blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3768705

EP3768705 - MULTIVALENT BINDING MOLECULES [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  25.12.2020
Database last updated on 25.09.2024
FormerThe international publication has been made
Status updated on  28.09.2019
Formerunknown
Status updated on  20.04.2018
Most recent event   Tooltip22.03.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Universität Stuttgart
Keplerstr. 7
70569 Stuttgart / DE
[2021/04]
Inventor(s)01 / SEIFERT, Oliver
Zuffenhäuser Heide 1
70437 Stuttgart / DE
02 / KONTERMANN, Roland
Gothaer Str. 6
72622 Nürtingen / DE
03 / RICHTER, Fabian
Cranachweg 11
73230 Kirchheim unter Teck / DE
 [2021/04]
Representative(s)Zwicker, Jörk
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[2021/04]
Application number, filing date18716145.022.03.2018
[2021/04]
WO2018EP57331
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019179627
Date:26.09.2019
Language:EN
[2019/39]
Type: A1 Application with search report 
No.:EP3768705
Date:27.01.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 26.09.2019 takes the place of the publication of the European patent application.
[2021/04]
Search report(s)International search report - published on:EP26.09.2019
ClassificationIPC:C07K16/18, C07K16/28, C07K16/32, C07K16/46
[2021/04]
CPC:
C07K16/2878 (EP,US); C07K16/2863 (EP,US); A61K39/39533 (US);
A61P35/00 (US); C07K16/32 (EP,US); C07K16/468 (EP);
A61K38/00 (US); C07K2317/30 (US); C07K2317/526 (EP,US);
C07K2317/60 (EP,US); C07K2317/62 (EP,US); C07K2317/64 (EP,US);
C07K2317/66 (EP,US); C07K2317/73 (EP,US); C07K2317/75 (EP,US);
C07K2317/90 (EP); C07K2317/92 (EP,US); C07K2317/94 (EP,US);
G01N33/5091 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/04]
TitleGerman:MULTIVALENTE BINDUNGSMOLEKÜLE[2021/04]
English:MULTIVALENT BINDING MOLECULES[2021/04]
French:MOLÉCULES DE LIAISON MULTIVALENTES[2021/04]
Entry into regional phase09.10.2020National basic fee paid 
09.10.2020Designation fee(s) paid 
09.10.2020Examination fee paid 
Examination procedure09.10.2020Examination requested  [2021/04]
09.10.2020Date on which the examining division has become responsible
05.05.2021Amendment by applicant (claims and/or description)
Fees paidRenewal fee
09.10.2020Renewal fee patent year 03
22.03.2021Renewal fee patent year 04
22.03.2022Renewal fee patent year 05
22.03.2023Renewal fee patent year 06
21.03.2024Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[XI]WO0202781  (VLAAMS INTERUNIV INST BIOTECH [BE], et al) [X] 1,3-7,10,15 * page 8, line 19 - line 21 * * page 6, line 25 - line 28 * * figures 1,2 * [I] 2,8,9,11-14;
 [Y]WO2007024715  (ABBOTT LAB [US], et al) [Y] 1-15* figure 1 *;
 [A]WO2013156148  (UNIV STUTTGART [DE]) [A] 5-8 * page 1 - page 2 *;
 [XI]US2014213772  (GHAYUR TARIQ [US], et al) [X] 1-10,15 * paragraph [0128]; figure 1; claim 1 * [I] 11-14;
 [A]  - SPIESS CHRISTOPH ET AL, "Alternative molecular formats and therapeutic applications for bispecific antibodies", MOLECULAR IMMUNOLOGY, PERGAMON, GB, (20150127), vol. 67, no. 2, doi:10.1016/J.MOLIMM.2015.01.003, ISSN 0161-5890, pages 95 - 106, XP029246892 [A] 1-15 * figure 1 *

DOI:   http://dx.doi.org/10.1016/j.molimm.2015.01.003
 [Y]  - ANKE STEINMETZ ET AL, "CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications", MABS, US, (20160316), vol. 8, no. 5, doi:10.1080/19420862.2016.1162932, ISSN 1942-0862, pages 867 - 878, XP055343765 [Y] 1-15 * page 868, column 1, paragraph 1; figure 1 *

DOI:   http://dx.doi.org/10.1080/19420862.2016.1162932
by applicantUS2003118592
 US2003133939
    - PRESTA, LG., "Molecular engineering and design of therapeutic antibodies", Curr Opin. Immunol., (20080000), vol. 20, doi:doi:10.1016/j.coi.2008.06.012, pages 460 - 470, XP025771205

DOI:   http://dx.doi.org/10.1016/j.coi.2008.06.012
    - KONTERMANN, "Dual targeting strategies with bispecific antibodies", mAbs, (20120000), vol. 4, doi:doi:10.4161/mabs.4.2.19000, pages 182 - 197, XP009160769

DOI:   http://dx.doi.org/10.4161/mabs.4.2.19000
    - GARBER K., "Bispecific antibodies rise again", Nat. Rev. Drug Discov., (20140000), vol. 13, doi:doi:10.1038/nrd4478, pages 799 - 801, XP055242329

DOI:   http://dx.doi.org/10.1038/nrd4478
    - BRINKMANN; KONTERMANN, "The making of bispecific antibodies", mAbs, (20170000), vol. 9, doi:doi:10.1080/19420862.2016.1268307, pages 182 - 212, XP055374463

DOI:   http://dx.doi.org/10.1080/19420862.2016.1268307
    - SEGAL et al., "Bispecific antibodies in cancer therapy", Curr. Opin. Immunol., (19990000), vol. 11, doi:doi:10.1016/S0952-7915(99)00015-1, pages 558 - 562, XP004257585

DOI:   http://dx.doi.org/10.1016/S0952-7915(99)00015-1
    - KONTERMANN; BRINKMANN, "Bispecific antibodies", Drug Discov. Today, (20150000), vol. 20, doi:doi:10.1016/j.drudis.2015.02.008, pages 838 - 847, XP055251363

DOI:   http://dx.doi.org/10.1016/j.drudis.2015.02.008
    - SPIESS et al., "Alternative molecular formats and therapeutic applications for bispecific antibodies", Mol. Immunol., (20150000), vol. 67, doi:doi:10.1016/j.molimm.2015.01.003, pages 95 - 106, XP029246892

DOI:   http://dx.doi.org/10.1016/j.molimm.2015.01.003
    - WARD et al., Nature, (19890000), vol. 341, pages 544 - 546
    - BIRD et al., Science, (19880000), vol. 242, pages 423 - 426
    - HUSTON et al., Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, pages 5879 - 5883
    - HOLLIGER P. et al., Proc. Natl. Acad. Sci. U.S.A., (19930000), vol. 90, no. 14, pages 6444 - 6448
    - BRODY E.N.; GOLD L., "Aptamers as therapeutic and diagnostic agents", J. Biotechnol., (20000000), vol. 74, no. 1, pages 5 - 13, XP009031105
    - BINZ H.K. et al., "Engineering novel binding proteins from nonimmunoglobulin domains", Nat. Biotechnol., (20050000), vol. 23, no. 10, doi:doi:10.1038/nbt1127, pages 1257 - 1268, XP002381839

DOI:   http://dx.doi.org/10.1038/nbt1127
    - SMITH; WATERMAN, Adv. Appl. Math., (19700000), vol. 2, page 482
    - NEEDLEMAN; WUNSCH, J. Mol. Biol., (19700000), vol. 48, page 443
    - PEARSON; LIPMAN, Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, page 2444
    - ALTSCHUL et al., Nuc. Acids Res., (19770000), vol. 25, pages 3389 - 3402
    - ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, pages 403 - 410
    - HENIKOFF; HENIKOFF, Proc. Natl. Acad. Sci. USA, (19890000), vol. 89, page 10915
    - KARLIN; ALTSCHUL, Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 5873 - 5887
    - NIELSEN et al., Science, (19910000), vol. 254, pages 1497 - 1500
    - CHUDAKOV et al., Physiol. Rev., (20100000), vol. 90, pages 1103 - 1163
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.