EP3615522 - C5-ANILINOQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.06.2022 Database last updated on 03.06.2024 | |
Former | The patent has been granted Status updated on 02.07.2021 | ||
Former | Grant of patent is intended Status updated on 28.03.2021 | ||
Former | Examination is in progress Status updated on 13.08.2020 | ||
Former | Request for examination was made Status updated on 31.01.2020 | ||
Former | The international publication has been made Status updated on 02.11.2018 | ||
Former | unknown Status updated on 15.05.2018 | Most recent event Tooltip | 10.05.2024 | Lapse of the patent in a contracting state New state(s): HU | published on 12.06.2024 [2024/24] | Applicant(s) | For all designated states Astrazeneca AB 151 85 Södertälje / SE | [2021/31] |
Former [2020/10] | For all designated states Astrazeneca AB 151 85 Södertälje / SE | Inventor(s) | 01 /
GRECU, Tudor 1 Francis Crick Avenue Cambridge Biomedical Campus Cambridge Cambridgeshire CB2 0AA / GB | 02 /
KETTLE, Jason, Grant 1 Francis Crick Avenue Cambridge Biomedical Campus Cambridge Cambridgeshire CB2 0AA / GB | 03 /
PACKER, Martin, John 1 Francis Crick Avenue Cambridge Biomedical Campus Cambridge Cambridgeshire CB2 0AA / GB | 04 /
PEARSON, Stuart, Eric 1 Francis Crick Avenue Cambridge Biomedical Campus Cambridge Cambridgeshire CB2 0AA / GB | 05 /
SMITH, James, Michael 1 Francis Crick Avenue Cambridge Biomedical Campus Cambridge Cambridgeshire CB2 0AA / GB | [2020/10] | Representative(s) | Cabinet Becker et Associés 25, rue Louis le Grand 75002 Paris / FR | [2020/10] | Application number, filing date | 18721348.3 | 26.04.2018 | [2020/10] | WO2018EP60798 | Priority number, date | US201762490859P | 27.04.2017 Original published format: US 201762490859 P | [2020/10] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2018197642 | Date: | 01.11.2018 | Language: | EN | [2018/44] | Type: | A1 Application with search report | No.: | EP3615522 | Date: | 04.03.2020 | Language: | EN | The application published by WIPO in one of the EPO official languages on 01.11.2018 takes the place of the publication of the European patent application. | [2020/10] | Type: | B1 Patent specification | No.: | EP3615522 | Date: | 04.08.2021 | Language: | EN | [2021/31] | Search report(s) | International search report - published on: | EP | 01.11.2018 | Classification | IPC: | C07D403/12, C07D405/14, A61K31/517, A61P35/00 | [2020/10] | CPC: |
C07D403/12 (EP,KR,RU,US);
A61K31/517 (KR,RU);
A61K31/5377 (RU);
A61P35/00 (EP,KR,RU,US);
C07D405/14 (EP,RU,US);
A61K2121/00 (KR,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2020/10] | Extension states | BA | 27.11.2019 | ME | 27.11.2019 | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | C5-QUINAZOLIN VERBINDUNGEN UND IHRE VERWENDUNG ZUR KREBSBEHANDLUNG | [2021/15] | English: | C5-ANILINOQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER | [2020/10] | French: | COMPOSÉS DE C5-QUINAZOLEINE ET LEUR UTILISATION POUR LA TRAITENET DE LA CANCER. | [2021/15] |
Former [2020/10] | C5-ANILINOCHINAZOLINVERBINDUNGEN UND IHRE VERWENDUNG ZUR BEHANDLUNG VON KREBS | ||
Former [2020/10] | COMPOSÉS DE C5-ANILINOQUINAZOLINE ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER | Entry into regional phase | 27.11.2019 | National basic fee paid | 27.11.2019 | Designation fee(s) paid | 27.11.2019 | Examination fee paid | Examination procedure | 27.11.2019 | Examination requested [2020/10] | 27.11.2019 | Date on which the examining division has become responsible | 08.06.2020 | Amendment by applicant (claims and/or description) | 12.08.2020 | Despatch of a communication from the examining division (Time limit: M04) | 10.12.2020 | Reply to a communication from the examining division | 29.03.2021 | Communication of intention to grant the patent | 28.06.2021 | Fee for grant paid | 28.06.2021 | Fee for publishing/printing paid | 28.06.2021 | Receipt of the translation of the claim(s) | Opposition(s) | 06.05.2022 | No opposition filed within time limit [2022/28] | Fees paid | Renewal fee | 31.03.2020 | Renewal fee patent year 03 | 19.04.2021 | Renewal fee patent year 04 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 26.04.2018 | AL | 04.08.2021 | AT | 04.08.2021 | CY | 04.08.2021 | CZ | 04.08.2021 | DK | 04.08.2021 | EE | 04.08.2021 | FI | 04.08.2021 | HR | 04.08.2021 | LT | 04.08.2021 | LV | 04.08.2021 | MC | 04.08.2021 | MK | 04.08.2021 | NL | 04.08.2021 | PL | 04.08.2021 | RO | 04.08.2021 | RS | 04.08.2021 | SE | 04.08.2021 | SI | 04.08.2021 | SK | 04.08.2021 | SM | 04.08.2021 | BG | 04.11.2021 | NO | 04.11.2021 | GR | 05.11.2021 | IS | 04.12.2021 | PT | 06.12.2021 | IE | 26.04.2022 | LU | 26.04.2022 | [2024/24] |
Former [2024/23] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CY | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
MC | 04.08.2021 | ||
MK | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SI | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
IE | 26.04.2022 | ||
LU | 26.04.2022 | ||
Former [2024/20] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CY | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
MC | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SI | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
IE | 26.04.2022 | ||
LU | 26.04.2022 | ||
Former [2023/20] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
MC | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SI | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
IE | 26.04.2022 | ||
LU | 26.04.2022 | ||
Former [2023/08] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
MC | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SI | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
LU | 26.04.2022 | ||
Former [2023/06] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
MC | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SI | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/36] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SI | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/29] | AL | 04.08.2021 | |
AT | 04.08.2021 | ||
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/25] | AT | 04.08.2021 | |
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SK | 04.08.2021 | ||
SM | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/24] | AT | 04.08.2021 | |
CZ | 04.08.2021 | ||
DK | 04.08.2021 | ||
EE | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RO | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
SK | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/21] | AT | 04.08.2021 | |
DK | 04.08.2021 | ||
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/16] | AT | 04.08.2021 | |
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
NL | 04.08.2021 | ||
PL | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/10] | AT | 04.08.2021 | |
FI | 04.08.2021 | ||
HR | 04.08.2021 | ||
LT | 04.08.2021 | ||
LV | 04.08.2021 | ||
PL | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
GR | 05.11.2021 | ||
IS | 04.12.2021 | ||
PT | 06.12.2021 | ||
Former [2022/09] | AT | 04.08.2021 | |
FI | 04.08.2021 | ||
LT | 04.08.2021 | ||
RS | 04.08.2021 | ||
SE | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
PT | 06.12.2021 | ||
Former [2022/08] | AT | 04.08.2021 | |
FI | 04.08.2021 | ||
LT | 04.08.2021 | ||
SE | 04.08.2021 | ||
BG | 04.11.2021 | ||
NO | 04.11.2021 | ||
Former [2022/07] | AT | 04.08.2021 | |
LT | 04.08.2021 | ||
NO | 04.11.2021 | Cited in | International search | [A]US2006178382 (MORTLOCK ANDREW A [GB], et al) [A] 1-20 * paragraph [[0008]]; example -; claim - *; | [A]US7709479 (MORTLOCK ANDREW AUSTEN [GB], et al) [A] 1-20 * claim -; table 4 *; | [A] - G-W RAO ET. AL., "Synthesis, Antitumor Evaluation, and Docking Study of Novel 4-Anilinoquinazoline Derivatives as Potential Epidermal Growth Factor (EGFR) Inhibitors.", CHEMMEDCHEM, (20130601), vol. 8, no. 6, doi:10.1002/cmdc.201300120, pages 928 - 933, XP002781576 [A] 1-20 * Table 1, compounds 4a to 4g * DOI: http://dx.doi.org/10.1002/cmdc.201300120 | by applicant | - M. A. LEMMON; K. M. FERGUSON, Cell, (20070000), vol. 130, page 213 | - K. VERSTRAETE; S. N. SAVVIDES, Nat. Rev. Cancer, (20120000), vol. 12, page 753 | - J. LENNARTSSON; L. RONNSTRAND, Physiol Rev., (20120000), vol. 92, page 1619 | - J. P. DINITTO et al., J. Biochem., (20100000), vol. 147, page 601 | - C. BAHLAWANE et al., Cell Commun. Signal., (20150000), vol. 13, page 21 | - C. M. BARNETT; C. L. CORLESS; M. C. HEINRICH, Hematol. Oncol. Clin. North Am., (20130000), vol. 27, page 871 | - S. HIROTA et al., Science, (19980000), vol. 279, page 577 | - J. A. FLETCHER, Cancer Res., (20160000), vol. 76, page 6140 | - G. D. DEMETRI et al., N. Engl. J. Med., (20020000), vol. 347, page 472 | - J. VERWEIJ et al., Lancet, (20040000), vol. 364, page 1127 | - C. D. BLANKE et al., J. Clin. Oncol., (20080000), vol. 26, page 626 | - METAGIST, J. Clin. Oncol., (20100000), vol. 28, page 1247 | - C. R. ANTONESCU et al., Clin. Cancer Res., (20050000), vol. 11, page 4182 | - M. C. HEINRICH et al., J. Clin. Oncol., (20060000), vol. 24, page 4764 | - G. D. DEMETRI et al., Lancet, (20060000), vol. 368, page 1329 | - M. C. HEINRICH et al., J. Clin. Oncol., (20080000), vol. 26, page 5352 | - G. D. DEMETRI et al., Lancet, (20130000), vol. 381, page 295 | - STERN et al., Critical Reviews in Oncology/Haematology, (20050000), vol. 54, pages 1 - 29 |