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Extract from the Register of European Patents

EP About this file: EP3503886

EP3503886 - COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  03.09.2021
Database last updated on 03.10.2024
FormerRequest for examination was made
Status updated on  31.05.2019
FormerThe international publication has been made
Status updated on  03.03.2018
Most recent event   Tooltip03.09.2021Withdrawal of applicationpublished on 06.10.2021  [2021/40]
Applicant(s)For all designated states
Calithera Biosciences, Inc.
343 Oyster Point Boulevard
Suite 200
South San Francisco, CA 94080 / US
[2019/27]
Inventor(s)01 / PARLATI, Francesco
1035 York Street
San Francisco, California 94110 / US
02 / ORFORD, Keith
3819 Charter Club Drive
Doylestown, Pennsylvania 18902 / US
03 / WHITING, Sam H.
8920 Sand Point Way NE
Seattle, Washington 98115 / US
 [2019/27]
Representative(s)HGF
HGF Limited
1 City Walk
Leeds LS11 9DX / GB
[N/P]
Former [2019/27]HGF Limited
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Application number, filing date17844477.425.08.2017
[2019/27]
WO2017US48581
Priority number, dateUS201662379604P25.08.2016         Original published format: US 201662379604 P
[2019/27]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018039544
Date:01.03.2018
Language:EN
[2018/09]
Type: A1 Application with search report 
No.:EP3503886
Date:03.07.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 01.03.2018 takes the place of the publication of the European patent application.
[2019/27]
Search report(s)International search report - published on:IL01.03.2018
(Supplementary) European search report - dispatched on:EP24.06.2020
ClassificationIPC:A61K31/433, A61K31/501, A61P35/00, C07D417/02, C07D417/14, A61K31/4439, A61K31/4545, A61K31/47, A61K31/5377, A61K45/06
[2020/17]
CPC:
A61K31/501 (EP,KR,US); A61K31/4439 (EP,KR,US); A61K31/4545 (EP,KR,US);
A61K31/47 (EP,KR,US); A61K31/5377 (EP,US); A61K45/06 (EP,KR,US);
A61P35/00 (EP,KR); A61P35/02 (EP); A61P43/00 (EP);
A61K2300/00 (KR) (-)
C-Set:
A61K31/4439, A61K2300/00 (US,EP);
A61K31/4545, A61K2300/00 (US,EP);
A61K31/47, A61K2300/00 (US,EP);
A61K31/501, A61K2300/00 (EP,US);
A61K31/5377, A61K2300/00 (EP,US)
(-)
Former IPC [2019/27]A61K31/433, A61K31/501, A61P35/00, C07D417/02, C07D417/14
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/27]
TitleGerman:KOMBINATIONSTHERAPIE MIT GLUTAMINASEINHIBITOREN[2019/27]
English:COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS[2019/27]
French:POLYTHÉRAPIE COMPRENANT DES INHIBITEURS DE GLUTAMINASE[2019/27]
Entry into regional phase18.03.2019National basic fee paid 
18.03.2019Search fee paid 
18.03.2019Designation fee(s) paid 
18.03.2019Examination fee paid 
Examination procedure18.03.2019Examination requested  [2019/27]
17.02.2021Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
14.04.2021Amendment by applicant (claims and/or description)
31.08.2021Application withdrawn by applicant  [2021/40]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
14.04.2021Request for further processing filed
14.04.2021Full payment received (date of receipt of payment)
Request granted
27.04.2021Decision despatched
Fees paidRenewal fee
15.08.2019Renewal fee patent year 03
13.08.2020Renewal fee patent year 04
13.08.2021Renewal fee patent year 05
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Documents cited:Search[A]US2014142081  (LEMIEUX RENE M [US], et al) [A] 1-11,14,15 * claims 1,10-19 * * paragraph [0143] *;
 [X]WO2016077632  (BUCK INST FOR RES ON AGING [US]) [X] 1-11,14,15 * claims 1,2,42,46,54,55 ** paragraphs [0005] , [0006] *
International search[Y]WO2014078645  (CALITHERA BIOSCIENCES INC [US], et al) [Y] 1-73, 76-81 * Pages 106-107, examples 7 and 9, and figures 5 and 7 *;
 [Y]WO2015192014  (CALITHERA BIOSCIENCES INC [US]) [Y] 1-73, 76-81 * Examples 2-3 (pages 65-66) *;
 [A]WO2016004418  (UNIV TEXAS [US]) [A] 1-81* Whole document *;
 [XY]  - Anonymous, "Study of the Glutaminase Inhibitor CB-839 in Solid Tumors", (20160822), pages 1 - 9, National Library of Medicine, URL: https://clinicaltrials.gov/ct2/show/NCT02071862, XP055468661 [X] 1-8, 11-73, 78-81 * The whole document * [Y] 1-73, 76-81
 [Y]  - XIANG, YAN et al., "Targeted inhibition of tumor-specific glutaminase diminishes cell - autonomous tumorigenesis", The Journal of clinical investigation, (20150425), vol. 125, no. 6, pages 2293 - 2306, XP055217500 [Y] 1-73, 76-81 * Discussion section, page 2302 *

DOI:   http://dx.doi.org/10.1172/JCI75836
 [Y]  - SCHILLER, JOAN H. et al., "Efficacy and safety of axitinib in patients with advanced non-small- cell lung cancer: results from a phase II study", Journal of Clinical Oncology, (20090810), vol. 27, no. 23, pages 3836 - 3841, XP055470264 [Y] 1-7, 10-70, 76-81 * Page 3840, two last paragraph of the discussion section *

DOI:   http://dx.doi.org/10.1200/JCO.2008.20.8355
 [Y]  - TANIZAKI, JUNKO et al., "MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations", Journal of Thoracic Oncology, (20151120), vol. 6, no. 10, pages 1624 - 1631, XP055470266 [Y] 1-7, 9, 11-70, 78-81 * Whole document *

DOI:   http://dx.doi.org/10.1097/JTO.0b013e31822591e9
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