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EP About this file: EP3630975

EP3630975 - ALTERED GUIDE RNAS FOR MODULATING CAS9 ACTIVITY AND METHODS OF USE [Right-click to bookmark this link]
Status	Examination is in progress Status updated on 17.12.2021 Database last updated on 21.05.2024
Former	Request for examination was made Status updated on 06.03.2020
Former	The international publication has been made Status updated on 01.12.2018
Most recent event Tooltip	03.04.2024	New entry: Renewal fee paid
Applicant(s)	For all designated states North Carolina State University 1021 Main Campus Drive 2nd Floor Raleigh, NC 27606 / US
	[2020/15]
Inventor(s)	01 / BARRANGOU, Rodolphe North Carolina State University College of Agriculture and Life Sciences Raleigh North Carolina 27695 / US
	02 / CRAWLEY, Alexandra Briner North Carolina State University College of Agriculture and Life Sciences Raleigh NorthCarolina 27695 / US
	[2020/15]
Representative(s)	HGF HGF Limited 1 City Walk Leeds LS11 9DX / GB
	[N/P]
Former [2020/15]	HGF Limited Delta House 50 West Nile Street Glasgow G1 2NP / GB
Application number, filing date	18806333.3	24.05.2018
	[2020/15]
	WO2018US34322
Priority number, date	US201762511462P	26.05.2017 Original published format: US 201762511462 P
	[2020/15]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2018217981
	Date:	29.11.2018
	Language:	EN
	[2018/48]
	Type:	A1 Application with search report
	No.:	EP3630975
	Date:	08.04.2020
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 29.11.2018 takes the place of the publication of the European patent application.
	[2020/15]
Search report(s)	International search report - published on:	RU	29.11.2018
	(Supplementary) European search report - dispatched on:	EP	09.02.2021
Classification	IPC:	C12N15/11, C12N15/63, C12N9/22, A61K48/00, A61K47/61	[2020/15]
	CPC:	C12N15/63 (EP,US); A61K47/549 (EP,US); C12N15/102 (EP,US); C12N15/111 (EP,US); C12N15/90 (EP,US); C12N9/22 (EP,US); (+) C12N2310/20 (EP,US); C12N2310/3519 (EP,US); C12N2310/533 (EP,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2020/15]
Title	German:	VERÄNDERTE GUIDE-RNAS ZUR MODULIERUNG DER CAS9-AKTIVITÄT UND VERWENDUNGSVERFAHREN	[2020/15]
	English:	ALTERED GUIDE RNAS FOR MODULATING CAS9 ACTIVITY AND METHODS OF USE	[2020/15]
	French:	ARN GUIDES MODIFIÉS POUR MODULER L'ACTIVITÉ CAS9 ET PROCÉDÉS D'UTILISATION	[2020/15]
Entry into regional phase	02.12.2019	National basic fee paid
	02.12.2019	Search fee paid
	02.12.2019	Designation fee(s) paid
	02.12.2019	Examination fee paid
Examination procedure	02.12.2019	Examination requested [2020/15]
	20.07.2021	Amendment by applicant (claims and/or description)
	17.12.2021	Despatch of a communication from the examining division (Time limit: M04)
	18.01.2022	Reply to a communication from the examining division
	26.09.2022	Despatch of a communication from the examining division (Time limit: M04)
	16.01.2023	Reply to a communication from the examining division
Fees paid	Renewal fee
	27.05.2020	Renewal fee patent year 03
	13.05.2021	Renewal fee patent year 04
	13.04.2022	Renewal fee patent year 05
	21.03.2023	Renewal fee patent year 06
	02.04.2024	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]WO2015112896 (UNIV NORTH CAROLINA STATE [US]) [X] 1-15 * the whole document, in particular the claims *;
		[X]US2016186213 (ZHANG FENG [US], et al) [X] 1-15 * the whole document in particular [1060-1075], Table F, Fig.45A, Fig. 45B *;
		[X]US2017002339 (BARRANGOU RODOLPHE [US], et al) [X] 1-15 * the whole document, in particular the claims *;
		[XI]WO2017044776 (UNIV TEXAS TECH SYSTEM [US]) [X] 1-12 * the whole document, in particular the claims and Fig. 1A *[I] 13-15;
		[XI] - YING DANG ET AL, "Optimizing sgRNA structure to improve CRISPR-Cas9 knockout efficiency", GENOME BIOLOGY, (20150101), vol. 16, no. 280, doi:10.1186/s13059-015-0846-3, pages 1 - 10, XP055369116 [X] 1-12 * the whole document, in particular Fig. 1 and 7 * [I] 13-15 DOI: http://dx.doi.org/10.1186/s13059-015-0846-3
	International search	[A]US2016186213 (ZHANG FENG [US], et al) [A] 1-28 * , figs 38A, 38B, claims *;
		[X]WO2017027423 (CARIBOU BIOSCIENCES INC [US]) [X] 1-28 * , examples 1, 3, 8, 10-13, 20, tables 10, 24, claims *;
		[A] - BRINER A. et al., "Guide RNA functional modules direct Cas9 activity and orthogonality", Molecular cell, (20140000), vol. 56, no. 2, pages 333 - 339, XP055376599 [A] 1-28 * , abstract, fig.l * DOI: http://dx.doi.org/10.1016/j.molcel.2014.09.019
		[A] - JINEK M. et al., "A programmable dual-RNADNA endonuclease in adaptive bacterial immunity", Science, (20120800), vol. 337, no. 6096, pages 816 - 821, XP055549487 [A] 1-28 * , abstract, fig.5A * DOI: http://dx.doi.org/10.1126/science.1225829
	by applicant	US2014186919
		WO2015112896
		US2016186213
		US2017002339
		WO2017027423
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		- YING DANG et al., "Optimizing sgRNA structure to improve CRISPR-Cas9 knockout efficiency", GENOME BIOLOGY, (20150101), vol. 16, no. 280, doi:10.1186/s13059-015-0846-3, XP055369116 DOI: http://dx.doi.org/10.1186/s13059-015-0846-3
		- BRINER A. et al., "Guide RNA functional modules direct Cas9 activity and orthogonality", Molecular cell, (20140000), vol. 56, no. 2, doi:10.1016/j.molcel.2014.09.019, pages 333 - 339, XP055376599 DOI: http://dx.doi.org/10.1016/j.molcel.2014.09.019
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		- NISHIMASU et al., Cell, (20140000), vol. 156, no. 5, pages 935 - 949

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