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Extract from the Register of European Patents

EP About this file: EP3436025

EP3436025 - METHODS FOR THE SEPARATION AND DETECTION OF AN OXYSTEROL [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.01.2022
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  29.01.2021
FormerGrant of patent is intended
Status updated on  16.09.2020
FormerExamination is in progress
Status updated on  24.06.2020
FormerRequest for examination was made
Status updated on  04.01.2019
FormerThe international publication has been made
Status updated on  07.10.2017
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024 [2024/42]
Applicant(s)For all designated states
Warsaw Orthopedic, Inc.
2500 Silveus Crossing
Warsaw, IN 46581 / US
[2019/06]
Inventor(s)01 / HARRINGTON, Roger, E.
1018 Smoky Oaks Lane
Collierville, TN 38017 / US
02 / JACOBS, Jerbrena, C.
81 Doe Creek Cove
Hernando, MS 38632 / US
 [2019/06]
Representative(s)FRKelly
Waterways House
Grand Canal Quay
Dublin D02 PD39 / IE
[N/P]
Former [2019/06]FRKelly
27 Clyde Road
Dublin D04 F838 / IE
Application number, filing date17776387.727.03.2017
[2019/06]
WO2017US24295
Priority number, dateUS20161508266528.03.2016         Original published format: US201615082665
[2019/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017172612
Date:05.10.2017
Language:EN
[2017/40]
Type: A1 Application with search report 
No.:EP3436025
Date:06.02.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 05.10.2017 takes the place of the publication of the European patent application.
[2019/06]
Type: B1 Patent specification 
No.:EP3436025
Date:03.03.2021
Language:EN
[2021/09]
Search report(s)International search report - published on:US05.10.2017
(Supplementary) European search report - dispatched on:EP08.10.2019
ClassificationIPC:A61K31/575, C07J3/00, C12P7/64, G01N21/67, G01N30/89, G01N33/74
[2019/45]
CPC:
A61K31/575 (EP,US); G01N33/743 (EP,US)
Former IPC [2019/06]A61K31/575, C07J3/00, C12P7/64, G01N21/67, G01N30/89
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/06]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:VERFAHREN ZUR TRENNUNG ODER DETEKTION EINES OXYSTEROLS[2019/06]
English:METHODS FOR THE SEPARATION AND DETECTION OF AN OXYSTEROL[2019/06]
French:PROCÉDÉS DE SÉPARATION ET DE DÉTECTION D'UN OXYSTÉROL[2019/06]
Entry into regional phase17.10.2018National basic fee paid 
17.10.2018Search fee paid 
17.10.2018Designation fee(s) paid 
17.10.2018Examination fee paid 
Examination proceduredeletedDate on which the examining division has become responsible
17.10.2018Examination requested  [2019/06]
18.05.2020Amendment by applicant (claims and/or description)
29.06.2020Despatch of a communication from the examining division (Time limit: M02)
27.08.2020Reply to a communication from the examining division
17.09.2020Communication of intention to grant the patent
26.01.2021Fee for grant paid
26.01.2021Fee for publishing/printing paid
26.01.2021Receipt of the translation of the claim(s)
Divisional application(s)EP21153543.0  / EP3827833
Opposition(s)06.12.2021No opposition filed within time limit [2022/06]
Fees paidRenewal fee
22.03.2019Renewal fee patent year 03
20.03.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.03.2017
AL03.03.2021
AT03.03.2021
CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
ES03.03.2021
FI03.03.2021
HR03.03.2021
IT03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
MK03.03.2021
MT03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
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IE27.03.2021
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BE31.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
[2024/42]
Former [2024/23]HU27.03.2017
AL03.03.2021
AT03.03.2021
CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
ES03.03.2021
FI03.03.2021
HR03.03.2021
IT03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
MK03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
RS03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
SM03.03.2021
IE27.03.2021
LU27.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2023/33]HU27.03.2017
AL03.03.2021
AT03.03.2021
CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
ES03.03.2021
FI03.03.2021
HR03.03.2021
IT03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
RS03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
SM03.03.2021
IE27.03.2021
LU27.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2023/30]AL03.03.2021
AT03.03.2021
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CZ03.03.2021
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EE03.03.2021
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FI03.03.2021
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IT03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
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SK03.03.2021
SM03.03.2021
IE27.03.2021
LU27.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
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GR04.06.2021
IS03.07.2021
PT05.07.2021
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IE27.03.2021
LU27.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/23]AL03.03.2021
AT03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
ES03.03.2021
FI03.03.2021
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MC03.03.2021
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PL03.03.2021
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IE27.03.2021
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CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/22]AL03.03.2021
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CZ03.03.2021
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NL03.03.2021
PL03.03.2021
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RS03.03.2021
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SI03.03.2021
SK03.03.2021
SM03.03.2021
IE27.03.2021
LU27.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
GB03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2022/11]AL03.03.2021
AT03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
ES03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
RS03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
SM03.03.2021
IE27.03.2021
LU27.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2022/10]AL03.03.2021
AT03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
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FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
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SM03.03.2021
IE27.03.2021
LU27.03.2021
CH31.03.2021
LI31.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2022/08]AL03.03.2021
AT03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
ES03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
RS03.03.2021
SE03.03.2021
SK03.03.2021
SM03.03.2021
IE27.03.2021
LU27.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/07]AL03.03.2021
AT03.03.2021
CZ03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
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SE03.03.2021
SK03.03.2021
SM03.03.2021
IE27.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2021/51]AT03.03.2021
CZ03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
NL03.03.2021
PL03.03.2021
RO03.03.2021
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SE03.03.2021
SK03.03.2021
SM03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2021/50]AT03.03.2021
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SE03.03.2021
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SM03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2021/48]AT03.03.2021
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PL03.03.2021
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Documents cited:Search[Y]  - SCOTT R MONTGOMERY ET AL, "A Novel Osteogenic Oxysterol Compound for Therapeutic Development to Promote Bone Growth: Activation of Hedgehog Signaling and Osteogenesis Through Smoothened Binding", JOURNAL OF BONE AND MINERAL RESEARCH, US, (20140721), vol. 29, no. 8, doi:10.1002/jbmr.2213, ISSN 0884-0431, pages 1872 - 1885, XP055627151 [Y] 1-15 * page 1874 * * abstract *

DOI:   http://dx.doi.org/10.1002/jbmr.2213
 [Y]  - ROHINI NARAYANASWAMY ET AL, "Simultaneous Determination of Oxysterols, Cholesterol and 25-Hydroxy-Vitamin D3 in Human Plasma by LC-UV-MS", PLOS ONE, (20150413), vol. 10, no. 4, doi:10.1371/journal.pone.0123771, page e0123771, XP055627175 [Y] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pone.0123771
 [Y]  - HIROSHI SUGIMOTO ET AL, "Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode : Liquid Chromatography", JOURNAL OF SEPARATION SCIENCE., DE, (20150910), vol. 38, no. 20, doi:10.1002/jssc.201500719, ISSN 1615-9306, pages 3516 - 3524, XP055627174 [Y] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1002/jssc.201500719
 [Y]  - JOS F. BROUWERS ET AL, "Mass Spectrometric Detection of Cholesterol Oxidation in Bovine Sperm", BIOLOGY OF REPRODUCTION, US, (20111117), vol. 85, no. 1, doi:10.1095/biolreprod.111.091207, ISSN 0006-3363, pages 128 - 136, XP055627176 [Y] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1095/biolreprod.111.091207
 [Y]  - INES BURKARD ET AL, "Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry", JOURNAL OF LIPID RESEARCH, US, (20040116), vol. 45, no. 4, doi:10.1194/jlr.D300036-JLR200, ISSN 0022-2275, pages 776 - 781, XP055627179 [Y] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1194/jlr.D300036-JLR200
 [Y]  - MUTEMBEREZI VALENTIN ET AL, "Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols, endocannabinoids, and ceramides: variations in metabolic syndrome", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER, DE, vol. 408, no. 3, doi:10.1007/S00216-015-9150-Z, ISSN 1618-2642, (20151112), pages 733 - 745, (20151112), XP035867861 [Y] 1-8 * abstract *

DOI:   http://dx.doi.org/10.1007/s00216-015-9150-z
 [Y]  - HAZOTTE ET AL, "Comparison of universal detectors for high-temperature micro liquid chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, (20071011), vol. 1170, no. 1-2, doi:10.1016/J.CHROMA.2007.09.008, ISSN 0021-9673, pages 52 - 61, XP022296350 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.chroma.2007.09.008
 [Y]  - GRZEGORZ KIELBOWICZ ET AL, "Separation and Quantification of Phospholipid and Neutral Lipid Classes by HPLC-CAD: Application to Egg Yolk Lipids", JOURNAL OF LIQUID CHROMATOGRAPHY AND RELATED TECHNOLOGIES, US, (20150219), vol. 38, no. 8, doi:10.1080/10826076.2014.991869, ISSN 1082-6076, pages 898 - 903, XP055627207 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1080/10826076.2014.991869
 [Y]  - ROBERT A. MOREAU, "The analysis of lipids via HPLC with a charged aerosol detector", LIPIDS, DE, (20060701), vol. 41, no. 7, doi:10.1007/s11745-006-5024-7, ISSN 0024-4201, pages 727 - 734, XP055627205 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1007/s11745-006-5024-7
International search[A]US2015001018  (KARIYAMA OSAMU [JP], et al) [A] 1-20 * entire document *;
 [A]US2015118277  (PARHAMI FARHAD [US], et al) [A] 1-20 * entire document *;
 [A]US2015140059  (PARHAMI FARHAD [US], et al) [A] 1-20 * entire document *;
 [PX]US2016159848  (HARRINGTON ROGER E [US], et al) [PX] 1-20* entire document *
by applicantUS6568245
 WO2013169399
    - SCOTT R MONTGOMERY et al., Journal of Bone and Mineral Research, (20140000), vol. 29, pages 1872 - 1885
    - ROHINI NARAYANASWAMY et al., PLOS ONE, (20150000), vol. 10
    - HIROSHI SUGIMOTO, Journal of Separation Science, (20150000), vol. 38, pages 3516 - 3524
    - JOS F. BROUWERS et al., Biology of Reproduction, (20110000), vol. 85, pages 128 - 136
    - INES BURKARD et al., Journal of Lipid Research, (20040000), vol. 45, pages 776 - 781
    - VALENTIN MUTEMBEREZI et al., Analytical and Bioanalytical Chemistry, (20160000), vol. 408, pages 733 - 745
    - AURELIE HAZOTTE et al., Journal of Chromatography A., (20070000), vol. 1170, pages 52 - 61
    - GRZEGORZ KIELBOWICZ et al., Journal of Liquid Chromatography and Related Technologies, (20150000), vol. 38, pages 898 - 903
    - ROBERT A. MOREAU, Lipids, (20060000), vol. 41, pages 727 - 734
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.