EP3551639 - NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 27.06.2024 Database last updated on 24.08.2024 | |
Former | The patent has been granted Status updated on 21.07.2023 | ||
Former | Grant of patent is intended Status updated on 23.04.2023 | ||
Former | Examination is in progress Status updated on 17.07.2020 | ||
Former | Request for examination was made Status updated on 13.09.2019 | ||
Former | The international publication has been made Status updated on 16.06.2018 | ||
Former | unknown Status updated on 03.01.2018 | Most recent event Tooltip | 02.08.2024 | Lapse of the patent in a contracting state New state(s): SI | published on 04.09.2024 [2024/36] | Applicant(s) | For all designated states Boehringer Ingelheim International GmbH Binger Strasse 173 55216 Ingelheim am Rhein / DE | [2019/42] | Inventor(s) | 01 /
BISWAS, Soumik c/o VP IP Legal Boehringer USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 02 /
DESROSIERS, Jean-Nicolas c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box368 Ridgefield, Connecticut 06877 / US | 03 /
LAO, Kendricks c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 04 /
MANGUNURU, Hari P.R. c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 05 /
QU, Bo c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 06 /
RODRIGUEZ, Sonia c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 07 /
SENANAYAKE, Chris Hugh c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 08 /
SIEBER, Joshua Daniel c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 09 /
WANG, Xiao-Jun c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 10 /
YEE, Nathan K. c/o VP IP Legal Boehringer Ingeheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | 11 /
ZHANG, Yongda c/o VP IP Legal Boehringer Ingelheim USA Corp. 900 Ridgebury Road PO Box 368 Ridgefield, Connecticut 06877 / US | [2019/42] | Representative(s) | Schippling, Susanne Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE | [2019/42] | Application number, filing date | 17817612.9 | 05.12.2017 | [2019/42] | WO2017US64582 | Priority number, date | US201662430375P | 06.12.2016 Original published format: US 201662430375 P | [2019/42] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2018106621 | Date: | 14.06.2018 | Language: | EN | [2018/24] | Type: | A1 Application with search report | No.: | EP3551639 | Date: | 16.10.2019 | Language: | EN | The application published by WIPO in one of the EPO official languages on 14.06.2018 takes the place of the publication of the European patent application. | [2019/42] | Type: | B1 Patent specification | No.: | EP3551639 | Date: | 23.08.2023 | Language: | EN | [2023/34] | Search report(s) | International search report - published on: | EP | 14.06.2018 | Classification | IPC: | C07F9/6581, C07B53/00, C07F15/00, C07F9/6584 | [2023/19] | CPC: |
C07F9/65844 (EP,US);
C07B53/00 (EP,US);
C07F15/0073 (EP,US);
C07F9/65811 (EP,US)
|
Former IPC [2019/42] | C07F9/6581, C07B53/00, C07F15/00 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/42] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | NEUARTIGE CHIRALE DIHYDROBENZOAZAPHOSPHOLLIGANDEN UND SYNTHESE DAVON | [2019/42] | English: | NOVEL CHIRAL DIHYDROBENZOAZAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | [2019/42] | French: | NOUVEAUX LIGANDS CHIRAUX DE DIHYDROBENZOAZAPHOSPHOLE ET LEUR SYNTHÈSE | [2019/42] | Entry into regional phase | 08.07.2019 | National basic fee paid | 08.07.2019 | Designation fee(s) paid | 08.07.2019 | Examination fee paid | Examination procedure | 08.07.2019 | Examination requested [2019/42] | 08.07.2019 | Date on which the examining division has become responsible | 17.01.2020 | Amendment by applicant (claims and/or description) | 21.07.2020 | Despatch of a communication from the examining division (Time limit: M06) | 20.01.2021 | Reply to a communication from the examining division | 24.08.2021 | Despatch of a communication from the examining division (Time limit: M06) | 24.02.2022 | Reply to a communication from the examining division | 24.04.2023 | Communication of intention to grant the patent | 17.07.2023 | Fee for grant paid | 17.07.2023 | Fee for publishing/printing paid | 17.07.2023 | Receipt of the translation of the claim(s) | Opposition(s) | 24.05.2024 | No opposition filed within time limit [2024/31] | Fees paid | Renewal fee | 02.01.2020 | Renewal fee patent year 03 | 11.01.2021 | Renewal fee patent year 04 | 03.01.2022 | Renewal fee patent year 05 | 02.01.2023 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 23.08.2023 | CZ | 23.08.2023 | DK | 23.08.2023 | EE | 23.08.2023 | ES | 23.08.2023 | FI | 23.08.2023 | HR | 23.08.2023 | IT | 23.08.2023 | LT | 23.08.2023 | LV | 23.08.2023 | NL | 23.08.2023 | PL | 23.08.2023 | RO | 23.08.2023 | RS | 23.08.2023 | SE | 23.08.2023 | SI | 23.08.2023 | SK | 23.08.2023 | SM | 23.08.2023 | NO | 23.11.2023 | GR | 24.11.2023 | IS | 23.12.2023 | PT | 26.12.2023 | [2024/36] |
Former [2024/26] | AT | 23.08.2023 | |
CZ | 23.08.2023 | ||
DK | 23.08.2023 | ||
EE | 23.08.2023 | ||
ES | 23.08.2023 | ||
FI | 23.08.2023 | ||
HR | 23.08.2023 | ||
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RS | 23.08.2023 | ||
SE | 23.08.2023 | ||
SK | 23.08.2023 | ||
SM | 23.08.2023 | ||
NO | 23.11.2023 | ||
GR | 24.11.2023 | ||
IS | 23.12.2023 | ||
PT | 26.12.2023 | ||
Former [2024/23] | AT | 23.08.2023 | |
CZ | 23.08.2023 | ||
DK | 23.08.2023 | ||
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PL | 23.08.2023 | ||
RO | 23.08.2023 | ||
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SK | 23.08.2023 | ||
SM | 23.08.2023 | ||
NO | 23.11.2023 | ||
GR | 24.11.2023 | ||
IS | 23.12.2023 | ||
PT | 26.12.2023 | ||
Former [2024/22] | AT | 23.08.2023 | |
CZ | 23.08.2023 | ||
DK | 23.08.2023 | ||
FI | 23.08.2023 | ||
HR | 23.08.2023 | ||
LT | 23.08.2023 | ||
LV | 23.08.2023 | ||
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PL | 23.08.2023 | ||
RO | 23.08.2023 | ||
RS | 23.08.2023 | ||
SE | 23.08.2023 | ||
SM | 23.08.2023 | ||
NO | 23.11.2023 | ||
GR | 24.11.2023 | ||
IS | 23.12.2023 | ||
PT | 26.12.2023 | ||
Former [2024/20] | AT | 23.08.2023 | |
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SM | 23.08.2023 | ||
NO | 23.11.2023 | ||
GR | 24.11.2023 | ||
IS | 23.12.2023 | ||
PT | 26.12.2023 | ||
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NO | 23.11.2023 | ||
GR | 24.11.2023 | ||
IS | 23.12.2023 | ||
PT | 26.12.2023 | ||
Former [2024/09] | AT | 23.08.2023 | |
FI | 23.08.2023 | ||
LT | 23.08.2023 | ||
NL | 23.08.2023 | ||
SE | 23.08.2023 | ||
NO | 23.11.2023 | ||
GR | 24.11.2023 | ||
IS | 23.12.2023 | ||
Former [2024/08] | LT | 23.08.2023 | |
NL | 23.08.2023 | ||
NO | 23.11.2023 | ||
GR | 24.11.2023 | Cited in | International search | [YA]WO2011056737 (BOEHRINGER INGELHEIM INT [DE], et al) [Y] 3-5 * 7-oxa-substituted benzophosphazoles as defined by Markush formula (I) of claim 1, dimers thereof (compound 7a) and their use as ligand in catalyzing asymmetric hydrogenation (claim 15) * * Compounds 7c-7d, 8a-8d, 10a-10b, 11a-11b * [A] 6-9; | [XY] - CANDICE L. JOE ET AL, "Enantioselective Hydroformylation of Aniline Derivatives", JOURNAL OF ORGANIC CHEMISTRY , 28, 1105-7 CODEN: JOCEAH; ISSN: 0022-3263, (20110916), vol. 76, no. 18, doi:10.1021/jo201328d, ISSN 0022-3263, pages 7590 - 7596, XP055450934 [X] 1,2 * compound 1 * * Use as ligand in enantioselective catalysis of hydroformylation: abstract * [Y] 3-5 DOI: http://dx.doi.org/10.1021/jo201328d | [XY] - THOMAS E LIGHTBURN ET AL, "Catalytic Scaffolding Ligands: An Efficient Strategy for Directing Reactions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 130, no. 29, doi:10.1021/JA803011D, ISSN 0002-7863, (2008), pages 9210 - 9211, (20080625), XP002624449 [X] 1,2 * compounds 2a-2c in table 1 and the use as ligand in asymmetrically catalyzed hydroformylation reactions (table 2) * [Y] 3-5 DOI: http://dx.doi.org/10.1021/JA803011D | [XY] - AMANDA D WORTHY ET AL, "Regioselective Hydroformylation of Sulfonamides using a Scaffolding Ligand", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052,, vol. 11, no. 13, doi:10.1021/OL900921E, ISSN 1523-7060, (2009), pages 2764 - 2767, (20090602), XP002624441 [X] 1,2 * Compound 1 in scheme 1 and the use of this compound as ligand in asymmetric catalysis of hydroformylations (tables 2-3) * [Y] 3-5 DOI: http://dx.doi.org/10.1021/OL900921E | [X] - BHASKAR R. ALURI ET AL, "[pi]-Excess Aromatic [sigma] 2 P Ligands: Formation of a Heterocyclic 1,2-Diphosphine by the Addition of t BuLi and Subsequent Inverse Addition of the Product at the P=C Bonds of Two Molecules of 1-Neopentyl-1,3-benzazaphosphole : [pi]-Excess Aromatic [sigma] 2 P Ligands", HETEROATOM CHEMISTRY, US, (201511), vol. 26, no. 6, doi:10.1002/hc.21277, ISSN 1042-7163, pages 426 - 435, XP055451141 [X] 1,10 * dimeric phosphazole compounds 3, 3a, 3b, 3c (scheme 2) * * compounds 2b, 4, 4b, 4c * * use of compound 3c for complexation and catalytic studies: page 43, conclusions, last sentence * DOI: http://dx.doi.org/10.1002/hc.21277 | [X] - JOACHIM HEINICKE ET AL, "Ambident Reactivity of P?CH-N-Heterocycles: Lithiation and Substitution Sites", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, US, (20110331), vol. 186, no. 4, doi:10.1080/10426507.2010.514486, ISSN 1042-6507, pages 683 - 687, XP055450967 [X] 1 * Compounds 12a,b and 14 * DOI: http://dx.doi.org/10.1080/10426507.2010.514486 | [X] - BHASKAR R ALURI ET AL, "Sterically and Polarity-Controlled Reactions of tBuLi with PCH-NR Heterocycles: Novel Heterocyclic P- and P,O-Ligands and Preliminary Tests in Transition-Metal Catalysis", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 14, no. 14, doi:10.1002/CHEM.200702016, ISSN 0947-6539, (20080509), pages 4328 - 4335, (20080325), XP002624440 [X] 1 * Compounds 4b, 4c, 10b * DOI: http://dx.doi.org/10.1002/CHEM.200702016 | [X] - MOHAMMED GHALIB ET AL, "Solvent-controlled lithiation of PC-N-heterocycles: Synthesis of mono- and bis(trimethylsilyl)-tert-butyl-dihydrobenzazaphospholes - A new type of highly bulky and basic phosphine ligands", JOURNAL OF ORGANOMETALLIC CHEMISTRY., CH, (201408), vol. 763-764, doi:10.1016/j.jorganchem.2014.04.014, ISSN 0022-328X, pages 44 - 51, XP055451131 [X] 1 * Compounds 5b, 6a, 6b, 7a, 7b, 8a, 9b * DOI: http://dx.doi.org/10.1016/j.jorganchem.2014.04.014 | by applicant | US2004229846 | WO2005087370 | US8552212 | US8946418 | US9096626 | - KNOWLES, W. S., Acc. Chem. Res., (19830000), vol. 16, page 106 | - KAGAN et al., J. Am. Chem. Soc., (19720000), vol. 94, page 6429 | - NOYORI, R., Chem. Soc. Rev., (19890000), vol. 18, page 187 | - BURK, M. J. et al., Organometallics, (19900000), vol. 9, page 2653 | - BURK, M. J. et al., Angew. Chem., Int. Ed. Engl., (19900000), vol. 29, page 1462 | - IMAMOTO, T. et al., J. Am. Chem. Soc., (19970000), vol. 119, page 1799 | - ZHANG, X. et al., Angew. Chem. Int. Ed. Engl., (19990000), vol. 38, page 516 | - ZHANG, X. et al., Angew. Chem. Int. Ed., (20020000), vol. 41, page 1613 | - HOGE, G. et al., J. Am. Chem. Soc., (20040000), vol. 126, page 5966 |