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Extract from the Register of European Patents

EP About this file: EP3691683

EP3691683 - METHODS FOR PREVENTING DISULFIDE BOND REDUCTION IN CELL CULTURE HARVEST [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.01.2023
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  11.02.2022
FormerGrant of patent is intended
Status updated on  04.10.2021
FormerExamination is in progress
Status updated on  19.02.2021
FormerRequest for examination was made
Status updated on  10.07.2020
FormerThe international publication has been made
Status updated on  13.04.2019
Formerunknown
Status updated on  30.10.2018
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR		published on 17.07.2024 [2024/29]
Applicant(s)For all designated states
Bayer HealthCare LLC
100 Bayer Boulevard
PO Box 915
Whippany, NJ 07981 / US
[2020/33]
Inventor(s)01 / KWANT, Kathryn
2581 Rosewood Drive
San Bruno, CA 94066 / US
 [2022/11]
Former [2020/33]01 / KWANT, Kathryn
583 59th St.
Apt. B
Oakland, California 94609 / US
Representative(s)BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 50
40789 Monheim am Rhein / DE
[N/P]
Former [2020/33]BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 10
40789 Monheim am Rhein / DE
Application number, filing date18789293.026.09.2018
[2020/33]
WO2018US52800
Priority number, dateUS201762566746P02.10.2017         Original published format: US 201762566746 P
[2020/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019070469
Date:11.04.2019
Language:EN
[2019/15]
Type: A1 Application with search report 
No.:EP3691683
Date:12.08.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 11.04.2019 takes the place of the publication of the European patent application.
[2020/33]
Type: B1 Patent specification 
No.:EP3691683
Date:16.03.2022
Language:EN
[2022/11]
Search report(s)International search report - published on:EP11.04.2019
ClassificationIPC:A61K39/395
[2020/33]
CPC:
A61K39/39591 (EP,IL,KR,US); C07K1/1133 (KR); C07K16/00 (US);
C07K16/065 (KR); C12N15/85 (KR); C12N5/0682 (US);
C12N2510/02 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/33]
Extension statesBA04.05.2020
ME04.05.2020
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR VERHINDERUNG DER DISULFIDBINDUNGSVERRINGERUNG BEI EINER ZELLKULTURERNTE[2020/33]
English:METHODS FOR PREVENTING DISULFIDE BOND REDUCTION IN CELL CULTURE HARVEST[2020/33]
French:PROCÉDÉS POUR EMPÊCHER UNE RÉDUCTION DES LIAISONS DISULFURE DANS UNE RÉCOLTE DE CULTURE CELLULAIRE[2020/33]
Entry into regional phase04.05.2020National basic fee paid 
04.05.2020Designation fee(s) paid 
04.05.2020Examination fee paid 
Examination procedure04.05.2020Examination requested  [2020/33]
04.05.2020Date on which the examining division has become responsible
07.10.2020Amendment by applicant (claims and/or description)
22.02.2021Despatch of a communication from the examining division (Time limit: M04)
24.06.2021Reply to a communication from the examining division
05.10.2021Communication of intention to grant the patent
07.02.2022Fee for grant paid
07.02.2022Fee for publishing/printing paid
07.02.2022Receipt of the translation of the claim(s)
Divisional application(s)EP22155565.9  / EP4074340
Opposition(s)19.12.2022No opposition filed within time limit [2023/08]
Fees paidRenewal fee
14.09.2020Renewal fee patent year 03
15.09.2021Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.09.2018
AL16.03.2022
AT16.03.2022
CY16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
IT16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
MK16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
TR16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
BE30.09.2022
CH30.09.2022
LI30.09.2022
[2024/29]
Former [2024/27]HU26.09.2018
AL16.03.2022
AT16.03.2022
CY16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
IT16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
MK16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
BE30.09.2022
CH30.09.2022
LI30.09.2022
Former [2024/24]HU26.09.2018
AL16.03.2022
AT16.03.2022
CY16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
IT16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
BE30.09.2022
CH30.09.2022
LI30.09.2022
Former [2024/21]AL16.03.2022
AT16.03.2022
CY16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
IT16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
BE30.09.2022
CH30.09.2022
LI30.09.2022
Former [2023/42]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
IT16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
BE30.09.2022
CH30.09.2022
LI30.09.2022
Former [2023/35]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
IT16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
CH30.09.2022
LI30.09.2022
Former [2023/33]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
IE26.09.2022
LU26.09.2022
Former [2023/30]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
LU26.09.2022
Former [2023/22]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
MC16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
Former [2023/10]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SI16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
Former [2023/07]AL16.03.2022
AT16.03.2022
CZ16.03.2022
DK16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
Former [2023/01]AL16.03.2022
AT16.03.2022
CZ16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
Former [2022/51]AT16.03.2022
CZ16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
IS16.07.2022
PT18.07.2022
Former [2022/50]AT16.03.2022
CZ16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
PL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
PT18.07.2022
Former [2022/49]AT16.03.2022
CZ16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SK16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
PT18.07.2022
Former [2022/48]AT16.03.2022
CZ16.03.2022
EE16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
PT18.07.2022
Former [2022/47]AT16.03.2022
ES16.03.2022
FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
RO16.03.2022
RS16.03.2022
SE16.03.2022
SM16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
PT18.07.2022
Former [2022/44]FI16.03.2022
HR16.03.2022
LT16.03.2022
LV16.03.2022
NL16.03.2022
RS16.03.2022
SE16.03.2022
BG16.06.2022
NO16.06.2022
GR17.06.2022
Former [2022/39]FI16.03.2022
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LT16.03.2022
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RS16.03.2022
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NO16.06.2022
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Former [2022/33]LT16.03.2022
NO16.06.2022
Cited inInternational search[I]AU2013203411  (GENENTECH INC) [I] 1-16 * abstract * * page 31 - page 32 *;
 [I]  - WAI KEEN CHUNG ET AL, "Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability : Effects of Antibody Disulfide Bond Reduction", BIOTECHNOLOGY AND BIOENGINEERING, US, (20170601), vol. 114, no. 6, doi:10.1002/bit.26265, ISSN 0006-3592, pages 1264 - 1274, XP055522850 [I] 1-16 * abstract * * page 1264, column 2, paragraph 2 - page 1265, column 1, paragraph 2 * * table 1 * * page 1273, column 2, paragraph 5 - page 1274, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1002/bit.26265
 [I]  - KAO Y H ET AL, "Mechanism of Antibody Reduction in Cell Culture Production Processes", BIOTECHNOLOGY AND BIOENGINEERING, WILEY, US, vol. 107, no. 4, doi:10.1002/BIT.22848, ISSN 0006-3592, (20101101), pages 622 - 632, (20100629), XP002694207 [I] 1-16 * abstract * * page 622, column 2, line last sentence, paragraph 1 * * page 623, column 1, paragraph 2 * * page 629, column 2, paragraph 3 - page 631, column 2, paragraph 1 * * table 1 *

DOI:   http://dx.doi.org/10.1002/bit.22848
 [T]  - LI LAN ET AL, "Low level formation of potent catalytic IgG fragments mediated by disulfide bond instability", MOLECULAR IMMUNOLOGY, PERGAMON, GB, (19960101), vol. 33, no. 7-8, doi:10.1016/0161-5890(96)00021-1, ISSN 0161-5890, pages 593 - 600, XP002519389 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/0161-5890(96)00021-1
 [T]  - KATARINA M HUTTERER, "Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects.", MABS, (20130101), vol. 54, doi:10.4161/mabs.2475, pages 608 - 613, XP055514733 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.4161/mabs.2475
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    - BIRD et al., Science, (19880000), vol. 242, pages 423 - 426
    - HUSTON et al., Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, pages 5879 - 5883
    - WU TT; KABAT EA; BILOFSKY H, Proc Natl Acad Sci U S A., (19751200), vol. 72, no. 12, page 5107
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.