302 - 308
    - HA, G. et al., Genome Res., (20120000), vol. 22, pages 1995 - 2007
    - OLSHEN et al., Biostatistics, (20040000), vol. 5, pages 557 - 572
    - KNOUSE et al., Genome Res. gr.198937., (20160000), vol. 115
    - "An integrated encyclopedia of DNA elements in the human genome", Nature, (20120000), vol. 489, pages 57 - 74
    - MCCONNELL, M. J. et al., "Mosaic Copy Number Variation in Human Neurons", Science (80., (20130000), vol. 342, doi:doi:10.1126/science.1243472, pages 632 - 637, XP055150893

DOI:   http://dx.doi.org/10.1126/science.1243472
    - CAI, X. et al., "Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain", Cell Rep., (20140000), vol. 8, pages 1280 - 1289
    - KNOUSE, K. A.; WU, J.; WHITTAKER, C. A.; AMON, A., "Single cell sequencing reveals low levels of aneuploidy across mammalian tissues", Proc Natl Acad Sci USA, (20140000), vol. 111, pages 13409 - 13414
    - REHEN, S. K. et al., "Chromosomal variation in neurons of the developing and adult mammalian nervous system", Proc. Natl. Acad. Sci. U. S. A., (20010000), vol. 98, doi:doi:10.1073/pnas.231487398, pages 13361 - 6, XP003013102

DOI:   http://dx.doi.org/10.1073/pnas.231487398
    - NAVIN, N. et al., "Tumour evolution inferred by single-cell sequencing", Nature, (20110000), vol. 472, doi:doi:10.1038/nature09807, pages 90 - 94, XP055042936

DOI:   http://dx.doi.org/10.1038/nature09807
    - EIREW, P. et al., "Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution", Nature, (20140000), vol. 518, pages 422 - 6
    - GAWAD, C.; KOH, W.; QUAKE, S. R., "Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics", Proc. Natl. Acad. Sci. U. S. A., (20140000), vol. 111, no. 52, page 17947
    - GAO, R. et al., "Punctuated copy number evolution and clonal stasis in triple-negative breast cancer", Nat. Genet., (20160000), vol. 1, page 15
    - ZONG, C.; LU, S.; CHAPMAN, A. R.; XIE, X. S., "Genome-Wide Detection of Single Nucleotide and Copy Number Variations of a Single Human Cell", Science (80-.), (20120000), vol. 338, doi:doi:10.1126/science.1229164, pages 1622 - 1626, XP055183862

DOI:   http://dx.doi.org/10.1126/science.1229164
    - BASLAN, T. et al., "Optimizing sparse sequencing of single cells for highly multiplex copy number profiling", Genome Res, (20150000), vol. 125, doi:doi:10.1101/gr.188060.114, pages 714 - 724, XP055373794

DOI:   http://dx.doi.org/10.1101/gr.188060.114
    - KNOUSE, K. A.; WU, J.; AMON, A., "ssessment of megabase-scale somatic copy number variation using single cell sequencing", Genome Res. gr.198937., (20160000), page 115
    - GAWAD, C.; KOH, W.; QUAKE, S. R., "Single-cell genome sequencing: current state of the science", Nat. Rev. Genet., (20160000), vol. 17, doi:doi:10.1038/nrg.2015.16, pages 175 - 88, XP055370794

DOI:   http://dx.doi.org/10.1038/nrg.2015.16
    - ADEY, A. et al., "Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition", Genome Biol., (20100000), vol. 11, doi:doi:10.1186/gb-2010-11-12-r119, page R119, XP021091768

DOI:   http://dx.doi.org/10.1186/gb-2010-11-12-r119
    - AMINI, S. et al., "Haplotype-resolved whole-genome sequencing by contiguity-preserving transposition and combinatorial indexing", Nat. Genet., (20140000), vol. 46, doi:doi:10.1038/ng.3119, pages 1343 - 9, XP002753798

DOI:   http://dx.doi.org/10.1038/ng.3119
    - ADEY, A. et al., "In vitro, long-range sequence information for de novo genome assembly via transposase contiguity", Genome Res, (20140000), vol. 24, pages 2041 - 2049
    - BUENROSTRO, J. D.; GIRESI, P. G.; ZABA, L. C.; CHANG, H. Y.; GREENLEAF, W. J., "Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position", Nat. Methods, (20130000), vol. 10, doi:doi:10.1038/nmeth.2688, pages 1213 - 8, XP002764310

DOI:   http://dx.doi.org/10.1038/nmeth.2688
    - CUSANOVICH, D. A et al., "Epigenetics. Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing", Science, (20150000), vol. 348, pages 910 - 4
    - STERGACHIS, A. et al., "Developmental fate and cellular maturity encoded in human regulatory DNA landscapes", Cell, (20130000), vol. 154, pages 888 - 903
    - ADEY, A. et al., "The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line", Nature, (20130000), vol. 500, pages 207 - 211
    - MACOSKO, E. Z. et al., "Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets", Cell, (20150000), vol. 161, doi:doi:10.1016/j.cell.2015.05.002, pages 1202 - 1214, XP055323004

DOI:   http://dx.doi.org/10.1016/j.cell.2015.05.002
    - GORYSHIN, I. Y.; MILLER, J. A.; KIL, Y. V.; LANZOV, V. A.; REZNIKOFF, W. S., "Tn5/IS50 target recognition", Proc. Natl. Acad. Sci. USA, (19980000), vol. 95, doi:doi:10.1073/pnas.95.18.10716, pages 10716 - 10721, XP001097740

DOI:   http://dx.doi.org/10.1073/pnas.95.18.10716
    - OLSHEN, A. B.; VENKATRAMAN, E. S.; LUCITO, R.; WIGLER, M., "Circular binary segmentation for the analysis of array-based DNA copy number data", Biostatistics, (20040000), vol. 5, pages 557 - 572
    - HA, G. et al., "Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer", Genome Res., (20120000), vol. 22, pages 1995 - 2007
    - WADDELL, N. et al., "Whole genomes redefine the mutational landscape of pancreatic cancer.", Nature, (20150000), vol. 518, pages 495 - 501
    - DE KOUCHKOVSKY, I.; ABDUL-HAY, M., "Acute myeloid leukemia: a comprehensive review and 2016 update", Blood Cancer J., (20160000), vol. 6, page e441
    - KUMAGAI, T. et al., "Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells", Int J Cancer, (20090000), vol. 124, pages 827 - 833, XP009188447
    - PERKINS, N. D., "Integrating cell-signalling pathways with NF-kappaB and IKK function", Nat. Rev. Mol. Cell Biol, (20070000), vol. 8, pages 49 - 62, XP009150545
    - STAHLEY, S. N.; KOWALCZYK, A. P., "Desmosomes in acquired disease", Cell Tissue Res, (20150000), vol. 360, pages 439 - 56
    - FORBES, S. A. et al., "COSMIC: Exploring the world's knowledge of somatic mutations in human cancer", Nucleic Acids Res, (20150000), vol. 43, doi:doi:10.1093/nar/gku1075, pages D805 - D811, XP055386484

DOI:   http://dx.doi.org/10.1093/nar/gku1075
    - BAILEY, P. et al., "Genomic analyses identify molecular subtypes of pancreatic cancer", Nature, (20160000), vol. 531, pages 47 - 52
    - SOS et al., "Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay", Genome Biol, (20160000), vol. 17, page 20
    - AMINI et al., Nat. Genet., (20140000), vol. 46, pages 143 - 1349
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