blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3573994

EP3573994 - CYSTEAMINE PRODRUGS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  17.02.2023
Database last updated on 29.07.2024
FormerRequest for examination was made
Status updated on  01.11.2019
FormerThe international publication has been made
Status updated on  04.08.2018
Most recent event   Tooltip06.07.2024New entry: Application deemed to be withdrawn: despatch of communication + time limit 
Applicant(s)For all designated states
Children's Hospital Center, d/b/a Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, OH 45229-3039 / US
[2022/22]
Former [2019/49]For all designated states
Adare Pharmaceuticals, Inc.
1200 Lenox Drive, Suite 100
Lawrenceville, NJ 08648 / US
Inventor(s)01 / PERRETT, Stephen
c/o ADARE PHARMACEUTICALS INC.
1200 Lenox Drive
Suite 100
Lawrenceville New Jersey 08648 / US
 [2019/49]
Representative(s)Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
[N/P]
Former [2019/49]Cooley (UK) LLP
Dashwood
69 Old Broad Street
London EC2M 1QS / GB
Application number, filing date18745367.525.01.2018
[2019/49]
WO2018US15218
Priority number, dateUS201762450431P25.01.2017         Original published format: US 201762450431 P
US201762466589P03.03.2017         Original published format: US 201762466589 P
[2019/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018140594
Date:02.08.2018
Language:EN
[2018/31]
Type: A1 Application with search report 
No.:EP3573994
Date:04.12.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 02.08.2018 takes the place of the publication of the European patent application.
[2019/49]
Search report(s)International search report - published on:US02.08.2018
(Supplementary) European search report - dispatched on:EP13.10.2020
ClassificationIPC:C07C329/06, C07C323/25, A61P35/00, A61P25/00, A61P1/00, A61K31/325, A61K31/27
[2020/46]
CPC:
C07C329/06 (EP); A61K31/25 (US); A61K31/573 (US);
A61P1/00 (EP); C07C323/25 (EP); C07C323/60 (US)
Former IPC [2019/49]C07H5/10, C07H15/00, C07H17/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/49]
TitleGerman:CYSTEAMIN-PRODRUGS[2019/49]
English:CYSTEAMINE PRODRUGS[2019/49]
French:PROMÉDICAMENTS DE CYSTÉAMINE[2019/49]
Entry into regional phase13.08.2019National basic fee paid 
13.08.2019Search fee paid 
13.08.2019Designation fee(s) paid 
13.08.2019Examination fee paid 
Examination procedure13.08.2019Examination requested  [2019/49]
01.09.2021Amendment by applicant (claims and/or description)
20.02.2023Despatch of a communication from the examining division (Time limit: M06)
26.06.2023Reply to a communication from the examining division
14.02.2024Despatch of a communication from the examining division (Time limit: M04)
05.07.2024Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
Request for further processing for:The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application
01.09.2021Request for further processing filed
01.09.2021Full payment received (date of receipt of payment)
Request granted
17.09.2021Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
01.09.2021Request for further processing filed
01.09.2021Full payment received (date of receipt of payment)
Request granted
17.09.2021Decision despatched
Fees paidRenewal fee
27.01.2020Renewal fee patent year 03
27.01.2021Renewal fee patent year 04
27.01.2022Renewal fee patent year 05
27.01.2023Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.01.202407   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XP]US2017081279  (NGUYEN MARK QUANG [US]) [XP] 1-15* paragraphs [0110] , [0129] , [0134] , [0147] - [0199] *;
 [XI]  - FROST LISA ET AL, "Synthesis of diacylated [gamma]-glutamyl-cysteamine prodrugs, andin vitroevaluation of their cytotoxicity and intracellular delivery of cysteamine", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, (20151224), vol. 109, doi:10.1016/J.EJMECH.2015.12.027, ISSN 0223-5234, pages 206 - 215, XP029399586 [X] 1,2,5-7,9,12-15 * page 207, scheme 1: cysteine-cysteamine dimer * * page 208; figure 1; compounds 1a-c, 2a-c, 3a-c, 4 * * page 209, scheme 3, compounds 8a-c, 9a-c, 10a-c, 11a-c * * page 211, conclusion * * abstract * [I] 1-15

DOI:   http://dx.doi.org/10.1016/j.ejmech.2015.12.027
 [XI]  - ROBERTS J C ET AL, "THIAZOLIDINE PRODRUGS OF CYSTEAMINE AND CYSTEINE AS RADIOPROTECTIVEAGENTS", RADIATION RESEARCH, ACADEMIC PRESS INC, US, (1995), vol. 143, no. 2, ISSN 0033-7587, pages 203 - 213, XP001029418 [X] 1-5,12-15 * page 204; figure 1; compounds RibCyst, GlcCyst * * abstract * * page 212, column left, paragraph last * [I] 1-15
International search[A]US6340746  (ROBERTS JEANNETTE C [US], et al) [A] 1-3 * Entire Document *;
 [A]US2009048154  (CHAN BILL PIU [CN], et al) [A] 1-3* Entire Document *;
 [A]US2014322315  (DOHIL RANJAN [US], et al) [A] 1-3 * Entire Document *;
 [X]US2016102052  (O'NEIL DEBORAH [GB], et al) [X] 1-3 * para [0039] *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.