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Extract from the Register of European Patents

EP About this file: EP3535402

EP3535402 - LENT-ON-PLUS SYSTEM FOR CONDITIONAL EXPRESSION IN HUMAN STEM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.04.2024
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  05.05.2023
FormerGrant of patent is intended
Status updated on  19.06.2022
FormerExamination is in progress
Status updated on  28.03.2020
FormerRequest for examination was made
Status updated on  09.08.2019
FormerThe international publication has been made
Status updated on  11.05.2018
Formerunknown
Status updated on  28.11.2017
Most recent event   Tooltip05.07.2024Lapse of the patent in a contracting state
New state(s): MC		published on 07.08.2024 [2024/32]
Applicant(s)For all designated states
Fundación Pública Andaluza Progreso y Salud
Avda. Américo Vespucio nº 15
Edificio S-2
Parque Científico y Tecnológico Cartuja
41092 Sevilla / ES
[N/P]
Former [2019/37]For all designated states
Fundación Pública Andaluza Progreso Y Salud
Avda. Américo Vespucio nº 15
Edificio S-2
Parque Científico y Tecnológico Cartuja
41092 Sevilla / ES
Inventor(s)01 / MARTÍN MOLINA, Francisco
Avda. Américo Vespucio no. 15, Edificio S-2
Parque Cientifico y Tecnológico Cartuja
41092 Sevilla / ES
02 / BENABDELLAH ELKHLANJI, Karim
Avda. Américo Vespucio no. 15, Edificio S-2
Parque Cientifico y Tecnológico Cartuja
41092 Sevilla / ES
03 / MUÑOZ FERNÁNDEZ, Pilar
Avda. Américo Vespucio no. 15, Edificio S-2
Parque Cientifico y Tecnológico Cartuja
41092 Sevilla / ES
04 / COBO PULIDO, Marién
Avda. Américo Vespucio no. 15, Edificio S-2
Parque Cientifico y Tecnológico Cartuja
41092 Sevilla / ES
 [2019/37]
Representative(s)Hoffmann Eitle
Hoffmann Eitle S.L.U.
Paseo de la Castellana 140, 3a planta
Edificio LIMA
28046 Madrid / ES
[2019/37]
Application number, filing date17800454.503.11.2017
[2019/37]
WO2017EP78246
Priority number, dateES2016003140604.11.2016         Original published format: ES 201631406
[2019/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018083274
Date:11.05.2018
Language:EN
[2018/19]
Type: A1 Application with search report 
No.:EP3535402
Date:11.09.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 11.05.2018 takes the place of the publication of the European patent application.
[2019/37]
Type: B1 Patent specification 
No.:EP3535402
Date:07.06.2023
Language:EN
[2023/23]
Search report(s)International search report - published on:EP11.05.2018
ClassificationIPC:C12N15/86, A61K48/00
[2019/37]
CPC:
C12N15/86 (EP,US); A61K48/00 (EP,US); C07K2319/09 (EP);
C12N2740/15043 (EP,US); C12N2830/003 (EP,US); C12N2830/40 (EP,US);
C12N2830/46 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/37]  
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:LENT-ON-PLUS-SYSTEM ZUR BEDINGTEN EXPRESSION IN MENSCHLICHEN STAMMZELLEN[2019/37]
English:LENT-ON-PLUS SYSTEM FOR CONDITIONAL EXPRESSION IN HUMAN STEM CELLS[2019/37]
French:SYSTÈME LENT-ON-PLUS POUR L'EXPRESSION CONDITIONNELLE DANS DES CELLULES SOUCHES HUMAINES[2019/37]
Entry into regional phase03.06.2019National basic fee paid 
03.06.2019Designation fee(s) paid 
03.06.2019Examination fee paid 
Examination procedure03.06.2019Examination requested  [2019/37]
03.06.2019Date on which the examining division has become responsible
31.12.2019Amendment by applicant (claims and/or description)
01.04.2020Despatch of a communication from the examining division (Time limit: M06)
12.10.2020Reply to a communication from the examining division
25.02.2021Despatch of a communication from the examining division (Time limit: M02)
06.05.2021Reply to a communication from the examining division
20.06.2022Communication of intention to grant the patent
22.11.2022Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
01.02.2023Fee for grant paid
01.02.2023Fee for publishing/printing paid
01.02.2023Receipt of the translation of the claim(s)
Opposition(s)08.03.2024No opposition filed within time limit [2024/20]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
01.02.2023Request for further processing filed
01.02.2023Full payment received (date of receipt of payment)
Request granted
03.02.2023Decision despatched
Fees paidRenewal fee
29.11.2019Renewal fee patent year 03
30.11.2020Renewal fee patent year 04
29.11.2021Renewal fee patent year 05
30.11.2022Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCZ07.06.2023
HR07.06.2023
MC07.06.2023
PL07.06.2023
RO07.06.2023
RS07.06.2023
SK07.06.2023
SM07.06.2023
NO07.09.2023
GR08.09.2023
IS07.10.2023
[2024/32]
Former [2024/10]CZ07.06.2023
HR07.06.2023
PL07.06.2023
RO07.06.2023
RS07.06.2023
SK07.06.2023
SM07.06.2023
NO07.09.2023
GR08.09.2023
IS07.10.2023
Former [2024/08]HR07.06.2023
RS07.06.2023
SK07.06.2023
SM07.06.2023
NO07.09.2023
GR08.09.2023
Former [2023/51]HR07.06.2023
RS07.06.2023
NO07.09.2023
GR08.09.2023
Former [2023/50]NO07.09.2023
GR08.09.2023
Former [2023/48]NO07.09.2023
Cited inInternational search[Y]WO2012156535  (FUNDACION PROGRESO Y SALUD [ES], et al) [Y] 1-28 * abstract * * page 3, line 1 - line 17 * * page 19, line 1 - line 25 * * page 24, line 4 - page 25, line 13 * * page 32, line 15 - line 27; figure 5; examples 3,4; claims 1-35 *;
 [Y]WO2014140218  (FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD [ES], et al) [Y] 1-28 * abstract * * page 3, line 15 - line 27 * * page 5, line 10 - line 22 * * page 12, line 26 - page 13, line 5; figures 4a, 5a; example 4; claims 1-24 *;
 [YD]  - KARIM BENABDELLAH ET AL, "Development of an All-in-One Lentiviral Vector System Based on the Original TetR for the Easy Generation of Tet-ON Cell Lines", PLOS ONE, (20110101), vol. 6, no. 8, doi:10.1371/journal.pone.0023734, ISSN 1932-6203, pages e23734 - e23734, XP055038075 [YD] 1-28 * abstract * * page 8, column 1, paragraph 4 - column 2, paragraph 1; figure 3 *

DOI:   http://dx.doi.org/10.1371/journal.pone.0023734
 [AD]  - KARIM BENABDELLAH ET AL, "A Chimeric HS4-SAR Insulator (IS2) That Prevents Silencing and Enhances Expression of Lentiviral Vectors in Pluripotent Stem Cells", PLOS ONE, (20140106), vol. 9, no. 1, doi:10.1371/journal.pone.0084268, page e84268, XP055127119 [AD] 1-28 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pone.0084268
 [A]  - PLUTA KRZYSZTOF ET AL, "TIGHT CONTROL OF TRANSGENE EXPRESSION BY LENTIVIRUS VECTORS CONTAINING SECOND-GENERATION TETRACYCLINE-RESPONSIVE PROMOTERS", JOURNAL OF GENE MEDI, JOHN WILEY & SONS, INC, US, (20050601), vol. 7, no. 6, doi:10.1002/JGM.712, ISSN 1099-498X, pages 803 - 817, XP009078421 [A] 1-28 * abstract *

DOI:   http://dx.doi.org/10.1002/jgm.712
 [A]  - VAYSSE L ET AL, "Development of a Self-assembling Nuclear Targeting Vector System Based on the Tetracycline Repressor Protein", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 279, no. 7, doi:10.1074/JBC.M311894200, ISSN 0021-9258, (20040213), pages 5555 - 5564, (20031107), XP002509635 [A] 1-28 * abstract *

DOI:   http://dx.doi.org/10.1074/JBC.M311894200
 [XP]  - KARIM BENABDELLAH ET AL, "Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells", SCIENTIFIC REPORTS, (20161117), vol. 6, no. 1, doi:10.1038/srep37289, XP055443844 [XP] 1-28 * the whole document *

DOI:   http://dx.doi.org/10.1038/srep37289
by applicant   - SAMBROOK et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press
 EP20130382080
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.