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EP About this file: EP3483142

EP3483142 - AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  18.12.2020
Database last updated on 02.07.2024
FormerRequest for examination was made
Status updated on  12.04.2019
FormerThe international publication has been made
Status updated on  12.01.2018
Most recent event   Tooltip18.09.2023New entry: Reply to examination report 
Applicant(s)For all designated states
Guangzhou Maxinovel Pharmaceuticals Co., Ltd.
Building G5-616
Southern China New Material Innovation Park
Building Two
31 Kefeng Road, Guangzhou Hitech Park, Guangzhou
Guangdong 510000 / CN
[2019/20]
Inventor(s)01 / WANG, Yuguang
Building G5-616,
Southern China New Material Innovation Park
Building Two, 31 Kefeng Road
Guangzhou Hitech Park
Guangzhou Guangdong 510000 / CN
02 / XU, Zusheng
Building G5-616,
Southern China New Material Innovation Park
Building Two, 31 Kefeng Road
Guangzhou Hitech Park
Guangzhou Guangdong 510000 / CN
03 / WU, Tianzhi
Building G5-616,
Southern China New Material Innovation Park
Building Two, 31 Kefeng Road
Guangzhou Hitech Park
Guangzhou Guangdong 510000 / CN
04 / HE, Min
Building G5-616,
Southern China New Material Innovation Park
Building Two, 31 Kefeng Road
Guangzhou Hitech Park
Guangzhou Guangdong 510000 / CN
05 / ZHANG, Nong
Building G5-616,
Southern China New Material Innovation Park
Building Two, 31 Kefeng Road
Guangzhou Hitech Park
Guangzhou Guangdong 510000 / CN
 [2019/20]
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2019/20]Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Application number, filing date17823607.104.07.2017
[2019/20]
WO2017CN91643
Priority number, dateCN20161052383605.07.2016         Original published format: CN201610523836
[2019/20]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018006795
Date:11.01.2018
Language:ZH
[2018/02]
Type: A1 Application with search report 
No.:EP3483142
Date:15.05.2019
Language:EN
[2019/20]
Search report(s)International search report - published on:CN11.01.2018
(Supplementary) European search report - dispatched on:EP01.04.2019
ClassificationIPC:C07D207/08, A61P35/00, C07D211/60, C07D319/18, C07D231/12, C07D405/04, C07D405/10, C07C215/00, C07D213/38, C07D213/48, A61K31/4025
[2019/20]
CPC:
A61P35/00 (EP,KR,US); C07D405/10 (EP,KR,US); A61K31/165 (KR);
A61K31/357 (KR); A61K31/40 (KR); A61K31/4025 (KR);
A61K31/44 (KR); C07C215/10 (EP,US); C07C217/58 (EP,US);
C07C22/04 (EP,US); C07C22/08 (EP,US); C07C229/22 (EP,US);
C07C229/24 (EP,US); C07C229/64 (EP,US); C07C233/18 (EP,US);
C07C235/84 (EP,US); C07C237/30 (EP,US); C07C25/13 (KR);
C07C25/24 (EP,US); C07C255/56 (EP,US); C07C43/225 (EP,KR,US);
C07C47/548 (EP,KR,US); C07C47/55 (EP,US); C07C47/575 (EP,KR,US);
C07C69/94 (EP,US); C07D207/08 (EP,KR,US); C07D211/42 (KR);
C07D211/60 (EP,KR,US); C07D213/36 (KR); C07D213/38 (EP,US);
C07D213/48 (EP,US); C07D213/64 (KR); C07D231/10 (US);
C07D231/12 (EP,US); C07D319/18 (EP,KR,US); C07D405/04 (EP,US);
C07B2200/07 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/20]
TitleGerman:AROMATISCHES ACETYLEN ODER AROMATISCHE ETHYLENVERBINDUNG, ZWISCHENPRODUKT, HERSTELLUNGSVERFAHREN, PHARMAZEUTISCHE ZUSAMMENSETZUNG UND VERWENDUNG DAVON[2019/20]
English:AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF[2019/20]
French:COMPOSÉ D'ACÉTYLÈNE AROMATIQUE OU D'ÉTHYLÈNE AROMATIQUE, PRODUIT INTERMÉDIAIRE, PROCÉDÉ DE PRÉPARATION, COMPOSITION PHARMACEUTIQUE ET LEUR UTILISATION[2019/20]
Entry into regional phase05.02.2019Translation filed 
05.02.2019National basic fee paid 
05.02.2019Search fee paid 
05.02.2019Designation fee(s) paid 
05.02.2019Examination fee paid 
Examination procedure05.02.2019Examination requested  [2019/20]
25.10.2019Amendment by applicant (claims and/or description)
17.12.2020Despatch of a communication from the examining division (Time limit: M04)
21.04.2021Reply to a communication from the examining division
07.12.2021Despatch of a communication from the examining division (Time limit: M04)
14.04.2022Reply to a communication from the examining division
22.03.2023Despatch of a communication from the examining division (Time limit: M06)
15.09.2023Reply to a communication from the examining division
Fees paidRenewal fee
16.07.2019Renewal fee patent year 03
26.07.2020Renewal fee patent year 04
14.07.2021Renewal fee patent year 05
18.07.2022Renewal fee patent year 06
20.07.2023Renewal fee patent year 07
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Documents cited:Search[X]WO9804528  (BAYER AG [US], et al) [X] 1-7,9,15 * example 225; claims 1, 7 *;
 [X]WO0153268  (AGOURON PHARMA [US]) [X] 1,3-8,13-15 * examples 53, 58, 61, 65, 68, 69, 71; claims 1, 6, 7 *;
 [X]WO0162233  (HOFFMANN LA ROCHE [CH]) [X] 1-9,15 * claims 1, 2; compounds 130, 131, 149, 151 *;
 [X]WO2004014865  (MERCK SHARP & DOHME [GB], et al) [X] 1,3-7,9,15 * claims 1, 7, 8, 10 *;
 [X]WO2011045344  (PF MEDICAMENT [FR], et al) [X] 1,3-7,9,13-15 * claims 1, 8-10; compound 273 *;
 [IA]WO2015034820  (BRISTOL MYERS SQUIBB CO [US]) [I] 1-9,11-15 * claims 1, 10-12 * [A] 10;
 [X]EP2952503  (SHIONOGI & CO [JP]) [X] 1-7 * page 161; compound 95 *;
 [IP]WO2017066227  (BRISTOL MYERS SQUIBB CO [US]) [IP] 1,3-9,11,13-15* page 747 - page 752; example 4517; claims 1, 17, 21 *;
 [X]  - BLY R K ET AL, "Heterocyclic studies. XIII. The aldol condensation of 2,3-dihydro-5-methyL-6-phenyl-4H-1,2diazepin-4-one and rearrangement to a pyridazine", JOURNAL OF ORGANIC CHEMISTRY,, (19640101), vol. 29, no. 8, doi:10.1021/JO01031A005, ISSN 0022-3263, pages 2128 - 2135, XP002257943 [X] 1,3-9 * compound 10 *

DOI:   http://dx.doi.org/10.1021/jo01031a005
 [X]  - IMRAN MALIK ET AL, "Synthesis and Photophysical Properties of Alkynylated Pyrimidines by Site-Selective Sonogashira Reactions of 2,4,5,6-Tetrachloropyrimidine; First Synthesis of Tetraalkynyl-pyrimidines", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, DE, (20110401), vol. 2011, no. 11, doi:10.1002/ejoc.201001622, ISSN 1434-193X, pages 2088 - 2093, XP055571823 [X] 1-7 * compound 8 *

DOI:   http://dx.doi.org/10.1002/ejoc.201001622
 [X]  - PHI-HUNG NGUYEN ET AL, "Insulin-Mimetic Selaginellins from Selaginella tamariscina with Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity", JOURNAL OF NATURAL PRODUCTS, (20150123), vol. 78, no. 1, doi:10.1021/np5005856, ISSN 0163-3864, pages 34 - 42, XP055169698 [X] 1-7 * compounds 4, 5 *

DOI:   http://dx.doi.org/10.1021/np5005856
International search[A]CN105705489  (BRISTOL MYERS SQUIBB CO) [A] 1-19* description, paragraphs [0011]-[0584] *;
 [X]  - LIU JIA-KUO et al., "Design and synthesis of 3, - (prop-2-yn-l-yloxy) -biphenyl substituted cyclic acylguanidine compounds as BACE1 inhibitors", Chinese Chemical Letters, (20160302), vol. 27, no. 6, pages 961 - 963, XP029584546 [X] 1-8, 11 * , see pp. 962 *

DOI:   http://dx.doi.org/10.1016/j.cclet.2016.02.006
 [X]  - LIU JIA-KUO et al., "Design and synthesis of cyclic acylguanidines as BACE1 inhibitors", Chinese Chemical Letters, (20150723), vol. 26, no. 10, pages 1327 - 1330, XP029294987 [X] 1-8, 11 * , see pp. 1329 *

DOI:   http://dx.doi.org/10.1016/j.cclet.2015.07.020
 [X]  - REGISTRY, (20160427), Database accession no. 1899005-22-1, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20150211), Database accession no. 1646560-09-9, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20141211), Database accession no. 1638536-50-1, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20100527), Database accession no. 1225389-46-7, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20100527), Database accession no. 1225389-45-6, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20090130), Database accession no. 1098107-07-3, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20090130), Database accession no. 1098106-07-0, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20090130), Database accession no. 1098104-35-8, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20000508), Database accession no. 263916-95-6, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (19990528), Database accession no. 223654-82-8, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20150908), Database accession no. 1803418-36-1, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20140407), Database accession no. 1581311-49-0, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20140407), Database accession no. 1581311-48-9, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20110324), Database accession no. 1269763-65-6, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20090215), Database accession no. 1106005-31-5, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20090215), Database accession no. 1106005-25-7, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20080922), Database accession no. 1051472-23-1, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20070510), Database accession no. 934537-51-6, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20040116), Database accession no. 638214-15-0, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20110105), Database accession no. 1258410-97-7, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (20000516), Database accession no. 264912-33-6, URL: STN [X] 1-8, 11 * ), *
 [X]  - REGISTRY, (19841116), Database accession no. 52500-13-7, URL: STN [X] 1-8, 11 * ), *
by applicantWO2012168944
 WO2015033299
 WO2015033301
 WO2015034820
 WO2015036927
 WO2015044900
 WO2015160641
    - Eur. J. Immunol., (20020000), vol. 32, no. 3, pages 634 - 643
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