blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3534901

EP3534901 - POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.04.2023
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  20.05.2022
FormerGrant of patent is intended
Status updated on  12.01.2022
FormerExamination is in progress
Status updated on  08.12.2021
FormerGrant of patent is intended
Status updated on  29.07.2021
FormerExamination is in progress
Status updated on  18.12.2020
FormerRequest for examination was made
Status updated on  09.08.2019
FormerThe international publication has been made
Status updated on  11.05.2018
Most recent event   Tooltip31.05.2024Lapse of the patent in a contracting state
New state(s): MK		published on 03.07.2024 [2024/27]
Applicant(s)For all designated states
Vanderbilt University
305 Kirkland Hall
2201 West End Avenue
Nashville, TN 37240 / US
[2022/25]
Former [2019/37]For all designated states
Vanderbilt University
305 Kirkland Hall
2201 West End Avenue
Nashville, TN 37240 / US
Inventor(s)01 / LINDSLEY, Craig, W.
9281 Wardley Park Lane
Brentwood, TN 37027 / US
02 / ENGERS, Darren, W.
1744 Stillwater Circle
Brentwood, TN 37027 / US
03 / CONN, P., Jeffrey
2806 Acklen Avenue
Nashville, TN 37212 / US
04 / BOLLINGER, Sean, R.
140 Melstone Court
Murfreesboro, TN 37127 / US
05 / ENGERS, Julie, L.
1744 Stillwater Circle
Brentwood, TN 37027 / US
 [2019/37]
Representative(s)Stafford, Jonathan Alan Lewis
Marks & Clerk LLP
1 New York Street
Manchester M1 4HD / GB
[2022/25]
Former [2019/37]H. Lundbeck A/S
Ottiliavej 9
2500 Valby / DK
Application number, filing date17867018.807.11.2017
[2019/37]
WO2017US60306
Priority number, dateUS201662418651P07.11.2016         Original published format: US 201662418651 P
US201762542621P08.08.2017         Original published format: US 201762542621 P
[2019/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018085803
Date:11.05.2018
Language:EN
[2018/19]
Type: A1 Application with search report 
No.:EP3534901
Date:11.09.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 11.05.2018 takes the place of the publication of the European patent application.
[2019/37]
Type: B1 Patent specification 
No.:EP3534901
Date:22.06.2022
Language:EN
[2022/25]
Search report(s)International search report - published on:US11.05.2018
(Supplementary) European search report - dispatched on:EP25.03.2020
ClassificationIPC:A61K31/4365, A61K31/4375, A61K31/5025, A61P25/00, C07D495/14
[2020/17]
CPC:
A61P25/00 (EP); C07D495/14 (EP,US)
Former IPC [2019/37]A61K31/4365, A61K31/4375, A61K31/5025, A61P25/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/37]
Extension statesBA07.06.2019
ME07.06.2019
Validation statesMA07.06.2019
TitleGerman:POSITIVE ALLOSTERISCHE MODULATOREN DES MUSKARINISCHEN ACETYLCHOLINREZEPTORS M4[2019/37]
English:POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4[2019/37]
French:MODULATEURS ALLOSTÉRIQUES POSITIFS DU RÉCEPTEUR MUSCARINIQUE À L'ACÉTYLCHOLINE M4[2019/37]
Entry into regional phase07.06.2019National basic fee paid 
07.06.2019Search fee paid 
07.06.2019Designation fee(s) paid 
07.06.2019Examination fee paid 
Examination procedure07.06.2019Examination requested  [2019/37]
05.10.2020Amendment by applicant (claims and/or description)
22.12.2020Despatch of a communication from the examining division (Time limit: M04)
16.04.2021Reply to a communication from the examining division
30.07.2021Communication of intention to grant the patent
07.12.2021Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
13.01.2022Communication of intention to grant the patent
13.05.2022Fee for grant paid
13.05.2022Fee for publishing/printing paid
13.05.2022Receipt of the translation of the claim(s)
Opposition(s)23.03.2023No opposition filed within time limit [2023/22]
Fees paidRenewal fee
02.12.2019Renewal fee patent year 03
30.11.2020Renewal fee patent year 04
29.11.2021Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.11.2017
AL22.06.2022
AT22.06.2022
CY22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
IT22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
MK22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
IE07.11.2022
LU07.11.2022
BE30.11.2022
CH30.11.2022
LI30.11.2022
[2024/27]
Former [2024/21]HU07.11.2017
AL22.06.2022
AT22.06.2022
CY22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
IT22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
IE07.11.2022
LU07.11.2022
BE30.11.2022
CH30.11.2022
LI30.11.2022
Former [2024/18]HU07.11.2017
AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
IT22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
IE07.11.2022
LU07.11.2022
BE30.11.2022
CH30.11.2022
LI30.11.2022
Former [2024/11]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
IT22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
IE07.11.2022
LU07.11.2022
BE30.11.2022
CH30.11.2022
LI30.11.2022
Former [2023/49]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
IE07.11.2022
LU07.11.2022
BE30.11.2022
CH30.11.2022
LI30.11.2022
Former [2023/48]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
IE07.11.2022
LU07.11.2022
CH30.11.2022
LI30.11.2022
Former [2023/37]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SI22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
LU07.11.2022
CH30.11.2022
LI30.11.2022
Former [2023/35]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
CH30.11.2022
LI30.11.2022
Former [2023/31]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
MC22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
Former [2023/21]AL22.06.2022
AT22.06.2022
CZ22.06.2022
DK22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
Former [2023/17]AL22.06.2022
AT22.06.2022
CZ22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
Former [2023/12]AT22.06.2022
CZ22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
IS22.10.2022
PT24.10.2022
Former [2023/11]AT22.06.2022
CZ22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
PL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
PT24.10.2022
Former [2023/09]AT22.06.2022
CZ22.06.2022
EE22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
RO22.06.2022
RS22.06.2022
SE22.06.2022
SK22.06.2022
SM22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
PT24.10.2022
Former [2023/08]AT22.06.2022
ES22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
RS22.06.2022
SE22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
Former [2023/07]AT22.06.2022
FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
RS22.06.2022
SE22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
Former [2023/02]FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
NL22.06.2022
RS22.06.2022
SE22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
Former [2022/50]FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
RS22.06.2022
SE22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
Former [2022/49]FI22.06.2022
HR22.06.2022
LT22.06.2022
LV22.06.2022
SE22.06.2022
BG22.09.2022
NO22.09.2022
GR23.09.2022
Former [2022/47]FI22.06.2022
LT22.06.2022
SE22.06.2022
NO22.09.2022
Documents cited:Search   [ ] - No further relevant documents disclosed
International search[A]US2014357615  (CONN JEFFREY P [US], et al) [A] 1-7, 13-14, 18-27, 31 * para [0010]-[0011], pg 190, Table 1; para [0831], Table II *;
 [A]US2014364409  (LINDSLEY CRAIG W [US], et al) [A] 1-7, 13-14, 18-27, 31 * para [0010]-[0011], [1015], pg 192, Table I; para [1020], Table II *;
 [A]US2016137668  (GENESTE HERVÉ [DE], et al) [A] 1-7, 13-14, 18-27, 31 * para [1018], [1319], Table 1 *;
 [A]US2016207935  (LINDSLEY CRAIG W [US], et al) [A] 1-7, 13-14, 18-27, 31* para [0826], Table *;
 [A]  - WOOD et al., "Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition", Bioorg Med Chem Lett., (20160901), vol. 26, no. 17, pages 4282 - 4286, XP055501824 [A] 1-7, 13-14, 18-27, 31

DOI:   http://dx.doi.org/10.1016/j.bmcl.2016.07.042
by applicantUS2014357615
 US2014364409
    - BYMASTER et al., Eur. J. Pharmacol., (19980000), vol. 356, page 109
    - BYMASTER et al., Life Sci., (19990000), vol. 64, page 527
    - SHANNON et al., J. Pharmacol. Exp. Ther., (19990000), vol. 290, page 901
    - SHANNON et al., Schizophrenia Res., (20000000), vol. 42, page 249
    - BODICK et al., Arch. Neurol., (19970000), vol. 54, page 465
    - "Periodic Table of the Elements, CAS version", Handbook of Chemistry and Physics
    - SECTION E, "Fundamental Stereochemistry", Pure Appl. Chem., (19760000), vol. 45, pages 13 - 30
    - C.T.F.A. Cosmetic Ingredient Handbook, Meade Publishing Co., (19920000), pages 587 - 592
    - Remington's Pharmaceutical Sciences, (19750000), pages 335 - 337
    - "Emulsifiers & Detergents", McCutcheon's Volume, (19940000), vol. 1, pages 236 - 239
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.