| EP3461848 - TRANSGENIC MICE [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 15.08.2024 Database last updated on 28.03.2026 | |
| Former | The patent has been granted Status updated on 08.09.2023 | ||
| Former | Grant of patent is intended Status updated on 07.05.2023 | ||
| Former | Examination is in progress Status updated on 21.05.2021 | ||
| Former | Request for examination was made Status updated on 04.10.2019 | ||
| Former | The application has been published Status updated on 01.03.2019 | Most recent event Tooltip | 19.12.2025 | Lapse of the patent in a contracting state New state(s): TR | published on 21.01.2026 [2026/04] | Applicant(s) | For all designated states Crescendo Biologics Limited Meditrina Building 260 Babraham Research Campus Cambridge CB22 3AT / GB | [2019/14] | Inventor(s) | 01 /
TENG, Yumin c/o Crescendo Biologics Ltd Meditrina Building Babraham Research Campus Cambridge, Cambridgeshire CB22 3AT / GB | 02 /
YOUNG, Joyce c/o Crescendo Biologics Ltd Meditrina Building Babraham Research Campus Cambridge, Cambridgeshire CB22 3AT / GB | 03 /
MCGUINNESS, Brian c/o Crescendo Biologics Ltd Meditrina Building Babraham Research Campus Cambridge, Cambridgeshire CB22 3AT / GB | 04 /
ROMANOS, Mike c/o Crescendo Biologics Ltd Meditrina Building Babraham Research Campus Cambridge, Cambridgeshire CB22 3AT / GB | 05 /
BRUEGGEMANN, Marianne 2 Station Road Foxton Cambridge, Cambridgeshire CB2 6SA / GB | [2019/14] | Representative(s) | Appleyard Lees IP LLP G Mill Dean Clough Industrial Park Halifax HX3 5AH / GB | [N/P] |
| Former [2019/14] | Appleyard Lees IP LLP 15 Clare Road Halifax HX1 2HY / GB | Application number, filing date | 18192313.7 | 22.10.2014 | [2019/14] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3461848 | Date: | 03.04.2019 | Language: | EN | [2019/14] | Type: | B1 Patent specification | No.: | EP3461848 | Date: | 11.10.2023 | Language: | EN | [2023/41] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 15.01.2019 | Classification | IPC: | C07K16/46, C12N7/00, C12N15/00 | [2019/14] | CPC: |
C07K16/00 (EP,CN,GB,IL,KR,US);
C12N15/8509 (EP,CN,GB,IL,KR,US);
A01K67/0275 (US);
A01K67/0278 (EP,GB,IL,KR,US);
C07K16/46 (EP,IL,KR,US);
A01K2217/05 (US);
A01K2217/052 (EP,GB,IL,KR,US);
A01K2217/07 (US);
A01K2217/072 (US);
A01K2217/075 (EP,GB,IL,KR,US);
A01K2217/15 (EP,GB,IL,KR,US);
A01K2227/105 (EP,GB,IL,KR,US);
A01K2267/01 (EP,GB,IL,KR,US);
C07K2317/569 (EP,CN,GB,IL,KR,US);
C07K2317/92 (EP,CN,GB,IL,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/45]
|
| Former [2019/14] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Title | German: | TRANSGENE MÄUSE | [2019/14] | English: | TRANSGENIC MICE | [2019/14] | French: | SOURIS TRANSGÉNIQUES | [2019/14] | Examination procedure | 02.10.2019 | Examination requested [2019/45] | 02.10.2019 | Date on which the examining division has become responsible | 13.11.2019 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time | 21.01.2020 | Amendment by applicant (claims and/or description) | 28.04.2020 | Observations by third parties | 25.05.2021 | Despatch of a communication from the examining division (Time limit: M06) | 03.12.2021 | Reply to a communication from the examining division | 29.04.2022 | Despatch of a communication from the examining division (Time limit: M04) | 08.08.2022 | Reply to a communication from the examining division | 08.05.2023 | Communication of intention to grant the patent | 04.09.2023 | Fee for grant paid | 04.09.2023 | Fee for publishing/printing paid | 04.09.2023 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP14790686.1 / EP3209698 | Opposition(s) | 12.07.2024 | No opposition filed within time limit [2024/38] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 21.01.2020 | Request for further processing filed | 21.01.2020 | Full payment received (date of receipt of payment) Request granted | 30.01.2020 | Decision despatched | Fees paid | Renewal fee | 03.09.2018 | Renewal fee patent year 03 | 03.09.2018 | Renewal fee patent year 04 | 03.09.2018 | Renewal fee patent year 05 | 21.10.2019 | Renewal fee patent year 06 | 14.10.2020 | Renewal fee patent year 07 | 21.10.2021 | Renewal fee patent year 08 | 14.10.2022 | Renewal fee patent year 09 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | CY | 22.10.2014 | HU | 22.10.2014 | CZ | 11.10.2023 | ES | 11.10.2023 | HR | 11.10.2023 | MC | 11.10.2023 | PL | 11.10.2023 | RO | 11.10.2023 | RS | 11.10.2023 | SK | 11.10.2023 | SM | 11.10.2023 | TR | 11.10.2023 | IE | 22.10.2023 | NO | 11.01.2024 | GR | 12.01.2024 | IS | 11.02.2024 | [2026/04] |
| Former [2025/39] | CY | 22.10.2014 | |
| HU | 22.10.2014 | ||
| CZ | 11.10.2023 | ||
| ES | 11.10.2023 | ||
| HR | 11.10.2023 | ||
| MC | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RO | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SK | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| IE | 22.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2025/36] | CY | 22.10.2014 | |
| CZ | 11.10.2023 | ||
| ES | 11.10.2023 | ||
| HR | 11.10.2023 | ||
| MC | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RO | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SK | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| IE | 22.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/46] | CZ | 11.10.2023 | |
| ES | 11.10.2023 | ||
| HR | 11.10.2023 | ||
| MC | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RO | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SK | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| IE | 22.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/40] | CZ | 11.10.2023 | |
| ES | 11.10.2023 | ||
| HR | 11.10.2023 | ||
| MC | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RO | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SK | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/36] | CZ | 11.10.2023 | |
| ES | 11.10.2023 | ||
| HR | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RO | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SK | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/35] | CZ | 11.10.2023 | |
| ES | 11.10.2023 | ||
| HR | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RO | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/33] | ES | 11.10.2023 | |
| HR | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| SM | 11.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/25] | ES | 11.10.2023 | |
| HR | 11.10.2023 | ||
| PL | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/24] | ES | 11.10.2023 | |
| HR | 11.10.2023 | ||
| RS | 11.10.2023 | ||
| NO | 11.01.2024 | ||
| GR | 12.01.2024 | ||
| IS | 11.02.2024 | ||
| Former [2024/20] | GR | 12.01.2024 | |
| IS | 11.02.2024 | Documents cited: | Search | [XY] GB2495083 (KYMAB LTD et al.) | [Y] WO0076310 (ABGENIX INC et al.) | [A] US2014283150 (BRADLEY ALLAN et al.) | by applicant | US45591309 | WO2006008548 | WO03000737 | WO2004076618 | WO2004001095 | PADLAN, E.A., MOL. IMMUNOL., vol. 31, 1994, pages 169 - 217 | GREENBERG ET AL., EUR. J. IMMUNOL., vol. 26, 1996, pages 1123 - 1129 | RAST ET AL., IMMUNOGENETICS, vol. 47, 1998, pages 234 - 245 | BRUSCHI, C.V.; GJURACIC, K.: "ENCYCLOPEDIA OF LIFE SCIENCES", 2002, MACMILLAN PUBLISHERS LTD, NATURE PUBLISHING GROUP, article "Yeast Artificial Chromosomes" | DUCRY ET AL., BIOCONJUGATE CHEM., vol. 21, 2010, pages 5 - 13 | METHODS IN MOLECULAR BIOLOGY, vol. 54 and 3 | REN, L. ET AL., GENOMICS, vol. 84, 2004, pages 686 - 695 | ZOU, X. ET AL., EJI, vol. 25, 1995, pages 2154 - 2162 | ZOU, X. ET AL., JI, vol. 170, 2003, pages 1354 - 1361 | YING, Q.L. ET AL., NATURE, vol. 453, 2008, pages 519 - 523 | NICHOLS, J. ET AL., DEVELOPMENT, vol. 1136, 2009, pages 3215 - 3222 | NAGY, K.; NICHOLS, J.: "Advanced Protocols for Animal Transgenesis. An ISTT Manual", SHIRLEY PEASE & THOMAS L. SAUNDERS, article "Derivation of Murine ES Cell Lines", pages: 431 - 455 | K. BECKER; B. JERCHOW: "Advanced Protocols for Animal Transgenesis. An ISTT Manual", 2011, SHIRLEY PEASE & THOMAS L. SAUNDERS, article "Generation of Transgenic Mice by Pronuclear Microinjection", pages: 99 - 115 | HAMER ET AL., PNAS, vol. 92, no. 25, 1995, pages 11706 - 10 | A. FERNANDEZ; D. MUNOZ; L. MONTOLIU: "Advanced Protocols for Animal Transgenesis. An ISTT Manual", 2011, SHIRLEY PEASE & THOMAS L. SAUNDERS, article "Generation of Transgenic Animals by Use of YACs", pages: 137 - 158 | DAVIES, N. ET AL.: "Antibody Engineering. A Practical Approach", 1996, IRL PRESS AT OXFORD UNIVERSITY PRESS, article "Human antibody repertoires in transgenic mice: manipulation and transfer of YACs", pages: 59 - 76 | "Genbank", Database accession no. X55929.1 | T.J. KINDT; R.A. GOLDSBY; B.A. OSBORNE; J KUBY: "Kuby Immunology, 6th ed.", 2007, W.H. FREEMAN AND COMPANY | BENNY LO: "Antibody Engineering", 2004, article "chapter 8", pages: 161 - 176 | BEBIN AG; CARRION C; MARQUET M; COGNE N; LECARDEUR S; COGNE M; PINAUD E: "In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse", J IMMUNOL., vol. 184, 2010, pages 3710 - 7 | BROWNSTEIN BH; SILVERMAN GA; LITTLE RD; BURKE DT; KORSMEYER SJ; SCHLESSINGER D; OLSON MV: "Isolation of single-copy human genes from a library of yeast artificial chromosome clones", SCIENCE, vol. 244, 1989, pages 1348 - 51, XP001208142, DOI: doi:10.1126/science.2544027 DOI: http://dx.doi.org/10.1126/science.2544027 | CHATTERJEE S; JU Z; HASSAN R; VOLPI SA; EMELYANOV AV; BIRSHTEIN BK: "Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching", J BIOL CHEM., vol. 286, 2011, pages 29303 - 12 | COGNE M; LANSFORD R; BOTTARO A; ZHANG J; GORMAN J; YOUNG F; CHENG HL; ALT FW: "A class switch control region at the 3' end of the immunoglobulin heavy chain locus", CELL, vol. 77, 1994, pages 737 - 47, XP024244761, DOI: doi:10.1016/0092-8674(94)90057-4 DOI: http://dx.doi.org/10.1016/0092-8674(94)90057-4 | DAVIES NP; ROSEWELL IR; BRUGGEMANN M: "Targeted alterations in yeast artificial chromosomes for inter-species gene transfer", NUCLEIC ACIDS RES., vol. 20, 1992, pages 2693 - 8, XP002025624 | GARRETT FE; EMELYANOV AV; SEPULVEDA MA; FLANAGAN P; VOLPI S; LI F; LOUKINOV D; ECKHARDT LA; LOBANENKOV W; BIRSHTEIN BK: "Chromatin architecture near a potential 3' end of the Igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites", MOL CELL BIOL, vol. 25, 2005, pages 1511 - 25 | GIBSON DG; BENDERS GA; AXELROD KC; ZAVERI J; ALGIRE MA; MOODIE M; MONTAGUE MG; VENTER JC; SMITH HO; HUTCHISON CA 3: "One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome", PROCNATIACADSCIUSA, vol. 105, 2008, pages 20404 - 9, XP002584295, DOI: doi:10.1073/PNAS.0811011106 DOI: http://dx.doi.org/10.1073/PNAS.0811011106 | HAMER L; JOHNSTON M; GREEN ED: "Isolation of yeast artificial chromosomes free of endogenous yeast chromosomes: construction of alternate hosts with defined karyotypic alterations", PROCNATLACADSCI USA, vol. 92, 1995, pages 11706 - 10, XP002084324, DOI: doi:10.1073/pnas.92.25.11706 DOI: http://dx.doi.org/10.1073/pnas.92.25.11706 | LIEBERSON R; ONG J; SHI X; ECKHARDT LA: "Immunoglobulin gene transcription ceases upon deletion of a distant enhancer", EMBO J., vol. 14, 1995, pages 6229 - 38, XP001055250 | MANIS JP; VAN DER STOEP N; TIAN M; FERRINI R; DAVIDSON L; BOTTARO A; ALT FW: "Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers", J. EXP. MED., vol. 188, 1998, pages 1421 - 1431 | MARKIE D: "Markers, selection, and media in yeast artificial chromosome cloning", METHODS MOL BIOL., vol. 349, 2006, pages 1 - 12 | NEUBERGER MS: "Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells", EMBO J., vol. 2, 1983, pages 1373 - 8, XP002713612 | PETTERSSON S; COOK GP; BRUGGEMANN M; WILLIAMS GT; NEUBERGER MS: "A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus", NATURE, vol. 344, 1990, pages 165 - 8, XP000652015, DOI: doi:10.1038/344165a0 DOI: http://dx.doi.org/10.1038/344165a0 | SANCHEZ CP; LANZER M: "Construction of yeast artificial chromosome libraries from pathogens and nonmodel organisms", YAC PROTOCOLS, 2ND.METHODS IN MOLECULAR BIOLOGY, vol. 349, 2006, pages 13 - 26 | TOSATO V; WAGHMARE SK; BRUSCHI CV: "Non-reciprocal chromosomal bridge-induced translocation (BIT) by targeted DNA integration in yeast", CHROMOSOMA, vol. 114, no. 1, 2005, pages 15 - 27, XP019342028, DOI: doi:10.1007/s00412-005-0332-x DOI: http://dx.doi.org/10.1007/s00412-005-0332-x | VINCENT-FABERT C; FIANCETTE R; PINAUD E; TRUFFINET V; COGNE N; COGNE M; DENIZOT Y: "Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes", BLOOD, vol. 116, 2010, pages 1895 - 8, XP055130149, DOI: doi:10.1182/blood-2010-01-264689 DOI: http://dx.doi.org/10.1182/blood-2010-01-264689 | VINCENT-FABERT C; TRUFFINET V; FIANCETTE R; COGNE N; COGNE M; DENIZOT Y: "Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region", J IMMUNOL., vol. 182, 2009, pages 6926 - 32 | ZHANG B; ALAIE-PETRILLO A; KON M; LI F; ECKHARDT LA: "Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory region", J IMMUNOL., vol. 178, 2007, pages 6297 - 306 | other | WO2015143414 | WO2014141192 | MURPHY ET AL.: "Janeway's Immunobiology, 7th ed.", 2008, pages: 171 - 175, XP055628376 | DATABASE Nucleotide 6 December 1983 (1983-12-06), XP055628385, retrieved from NCBI Database accession no. V01523 | GILLIES ET AL.: "A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene", CELL, vol. 33, no. 3, 1983, pages 717 - 728, XP000918756 DOI: http://dx.doi.org/10.1016/0092-8674(83)90014-4 | DATABASE Nucleotide 14 February 2002 (2002-02-14), XP055628392, retrieved from NCBI Database accession no. AF446347 | SCHRADER ET AL.: "Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 195, no. 3, 2002, pages 367 - 373, XP055628395 DOI: http://dx.doi.org/10.1084/jem.20011877 | GARRETT ET AL.: "Chromatin Architecture near a Potential 3' End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites", MOLECULAR AND CELLULAR BIOLOGY, vol. 25, no. 4, 2005, pages 1511 - 1525, XP055628379 DOI: http://dx.doi.org/10.1128/MCB.25.4.1511-1525.2005 | MENDEZ ET AL.: "Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice", NATURE GENETICS, vol. 15, 1997, pages 146 - 156, XP002067603 DOI: http://dx.doi.org/10.1038/ng0297-146 | MURPHY ET AL.: "RECOMBINANT ANTIBODIES FOR IMMUNOTHERAPY", 2009, CAMBRIDGE UNIVERSITY PRESS, article "Chapter 8: VelocImmune: Immunoglobulin Variable Region Humanized Mice", pages: 100 - 107, XP055628415 |