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Extract from the Register of European Patents

EP About this file: EP3638313

EP3638313 - NON-COVALENTLY ASSEMBLED BIOMATRIX LAYER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.09.2023
Database last updated on 24.08.2024
FormerThe patent has been granted
Status updated on  21.10.2022
FormerGrant of patent is intended
Status updated on  06.07.2022
FormerExamination is in progress
Status updated on  26.11.2021
FormerRequest for examination was made
Status updated on  20.03.2020
FormerThe international publication has been made
Status updated on  22.12.2018
Formerunknown
Status updated on  23.06.2018
Most recent event   Tooltip24.05.2024Lapse of the patent in a contracting state
New state(s): IT
published on 26.06.2024  [2024/26]
Applicant(s)For all designated states
Denovomatrix GmbH
Tatzberg 47/49
01307 Dresden / DE
[2020/17]
Inventor(s)01 / ZHANG, Yixin
Wormser Str. 63
01309 Dresden / DE
02 / THOMAS, Alvin
Karl-Zörgiebel-Str. 50
55128 Mainz / DE
03 / WETZEL, Richard
Glash tter Str. 22
01309 Dresden / DE
04 / HUSMAN, Dejan
Bergmannstr. 43
01309 Dresden / DE
05 / WIEDUWILD, Robert
Gerichtsstr. 14
01069 Dresden / DE
 [2020/33]
Former [2020/22]01 / ZHANG, Yixin
Wormser Str. 63
01309 Dresden / DE
02 / THOMAS, Alvin
Pflügersgrundstr. 40
68169 Mannheim / DE
03 / WETZEL, Richard
Glash tter Str. 22
01309 Dresden / DE
04 / HUSMAN, Dejan
Bergmannstr. 43
01309 Dresden / DE
05 / WIEDUWILD, Robert
Gerichtsstr. 14
01069 Dresden / DE
Former [2020/17]01 / ZHANG, Yixin
Wormser Str. 63
01309 Dresden / DE
02 / THOMAS, Alvin
Augsburger Str. 9
01309 Dresden / DE
03 / WETZEL, Richard
Glash tter Str. 22
01309 Dresden / DE
04 / HUSMAN, Dejan
Bergmannstr. 43
01309 Dresden / DE
05 / WIEDUWILD, Robert
Gerichtsstr. 14
01069 Dresden / DE
Representative(s)Maikowski & Ninnemann Patentanwälte Partnerschaft mbB
Postfach 15 09 20
10671 Berlin / DE
[2020/17]
Application number, filing date18730376.318.06.2018
[2020/17]
WO2018EP66145
Priority number, dateEP2017017635516.06.2017         Original published format: EP 17176355
[2020/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018229304
Date:20.12.2018
Language:EN
[2018/51]
Type: A1 Application with search report 
No.:EP3638313
Date:22.04.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 20.12.2018 takes the place of the publication of the European patent application.
[2020/17]
Type: B1 Patent specification 
No.:EP3638313
Date:23.11.2022
Language:EN
[2022/47]
Search report(s)International search report - published on:EP20.12.2018
ClassificationIPC:A61K47/69, A61K47/60, A61K47/61, A61K47/64, C12N5/00
[2022/26]
CPC:
A61K47/6903 (EP,KR,US); C12N5/0068 (EP,KR,US); A61K47/60 (EP,KR,US);
A61K47/61 (EP,KR); A61K47/64 (EP,KR); A61K47/6435 (EP,KR,US);
C12N2500/32 (EP,KR,US); C12N2533/30 (EP,KR); C12N2533/40 (EP,KR,US) (-)
Former IPC [2020/17]A61K47/69, A61K47/60, A61K47/61, A61K47/64
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/17]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:NICHTKOVALENT ZUSAMMENGESETZTE BIOMATRIXSCHICHT[2022/26]
English:NON-COVALENTLY ASSEMBLED BIOMATRIX LAYER[2020/17]
French:COUCHE DE BIOMATRICE ASSEMBLÉE DE MANIÈRE NON COVALENTE[2022/26]
Former [2020/17]NICHT KOVALENT ANGEORDNETE BIOMATRIXSCHICHT
Former [2020/17]COUCHE BIOMATRICE ASSEMBLÉE DE MANIÈRE NON COVALENTE
Entry into regional phase06.12.2019National basic fee paid 
06.12.2019Designation fee(s) paid 
06.12.2019Examination fee paid 
Examination procedure06.12.2019Examination requested  [2020/17]
06.12.2019Date on which the examining division has become responsible
23.07.2020Amendment by applicant (claims and/or description)
29.11.2021Despatch of a communication from the examining division (Time limit: M04)
30.03.2022Reply to a communication from the examining division
07.07.2022Communication of intention to grant the patent
18.10.2022Fee for grant paid
18.10.2022Fee for publishing/printing paid
18.10.2022Receipt of the translation of the claim(s)
Opposition(s)24.08.2023No opposition filed within time limit [2023/44]
Fees paidRenewal fee
30.06.2020Renewal fee patent year 03
29.06.2021Renewal fee patent year 04
22.06.2022Renewal fee patent year 05
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
IT23.11.2022
LT23.11.2022
LV23.11.2022
MC23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SI23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
IE18.06.2023
LU18.06.2023
BE30.06.2023
[2024/26]
Former [2024/24]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
MC23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SI23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
IE18.06.2023
LU18.06.2023
BE30.06.2023
Former [2024/21]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
MC23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SI23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
IE18.06.2023
LU18.06.2023
Former [2024/15]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
MC23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SI23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
LU18.06.2023
Former [2024/09]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
MC23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SI23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/51]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SI23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/38]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SK23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/37]AL23.11.2022
AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/35]AT23.11.2022
CZ23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RO23.11.2022
RS23.11.2022
SE23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/34]AT23.11.2022
EE23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RS23.11.2022
SE23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/33]AT23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RS23.11.2022
SE23.11.2022
SM23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/29]AT23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
NL23.11.2022
PL23.11.2022
RS23.11.2022
SE23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/25]AT23.11.2022
ES23.11.2022
FI23.11.2022
HR23.11.2022
LT23.11.2022
LV23.11.2022
PL23.11.2022
RS23.11.2022
SE23.11.2022
NO23.02.2023
GR24.02.2023
IS23.03.2023
PT23.03.2023
Former [2023/23]AT23.11.2022
ES23.11.2022
FI23.11.2022
LT23.11.2022
LV23.11.2022
SE23.11.2022
NO23.02.2023
GR24.02.2023
PT23.03.2023
Former [2023/22]AT23.11.2022
ES23.11.2022
FI23.11.2022
LT23.11.2022
SE23.11.2022
NO23.02.2023
PT23.03.2023
Former [2023/20]LT23.11.2022
NO23.02.2023
Cited inInternational search[ID]WO2014040591  (UNIV DRESDEN TECH [DE], et al) [ID] 1-7,9-11,14,16 * page 17, line 25 - page 46, line 6 * * page 11, line 19 - page 12, line 8 * * page 14, line 5 - page 15, line 1 *;
 [ID]  - ROBERT WIEDUWILD ET AL, "Noncovalent Hydrogel Beads as Microcarriers for Cell Culture", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, (20150204), vol. 54, no. 13, doi:10.1002/anie.201411400, ISSN 1433-7851, pages 3962 - 3966, XP055428360 [ID] 1-16 * abstract * * figures 1-5 * * page 3963, column 1, paragraph 2 - page 3964, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1002/anie.201411400
 [ID]  - CHRISTOPH TONDERA ET AL, "In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide-Oligosaccharide Interaction in Immunocompetent Nude Mice", ADVANCED FUNCTIONAL MATERIALS, DE, (20170401), vol. 27, no. 15, doi:10.1002/adfm.201605189, ISSN 1616-301X, page 1605189, XP055428378 [ID] 1-16 * abstract * * page 8, column 2, paragraph 3 - page 9, column 1, paragraph 3 *

DOI:   http://dx.doi.org/10.1002/adfm.201605189
 [ID]  - ROBERT WIEDUWILD ET AL, "Minimal Peptide Motif for Non-covalent Peptide-Heparin Hydrogels", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20130206), vol. 135, no. 8, doi:10.1021/ja312022u, ISSN 0002-7863, pages 2919 - 2922, XP055102301 [ID] 1-7,9-11,14,16 * abstract * * table 1 * * figures 1-3 * * page 2920, column 1, paragraph 2 - page 2921, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1021/ja312022u
by applicantUS6958212
 WO2008124165
 WO2014040591
    - MEI Y; SAHA K; BOGATYREV SR; YANG J; HOOK AL; KALCIOGLU ZI et al., "Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells", Nat Mater, (20100000), vol. 9, no. 9, pages 768 - 778
    - CELIZ AD; SMITH JGW; PATEL AK; HOOK AL; RAJAMOHAN D; GEORGE VT et al., "Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation", Advanced Materials, (20150000), vol. 27, no. 27, pages 4006 - 4012
    - KLAAS M; KANGUR T; VIIL J; MAEMETS-ALLAS K; MINAJEVA A; VADI K et al., "The alterations in the extracellular matrix composition guide the repair of damaged liver tissue", Scientific reports, (20160000), vol. 6, page 27398
    - RANGA A; GOBAA S; OKAWA Y; MOSIEWICZ K; NEGRO A; LUTOLF MP, "3D niche microarrays for systems-level analyses of cell fate", Nature Communications, (20140000), vol. 5, page 4324
    - KLIM JR; LI L; WRIGHTON PJ; PIEKARCZYK MS; KIESSLING LL, "A defined glycosaminoglycan-binding substratum for human pluripotent stem cells", Nat Methods, (20100000), vol. 7, no. 12, doi:doi:10.1038/nmeth.1532, pages 989 - 994, XP055061190

DOI:   http://dx.doi.org/10.1038/nmeth.1532
    - VEGAS AJ; VEISEH O; DOLOFF JC; MA M; TAM HH; BRATLIE K et al., "Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates", Nat Biotech, (20160000), vol. 34, no. 3, doi:doi:10.1038/nbt.3462, pages 345 - 352, XP055335259

DOI:   http://dx.doi.org/10.1038/nbt.3462
    - BEACHLEY VZ; WOLF MT; SADTLER K; MANDA SS; JACOBS H; BLATCHLEY MR et al., "Tissue matrix arrays for high-throughput screening and systems analysis of cell function", Nat Meth, (20150000), vol. 12, no. 12, pages 1197 - 1204
    - WIEDUWILD R; TSURKAN MV; CHWALEK K; MURAWALA P; NOWAK M; FREUDENBERG U et al., "Minimal Peptide Motif for Non-Covalent Peptide-Heparin Hydrogels", J Am Chem Soc, (20130000), vol. 135, no. 8, doi:doi:10.1021/ja312022u, pages 2919 - 2922, XP055102301

DOI:   http://dx.doi.org/10.1021/ja312022u
    - WIEDUWILD R; KRISHNAN S; CHWALEK K; BODEN A; NOWAK M; DRECHSEL D et al., "Noncovalent Hydrogel Beads as Microcarriers for Cell Culture", Angew Chem Int Ed, (20150000), vol. 56, no. 13, pages 1521 - 3773
    - TONDERA, C. et al., "Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide-Oligosaccharide Interaction in Immunocompetent Nude Mice", Adv. Funct. Mater., (20170000), vol. 27, no. 27, doi:doi:10.1002/adfm.201605189, page 1605189, XP055428378

DOI:   http://dx.doi.org/10.1002/adfm.201605189
    - NORI YAMAGUCHI et al., "Rheological Characterization of Polysaccharide-Poly(ethylene glycol) Star Copolymer Hydrogels", BIOMACROMOLECULES, (20050528), vol. 6, no. 4, doi:doi:10.1021/bm0500042, pages 1931 - 1940, XP055102352

DOI:   http://dx.doi.org/10.1021/bm0500042
    - NORI YAMAGUCHI et al., "Polysaccharide poly(ethylene glycol) star copolymer as a scaffold for the production of bioactive hydrogels", BIOMACROMOLECULES, (20050700), vol. 6, no. 4, doi:doi:10.1021/BM050003, pages 1921 - 1930, XP002539059

DOI:   http://dx.doi.org/10.1021/BM050003
    - KYUNG JAE JEONG et al., "Interplay between Covalent and Physical Interactions within Environment Sensitive Hydrogels", BIOMACROMOLECULES, (20090323), vol. 10, no. 5, doi:doi:10.1021/bm801270k, pages 1090 - 1099, XP055102304

DOI:   http://dx.doi.org/10.1021/bm801270k
    - MIKHAIL V. T et al., "Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties", CHEMICAL COMMUNICATIONS, (20091216), vol. 46, no. 7, pages 1141 - 1143
    - MIKHAIL V. TSURKAN et al., "Modular StarPEG-Heparin-Gels with Bifunctional Peptide Linkers", MACROMOLECULAR RAPID COMMUNICATIONS, (20100816), vol. 31, no. 17, doi:doi:10.1002/marc.201000155, pages 1529 - 1533, XP055102320

DOI:   http://dx.doi.org/10.1002/marc.201000155
    - SEAL B. L. et al., "Physical matrices stabilized by enzymatically sensitive covalent crosslinks", ACTA BIOMATERIALIA, (20060501), vol. 2, no. 3, doi:doi:10.1016/j.actbio.2005.12.008, pages 241 - 251, XP028009579

DOI:   http://dx.doi.org/10.1016/j.actbio.2005.12.008
    - ALISON B. PRATT et al., "Synthetic extracellular matrices for in situ tissue engineering", BIOTECHNOLOGY AND BIOENGINEERING, (20040212), vol. 86, no. 1, doi:doi:10.1002/bit.10897, pages 27 - 36, XP055102381

DOI:   http://dx.doi.org/10.1002/bit.10897
    - BRANDON I. SEAL et al., "Physical Polymer Matrices Based on Affinity Interactions between Peptides and Polysaccharides", BIOMACROMOLECULES, (20031101), vol. 4, doi:doi:10.1021/bm0342032, pages 1572 - 1582, XP055102384

DOI:   http://dx.doi.org/10.1021/bm0342032
    - FREUDENBERG U. et al., "A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases", BIOMATERIALS, (20091028), vol. 30, pages 5049 - 5060, XP026420872
    - NIE T. et al., "Production of heparin containing hydrogels for modulating cell responses", ACTA BIOMATERIALIA, (20090300), vol. 5, no. 3, doi:doi:10.1016/j.actbio.2008.12.004, pages 865 - 875, XP025990683

DOI:   http://dx.doi.org/10.1016/j.actbio.2008.12.004
    - BENOIT et al., "The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation", BIOMATERIALS, (20070101), vol. 28, no. 1, doi:doi:10.1016/j.biomaterials.2006.08.033, pages 66 - 77, XP005666653

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2006.08.033
    - BRANDON L. SEAL et al., "Viscoelastic Behavior of Environmentally Sensitive Biomimetic Polymer Matrices", MACROMOLECULES, (20060223), vol. 39, no. 6, doi:doi:10.1021/ma0524528, pages 2268 - 2274, XP055102566

DOI:   http://dx.doi.org/10.1021/ma0524528
    - BARANIAK P.R.; MCDEVITT T.C., "Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential", Cell Tissue Res., (20120300), vol. 347, no. 3, doi:doi:10.1007/s00441-011-1215-5, pages 701 - 11, XP035031359

DOI:   http://dx.doi.org/10.1007/s00441-011-1215-5
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.