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Extract from the Register of European Patents

EP About this file: EP3551639

EP3551639 - NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.06.2024
Database last updated on 24.08.2024
FormerThe patent has been granted
Status updated on  21.07.2023
FormerGrant of patent is intended
Status updated on  23.04.2023
FormerExamination is in progress
Status updated on  17.07.2020
FormerRequest for examination was made
Status updated on  13.09.2019
FormerThe international publication has been made
Status updated on  16.06.2018
Formerunknown
Status updated on  03.01.2018
Most recent event   Tooltip02.08.2024Lapse of the patent in a contracting state
New state(s): SI		published on 04.09.2024 [2024/36]
Applicant(s)For all designated states
Boehringer Ingelheim International GmbH
Binger Strasse 173
55216 Ingelheim am Rhein / DE
[2019/42]
Inventor(s)01 / BISWAS, Soumik
c/o VP IP Legal Boehringer USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
02 / DESROSIERS, Jean-Nicolas
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box368
Ridgefield, Connecticut 06877 / US
03 / LAO, Kendricks
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
04 / MANGUNURU, Hari P.R.
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
05 / QU, Bo
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
06 / RODRIGUEZ, Sonia
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
07 / SENANAYAKE, Chris Hugh
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
08 / SIEBER, Joshua Daniel
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
09 / WANG, Xiao-Jun
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
10 / YEE, Nathan K.
c/o VP IP Legal Boehringer Ingeheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
11 / ZHANG, Yongda
c/o VP IP Legal Boehringer Ingelheim USA Corp.
900 Ridgebury Road
PO Box 368
Ridgefield, Connecticut 06877 / US
 [2019/42]
Representative(s)Schippling, Susanne
Boehringer Ingelheim International GmbH
Binger Straße 173
55216 Ingelheim am Rhein / DE
[2019/42]
Application number, filing date17817612.905.12.2017
[2019/42]
WO2017US64582
Priority number, dateUS201662430375P06.12.2016         Original published format: US 201662430375 P
[2019/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018106621
Date:14.06.2018
Language:EN
[2018/24]
Type: A1 Application with search report 
No.:EP3551639
Date:16.10.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 14.06.2018 takes the place of the publication of the European patent application.
[2019/42]
Type: B1 Patent specification 
No.:EP3551639
Date:23.08.2023
Language:EN
[2023/34]
Search report(s)International search report - published on:EP14.06.2018
ClassificationIPC:C07F9/6581, C07B53/00, C07F15/00, C07F9/6584
[2023/19]
CPC:
C07F9/65844 (EP,US); C07B53/00 (EP,US); C07F15/0073 (EP,US);
C07F9/65811 (EP,US)
Former IPC [2019/42]C07F9/6581, C07B53/00, C07F15/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/42]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:NEUARTIGE CHIRALE DIHYDROBENZOAZAPHOSPHOLLIGANDEN UND SYNTHESE DAVON[2019/42]
English:NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF[2019/42]
French:NOUVEAUX LIGANDS CHIRAUX DE DIHYDROBENZOAZAPHOSPHOLE ET LEUR SYNTHÈSE[2019/42]
Entry into regional phase08.07.2019National basic fee paid 
08.07.2019Designation fee(s) paid 
08.07.2019Examination fee paid 
Examination procedure08.07.2019Examination requested  [2019/42]
08.07.2019Date on which the examining division has become responsible
17.01.2020Amendment by applicant (claims and/or description)
21.07.2020Despatch of a communication from the examining division (Time limit: M06)
20.01.2021Reply to a communication from the examining division
24.08.2021Despatch of a communication from the examining division (Time limit: M06)
24.02.2022Reply to a communication from the examining division
24.04.2023Communication of intention to grant the patent
17.07.2023Fee for grant paid
17.07.2023Fee for publishing/printing paid
17.07.2023Receipt of the translation of the claim(s)
Opposition(s)24.05.2024No opposition filed within time limit [2024/31]
Fees paidRenewal fee
02.01.2020Renewal fee patent year 03
11.01.2021Renewal fee patent year 04
03.01.2022Renewal fee patent year 05
02.01.2023Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT23.08.2023
CZ23.08.2023
DK23.08.2023
EE23.08.2023
ES23.08.2023
FI23.08.2023
HR23.08.2023
IT23.08.2023
LT23.08.2023
LV23.08.2023
NL23.08.2023
PL23.08.2023
RO23.08.2023
RS23.08.2023
SE23.08.2023
SI23.08.2023
SK23.08.2023
SM23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
PT26.12.2023
[2024/36]
Former [2024/26]AT23.08.2023
CZ23.08.2023
DK23.08.2023
EE23.08.2023
ES23.08.2023
FI23.08.2023
HR23.08.2023
IT23.08.2023
LT23.08.2023
LV23.08.2023
NL23.08.2023
PL23.08.2023
RO23.08.2023
RS23.08.2023
SE23.08.2023
SK23.08.2023
SM23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
PT26.12.2023
Former [2024/23]AT23.08.2023
CZ23.08.2023
DK23.08.2023
EE23.08.2023
ES23.08.2023
FI23.08.2023
HR23.08.2023
LT23.08.2023
LV23.08.2023
NL23.08.2023
PL23.08.2023
RO23.08.2023
RS23.08.2023
SE23.08.2023
SK23.08.2023
SM23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
PT26.12.2023
Former [2024/22]AT23.08.2023
CZ23.08.2023
DK23.08.2023
FI23.08.2023
HR23.08.2023
LT23.08.2023
LV23.08.2023
NL23.08.2023
PL23.08.2023
RO23.08.2023
RS23.08.2023
SE23.08.2023
SM23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
PT26.12.2023
Former [2024/20]AT23.08.2023
FI23.08.2023
HR23.08.2023
LT23.08.2023
LV23.08.2023
NL23.08.2023
PL23.08.2023
RS23.08.2023
SE23.08.2023
SM23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
PT26.12.2023
Former [2024/10]AT23.08.2023
FI23.08.2023
HR23.08.2023
LT23.08.2023
LV23.08.2023
NL23.08.2023
PL23.08.2023
RS23.08.2023
SE23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
PT26.12.2023
Former [2024/09]AT23.08.2023
FI23.08.2023
LT23.08.2023
NL23.08.2023
SE23.08.2023
NO23.11.2023
GR24.11.2023
IS23.12.2023
Former [2024/08]LT23.08.2023
NL23.08.2023
NO23.11.2023
GR24.11.2023
Cited inInternational search[YA]WO2011056737  (BOEHRINGER INGELHEIM INT [DE], et al) [Y] 3-5 * 7-oxa-substituted benzophosphazoles as defined by Markush formula (I) of claim 1, dimers thereof (compound 7a) and their use as ligand in catalyzing asymmetric hydrogenation (claim 15) * * Compounds 7c-7d, 8a-8d, 10a-10b, 11a-11b * [A] 6-9;
 [XY]  - CANDICE L. JOE ET AL, "Enantioselective Hydroformylation of Aniline Derivatives", JOURNAL OF ORGANIC CHEMISTRY , 28, 1105-7 CODEN: JOCEAH; ISSN: 0022-3263, (20110916), vol. 76, no. 18, doi:10.1021/jo201328d, ISSN 0022-3263, pages 7590 - 7596, XP055450934 [X] 1,2 * compound 1 * * Use as ligand in enantioselective catalysis of hydroformylation: abstract * [Y] 3-5

DOI:   http://dx.doi.org/10.1021/jo201328d
 [XY]  - THOMAS E LIGHTBURN ET AL, "Catalytic Scaffolding Ligands: An Efficient Strategy for Directing Reactions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 130, no. 29, doi:10.1021/JA803011D, ISSN 0002-7863, (2008), pages 9210 - 9211, (20080625), XP002624449 [X] 1,2 * compounds 2a-2c in table 1 and the use as ligand in asymmetrically catalyzed hydroformylation reactions (table 2) * [Y] 3-5

DOI:   http://dx.doi.org/10.1021/JA803011D
 [XY]  - AMANDA D WORTHY ET AL, "Regioselective Hydroformylation of Sulfonamides using a Scaffolding Ligand", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052,, vol. 11, no. 13, doi:10.1021/OL900921E, ISSN 1523-7060, (2009), pages 2764 - 2767, (20090602), XP002624441 [X] 1,2 * Compound 1 in scheme 1 and the use of this compound as ligand in asymmetric catalysis of hydroformylations (tables 2-3) * [Y] 3-5

DOI:   http://dx.doi.org/10.1021/OL900921E
 [X]  - BHASKAR R. ALURI ET AL, "[pi]-Excess Aromatic [sigma] 2 P Ligands: Formation of a Heterocyclic 1,2-Diphosphine by the Addition of t BuLi and Subsequent Inverse Addition of the Product at the P=C Bonds of Two Molecules of 1-Neopentyl-1,3-benzazaphosphole : [pi]-Excess Aromatic [sigma] 2 P Ligands", HETEROATOM CHEMISTRY, US, (201511), vol. 26, no. 6, doi:10.1002/hc.21277, ISSN 1042-7163, pages 426 - 435, XP055451141 [X] 1,10 * dimeric phosphazole compounds 3, 3a, 3b, 3c (scheme 2) * * compounds 2b, 4, 4b, 4c * * use of compound 3c for complexation and catalytic studies: page 43, conclusions, last sentence *

DOI:   http://dx.doi.org/10.1002/hc.21277
 [X]  - JOACHIM HEINICKE ET AL, "Ambident Reactivity of P?CH-N-Heterocycles: Lithiation and Substitution Sites", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, US, (20110331), vol. 186, no. 4, doi:10.1080/10426507.2010.514486, ISSN 1042-6507, pages 683 - 687, XP055450967 [X] 1 * Compounds 12a,b and 14 *

DOI:   http://dx.doi.org/10.1080/10426507.2010.514486
 [X]  - BHASKAR R ALURI ET AL, "Sterically and Polarity-Controlled Reactions of tBuLi with PCH-NR Heterocycles: Novel Heterocyclic P- and P,O-Ligands and Preliminary Tests in Transition-Metal Catalysis", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 14, no. 14, doi:10.1002/CHEM.200702016, ISSN 0947-6539, (20080509), pages 4328 - 4335, (20080325), XP002624440 [X] 1 * Compounds 4b, 4c, 10b *

DOI:   http://dx.doi.org/10.1002/CHEM.200702016
 [X]  - MOHAMMED GHALIB ET AL, "Solvent-controlled lithiation of PC-N-heterocycles: Synthesis of mono- and bis(trimethylsilyl)-tert-butyl-dihydrobenzazaphospholes - A new type of highly bulky and basic phosphine ligands", JOURNAL OF ORGANOMETALLIC CHEMISTRY., CH, (201408), vol. 763-764, doi:10.1016/j.jorganchem.2014.04.014, ISSN 0022-328X, pages 44 - 51, XP055451131 [X] 1 * Compounds 5b, 6a, 6b, 7a, 7b, 8a, 9b *

DOI:   http://dx.doi.org/10.1016/j.jorganchem.2014.04.014
by applicantUS2004229846
 WO2005087370
 US8552212
 US8946418
 US9096626
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.