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Extract from the Register of European Patents

EP About this file: EP3452451

EP3452451 - INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  25.10.2019
Database last updated on 15.06.2024
FormerRequest for examination was made
Status updated on  08.02.2019
FormerThe international publication has been made
Status updated on  10.11.2017
Most recent event   Tooltip25.10.2019Withdrawal of applicationpublished on 27.11.2019  [2019/48]
Applicant(s)For all designated states
Bristol-Myers Squibb Company
Route 206 and Province Line Road
Princeton, NJ 08543 / US
[2019/11]
Inventor(s)01 / WILLIAMS, David, K.
Route 206&Province Line Road
Princeton, NJ 08543 / US
02 / SHAN, Weifang
Route 206&Province Line Road
Princeton, NJ 08543 / US
03 / ZHANG, Liping
Route 206&Province Line Road
Princeton, NJ 08543 / US
04 / CHERNEY, Emily, Charlotte
Route 206&Province Line Road
Princeton, NJ 08543 / US
05 / BALOG, James, Aaron
Route 206&Province Line Road
Princeton, NJ 08543 / US
 [2019/11]
Representative(s)Reitstötter Kinzebach
Patentanwälte
Sternwartstraße 4
81679 München / DE
[N/P]
Former [2019/11]Reitstötter Kinzebach
Patentanwälte
Sternwartstrasse 4
81679 München / DE
Application number, filing date17793316.504.05.2017
[2019/11]
WO2017US30997
Priority number, dateUS201662331871P04.05.2016         Original published format: US 201662331871 P
[2019/11]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017192813
Date:09.11.2017
Language:EN
[2017/45]
Type: A1 Application with search report 
No.:EP3452451
Date:13.03.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 09.11.2017 takes the place of the publication of the European patent application.
[2019/11]
Search report(s)International search report - published on:US09.11.2017
(Supplementary) European search report - dispatched on:EP10.10.2019
ClassificationIPC:C07D213/84, C07D241/42, A61K31/444, A61K31/496, A61K31/4709, A61K31/47, A61P35/00, C07D215/14, C07D215/18, C07D215/46, C07D401/04, C07D401/06
[2019/46]
CPC:
C07D401/04 (EP,KR,US); C07D215/14 (EP,KR,US); A61K31/444 (EP,US);
A61K31/47 (EP,US); A61K31/4709 (EP,KR,US); A61K31/496 (EP,US);
A61P35/00 (EP,KR,US); C07D215/18 (EP,US); C07D215/46 (EP,KR,US);
C07D401/06 (EP,KR,US) (-)
Former IPC [2019/11]C07D213/84, C07D241/42
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/11]
TitleGerman:INHIBITOREN DER INDOLEAMIN-2,3-DIOXYGENASE UND VERFAHREN ZU DEREN VERWENDUNG[2019/11]
English:INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE[2019/11]
French:INHIBITEURS D'INDOLEAMINE 2,3-DIOXYGÉNASE ET LEURS MÉTHODES D'UTILISATION[2019/11]
Entry into regional phase21.11.2018National basic fee paid 
21.11.2018Search fee paid 
21.11.2018Designation fee(s) paid 
21.11.2018Examination fee paid 
Examination proceduredeletedDate on which the examining division has become responsible
21.11.2018Examination requested  [2019/11]
18.06.2019Amendment by applicant (claims and/or description)
22.10.2019Application withdrawn by applicant  [2019/48]
Fees paidRenewal fee
15.05.2019Renewal fee patent year 03
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]US2007004763  (BAINDUR NAND [US], et al) [X] 1,2,4-7,9-11,13,15 * [0006]; [0080]-[0097]; [0100]; page 14, Scheme 1; page 15, Scheme 3; examples, e.g. Examples 5, 6; [0583], activity data for compounds 5 and 6; [0588]; [0594]; [0605]; claims *;
 [Y]WO2014001247  (BAYER PHARMA AG [DE]) [Y] 1-15 * page 1, lines 1-4; examples, e.g. Examples 3 or 9; pages 44-45, IC50 values, e.g. IC50 of Example 3 or Example 9; see also pages 45, Table, IC50 for Example 9; page 46, Table and, for example, IC50 for Example 9; page 47, "Proliferation assay with LNCaP cells, for example see Example 3; page 48, "proliferation assay with LAPC-4 cells", Example 9; claims *;
 [X]WO2015188085  (FLEXUS BIOSCIENCES INC [US]) [X] 1-15 * [0011]; [0279]; [0281]; [0294]; [0318]-[0329]; [0364] *;
 [X]  - MEENA V. PATEL ET AL, "Discovery of 3-Methyl- N -(1-oxy-3',4',5',6'-tetrahydro-2' H -[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D 4 Agonist for the Treatment of Erectile Dysfunction", JOURNAL OF MEDICINAL CHEMISTRY, US, (2006), vol. 49, no. 25, doi:10.1021/jm060662k, ISSN 0022-2623, pages 7450 - 7465, XP055463963 [X] 1,3-7,9,10,13 * page 7453, Table 1, compound 5a, 5c, 5h; Experimental section, "General Procedure for Compounds 5a-s *

DOI:   http://dx.doi.org/10.1021/jm060662k
 [Y]  - MORELAND ET AL, "A-412997 is a selective dopamine D"4 receptor agonist in rats", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, ELSEVIER, US, (2005), vol. 82, no. 1, doi:10.1016/J.PBB.2005.08.001, ISSN 0091-3057, pages 140 - 147, XP005101940 [Y] 1-15 * page 141, A-412997.0 *

DOI:   http://dx.doi.org/10.1016/j.pbb.2005.08.001
 [Y]  - RAGHUPATHI R K ET AL, "ANALOGUES OF THE 5-HT1A SEROTONIN ANTAGONIST 1-(2-METHOXYPHENYL)-4- 4-(2-PHTHALIMIDO)BUTYL3?4PIPERAZINE WITH REDUCED ALPHA1-ADRENERGIC AFFINITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (1991), vol. 34, no. 8, doi:10.1021/JM00112A043, ISSN 0022-2623, pages 2633 - 2638, XP000986140 [Y] 1-15 * page 2634, compound 2k *

DOI:   http://dx.doi.org/10.1021/jm00112a043
International search[Y]WO2015188085  (FLEXUS BIOSCIENCES INC [US]) [Y] 1-3, 4/1-3, 7/1-3, 16 * ; abstract; paragraphs [0048], [0053]-[0055], [0058], [0110]-[0111] *;
 [Y]US2016022619  (BALOG JAMES AARON [US], et al) [Y] 1-3, 4/1-3, 7/1-3 * ; abstract; paragraphs [0013], [0015] *;
 [Y]WO2015006520  (SQUIBB BRISTOL MYERS CO [US]) [Y] 1, 16 * ; abstract; page 3, formula I; page 4, second and third paragraphs *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.