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Extract from the Register of European Patents

EP About this file: EP3463383

EP3463383 - DIRECT REPROGRAMMING OF A HUMAN SOMATIC CELL TO A SELECTED (PREDETERMINED) DIFFERENTIATED CELL WITH FUNCTIONALIZED NANOPARTICLES [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  04.06.2021
Database last updated on 22.08.2024
FormerRequest for examination was made
Status updated on  08.03.2019
FormerThe international publication has been made
Status updated on  08.12.2017
Most recent event   Tooltip06.08.2024New entry: Additional fee for renewal fee: despatch of communication + time limit 
Applicant(s)For all designated states
Stemgenics, Inc.
454 N 34th Street
Seattle, WA 98103 / US
[2019/15]
Inventor(s)01 / APRIKYAN, Andranik Andrew
454 N. 34th Street
Seattle WA 98103 / US
 [2019/15]
Representative(s)MacLean, Martin Robert
Mathys & Squire The Shard
32 London Bridge Street
London SE1 9SG / GB
[N/P]
Former [2019/15]MacLean, Martin Robert
Mathys & Squire LLP The Shard
32 London Bridge Street
London SE1 9SG / GB
Application number, filing date17807622.002.06.2017
[2019/15]
WO2017US35823
Priority number, dateUS201662345360P03.06.2016         Original published format: US 201662345360 P
[2019/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017210638
Date:07.12.2017
Language:EN
[2017/49]
Type: A1 Application with search report 
No.:EP3463383
Date:10.04.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 07.12.2017 takes the place of the publication of the European patent application.
[2019/15]
Search report(s)International search report - published on:US07.12.2017
(Supplementary) European search report - dispatched on:EP14.01.2020
ClassificationIPC:A61K31/7052, A61K31/7105, A61K38/02, A61K47/55, A61K47/66, A61K35/12, A61K35/30, A61K35/33, A61K35/39, A61K35/407, A61K47/69, C12N5/0793, G01N33/50, C12N5/077, A61K35/34
[2020/07]
CPC:
A61K47/6929 (EP,KR,US); C12N5/0618 (CN); A61K31/7105 (KR);
A61K35/12 (EP,US); A61K35/30 (EP,US); A61K35/33 (EP,US);
A61K35/34 (EP,US); A61K35/39 (EP,US); A61K35/407 (EP,US);
A61K47/65 (KR); A61K47/6923 (EP,KR,US); A61P43/00 (EP);
C12N5/0619 (EP,KR,US); C12N5/0654 (KR); C12N5/0656 (KR);
C12N5/0657 (EP,CN,KR,US); C12N5/067 (CN,KR); C12N5/0696 (CN);
C12Q1/025 (US); G01N33/5044 (EP,KR,US); C12N2501/60 (EP,CN,US);
C12N2501/65 (EP,CN,US); C12N2506/1307 (EP,CN,US); C12N2510/00 (EP,CN,US);
C12N2533/00 (EP,CN,US); C12N2535/00 (EP,CN,US) (-)
Former IPC [2019/15]A61K31/7052, A61K31/7105, A61K38/02, A61K47/55, A61K47/66
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/15]
TitleGerman:DIREKTE UMPROGRAMMIERUNG EINER MENSCHLICHEN SOMATISCHEN ZELLE AUF EINE AUSGEWÄHLTE (VORBESTIMMTE) DIFFERENZIERTE ZELLE MIT FUNKTIONALISIERTEN NANOPARTIKELN[2019/15]
English:DIRECT REPROGRAMMING OF A HUMAN SOMATIC CELL TO A SELECTED (PREDETERMINED) DIFFERENTIATED CELL WITH FUNCTIONALIZED NANOPARTICLES[2019/15]
French:REPROGRAMMATION DIRECTE D'UNE CELLULE SOMATIQUE HUMAINE EN CELLULE DIFFÉRENCIÉE (PRÉDÉTERMINÉE) SÉLECTIONNÉE AVEC DES NANOPARTICULES FONCTIONNALISÉES[2019/15]
Entry into regional phase17.12.2018National basic fee paid 
17.12.2018Search fee paid 
17.12.2018Designation fee(s) paid 
17.12.2018Examination fee paid 
Examination proceduredeletedDate on which the examining division has become responsible
17.12.2018Examination requested  [2019/15]
10.08.2020Amendment by applicant (claims and/or description)
08.06.2021Despatch of a communication from the examining division (Time limit: M06)
16.12.2021Reply to a communication from the examining division
20.03.2023Despatch of a communication from the examining division (Time limit: M06)
29.09.2023Reply to a communication from the examining division
Fees paidRenewal fee
27.06.2019Renewal fee patent year 03
15.06.2020Renewal fee patent year 04
14.06.2021Renewal fee patent year 05
15.06.2022Renewal fee patent year 06
20.12.2023Renewal fee patent year 07
Penalty fee
Additional fee for renewal fee
30.06.202307   M06   Fee paid on   20.12.2023
30.06.202408   M06   Not yet paid
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Documents cited:Search[XI]WO2013059831  (STEMGENICS INC [US]) [X] 1-4,7,10,11 * examples 1-3; claim all * [I] 5,6,12-15;
 [I]US2014087416  (SIMEONOV KAMEN P [US], et al) [I] 1-5,10-15 * paragraph [0129]; example 7 *;
 [XI]  - YIMIN ZHAO ET AL, "Microarc-oxidized titanium surfaces functionalized with microRNA-21-loaded chitosan/hyaluronic acid nanoparticles promote the osteogenic differentiation of human bone marrow mesenchymal stem cells", INTERNATIONAL JOURNAL OF NANOMEDICINE, (20151027), vol. 2015, no. 10, doi:10.2147/IJN.S94689, pages 6675 - 6687, XP055589035 [X] 1-3,10,12,13,15 * abstract * [I] 4-9,11,14

DOI:   http://dx.doi.org/10.2147/IJN.S94689
 [X]  - VAIBHAV PANDIT ET AL, "Multilayered Nanoparticles for Gene Delivery Used to Reprogram Human Foreskin Fibroblasts to Neurospheres", TISSUE ENGINEERING. PART C, METHODS DEC 2008, US, (20150801), vol. 21, no. 8, doi:10.1089/ten.tec.2014.0482, ISSN 1937-3384, pages 786 - 794, XP055358654 [X] 1-5,10-13,15 * abstract *

DOI:   http://dx.doi.org/10.1089/ten.tec.2014.0482
 [X]  - XIAO CHEN ET AL, "Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway", BIOMATERIALS., GB, (20150601), vol. 53, doi:10.1016/j.biomaterials.2015.02.071, ISSN 0142-9612, pages 239 - 250, XP055651275 [X] 1-3,10-13,15 * material and methods;; figure 1 *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2015.02.071
 [I]  - NAOTO MURAOKA ET AL, "Direct Reprogramming of Fibroblasts into Myocytes to Reverse Fibrosis", ANNUAL REVIEW OF PHYSIOLOGY, (20140210), vol. 76, no. 1, doi:10.1146/annurev-physiol-021113-170301, ISSN 0066-4278, pages 21 - 37, XP055138589 [I] 1-4,6,10-15 * material and methods *

DOI:   http://dx.doi.org/10.1146/annurev-physiol-021113-170301
 [I]  - Y.-J. NAM ET AL, "Reprogramming of human fibroblasts toward a cardiac fate", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20130304), vol. 110, no. 14, doi:10.1073/pnas.1301019110, ISSN 0027-8424, pages 5588 - 5593, XP055210948 [I] 1-4,6,10-15 * material and methods;; figure 2 *

DOI:   http://dx.doi.org/10.1073/pnas.1301019110
 [T]  - MIN WEI ET AL, "Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms", JOURNAL OF NANOBIOTECHNOLOGY, (20171025), vol. 15, no. 1, doi:10.1186/s12951-017-0310-5, XP055650869 [T] * the whole document *

DOI:   http://dx.doi.org/10.1186/s12951-017-0310-5
International search[A]US2014315988  (DAHL GARY [US], et al) [A] 1-4, 5/1-4, 6/1-4, 7/1-4, 33-34, 35/33-34* ; entire document *;
 [XY]US2014342004  (APRIKYAN ANDRANIK ANDREW [US], et al) [X] 1-4, 5/1-4, 7/1-4, 33-34, 35/33-34 * ; paragraphs [0009]-[0011], [0089]-[0091] * [Y] 6/1-4;
 [Y]  - ANOKYE-DANSO, F et al., "Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency", Cell Stem Cell, (20110408), vol. 8, no. 4, pages 376 - 388, XP028195323 [Y] 6/1-4 * ; abstract; DOI: 10.1016/j.stem.2011.03.001 *

DOI:   http://dx.doi.org/10.1016/j.stem.2011.03.001
 [Y]  - MYOSHI, N et al., "Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs", Cell Stem Cell, (20110603), vol. 8, no. 6, pages 633 - 638, XP028386705 [Y] 6/1-4 * ; abstract; DOI: 10.1016/j.stem.2011.05.001 *

DOI:   http://dx.doi.org/10.1016/j.stem.2011.05.001
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