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Extract from the Register of European Patents

EP About this file: EP3458107

EP3458107 - POLYNUCLEOTIDES ENCODING JAGGED1 FOR THE TREATMENT OF ALAGILLE SYNDROME [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  09.02.2024
Database last updated on 14.06.2024
FormerGrant of patent is intended
Status updated on  04.10.2023
FormerExamination is in progress
Status updated on  10.03.2023
FormerRequest for examination was made
Status updated on  22.02.2019
FormerThe international publication has been made
Status updated on  25.11.2017
Most recent event   Tooltip09.02.2024(Expected) grantpublished on 13.03.2024  [2024/11]
Applicant(s)For all designated states
ModernaTX, Inc.
200 Technology Square
Cambridge, MA 02139 / US
[2019/13]
Inventor(s)01 / BENENATO, Kerry
415 Lincoln Road
Sudbury MA 01776 / US
02 / HOGE, Stephen
66 Summit Avenue
Brookline MA 02446 / US
03 / MARTINI, Paolo
97 W. Springfield Street 1
Boston MA 02118 / US
04 / MCFADYEN, Iain
11 Amherst Street
Arlington MA 02474 / US
05 / PRESNYAK, Vladimir
123 Webster Avenue 3
Cambridge MA 02141 / US
06 / AN, Ding
572 Quinobequin Road
Waban MA 02468 / US
07 / KUMARASINGHE, Ellalahewage, Sathyajith
15 Littleton Road 4B
Harvard MA 01451 / US
 [2019/13]
Representative(s)Mathys & Squire
The Shard
32 London Bridge Street
London SE1 9SG / GB
[2024/11]
Former [2019/13]Miller, David James, et al
Mathys & Squire LLP The Shard
32 London Bridge Street
London SE1 9SG / GB
Application number, filing date17800205.118.05.2017
[2019/13]
WO2017US33413
Priority number, dateUS201662338170P18.05.2016         Original published format: US 201662338170 P
[2019/13]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017201342
Date:23.11.2017
Language:EN
[2017/47]
Type: A1 Application with search report 
No.:EP3458107
Date:27.03.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 23.11.2017 takes the place of the publication of the European patent application.
[2019/13]
Type: B1 Patent specification 
No.:EP3458107
Date:13.03.2024
Language:EN
[2024/11]
Search report(s)International search report - published on:AU23.11.2017
(Supplementary) European search report - dispatched on:EP17.01.2020
ClassificationIPC:A61K38/17, A61K38/20, C07H21/02, A61K48/00, C12N15/11, A61P35/00, A61P35/02, A61K9/127, A61K31/7105, A61K9/51, A61K47/10, A61K47/14, A61K47/16, A61K47/22, A61K47/24, A61K47/28, C07K14/705, C12N15/88
[2020/08]
CPC:
C12N15/88 (EP,US); A61K48/0066 (EP,US); A61K47/14 (EP,US);
A61K47/16 (EP,US); A61K47/22 (EP,US); A61K47/24 (EP,US);
A61K48/0041 (EP,US); A61K9/51 (US); A61P35/00 (EP);
A61P35/02 (EP); A61K47/10 (EP,US); A61K47/28 (EP,US);
A61K9/1271 (EP,US); A61K9/5123 (EP,US); C07K14/705 (EP,US) (-)
Former IPC [2019/13]A61K48/00, A61K9/51, A61K47/14, A61K47/16, A61K47/22, A61K47/24, C12N15/12, C12N15/88
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/13]
Extension statesBA14.12.2018
ME14.12.2018
Validation statesMA14.12.2018
MD14.12.2018
TitleGerman:FÜR JAGGED1 CODIERENDE POLYNUKLEOTIDE ZUR BEHANDLUNG VON ALAGILLE-SYNDROM[2019/13]
English:POLYNUCLEOTIDES ENCODING JAGGED1 FOR THE TREATMENT OF ALAGILLE SYNDROME[2019/13]
French:POLYNUCLÉOTIDES CODANT POUR JAGGED1 POUR LE TRAITEMENT DU SYNDROME D'ALAGILLE[2019/13]
Entry into regional phase14.12.2018National basic fee paid 
14.12.2018Search fee paid 
14.12.2018Designation fee(s) paid 
14.12.2018Examination fee paid 
Examination proceduredeletedDate on which the examining division has become responsible
14.12.2018Examination requested  [2019/13]
07.09.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
17.11.2020Amendment by applicant (claims and/or description)
09.03.2023Despatch of a communication from the examining division (Time limit: M04)
26.06.2023Reply to a communication from the examining division
05.10.2023Communication of intention to grant the patent
05.02.2024Fee for grant paid
05.02.2024Fee for publishing/printing paid
05.02.2024Receipt of the translation of the claim(s)
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
17.11.2020Request for further processing filed
17.11.2020Full payment received (date of receipt of payment)
Request granted
26.11.2020Decision despatched
Fees paidRenewal fee
28.05.2019Renewal fee patent year 03
31.03.2020Renewal fee patent year 04
12.05.2021Renewal fee patent year 05
20.03.2022Renewal fee patent year 06
14.03.2023Renewal fee patent year 07
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Documents cited:Search[I]  - ODA T ET AL, "Mutations in the human Jagged1 gene are responsible for Alagille syndrome", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, (19970101), vol. 16, no. 3, doi:10.1038/NG0797-235, ISSN 1061-4036, pages 235 - 242, XP002090587 [I] 1-17 * abstract *

DOI:   http://dx.doi.org/10.1038/ng0797-235
 [I]  - LI L ET AL, "Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, (19970101), vol. 16, no. 3, doi:10.1038/NG0797-243, ISSN 1061-4036, pages 243 - 251, XP002090590 [I] 1-17 * abstract *

DOI:   http://dx.doi.org/10.1038/ng0797-243
 [I]  - YUAN ET AL, "Human Jagged 1 Mutants Cause Liver Defect in Alagille Syndrome by Overexpression of Hepatocyte Growth Factor", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, (20060224), vol. 356, no. 3, doi:10.1016/J.JMB.2005.11.097, ISSN 0022-2836, pages 559 - 568, XP005253371 [I] 1-17 * abstract *

DOI:   http://dx.doi.org/10.1016/j.jmb.2005.11.097
International search[Y]WO2007024708  (UNIV PENNSYLVANIA [US], et al) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-122, and 130-138 * See [0038], [0047], [0069-0076], [0087-0096], [00103], [00118], [00132-3], [00285], Examples 6, 17, 18, 21 and Claims *;
 [Y]WO2014081507  (MODERNA THERAPEUTICS INC [US]) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-122, and 130-138 * See [00106-00199], [00242-00286], [00352-00393], [00444-00447], [00473-00520], Tables 6 and 7, and SEQ ID NO: 5018, 5022, 5030 and 5034 *;
 [Y]WO2014089121  (ICHIM THOMAS [US], et al) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-117, 121, and 130-138 * See [0010-11], [0015], and Claims *;
 [Y]WO2014093574  (MODERNA THERAPEUTICS INC [US]) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-122, and 130-138 * See [00155-00161], [00163-00173], [00176-00182], [00197], [00363-00453], [00462-00477], [00484], [00499-00529], [00703-00710], and Tables 2 and 3 *;
 [Y]WO2014179562  (MASSACHUSETTS INST TECHNOLOGY [US]) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-122, and 130-138 * See [0068-0070], [0088], [0095], [00146], [00156], [00203], [00205], [00218], [00226-00235] and Claims *;
 [Y]WO2016011306  (MODERNA THERAPEUTICS INC [US]) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-122, and 130-138 * See [000422-000634], [000744-000765], [000771], [000779-000932], [0001185-0001186], Tables 2, 3 and 30-34, and SEQ ID NO: 122, 123, 125, 127, 129, 137, 139 143, 177, 181, 185 and 190 *;
 [Y]WO2016061509  (BROAD INST INC [US], et al) [Y] 1-2, 8, 24-33, 37-43, 65-68, 70-114, 116-117, 121, and 130-138;
 [L]  - BOYER-DI PONIO , J. et al., "Biological function of mutant forms of JAGGED 1 proteins in Alagille syndrome: inhibitory effect on Notch signaling", Human Molecular Genetics, (20070000), vol. 16, no. 22, pages 2683 - 92, XP055440301 [L] 0 * Article 6 Objection *

DOI:   http://dx.doi.org/10.1093/hmg/ddm222
by applicantUS5082767
 WO9924595
 WO0018778
 WO0155371
 US6310197
 US6849405
 US2005032730
 US2005059005
 US2005261218
 US7183395
 WO2007024708
 US2007048776
 WO2007025008
 US2007117112
 US2008046192
 US2008076161
 WO2008078180
 US7456273
 US2009093049
 WO2009075886
 US7561973
 US2009226470
 US2010120024
 US2010129877
 US2010293625
 US2011082055
 US2011124100
 WO2012009644
 US8101385
 US8126653
 WO2012099755
 WO2012135805
 WO2012170889
 US8401798
 WO2013039857
 WO2013052523
 US2013115272
 WO2013086354
 EP2610341
 EP2610340
 US2013177581
 US8519110
 WO2013126803
 US2013259923
 WO2013151671
 WO2014028429
 US8710200
 WO2014093924
 US2014200261
 US2014228558
 WO2014164253
 US8999380
 WO2015199952
 WO2017075531
    - BERNICZEI-ROYKO et al., Med Sci Monit., (20140000), vol. 20, pages 476 - 80
    - TURNPENNY et al., Eur J Hum Genet., (20120000), vol. 20, no. 3, pages 251 - 7
    - ODA et al., Nat Genet., (19970000), vol. 16, no. 3, pages 235 - 42
    - "GenBank", Database accession no. NP 000205.1
    - "G enBank", Database accession no. NM 000214.2
    - BOYER et al., Hum Genet., (20050000), vol. 116, no. 6, pages 445 - 53
    - TADA et al., FEES J., (20120000), vol. 279, no. 12, pages 2096 - 107
    - GUARNACCIA C et al., FEES Lett., (20040000), vol. 574, no. 1-3, pages 156 - 60
    - SHIMIZU K et al., Biochem. Biophys. Res. Commun., (20000000), vol. 276, no. 1, pages 385 - 9
    - KRANTZ ID et al., Am. J. Hum. Genet., (19980000), vol. 62, no. 6, pages 1361 - 9
    - GUSTAFSSON et al., Journal/Trends Biotechnol, (20040000), vol. 22, pages 346 - 53
    - VILLALOBOS et al., Joumal/BMC Bioinformatics, (20060000), vol. 7, page 285
    - ALEXOPOULOU et al., Nature, (20010000), vol. 413, pages 732 - 738
    - WANG et al., Nat. Med., (20040000), vol. 10, pages 1366 - 1373
    - DIEBOLD et al., Science, (20040000), vol. 303, pages 1526 - 1529
    - HEMMI et al., Nature, (20000000), vol. 408, pages 740 - 745
    - DIEBOLD et al., Eur. J. Immunol., (20060000), vol. 36, pages 3256 - 3267
    - KARIKO et al., Immunity, (20050000), vol. 23, pages 165 - 175
    - KORMANN et al., Nature Biotechnology, (20100000), vol. 29, pages 154 - 157
    - GUSTAFSSON et al., Protein Expression and Purification, (20120000), vol. 83, pages 37 - 46
    - COMERONAGUADE, J. Mol. Evol., (19980000), vol. 47, pages 268 - 74
    - IKEMURA, J. Mol. Biol., (19810000), vol. 151, no. 3, pages 389 - 409
    - FOXERIL, DNA Res., (20100000), vol. 17, no. 3, pages 185 - 96
    - SHARPLI, Nucleic Acids Res., (19870000), vol. 15, no. 3, pages 1281 - 95
    - SUZUKI et al., DNA Res., (20080000), vol. 15, no. 6, pages 357 - 65
    - SANDHU et al., In Silico Biol., (20080000), vol. 8, no. 2, pages 187 - 92
    - WELCH et al., PLoS ONE, (20090000), vol. 4, no. 9, page e7002
    - CHUNG et al., BMC Systems Biology, (20120000), vol. 6, page 134
    - KIM et al., Nature, (19910000), vol. 351, no. 6324, pages 331 - 2
    - QUERIDO et al., J. Cell Sci., (20140000), vol. 124, pages 1703 - 1714
    - MANDALROSSI, Nat. Protoc., (20130000), vol. 8, no. 3, pages 568 - 82
    - YAKUBOV et al., Biochem. Biophys. Res. Commun., (20100000), vol. 394, no. 1, pages 189 - 193
    - CHAPPELL et al., PNAS, (20040000), vol. 101, pages 9590 - 9594
    - KEDDE et al., "A Pumilio-induced RNA structure switch in p27-3 UTR controls miR-221 and miR-22 accessibility", Nature Cell Biology, (20100000), vol. 12, no. 10, pages 1014 - 20
    - GRIMSON AFARH KKJOHNSTON WKGARRETT-ENGELE PLIM LPBARTEL DP, Mol Cell., (20070706), vol. 27, no. 1, pages 91 - 105
    - BONAUER et al., Curr Drug Targets, (20100000), vol. 11, pages 943 - 949
    - ANANDCHERESH, Curr Opin Hematol, (20110000), vol. 18, pages 171 - 176
    - CONTRERASRAO, Leukemia, (20111220), vol. 26, pages 404 - 413
    - BARTEL, Cell, (20090000), vol. 136, pages 215 - 233
    - LANDGRAFET, Cell, (20070000), vol. 129, pages 1401 - 1414
    - GENTNERNALDINI, Tissue Antigens, (20120000), vol. 80, pages 393 - 403
    - ANNONI A et al., blood, (20090000), vol. 114, pages 5152 - 5161
    - BROWN BD et al., Nat med., (20060000), vol. 12, no. 5, pages 585 - 591
    - BROWN BD et al., blood, (20070000), vol. 110, no. 13, pages 4144 - 4152
    - JIMA DD et al., Blood, (20100000), vol. 116, pages e118 - e127
    - VAZ C et al., BMC Genomics, (20100000), vol. 11, page 288
    - VOELLENKLE C et al., RNA, (20120000), vol. 18, pages 472 - 484
    - KUPPUSAMY KT et al., Curr. Mol Med, (20130000), vol. 13, no. 5, pages 757 - 764
    - VIDIGAL JAVENTURA A, Semin Cancer Biol., (20120000), vol. 22, no. 5-6, pages 428 - 436
    - GOFF LA et al., PLoS One, (20090000), vol. 4, page e7192
    - MORIN RD et al., Genome Res, (20080000), vol. 18, pages 610 - 621
    - YOO JK et al., Stem Cells Dev., (20120000), vol. 21, no. 11, pages 2049 - 2057
    - BAR M et al., Stem cells, (20080000), vol. 26, pages 2496 - 2505
    - MEIJER HA et al., Science, (20130000), vol. 340, pages 82 - 85
    - MATSUDA et al., PLoS One, (20100000), vol. 11, no. 5, page e15057
    - KORE et al., Bioorganic & Medicinal Chemistry, (20130000), vol. 21, pages 4570 - 4574
    - JUNJIE LI et al., Current Biology, (20050823), vol. 15, pages 1501 - 1507
    - TOURIOL et al., Biology of the Cell, (20030000), vol. 95, pages 169 - 178
    - MATSUDAMAURO, PLoS ONE, (20100000), vol. 5, page 11
    - BRIEBA et al., Biochemistry, (20020000), vol. 41, pages 5144 - 5149
    - ESVELT et al., Nature, (20110000), vol. 472, no. 7344, pages 499 - 503
    - CHENG et al., PNAS, (19940000), vol. 91, pages 5695 - 5699
    - SZEBENI, Molecular Immunology, (20140000), vol. 61, pages 163 - 173
 WO2014US21522
 WO2016US00129
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.