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Extract from the Register of European Patents

EP About this file: EP3461820

EP3461820 - METHOD FOR OBTAINING CRYSTALS OF MEGLUMINE SALT OF 1-(5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.06.2021
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  26.06.2020
FormerGrant of patent is intended
Status updated on  09.02.2020
FormerRequest for examination was made
Status updated on  11.10.2019
FormerThe application has been published
Status updated on  01.03.2019
Most recent event   Tooltip17.06.2022Lapse of the patent in a contracting state
New state(s): MT, TR		published on 20.07.2022  [2022/29]
Applicant(s)For all designated states
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
[2019/14]
Inventor(s)01 / SEPASSI, Kia
924 Hornblend Street 308
San Diego, CA 92109 / US
02 / RIZZOLIO, Michele C.
8525 Celtic Court
San Diego, CA 92129 / US
 [2019/14]
Representative(s)McGuire, Gillian Margaret
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2019/14]
Application number, filing date18191088.625.10.2012
[2019/14]
Priority number, dateUS201161551395P25.10.2011         Original published format: US 201161551395 P
[2019/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3461820
Date:03.04.2019
Language:EN
[2019/14]
Type: B1 Patent specification 
No.:EP3461820
Date:29.07.2020
Language:EN
[2020/31]
Search report(s)(Supplementary) European search report - dispatched on:EP14.12.2018
ClassificationIPC:C07D403/04
[2019/14]
CPC:
C07D403/04 (EP,CN,US); A61K31/4184 (CN,US); A61K47/38 (CN);
A61K9/0014 (CN); A61K9/06 (CN); A61P13/12 (EP);
A61P17/02 (EP); A61P19/02 (EP); A61P29/00 (EP);
A61P3/00 (EP); A61P3/04 (EP); A61P3/10 (EP);
A61P3/12 (EP); A61P37/06 (EP); A61P39/00 (EP);
A61P43/00 (EP); A61P7/06 (EP); A61P9/00 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/46]
Former [2019/14]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON CRYSTALLEN VON MEGLUMINSALZ VON 1-(5,6-DICHLOR-1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOL-4-CARBONSÄURE[2019/14]
English:METHOD FOR OBTAINING CRYSTALS OF MEGLUMINE SALT OF 1-(5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID[2019/14]
French:PROCÉDÉ POUR L'OBTENTION DE CRYSTAUX DE SEL DE MÉGLUMINE D'ACIDE 1- (5,6-DICHLORO-1H-BENZO [D] IMIDAZOL-2-YL) -1H-PYRAZOLE-4-CARBOXYLIQUE[2019/14]
Examination procedure03.10.2019Amendment by applicant (claims and/or description)
03.10.2019Examination requested  [2019/46]
03.10.2019Date on which the examining division has become responsible
10.02.2020Communication of intention to grant the patent
18.06.2020Fee for grant paid
18.06.2020Fee for publishing/printing paid
18.06.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP12781016.6  / EP2776023
EP16159121.9  / EP3091009
Opposition(s)30.04.2021No opposition filed within time limit [2021/27]
Fees paidRenewal fee
28.08.2018Renewal fee patent year 03
28.08.2018Renewal fee patent year 04
28.08.2018Renewal fee patent year 05
28.08.2018Renewal fee patent year 06
28.08.2018Renewal fee patent year 07
15.10.2019Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
MT29.07.2020
NL29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
TR29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
[2022/27]
Former [2021/36]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
NL29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/28]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
NL29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/25]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
NL29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/22]AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
NL29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/21]AT29.07.2020
DK29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
NL29.07.2020
PL29.07.2020
RS29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/17]AT29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
NL29.07.2020
PL29.07.2020
RS29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/10]AT29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RS29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/09]AT29.07.2020
FI29.07.2020
LT29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
PT30.11.2020
Former [2021/08]FI29.07.2020
LT29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
PT30.11.2020
Former [2021/07]FI29.07.2020
LT29.07.2020
NO29.10.2020
Documents cited:Search[A]WO0142238  (GLAXO WELLCOME SPA [IT], et al) [A] 1-8* the whole document *;
 [A]WO2009134750  (JANSSEN PHARMACEUTICA NV [BE], et al) [A] 1-8 * example 1 *
by applicantWO2004052284
 WO2004052285
 US2006276477
 WO2007070359
 WO2007103905
 WO2007150011
 US2007299086
 WO2009117269
    - IVAN et al., Science, (20010000), vol. 292, pages 464 - 68
    - JAAKKOLA et al., Science, (20010000), vol. 292, pages 468 - 72
    - EPSTEIN et al., Cell, (20010000), vol. 107, pages 43 - 54
    - KAELIN, Annu Rev Biochem., (20050000), vol. 74, pages 115 - 28
    - SCHMID et al., J Cell Mol Med., (20040000), vol. 8, pages 423 - 31
    - METZEN E et al., J Cell Sci., (20030000), vol. 116, no. 7, pages 1319 - 26
    - IVAN et al., Proc Natl Acad Sci. USA, (20020000), vol. 99, no. 21, pages 13459 - 64
    - BERRA et al., EMBO J., (20030000), vol. 22, pages 4082 - 90
    - Recent Patents on Inflammation & Allergy Drug Discovery, (20090000), vol. 3, pages 1 - 16
    - ROLFS et al., J Biol Chem., (19970000), vol. 272, no. 32, pages 20055 - 62
    - LOK et al., J Biol Chem., (19990000), vol. 274, no. 34, pages 24147 - 52
    - TACCHINI et al., J Biol Chem., (19990000), vol. 274, no. 34, pages 24142 - 46
    - MUKHOPADHYAY et al., J Biol Chem., (20000000), vol. 275, no. 28, pages 21048 - 54
    - PEYSSONNAUX et al., J Clin Invest., (20070000), vol. 117, no. 7, pages 1926 - 32
    - BRALIOU et al., J Hepatol., (20080000), vol. 48, pages 801 - 10
    - PERCY et al., PNAS, (20070000), vol. 103, no. 3, pages 654 - 59
    - A -SHEIKH et al., Blood Cells Mol Dis., (20080000), vol. 40, pages 160 - 65
    - BERNHARDT et al., Methods Enzymol., (20070000), vol. 435, pages 221 - 45
    - CAI et al., Cardiovasc Res., (20080000), vol. 77, no. 3, pages 463 - 70
    - PASUPATHY et al., Eur J Vase Endovasc Surg., (20050000), vol. 29, pages 106 - 15
    - MALLICK et al., Dig Dis Sci., (20040000), vol. 49, no. 9, pages 1359 - 77
    - ARAGONES et al., Nat Genet., (20080000), vol. 40, no. 2, pages 170 - 80
    - NATARAJAN et al., Circ Res., (20060000), vol. 98, no. 1, pages 133 - 40
    - CHIN et al., Proc Natl Acad Sci. U.S.A., (20070000), vol. 104, no. 12, pages 5109 - 14
    - BERNAUDIN et al., J Cereb Blood Flow Metab., (20020000), vol. 22, no. 4, pages 393 - 403
    - SIDDIQ et al., J Biol Chem., (20050000), vol. 280, no. 50, pages 41732 - 43
    - NATARAJAN et al., J Cardiovasc Pharmacol., (20080000), vol. 51, no. 2, pages 178 - 187
    - LIN et al., J Biol Chem., (20060000), vol. 281, no. 41, pages 30678 - 83
    - CARRIERE et al., J Biol Chem., (20040000), vol. 279, no. 39, pages 40462 - 69
    - FLOYD et al., J Cell Biochem., (20070000), vol. 101, pages 1545 - 57
    - YUN et al., Dev Cell., (20020000), vol. 2, pages 331 - 41
    - GROSFELD et al., J Biol Chem., (20020000), vol. 277, no. 45, pages 42953 - 57
    - SEMENZA et al., J Cell Biochem., (20070000), vol. 102, pages 840 - 47
    - SEMENZA, Exp Physiol., (20070000), vol. 92, no. 6, pages 988 - 91
    - GUSTAFSSON et al., Front Biosci., (20010000), vol. 6, pages D75 - 89
    - CARMELIET, J Intern Med., (20040000), vol. 255, pages 538 - 61
    - KELLY et al., Circ Res., (20030000), vol. 93, pages 1074 - 81
    - CERADINI et al., Nat Med., (20040000), vol. 10, no. 8, pages 858 - 64
    - THURSTON et al., Science, (19990000), vol. 286, pages 2511 - 14
    - THURSTON et al., Nat Med., (20000000), vol. 6, no. 4, pages 460 - 3
    - ELSON et al., Genes Dev., (20010000), vol. 15, no. 19, pages 2520 - 32
    - CERADINI et al., Trends Cardiovasc Med., (20050000), vol. 15, no. 2, pages 57 - 63
    - CHANG et al., Circulation, (20070000), vol. 116, no. 24, pages 2818 - 29
    - KELLY et al., Circ Res., (20030000), vol. 93, no. 11, pages 1074 - 81
    - CARMELIET, J Intern Med., (20040000), vol. 255, no. 5, pages 538 - 61
    - LUTTUN et al., Ann N Y Acad Sci., (20020000), vol. 979, pages 80 - 93
    - PAJUSOLA et al., FASEB J., (20050000), vol. 19, no. 10, pages 1365 - 7
    - VINCENT et al., Circulation, (20000000), vol. 102, pages 2255 - 61
    - SHYU et al., Cardiovasc Res., (20020000), vol. 54, pages 576 - 83
    - ABBOTT et al., Circulation, (20040000), vol. 110, no. 21, pages 3300 - 05
    - MACE et al., Wound Repair Regen., (20070000), vol. 15, no. 5, pages 636 - 45
    - ROBINSON et al., Gastroenterology, (20080000), vol. 134, no. 1, pages 145 - 55
    - SCHULTZ et al., Am J Physiol Heart Circ Physiol., (20060000), vol. 290, no. 6, pages H2528 - 34
    - YOSHIDA et al., J Neurooncol., (20060000), vol. 76, no. 1, pages 13 - 21
    - SIMON et al., Nat Rev Mol Cell Biol., (20080000), vol. 9, pages 285 - 96
    - HU et al., J Thorac Cardiovasc Surg., (20080000), vol. 135, no. 4, pages 799 - 808
    - PEYSSONNAUX et al., J Invest Dermatol., (20050000), vol. 115, no. 7, pages 1806 - 15
    - PEYSSONNAUX et al., J Invest Dermatol., (20080800), vol. 128, no. 8, pages 1964 - 8
    - PFANDER D et al., J Cell Sci., (20030000), vol. 116, pages 1819 - 26
    - WANG et al., J Clin Invest., (20070000), vol. 17, no. 6, pages 1616 - 26
    - WARSHAKOON et al., Bioorg Med Chem Lett., (20060000), vol. 16, no. 21, pages 5598 - 601
    - WARSHAKOON et al., Bioorg Med Chem Lett., (20060000), vol. 16, no. 21, pages 5616 - 20
    - WARSHAKOON et al., Bioorg Med Chem Lett., (20060000), vol. 16, no. 21, pages 5687 - 90
    - S.M. BERGE et al., "Pharmaceutical Salts", J. Pharm. Sci., (19770000), vol. 66, doi:doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560

DOI:   http://dx.doi.org/10.1002/jps.2600660104
    - FLEISHER et al., Adv. Drug Delivery Rev., (19960000), vol. 19, pages 115 - 130
    - GREENWALD et al., J. Med. Chem., (19960000), vol. 39, no. 10, pages 1938 - 40
    - BERTOLINI et al., J. Med. Chem., (19970000), vol. 40, pages 2011 - 2016
    - SHAN et al., J. Pharm. Sci., (19970000), vol. 86, no. 7, pages 765 - 767
    - BAGSHAWE, Drug Dev. Res., (19950000), vol. 34, pages 220 - 230
    - BODOR, Adv. Drug Res., (19840000), vol. 13, pages 224 - 331
    - Pharmaceutical Sciences, Remington, (19850000), pages 1585 - 1594
    - PERRY, Chemical Engineers Handbook, (19840000), pages 21-13 - 21-19
    - PARROT et al., J. Pharm.Sci., (19740000), vol. 61, no. 6, pages 813 - 829
    - HIXON et al., Chem. Engineering, (19900000), pages 94 - 103
    - ERLANDSSON, B., Polym. Degrad. and Stab., (20020000), vol. 78, pages 571 - 575
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.