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Extract from the Register of European Patents

EP About this file: EP3554639

EP3554639 - NOVEL RECOMBINANT PROTEIN UK 114 IN STABLE POLYMER FORM FOR USE IN THE TREATMENT OR PREVENTION OF MALIGNANT SOLID AND SYSTEMIC TUMOURS [Right-click to bookmark this link]
Former [2019/43]	NOVEL RECOMBINANT PROTEIN UK 114 IN STABLE POLYMER FORM FOR USE IN THE TREATMENT, DIAGNOSIS AND PREVENTION OF MALIGNANT SOLID AND SYSTEMIC TUMOURS
	[2026/15]
Status	Grant of patent is intended Status updated on 13.03.2026 Database last updated on 28.03.2026
Former	Examination is in progress Status updated on 24.02.2023
Former	Request for examination was made Status updated on 20.09.2019
Former	The international publication has been made Status updated on 23.06.2018
Former	unknown Status updated on 06.02.2018
Most recent event Tooltip	13.03.2026	New entry: Communication of intention to grant a patent
Applicant(s)	For all designated states Bartorelli Cusani, Alberto 7 Avenue Saint Roman 98000 Monte Carlo / MC
	[2019/43]
Inventor(s)	01 / see applicant ...
	[2019/43]
Representative(s)	Bianchetti & Minoja with Trevisan & Cuonzo IPS SRL Via Plinio, 63 20129 Milano / IT
	[N/P]
Former [2019/43]	Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 20129 Milano / IT
Application number, filing date	17835618.4	14.12.2017
	[2019/43]
	WO2017EP82849
Priority number, date	IT20160127428	16.12.2016 Original published format: IT201600127428
	[2019/43]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2018109096
	Date:	21.06.2018
	Language:	EN
	[2018/25]
	Type:	A1 Application with search report
	No.:	EP3554639
	Date:	23.10.2019
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 21.06.2018 takes the place of the publication of the European patent application.
	[2019/43]
Search report(s)	International search report - published on:	EP	21.06.2018
Classification	IPC:	A61K38/50, A61P35/00, A61K38/16, A61K35/66, A61K39/00, A61P37/04	[2026/15]
	CPC:	A61K35/66 (EP); C07K14/47 (US); A61K38/16 (EP); A61K38/50 (EP); A61K39/0011 (EP,US); A61P35/00 (EP,US); (+) A61P37/04 (EP); A61K2039/572 (US); A61K38/00 (US) (-)
	Former IPC [2019/43]	A61P35/00, A61K38/16, A61K35/66
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/43]
Title	German:	NEUARTIGES REKOMBINANTES PROTEIN UK 114 IN STABILER POLYMERFORM ZUR VERWENDUNG IN DER BEHANDLUNG ODER VORBEUGUNG VON SOLIDEN UND SYSTEMISCHEN MALIGNEN TUMOREN	[2026/15]
	English:	NOVEL RECOMBINANT PROTEIN UK 114 IN STABLE POLYMER FORM FOR USE IN THE TREATMENT OR PREVENTION OF MALIGNANT SOLID AND SYSTEMIC TUMOURS	[2026/15]
	French:	NOUVELLE PROTÉINE RECOMBINANTE UK 114 SOUS FORME DE POLYMÈRE STABLE DESTINÉE À ÊTRE UTILISÉE DANS LE TRAITEMENT OU LA PRÉVENTION DE TUMEURS MALIGNES SOLIDES ET SYSTÉMIQUES	[2026/15]
	Former [2019/43]	NEUARTIGES REKOMBINANTES PROTEIN UK 114 IN STABILER POLYMERFORM ZUR VERWENDUNG IN DER BEHANDLUNG, DIAGNOSE UND VORBEUGUNG VON SOLIDEN UND SYSTEMISCHEN MALIGNEN TUMOREN
	Former [2019/43]	NOVEL RECOMBINANT PROTEIN UK 114 IN STABLE POLYMER FORM FOR USE IN THE TREATMENT, DIAGNOSIS AND PREVENTION OF MALIGNANT SOLID AND SYSTEMIC TUMOURS
	Former [2019/43]	NOUVELLE PROTÉINE RECOMBINANTE UK 114 SOUS FORME DE POLYMÈRE STABLE DESTINÉE À ÊTRE UTILISÉE DANS LE TRAITEMENT, LE DIAGNOSTIC ET LA PRÉVENTION DE TUMEURS MALIGNES SOLIDES ET SYSTÉMIQUES
Entry into regional phase	24.06.2019	National basic fee paid
	24.06.2019	Designation fee(s) paid
	24.06.2019	Examination fee paid
Examination procedure	24.06.2019	Examination requested [2019/43]
	24.06.2019	Date on which the examining division has become responsible
	14.01.2020	Amendment by applicant (claims and/or description)
	28.02.2023	Despatch of a communication from the examining division (Time limit: M04)
	18.05.2023	Reply to a communication from the examining division
	31.07.2024	Despatch of a communication from the examining division (Time limit: M04)
	25.11.2024	Reply to a communication from the examining division
	27.11.2025	Despatch of a communication from the examining division (Time limit: M04)
	27.11.2025	Reply to a communication from the examining division
	13.03.2026	Communication of intention to grant the patent
Fees paid	Renewal fee
	18.12.2019	Renewal fee patent year 03
	14.12.2020	Renewal fee patent year 04
	15.12.2021	Renewal fee patent year 05
	14.10.2022	Renewal fee patent year 06
	14.12.2023	Renewal fee patent year 07
	11.12.2024	Renewal fee patent year 08
	18.12.2025	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[XY] WO2004076614 (HINZMANN BERND et al.)
		[XDY] WO0063368 (ZETESIS SPA et al.)
		[Y] WO9943340 (ZETESIS SPA et al.)
		[Y] BUSSOLATI G ET AL: "CYTOLYTIC AND TUMOR INHIBITORY ANTIBODIES AGAINST UK114 PROTEIN IN THE SERA OF CANCER PATIENTS", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 10, no. 4, 1 April 1997 (1997-04-01), pages 779 - 785, XP002040514, ISSN: 1019-6439
		[Y] FUNARO A ET AL: "Identification of a 220-kDa membrane tumor-associated antigen by human anti-UK114 monoclonal antibodies selected from the immunoglobulin repertoire of a cancer patient", EXPERIMENTAL CELL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 247, no. 2, 15 March 1999 (1999-03-15), pages 441 - 450, XP002116994, ISSN: 0014-4827, DOI: 10.1006/EXCR.1998.4384 DOI: http://dx.doi.org/10.1006/excr.1998.4384
		[Y] CECILIANI F ET AL: "THE PRIMARY STRUCTURE OF UK114 TUMOR ANTIGEN", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 393, 16 September 1996 (1996-09-16), pages 147 - 150, XP002040513, ISSN: 0014-5793, DOI: 10.1016/0014-5793(96)00850-2 DOI: http://dx.doi.org/10.1016/0014-5793(96)00850-2
	Examination	WO2004076644
	by applicant	WO9602567
		WO0063368
		BARTORELLI ET AL., J. TUMOR AND MARKER ONCOLOGY, vol. 9, 1994, pages 37
		LAMBRECHT JA ET AL., J.BIOL. CHEM., vol. 285, 2010, pages 34401 - 34407
		LAMBRECHT JA ET AL., J.BIOL. CHEM., vol. 287, 2012, pages 3454 - 3461
		MISTINIENE E ET AL., BIOCONJUGATE CHEM., vol. 14, 2003, pages 1243 - 1252
		DHAWAN L ET AL., MOL. CELL. BIOL., vol. 32, 2012, pages 3768 - 3775
		FLYNN JM ET AL., MOL. MICROBIOL., vol. 89, no. 4, 2013, pages 751 - 759
		ERNST DC ET AL., J. BACTERIOLOGY, vol. 196, no. 18, 2014, pages 3335 - 3342
		NIEHAUS TD ET AL., BMC GENOMICS, vol. 16, 2015, pages 382
		CECILIANI F. ET AL., FEBS LETTERS, vol. 393, 1996, pages 147 - 150
		BARTORELLI A ET AL., INT J ONCOL., vol. 8, no. 3, March 1996 (1996-03-01), pages 543 - 8
		BUSSOLATI G ET AL., INT J ONCOL., vol. 10, no. 4, April 1997 (1997-04-01), pages 779 - 85
		COLOMBO I ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1442, 1998, pages 49 - 59
		BURMAN JD ET AL., BMC STRUCTURAL BIOLOGY, 30 July 2007 (2007-07-30)
		DERIU D ET AL., ACTA CRYST., vol. D59, 2003, pages 1676 - 1678
		OKA ET AL., J.BIOL.CHEM., vol. 270, 1995, pages 30060 - 30067
		COLOMBO I. ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1442, 1998, pages 49 - 59
		COLOMBO I. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA
		INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 8, 1996, pages 543 - 548
		CALOGERO ET AL., BREAST CANCER RESEARCH, vol. 9, 2007, pages 21

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