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Extract from the Register of European Patents

EP About this file: EP3496756

EP3496756 - A LIPOSOMAL POLYGLUTAMATED ANTIFOLATE COMPOSITION COMPRISING AN ALPHA POLYGLUTAMATED ANTIFOLATE AND USES THEREOF [Right-click to bookmark this link]
Former [2019/25]ALPHA AND GAMMA-D POLYGLUTAMATED ANTIFOLATES AND USES THEREOF
[2021/44]
StatusExamination is in progress
Status updated on  21.02.2022
Database last updated on 15.06.2024
FormerGrant of patent is intended
Status updated on  21.10.2021
FormerExamination is in progress
Status updated on  03.04.2021
FormerRequest for examination was made
Status updated on  17.05.2019
FormerThe international publication has been made
Status updated on  17.02.2018
Most recent event   Tooltip16.01.2024New entry: Reply to examination report 
Applicant(s)For all designated states
L.E.A.F Holdings Group LLC
326 Overlook Lane
Gulph Mills, PA 19428 / US
[2019/25]
Inventor(s)01 / NIYIKIZA, Clet
326 Overlook Lane
Gulph Mills, PA 19428 / US
02 / MOYO, Victor, Mandla
2 Neshanic Drive
Ringoes, NJ 08551 / US
 [2019/25]
Representative(s)FRKelly
Waterways House
Grand Canal Quay
Dublin D02 PD39 / IE
[N/P]
Former [2019/25]FRKelly
27 Clyde Road
Dublin D04 F838 / IE
Application number, filing date17840396.012.08.2017
[2019/25]
WO2017US46666
Priority number, dateUS201662374458P12.08.2016         Original published format: US 201662374458 P
US20171567569511.08.2017         Original published format: US201715675695
US20171567570111.08.2017         Original published format: US201715675701
[2019/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018031979
Date:15.02.2018
Language:EN
[2018/07]
Type: A1 Application with search report 
No.:EP3496756
Date:19.06.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 15.02.2018 takes the place of the publication of the European patent application.
[2019/25]
Search report(s)International search report - published on:US15.02.2018
(Supplementary) European search report - dispatched on:EP24.06.2020
ClassificationIPC:A61K45/06, A61P35/00, A61K31/519, A61K9/127, A61K47/64
[2020/16]
CPC:
A61P35/00 (EP,EA,KR,US); A61K9/1271 (EP,EA,KR,US); A61K47/6913 (EP,US);
A61K31/517 (EP,US); A61K31/519 (EP,EA,KR,US); A61K45/06 (EP,US);
A61K47/10 (US); A61K47/545 (US); A61K47/64 (US);
A61K47/645 (EP,EA,KR,US); A61K47/6801 (US); A61K47/6849 (EP,US);
A61K47/6911 (US); A61K9/1277 (EP); A61P19/02 (EP,US);
A61P37/00 (KR); C07K16/28 (EP,US); A61K2300/00 (EP,US);
B82Y5/00 (US); C07K2317/73 (EP,US); C07K2317/76 (EP);
C07K2317/92 (EP); Y02A50/30 (EP) (-)
C-Set:
A61K31/519, A61K2300/00 (EP,US)
Former IPC [2019/25]A61K45/06, A61P35/00, A61K31/517
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/25]
TitleGerman:LIPOSOMALES POLYGLUTAMIERTES ANTIFOLATZUSAMMENSETZUNG, UMFASSEND EIN ALPHA-POLYGLUTAMIERTES ANTIFOLAT UND VERWENDUNGEN DAVON[2021/44]
English:A LIPOSOMAL POLYGLUTAMATED ANTIFOLATE COMPOSITION COMPRISING AN ALPHA POLYGLUTAMATED ANTIFOLATE AND USES THEREOF[2021/44]
French:COMPOSITION D'ANTIFOLATE POLYGLUTAMÉ LIPOSOMAL COMPRENANT UN ANTIFOLATE POLYGLUTAMÉ ALPHA ET LEURS UTILISATIONS.[2021/44]
Former [2019/25]ALPHA- UND GAMMA-D-POLYGLUTAMIERTE ANTIFOLATE UND VERWENDUNGEN DAVON
Former [2019/25]ALPHA AND GAMMA-D POLYGLUTAMATED ANTIFOLATES AND USES THEREOF
Former [2019/25]ANTIFOLATES ALPHA ET GAMMA-D DE POLYGLUTAMATES ET LEURS UTILISATIONS.
Entry into regional phase23.01.2019National basic fee paid 
23.01.2019Search fee paid 
23.01.2019Designation fee(s) paid 
23.01.2019Examination fee paid 
Examination proceduredeletedCommunication of intention to grant the patent
23.01.2019Examination requested  [2019/25]
25.01.2021Amendment by applicant (claims and/or description)
06.04.2021Despatch of a communication from the examining division (Time limit: M02)
10.06.2021Reply to a communication from the examining division
16.06.2021Despatch of a communication from the examining division (Time limit: M02)
23.08.2021Reply to a communication from the examining division
21.10.2021Communication of intention to grant the patent
18.02.2022Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
18.02.2022Fee for grant paid
18.02.2022Fee for publishing/printing paid
01.03.2022Despatch of a communication from the examining division (Time limit: M02)
07.03.2022Reply to a communication from the examining division
16.08.2022Despatch of a communication from the examining division (Time limit: M06)
08.02.2023Reply to a communication from the examining division
19.07.2023Despatch of a communication from the examining division (Time limit: M06)
16.01.2024Reply to a communication from the examining division
Divisional application(s)EP22167260.3  / EP4052729
Fees paidRenewal fee
08.08.2019Renewal fee patent year 03
17.08.2020Renewal fee patent year 04
09.08.2021Renewal fee patent year 05
29.08.2022Renewal fee patent year 06
28.08.2023Renewal fee patent year 07
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XY]US6569432  (ISRAELI RON S [US], et al) [X] 1,2,14 * figure 62 * * abstract * * column 20, paragraph last - column 22, paragraph 2 * [Y] 3-13,15;
 [Y]US2011280932  (GARCIA LOUIE DANIEL [US], et al) [Y] 3-13,15 * abstract ** claims 1-70 *;
 [X]  - SPRINGER C J ET AL, "PRODRUGS OF THYMIDYLATE SYNTHASE INHIBITORS: POTENTIAL FOR ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT)", ANTI-CANCER DRUG DESIGN, OXFORD UNIVERSITY PRESS, BASINGSTOKE, (19690101), vol. 11, no. 8, ISSN 0266-9536, pages 625 - 636, XP001002764 [X] 1,2,14 * abstract * * compounds 12,17 *
International search[XY]US4584375  (COWARD JAMES K [US]) [X] 1-7 * col 1, In 28-29; col 2, In 26-50 * [Y] 9, 12-13;
 [XY]US2014086939  (KARIN MICHAEL [US], et al) [X] 1, 8, 10-11, 14, 28, 37-40, 57-60, 65-67, 69-72 * para [0011]; [0017]; [0057]; [0091]-[0092]; [0153]-[0154]; [0213] * [Y] 9, 12-13, 25-27, 29-31, 41-43;
 [Y]US2009155345  (BARENHOLZ YECHEZKEL [IL], et al) [Y] 25-27 * para [0142] *;
 [Y]US2013259922  (HAAS HEINRICH [DE], et al) [Y] 29-31 * para [0013]; [0192] *;
 [YA]WO2014046630  (BANERJEE SREEPARNA [TR], et al) [Y] 41 * pg 7, In 15; pg 9, In 6-7; pg 10, In 6-7; pg 12, In 2-3 * [A] 14, 38;
 [Y]US2015239956  (KOGUMA ICHIRO [JP], et al) [Y] 42 * para [0032]; [0116] *;
 [A]US2008214585  (ROBERTS MICHAEL J [US], et al) [A] 1-14, 25-31, 37-43, 57- 60, 55-67, 69-72 * para [0005] *;
 [A]US2007270431  (TABUNOKI YUICHIRO [JP], et al) [A] 66 * para [0006] *;
 [A]US2013324727  (TARNCHOMPOO BONGKOCH [TH], et al) [A] 67 * para [0003] *;
 [A]US2005031679  (UNGER CLEMENS [DE], et al) [A] 69 * para [0015] *;
 [Y]  - ZWICKE et al., "Utilizing the folate receptor for active targeting of cancer nanotherapeutics", Nano Rev ., (20120000), vol. 3, page 18496, XP055347671 [Y] 43 * pg 6, col 1, para 3; Fig 4 *

DOI:   http://dx.doi.org/10.3402/nano.v3i0.18496
 [A]  - ABRAHAM et al., "Folate analogues. 33. Synthesis of folate and antifolate poly-gamma- glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma", J Med Chem., (19900000), vol. 33, no. 2, pages 711 - 717, XP002418703 [A] 1-14, 25-31, 37-43, 57- 60, 65-67, 69-72 * whole document *

DOI:   http://dx.doi.org/10.1021/jm00164a038
by applicantWO2016025882
 US6569432
 US2011280932
 US5225539
 US5639641
 US5646253
 US8388972
 US8871206
 US9133275
    - GONEN et al., Drug Resistance Updates, (20120000), vol. 15, pages 183 - 210
    - JONES et al., Nature, (19860000), vol. 321, pages 522 - 525
    - RIECHMANN et al., Nature, (19880000), vol. 332, pages 323 - 327
    - VERHOEYEN et al., Science, (19880000), vol. 239, pages 1534 - 1536
    - SAITO et al., Cancer Research, (20040000), vol. 64, pages 2572 - 2579
    - MAMOT et al., J. Neuro-Oncology, (20040000), vol. 68, pages 1 - 9
 WO2011US56966
 WO2012US46672
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.